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120373-24-2,MFCD00886951
Catalog No.:AA007PZX

120373-24-2 | Unoprostone isopropyl ester

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1mg
≥95%
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$82.00   $57.00
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5mg
≥95%
in stock  
$368.00   $257.00
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10mg
≥95%
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$652.00   $456.00
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50mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007PZX
Chemical Name:
Unoprostone isopropyl ester
CAS Number:
120373-24-2
Molecular Formula:
C25H44O5
Molecular Weight:
424.6139
MDL Number:
MFCD00886951
SMILES:
CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C/CCCC(=O)OC(C)C)O
Properties
Computed Properties
 
Complexity:
514  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
17  
XLogP3:
4.9  

Literature

Title: Improvement of central retinal sensitivity six months after topical isopropyl unoprostone in patients with retinitis pigmentosa.

Journal: Indian journal of ophthalmology 20130301

Title: Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease.

Journal: Expert opinion on pharmacotherapy 20130101

Title: Topical isopropyl unoprostone for retinitis pigmentosa: microperimetric results of the phase 2 clinical study.

Journal: Ophthalmology and therapy 20121201

Title: Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle.

Journal: Investigative ophthalmology & visual science 20120807

Title: Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels.

Journal: Molecular vision 20110101

Title: Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells.

Journal: Investigative ophthalmology & visual science 20091101

Title: Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20090401

Title: Local effect of topical FP-receptor agonists on retinal vessels of the ipsilateral posterior retina in normal rabbit eyes.

Journal: Clinical & experimental ophthalmology 20081101

Title: Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage.

Journal: Visual neuroscience 20080101

Title: Effects of topical travoprost and unoprostone on optic nerve head circulation in normal rabbits.

Journal: Current eye research 20070901

Title: Mechanism of unoprostone-induced cytosolic Ca2+ mobility in cultured porcine corneal endothelial cells.

Journal: Experimental eye research 20070801

Title: Cellular and molecular effects of unoprostone as a BK channel activator.

Journal: Biochimica et biophysica acta 20070501

Title: Travoprost compared with other prostaglandin analogues or timolol in patients with open-angle glaucoma or ocular hypertension: meta-analysis of randomized controlled trials.

Journal: Clinical & experimental ophthalmology 20061101

Title: [Long-term effects of isopropyl unoprostone monotherapy on intraocular pressure and visual field for normal-tension glaucoma and primary open-angle glaucoma patients].

Journal: Nippon Ganka Gakkai zasshi 20060901

Title: The effect of unoprostone isopropyl on Ca2+ release-activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060801

Title: Rescula as an alternative therapy for beta-blockers with long-term drift effect in glaucoma patients.

Journal: The Kaohsiung journal of medical sciences 20060601

Title: Sorption of unoprostone isopropyl to packaging materials.

Journal: International journal of pharmaceutics 20060113

Title: Additional reduction in intraocular pressure achieved with latanoprost in normal-tension glaucoma patients previously treated with unoprostone.

Journal: Japanese journal of ophthalmology 20060101

Title: The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling.

Journal: Cellular and molecular neurobiology 20060101

Title: The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice.

Journal: Investigative ophthalmology & visual science 20051101

Title: The efficacy of unoprostone isopropyl as an adjunct to topical beta-blocker in patients with open angle glaucoma: a-6-month study.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101

Title: Intraocular metabolites of isopropyl unoprostone.

Journal: Current eye research 20051001

Title: Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation.

Journal: Investigative ophthalmology & visual science 20050601

Title: Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model.

Journal: Experimental dermatology 20050501

Title: Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20050201

Title: Brimonidine 0.2% vs unoprostone 0.15% both added to timolol maleate 0.5% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

Journal: Eye (London, England) 20050101

Title: Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium.

Journal: Experimental eye research 20050101

Title: The effects of bimatoprost and unoprostone isopropyl on the intraocular pressure of normal cats.

Journal: Veterinary ophthalmology 20050101

Title: Effect of topical unoprostone isopropyl on optic nerve head circulation in controls and in normal-tension glaucoma patients.

Journal: Japanese journal of ophthalmology 20050101

Title: Effects of unoprostone and endothelin 1 on L-type channel currents in human trabecular meshwork cells.

