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1214-47-7,MFCD00016441
Catalog No.:AA00339Y

1214-47-7 | 2'-Hydroxychalcone

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5g
98%
in stock  
$23.00   $16.00
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25g
98%
in stock  
$62.00   $43.00
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100g
98%
in stock  
$96.00   $68.00
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500g
98%
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$116.00   $82.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00339Y
Chemical Name:
2'-Hydroxychalcone
CAS Number:
1214-47-7
Molecular Formula:
C15H12O2
Molecular Weight:
224.2546
MDL Number:
MFCD00016441
SMILES:
O=C(c1ccccc1O)/C=C/c1ccccc1
Properties
Properties
 
BP:
396.566 °C at 760 mmHg  
Form:
Solid  
MP:
86-88 °C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
277  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Downstream Synthesis Route

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Literature

Title: Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues.

Journal: Bioorganic & medicinal chemistry letters 20141101

Title: Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

Journal: Pharmacological research 20131001

Title: 2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.

Journal: Chemico-biological interactions 20130525

Title: Efficient NIR-light emission from solid-state complexes of boron difluoride with 2'-hydroxychalcone derivatives.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20121001

Title: Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Synthesis of chalcone derivatives as potential anti-diabetic agents.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.

Journal: Bioorganic & medicinal chemistry 20120101

Title: Solid-phase synthesis of 2'-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines.

Journal: Bioorganic & medicinal chemistry 20120101

Title: [Synthesis of structural fragments of natural flavonoids and flavolignans from 2'-hydroxychalcones].

Journal: Bioorganicheskaia khimiia 20120101

Title: Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.

Journal: European journal of medicinal chemistry 20101201

Title: Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Synthesis of stilbene-fused 2'-hydroxychalcones and flavanones.

Journal: Bioorganic chemistry 20100801

Title: Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones.

Journal: Journal of the American Chemical Society 20100602

Title: Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.

Journal: Journal of medicinal chemistry 20091126

Title: Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: High-performance liquid chromatography separation of enantiomers of flavanone and 2'-hydroxychalcone under reversed-phase conditions.

Journal: Journal of chromatography. A 20080509

Title: Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20070515

Title: Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile.

Journal: Life sciences 20070320

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Heme oxygenase-1 mediates the anti-inflammatory actions of 2'-hydroxychalcone in RAW 264.7 murine macrophages.

Journal: American journal of physiology. Cell physiology 20060401

Title: Synthesis and PPAR-gamma ligand-binding activity of the new series of 2'-hydroxychalcone and thiazolidinedione derivatives.

Journal: Chemical & pharmaceutical bulletin 20060301

Title: Microwave-assisted reaction of 2'-hydroxychalcones with hydrazides to synthesize flavanone hydrazone and 4,5-dihydropyrazole derivatives.

Journal: Journal of combinatorial chemistry 20060101

Title: Hydroxychalcones exhibit differential effects on XRE transactivation.

Journal: Toxicology 20050214

Title: Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells.

Journal: Biochemical pharmacology 20040415

Title: Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore.

Journal: Chemical research in toxicology 20031001

Title: Mechanistic approach to the cyclization reaction of a 2'-hydroxychalcone analogue with light and solvent.

Journal: Organic & biomolecular chemistry 20030621

Title: Efficient liquid-phase synthesis of 2'-hydroxychalcones.

Journal: Bioorganic & medicinal chemistry letters 20021007

Title: Chalcones and flavonoids as anti-tuberculosis agents.

Journal: Bioorganic & medicinal chemistry 20020801

Title: Inhibition of prostalglandin E2 production by 2'-hydoxychalcone derivatives and the mechanism of action.

Journal: The Journal of pharmacy and pharmacology 20010901

Title: Cytotoxic flavonoids with isoprenoid groups from Morus mongolica.

Journal: Journal of natural products 20010201

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

Journal: Anticancer research 20000101

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Tags:1214-47-7 Molecular Formula|1214-47-7 MDL|1214-47-7 SMILES|1214-47-7 2'-Hydroxychalcone