Title: The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition.
Journal: The FEBS journal 20161101
Title: Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme.
Journal: Scientific reports 20150101
Title: N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts.
Journal: Pflugers Archiv : European journal of physiology 20131001
Title: Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design.
Journal: Clinical and experimental pharmacology & physiology 20130801
Title: Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats.
Journal: American journal of physiology. Heart and circulatory physiology 20121101
Title: Antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline on bile duct ligation induced liver fibrosis in rats.
Journal: World journal of gastroenterology 20121007
Title: N-Acetyl-seryl-aspartyl-lysyl-proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts.
Journal: Pflugers Archiv : European journal of physiology 20121001
Title: MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition.
Journal: Journal of the American Society of Nephrology : JASN 20120901
Title: New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme.
Journal: Biological chemistry 20120501
Title: Establishment and clinical application of a highly sensitive enzyme immunoassay for determination of N-acetyl-seryl-aspartyl-lysyl-proline.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20120401
Title: On-line solid-phase extraction LC-MS/MS for the determination of Ac-SDKP peptide in human plasma from hemodialysis patients.
Journal: Biomedical chromatography : BMC 20120201
Title: Structure based drug design of angiotensin-I converting enzyme inhibitors.
Journal: Current medicinal chemistry 20120101
Title: Anemia in heart failure patients.
Journal: ISRN hematology 20120101
Title: A new antifibrotic target of Ac-SDKP: inhibition of myofibroblast differentiation in rat lung with silicosis.
Journal: PloS one 20120101
Title: Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.
Journal: Scientific reports 20120101
Title: Patterning cells and shear flow conditions: convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response.
Journal: Lab on a chip 20111221
Title: Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.
Journal: British journal of pharmacology 20110801
Title: Angiotensin II binding to angiotensin I-converting enzyme triggers calcium signaling.
Journal: Hypertension (Dallas, Tex. : 1979) 20110501
Title: Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE).
Journal: Current opinion in pharmacology 20110401
Title: Quantification of N-acetyl-seryl-aspartyl-lysyl-proline in hemodialysis patients administered angiotensin-converting enzyme inhibitors by stable isotope dilution liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20110325
Title: Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice.
Journal: Journal of hypertension 20110201
Title: Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension.
Journal: Nutrition & metabolism 20110101
Title: Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors.
Journal: Fibrogenesis & tissue repair 20110101
Title: N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal inflammation and tubulointerstitial fibrosis in rats.
Journal: International journal of molecular medicine 20101201
Title: The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.
Journal: The Journal of biological chemistry 20101112
Title: [Effect of N-acetyl-seryl-aspartyl-lysyl-proline on regulation of expression of ras-raf-ERK1/2 signal transduction pathway in lung of rats with silicosis].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20101001
Title: Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver.
Journal: Journal of hepatology 20100901
Title: The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients.
Journal: Archives of medical science : AMS 20100830
Title: New anti-fibrotic mechanisms of n-acetyl-seryl-aspartyl-lysyl-proline in silicon dioxide-induced silicosis.
Journal: Life sciences 20100814
Title: Ac-SDKP inhibits transforming growth factor-beta1-induced differentiation of human cardiac fibroblasts into myofibroblasts.
Journal: American journal of physiology. Heart and circulatory physiology 20100501
Title: Thymosin beta4 and its posttranslational modifications.
Journal: Annals of the New York Academy of Sciences 20100401
Title: Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases.
Journal: Annals of the New York Academy of Sciences 20100401
Title: Myelopoiesis modulation by ACE hyperfunction in kinin B(1) receptor knockout mice: relationship with AcSDKP levels.
Journal: Chemico-biological interactions 20100330
Title: N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass: council for high blood pressure research.
Journal: Hypertension (Dallas, Tex. : 1979) 20100201
Title: Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis.
Journal: Journal of neuroinflammation 20100101
Title: Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB.
Journal: Journal of inflammation (London, England) 20100101
Title: Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
Journal: PloS one 20100101
Title: Prevention of myocardial fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats.
Journal: Clinical science (London, England : 1979) 20091026
Title: [Role of extracellular signal-regulated kinase 1/2 on inhibition of N-acetyl-seryl-aspartyl-lysyl-proline on proliferation and collagen synthesis of cultured rat pulmonary fibroblasts induced by platelet-derived growth factor].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20090701
Title: [Antifibrotic effects of N-acetyl-seryl-aspartyl-lysyl-proline mediated by regulation of transforming growth factor beta and connective tissue growth factor expression on rats with silicosis].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20090701
Title: Angiotensin-converting enzyme is a modifier of hypertensive end organ damage.
Journal: The Journal of biological chemistry 20090605
Title: N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
Journal: American journal of physiology. Heart and circulatory physiology 20090201
Title: [Antifibrotic effects of N-acetyl-seryl-aspartyl-lysyl-proline mediated by the regulation of MCP-1 and ED-1 expression on rats with silicosis].
Journal: Wei sheng yan jiu = Journal of hygiene research 20081101
Title: Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.
Journal: American journal of physiology. Heart and circulatory physiology 20080901
Title: [Anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline in lung of rat with silicosis].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20080701
Title: Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.