Journal: Ophthalmic research 20050101

Title: Increase in outflow facility with unoprostone treatment in ocular hypertensive patients.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20041201

Title: Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro.

Journal: Current eye research 20041201

Title: Intraocular pressure fluctuations in response to the water-drinking provocative test in patients using latanoprost versus unoprostone.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041001

Title: Effect of different dose schedules of 0.15% unoprostone isopropyl on intraocular pressure and pupil size in the glaucomatous beagle.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041001

Title: Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%.

Journal: Ophthalmology 20040801

Title: The safety and efficacy of unoprostone 0.15% versus brimonidine 0.2%.

Journal: Acta ophthalmologica Scandinavica 20040401

Title: [Recent changes in glaucoma management].

Journal: Nippon Ganka Gakkai zasshi 20040401

Title: [The effect of substituting latanoprost 0.005% for unoprostone 0.12%].

Journal: Nippon Ganka Gakkai zasshi 20040401

Title: Vasodilatory mechanism of unoprostone isopropyl on isolated rabbit ciliary artery.

Journal: Current eye research 20040301

Title: [Long-term efficacy and safety of combined topical antiglaucoma therapy--timolol & unoprostone vs. betaxolol & unoprostone].

Journal: Nippon Ganka Gakkai zasshi 20040101

Title: [Theoretical and clinical aspects of the use of prostaglandins in glaucoma therapy].

Journal: Klinika oczna 20040101

Title: [Latanoprost topical ophthalmic combinations].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20040101

Title: Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy.

Journal: Journal of glaucoma 20031201

Title: Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

Title: Comparison of iridial pigmentation between latanoprost and isopropyl unoprostone: a long term prospective comparative study.

Journal: The British journal of ophthalmology 20030801

Title: Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.

Journal: Journal of glaucoma 20030801

Title: Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide.

Journal: The British journal of ophthalmology 20030501

Title: Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues.

Journal: Investigative ophthalmology & visual science 20030201

Title: Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

Journal: American journal of ophthalmology 20030201

Title: Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20030101

Title: Safety of unoprostone isopropyl 0.15% ophthalmic solution in patients with mild to moderate asthma.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

Title: Unoprostone isopropyl pretreatment decreases endothelin-1 release and the intra-ocular pressure spike induced by laser trabeculoplasty in the rabbit.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

Title: Randomized clinical trial of latanoprost and unoprostone in patients with elevated intraocular pressure.

Journal: American journal of ophthalmology 20021201

Title: A comparative clinical study of latanoprost and isopropyl unoprostone in Japanese patients with primary open-angle glaucoma and ocular hypertension.

Journal: Journal of glaucoma 20021201

Title: Comparative effects of latanoprost (Xalatan) and unoprostone (Rescula) in patients with open-angle glaucoma and suspected glaucoma.

Journal: American journal of ophthalmology 20021001

Title: Reappraising first-line treatment in glaucoma management.

Journal: Hospital medicine (London, England : 1998) 20020901

Title: Current status of prostaglandin therapy: latanoprost and unoprostone.

Journal: Survey of ophthalmology 20020801

Title: Mechanism and clinical significance of prostaglandin-induced iris pigmentation.

Journal: Survey of ophthalmology 20020801

Title: Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020801

Title: Comparison of the cardiovascular effects of unoprostone 0.15%, timolol 0.5% and placebo in healthy adults during exercise using a treadmill test.

Journal: Acta ophthalmologica Scandinavica 20020601

Title: Cystoid macular edema associated with ocular hypotensive lipids.

Journal: American journal of ophthalmology 20020301

Title: Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20020301

Title: Prostaglandin analog treatment of glaucoma and ocular hypertension.

Journal: The Annals of pharmacotherapy 20020301

Title: Effects of isopropyl unoprostone and latanoprost on melanogenesis in mouse epidermal melanocytes.

Journal: Journal of glaucoma 20020201

Title: A double-masked randomized comparison of the efficacy and safety of unoprostone with timolol and betaxolol in patients with primary open-angle glaucoma including pseudoexfoliation glaucoma or ocular hypertension. 6 month data.

