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1191951-57-1,MFCD18384970
Catalog No.:AA000I82

1191951-57-1 | PHT-427

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Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
10mg
98%
in stock  
$36.00   $25.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000I82
Chemical Name:
PHT-427
CAS Number:
1191951-57-1
Molecular Formula:
C20H31N3O2S2
Molecular Weight:
409.6090
MDL Number:
MFCD18384970
SMILES:
CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
14  
XLogP3:
7.4  

Literature

Title: Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

Journal: Molecular cancer therapeutics 20100301

Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Journal: Bioorganic & medicinal chemistry 20091001

Title: In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Journal: Cancer research 20090615

Title: Structure, regulation and function of PKB/AKT--a major therapeutic target.

Journal: Biochimica et biophysica acta 20040311

Title: Role of Akt signaling in vascular homeostasis and angiogenesis.

Journal: Circulation research 20020628

Title: Meuillet EJ, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17.

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