Home Other Building Blocks 119-24-4
119-24-4,MFCD27967230
Catalog No.:AA003JUK

119-24-4 | Pteroic acid

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100mg
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$8.00   $6.00
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250mg
95%
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$12.00   $8.00
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1g
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$21.00   $15.00
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5g
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10g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003JUK
Chemical Name:
Pteroic acid
CAS Number:
119-24-4
Molecular Formula:
C14H12N6O3
Molecular Weight:
312.2835
MDL Number:
MFCD27967230
SMILES:
OC(=O)c1ccc(cc1)NCc1cnc2c(n1)c(=O)[nH]c(n2)N
NSC Number:
14972
Properties
Properties
 
BP:
659.8°C at 760 mmHg  
Form:
Solid  
MP:
>400℃  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
503  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
-0.3  

Literature

Title: A novel (68)Ga-labeled pteroic acid-based pet tracer for tumor imaging via the folate receptor.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20130101

Title: Electrochemically synthesized polymers in molecular imprinting for chemical sensing.

Journal: Analytical and bioanalytical chemistry 20120401

Title: Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

Journal: Toxicology 20120127

Title: Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120116

Title: The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.

Journal: The Journal of biological chemistry 20111230

Title: Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol.

Journal: International journal of pharmaceutics 20111125

Title: Structure-based design of ricin inhibitors.

Journal: Toxins 20111001

Title: 7-Substituted pterins provide a new direction for ricin A chain inhibitors.

Journal: European journal of medicinal chemistry 20110901

Title: Use of ribosome-inactivating proteins from Sambucus for the construction of immunotoxins and conjugates for cancer therapy.

Journal: Toxins 20110501

Title: Electropolymerized molecularly imprinted polymer films of a bis-terthiophene dendron: folic acid quartz crystal microbalance sensing.

Journal: ACS applied materials & interfaces 20110201

Title: Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.

Journal: RNA (New York, N.Y.) 20110101

Title: Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

Journal: Arthritis research & therapy 20110101

Title: Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

Journal: BMC structural biology 20110101

Title: Ligand based virtual screening to find novel inhibitors against plant toxin Ricin by using the ZINC database.

Journal: Bioinformation 20110101

Title: Targeting of nanoparticles: folate receptor.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis.

Journal: PloS one 20100101

Title: Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor.

Journal: Pharmaceutical research 20090601

Title: Calculation of absolute ligand binding free energy to a ribosome-targeting protein as a function of solvent model.

Journal: The journal of physical chemistry. B 20081023

Title: Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.

Journal: Acta crystallographica. Section D, Biological crystallography 20080701

Title: Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site.

Journal: Biochemistry 20080226

Title: Reactivity of conjugated and unconjugated pterins with singlet oxygen (O2(1Deltag)): physical quenching and chemical reaction.

Journal: Photochemistry and photobiology 20070101

Title: Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.

Journal: BMC structural biology 20070101

Title: Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting.

Journal: European journal of nuclear medicine and molecular imaging 20060901

Title: Targeting the tumor-associated folate receptor with an 111In-DTPA conjugate of pteroic acid.

Journal: Journal of the American Chemical Society 20050525

Title: Substituent effects on the photophysical properties of pterin derivatives in acidic and alkaline aqueous solutions.

Journal: Photochemistry and photobiology 20050101

Title: Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design.

Journal: Structure (London, England : 1993) 20040901

Title: Chemiluminescence quenching of pteroic acid-N-sulfonyl-acridinium-9-carboxamide conjugates by folate binding protein.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo.

Journal: Bioconjugate chemistry 20030101

Title: Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding.

Journal: Archives of biochemistry and biophysics 20020601

Title: Synthesis of N-acetyl-D-galactosamine and folic acid conjugated ribozymes.

Journal: Bioconjugate chemistry 20020101

Title: 2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.

Journal: Proteins 20010515

Title: Synthesis and evaluation of pteroic acid-conjugated nitroheterocyclic phosphoramidates as folate receptor-targeted alkylating agents.

Journal: Journal of medicinal chemistry 20010104

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