Journal: American journal of ophthalmology 20020101

Title: Additive effect of unoprostone and latanoprost in patients with elevated intraocular pressure.

Journal: The British journal of ophthalmology 20020101

Title: Pharmacological considerations in the treatment of glaucoma.

Journal: Managed care (Langhorne, Pa.) 20020101

Title: Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus.

Journal: Japanese journal of ophthalmology 20020101

Title: Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism.

Journal: Experimental eye research 20020101

Title: Effects of isopropyl unoprostone, latanoprost, and prostaglandin E(2) on acute rise of aqueous flare in pigmented rabbits.

Journal: Ophthalmic research 20020101

Title: Safety of unoprostone isopropyl as mono- or adjunctive therapy in patients with primary open-angle glaucoma or ocular hypertension.

Journal: Drug safety 20020101

Title: Neuroprotective properties of a synthetic docosanoid, unoprostone isopropyl: clinical benefits in the treatment of glaucoma.

Journal: Drugs under experimental and clinical research 20020101

Title: Mechanisms of action of unoprostone on trabecular meshwork contractility.

Journal: Investigative ophthalmology & visual science 20011201

Title: A comparison of intraocular pressure-lowering effect of prostaglandin F2 -alpha analogues, latanoprost, and unoprostone isopropyl.

Journal: Journal of glaucoma 20011201

Title: Effect of topical unoprostone on circulation of human optic nerve head and retina.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201

Title: Effects of latanoprost and unoprostone when used alone or in combination for open-angle glaucoma.

Journal: American journal of ophthalmology 20011001

Title: Studies on receptor binding and signal transduction pathways of unoprostone isopropyl.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011001

Title: Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%.

Journal: American journal of ophthalmology 20010901

Title: Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%.

Journal: American journal of ophthalmology 20010901

Title: Isopropyl unoprostone increases the activities of matrix metalloproteinases in cultured monkey ciliary muscle cells.

Journal: Journal of glaucoma 20010801

Title: Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles.

Journal: Investigative ophthalmology & visual science 20010601

Title: A randomized double-masked crossover study comparing latanoprost 0.005% with unoprostone 0.12% in patients with primary open-angle glaucoma and ocular hypertension.

Journal: American journal of ophthalmology 20010501

Title: Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit.

Journal: American journal of ophthalmology 20010501

Title: The pros and cons of different prostanoids in the medical management of glaucoma.

Journal: Current opinion in ophthalmology 20010401

Title: In vitro corneal permeation of unoprostone isopropyl (UI) and its metabolism in the isolated pig eye.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401

Title: [Effects of topical prostaglandin analogues on the aqueous flare intensity in rabbit eyes at an early phase of endotoxin-induced uveitis].

Journal: Nippon Ganka Gakkai zasshi 20010401

Title: Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%.

Journal: American journal of ophthalmology 20010301

Title: A double-masked, randomized clinical trial comparing latanoprost with unoprostone in patients with open-angle glaucoma or ocular hypertension.

Journal: Ophthalmology 20010201

Title: Intraocular pressure-lowering efficacy of latanoprost in patients with normal-tension glaucoma or primary open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010201

Title: An evaluation of the effect of unoprostone isopropyl 0.15% on ocular hemodynamics in normal-tension glaucoma patients.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010201

Title: Effects of isopropyl unoprostone ophthalmic solution on cultured rabbit corneal epithelial cells.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

Title: Effects of isopropyl unoprostone on melanogenesis in mouse epidermal melanocytes.

Journal: Japanese journal of ophthalmology 20010101

Title: Photoreceptor protection against constant light-induced damage by isopropyl unoprostone, a prostaglandin F(2alpha) metabolite-related compound.

Journal: Ophthalmic research 20010101

Title: [Clinical evaluation of isopropyl unoprostone (Rescula), in the adjunctive treatment of primary open angle glaucoma].

Journal: Klinika oczna 20010101

Title: [Pharmacodynamics and pharmacokinetics of prostaglandins and their derivates in eye tissues].

Journal: Klinika oczna 20010101

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Tags:120373-24-2 Molecular Formula|120373-24-2 MDL|120373-24-2 SMILES|120373-24-2 Unoprostone isopropyl ester