Journal: American journal of physiology. Heart and circulatory physiology 20080301
Title: Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy.
Journal: Kidney international 20080201
Title: Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis.
Journal: Fibrogenesis & tissue repair 20080101
Title: Overexpression of the angiogenic tetrapeptide AcSDKP in human malignant tumors.
Journal: Anticancer research 20080101
Title: Erythropoietin stimulating agents in the management of anemia of chronic kidney disease.
Journal: Patient preference and adherence 20080101
Title: Rationale for combining blockers of the renin-angiotensin system.
Journal: Seminars in nephrology 20070901
Title: Decreased endogenous levels of Ac-SDKP promote organ fibrosis.
Journal: Hypertension (Dallas, Tex. : 1979) 20070701
Title: Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20070301
Title: Characterization and localization of Ac-SDKP receptor binding sites using 125I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts.
Journal: American journal of physiology. Heart and circulatory physiology 20070201
Title: [Effect of AcSDKP on the proliferation and collagen synthesis in cultured rat cardiac fibroblasts stimulated by PDGF].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201
Title: Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
Journal: Nature 20070111
Title: Anemia and heart failure: a cause of progression or only a consequence?
Journal: Heart international 20070101
Title: Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development.
Journal: Leukemia & lymphoma 20060901
Title: Assessment of patients' and physicians' compliance to an ACE inhibitor treatment based on urinary N-acetyl Ser-Asp-Lys-Pro determination in the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) study.
Journal: Diabetes care 20060601
Title: N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators.
Journal: Biochemical and biophysical research communications 20060414
Title: Signaling by the angiotensin-converting enzyme.
Journal: Circulation research 20060414
Title: N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis.
Journal: Journal of the American Society of Nephrology : JASN 20060301
Title: AcSDKP: a new potential marker of malignancy of the thyroid gland.
Journal: Langenbeck's archives of surgery 20060201
Title: Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans.
Journal: Clinical pharmacology and therapeutics 20060101
Title: [Ac-SDKP, a marker of the angiotensin-converting enzyme activity?].
Journal: Annales de biologie clinique 20060101
Title: Therapeutic potential of thymosin-beta4 and its derivative N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) in cardiac healing after infarction.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101
Title: Therapeutic measures in proteinuric nephropathy.
Journal: Kidney international. Supplement 20051201
Title: Angiotensin-converting enzyme inhibitors: a new mechanism of action.
Journal: Circulation 20051018
Title: Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure.
Journal: Circulation 20050920
Title: Synthesis of 4-substituted-3-aminopiperidin-2-ones: application to the synthesis of a conformationally constrained tetrapeptide N-acetyl-Ser-Asp-Lys-Pro.
Journal: The Journal of organic chemistry 20050722
Title: N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice.
Journal: Diabetes 20050301
Title: Usefulness of PKH fluorescent labelling to study leukemic cell proliferation with various cytostatic drugs or acetyl tetrapeptide--AcSDKP.
Journal: BMC cancer 20050101
Title: Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3.
Journal: Circulation 20041109
Title: N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo.
Journal: American journal of physiology. Heart and circulatory physiology 20041101
Title: Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells.
Journal: Blood 20040815
Title: Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20040501
Title: Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.
Journal: Hypertension (Dallas, Tex. : 1979) 20040501
Title: N-Domain angiotensin I-converting enzyme expression in renal artery of Wistar, Wistar Kyoto, and spontaneously hypertensive rats.
Journal: Transplantation proceedings 20040501
Title: Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice.
Journal: The Journal of biological chemistry 20040416
Title: Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction.
Journal: Hypertension (Dallas, Tex. : 1979) 20040201
Title: Local induction of angiotensin-converting enzyme in the kidney as a mechanism of progressive renal diseases.
Journal: Kidney international. Supplement 20031001
Title: Do studies with ACE N- and C-domain-selective inhibitors provide evidence for a non-ACE, non-chymase angiotensin II-forming pathway?
Journal: Circulation research 20030725
Title: The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo.
Journal: Blood 20030415
Title: N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells.
Journal: Journal of the American Society of Nephrology : JASN 20030401
Title: Physiologic consequences of vasopeptidase inhibition in humans: effect of sodium intake.
Journal: Journal of the American Society of Nephrology : JASN 20021001
Title: N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts.
Journal: Hypertension (Dallas, Tex. : 1979) 20020801
Title: Functional consequences of angiotensin-converting enzyme gene polymorphism on N-acetyl-Ser-Asp-Lys-Pro degradation and angiotensin II production.
Journal: Journal of molecular medicine (Berlin, Germany) 20020801
Title: Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline.
Journal: Clinical and experimental pharmacology & physiology 20011201
Title: Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension.
Journal: Circulation 20010626
Title: RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis.
Journal: The Journal of pharmacology and experimental therapeutics 20010501
Title: Synthesis and biological evaluation of analogues of the tetrapeptide N-Acetyl-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of primitive haematopoietic cell proliferation.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20010501
Title: Characterization of immunoreactive acetyl-Ser-Asp-Lys-Pro in human plasma and urine by liquid chromatography-electrospray mass spectrometry.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010305
Title: Inhibitory effect of reactive oxygen species on angiotensin I-converting enzyme (kininase II).
Journal: Clinical and experimental pharmacology & physiology 20010301
Title: Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.
Journal: Hypertension (Dallas, Tex. : 1979) 20010301
Title: Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.
Journal: Experimental hematology 20010201
Title: Antifibrotic effects of N-acetyl-seryl-aspartyl-Lysyl-proline on the heart and kidney in aldosterone-salt hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Bone marrow endothelial cells secrete thymosin beta4 and AcSDKP.
Journal: Experimental hematology 20010101
Title: Angiotensin converting enzymes from human urine of mild hypertensive untreated patients resemble the N-terminal fragment of human angiotensin I-converting enzyme.
Journal: The international journal of biochemistry & cell biology 20010101
Title: Development of an enzyme immunoassay for a stable amidated analog of the hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro.
Journal: Journal of immunoassay & immunochemistry 20010101
Title: Activity of acetyl-Ser-Asp-Lys-Pro (AcSDKP) on human hematopoietic progenitor cells in short-term and long-term bone marrow cultures.
Journal: Journal of hematotherapy & stem cell research 20000801
Title: Angiotensin I-converting enzyme isoforms (high and low molecular weight) in urine of premature and full-term infants.
Journal: Hypertension (Dallas, Tex. : 1979) 20000601
Title: Captopril inhibits in vitro and in vivo the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation but has no effect on myeloid leukaemia cell proliferation.
Journal: British journal of haematology 20000601
Title: Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells.
Journal: Blood 20000501
Title: Coumarin-Ser-Asp-Lys-Pro-OH, a fluorescent substrate for determination of angiotensin-converting enzyme activity via high-performance liquid chromatography.
Journal: Analytical biochemistry 20000410
Title: Effect of angiotensin-converting enzyme inhibition on plasma, urine, and tissue concentrations of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro in rats.
Journal: The Journal of pharmacology and experimental therapeutics 19991201
Title: In vivo assessment of captopril selectivity of angiotensin I-converting enzyme inhibition: differential inhibition of acetyl-ser-asp-lys-pro and angiotensin I hydrolysis.
Journal: The Journal of pharmacology and experimental therapeutics 19990601
Title: N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline.
Journal: Biochemical pharmacology 19990315
Title: Chronopharmacologic aspects of continuous AcSDKP infusion in mice.
Journal: Experimental hematology 19990101
Title: Lisinopril, an angiotensin I-converting enzyme inhibitor, prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo.
Journal: Experimental hematology 19981001
Title: In vivo modifications of AcSDKP metabolism and haematopoiesis in mice treated with 5-fluorouracil and Goralatide.
Journal: European journal of clinical investigation 19981001
Title: The tetrapeptide AcSDKP reduces the sensitivity of murine CFU-MK and CFU-GM progenitors to aracytine in vitro and in vivo.
Journal: International journal of hematology 19980801
Title: Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I.
Journal: Molecular pharmacology 19970601
Title: Single-domain angiotensin I converting enzyme (kininase II): characterization and properties.
Journal: The Journal of pharmacology and experimental therapeutics 19961201
Title: In vivo effect of platelet factor 4 (PF4) and tetrapeptide AcSDKP on haemopoiesis of mice treated with 5-fluorouracil.
Journal: British journal of haematology 19960901
Title: Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity.
Journal: The Biochemical journal 19960815
Title: Catabolism of the hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro: a new insight into the physiological role of the angiotensin-I-converting enzyme N-active site.
Journal: Bioorganic & medicinal chemistry 19960701
Title: Inhibitory peptides in hematopoiesis.
Journal: Experimental hematology 19950601
Title: The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme.
Journal: The Journal of biological chemistry 19950224
Title: Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl-seryl-aspartyl-lysyl-proline.
Journal: The Biochemical journal 19931201
Title: Serum levels of a negative regulator of cell proliferation (AcSDKP) are increased in certain human haemopathies.
Journal: Leukemia 19930601
Title: Catabolism of the tetrapeptide N-Ac-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of hematopoietic stem cell (CFU-S) proliferation, following in vitro incubation with hematopoietic tissues from normal and leukemic mice.
Journal: Bulletin du cancer 19930501
Title: Optimization of cell culture conditions for the evaluation of the biological activities of the tetrapeptide N-Acetyl-Ser-Asp-Lys-Pro, a natural hemoregulatory factor.
Journal: Growth factors (Chur, Switzerland) 19930101
Title: Haemoprotection against cytostatic drugs by stem cell inhibition.
Journal: Trends in pharmacological sciences 19910801
Title: Formation of acetyl-Ser-Asp-Lys-Pro, a new regulator of the hematopoietic system, through enzymatic processing of thymosin beta 4.
Journal: Annals of the New York Academy of Sciences 19910101
Title: In vivo effect of the tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro, on the G1-S transition of rat hepatocytes.
Journal: Cell and tissue kinetics 19900301
Title: Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19890201
Title: Suppression of mast cell colony formation by a low molecular weight fraction of fetal calf bone marrow extract.
Journal: Leukemia research 19890101
