Home Other Building Blocks 122-00-9
122-00-9,MFCD00008751
Catalog No.:AA003411

122-00-9 | 4'-Methylacetophenone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
97%
in stock  
$7.00   $5.00
- +
100g
97%
in stock  
$12.00   $8.00
- +
500g
97%
in stock  
$46.00   $32.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003411
Chemical Name:
4'-Methylacetophenone
CAS Number:
122-00-9
Molecular Formula:
C9H10O
Molecular Weight:
134.1751
MDL Number:
MFCD00008751
SMILES:
Cc1ccc(cc1)C(=O)C
NSC Number:
9401
FEMA Number:
2677
Properties
Properties
 
BP:
226°C at 760 mmHg  
Form:
Liquid  
MP:
22-24°C  
Refractive Index:
n20/D 1.533(lit.)  
Solubility:
2.07g/l  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
121  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.1  

Upstream Synthesis Route

[1]JustusLiebigsAnnalenderChemie,1956,vol.600,p.176,188

[1]ChineseChemicalLetters,2014,vol.25,#1,p.179-182

[2]Synlett,2005,#17,p.2664-2666

[3]EuropeanJournalofOrganicChemistry,2006,#2,p.483-488

[4]EuropeanJournalofOrganicChemistry,2006,#2,p.483-488

[5]Biochemistry,2010,vol.49,#36,p.7913-7919

[6]TetrahedronLetters,2011,vol.52,#11,p.1217-1221

[1]Heterocycles,1992,vol.34,#4,p.747-756

[2]SyntheticCommunications,2013,vol.43,#19,p.2603-2614

[3]RSCAdvances,2014,vol.4,#49,p.25898-25903

[4]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2012,vol.51,#11,p.1649-1654

[5]TetrahedronLetters,2012,vol.53,#2,p.191-195

[6]TetrahedronLetters,2016,vol.57,#9,p.1031-1034

[7]MedicinalChemistryResearch,2016,vol.25,#10,p.2335-2348

[8]SyntheticCommunications,2003,vol.33,#8,p.1399-1403

[9]SyntheticCommunications,2016,vol.46,#2,p.165-168

[10]Patent:WO2007/64444,2007,A1,.Locationinpatent:Page/Pagecolumn12

[11]Heterocycles,2012,vol.85,#11,p.2693-2712

[12]RSCAdvances,2016,vol.6,#79,p.75651-75663

[13]SyntheticCommunications,2006,vol.36,#19,p.2877-2881

[14]JournalofHeterocyclicChemistry,2013,vol.50,#SUPPL.1,p.E126-E130

[15]JournalofMedicinalChemistry,2014,vol.57,#15,p.6572-6582

[16]BioorganicandMedicinalChemistryLetters,2016,vol.26,#23,p.5749-5753

[17]ChemistryLetters,2006,vol.35,#3,p.270-271

[18]SyntheticCommunications,2007,vol.37,#1,p.87-90

[19]AustralianJournalofChemistry,2007,vol.60,#5,p.358-362

[20]Patent:US2007/281965,2007,A1,.Locationinpatent:Page/Pagecolumn53

[21]TetrahedronLetters,2016,vol.57,#44,p.4918-4921

[22]BulletinoftheChemicalSocietyofJapan,1987,vol.60,#3,p.1159-1160

[23]OrientalJournalofChemistry,2012,vol.28,#1,p.153-164

[24]SyntheticCommunications,2010,vol.40,#12,p.1736-1742

[25]BioorganicandMedicinalChemistryLetters,2017,vol.27,#6,p.1379-1384

[26]MedChemComm,2017,vol.8,#12,p.2258-2262

[27]RSCAdvances,2014,vol.4,#107,p.62308-62320

[28]TetrahedronLetters,2003,vol.44,#3,p.439-442

[29]SyntheticCommunications,2003,vol.33,#11,p.1917-1922

[30]EuropeanJournalofOrganicChemistry,2013,#8,p.1551-1557

[31]BioorganicandMedicinalChemistryLetters,2018,vol.28,#17,p.2861-2864

[32]Patent:CN108623537,2018,A,.Locationinpatent:Paragraph0093;0094

[33]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2005,vol.44,#1,p.184-187

[34]ACSMedicinalChemistryLetters,2016,vol.7,#7,p.686-691

[35]Patent:WO2005/40163,2005,A1,.Locationinpatent:Page/Pagecolumn61

[36]BioorganicandMedicinalChemistry,2006,vol.14,#21,p.7146-7153

[37]SyntheticCommunications,2014,vol.44,#2,p.181-187

[38]Patent:CN107629023,2018,A,.Locationinpatent:Paragraph0125;0129;0130;0131

[39]Patent:CN107629022,2018,A,.Locationinpatent:Paragraph0204;0205;0206;0207;0208

[40]BulletinoftheChemicalSocietyofJapan,1994,vol.67,#6,p.1769-1772

[41]BulletindelaSocieteChimiquedeFrance,1980,vol.2,#7-8,p.385-388

[42]BulletindelaSocieteChimiquedeFrance,1980,vol.2,#7-8,p.389-394

[43]ChemischeBerichte,1897,vol.30,p.576

[44]BulletindelaSocieteChimiquedeFrance,1897,vol.<3>17,p.909

[45]BulletindelaSocieteChimiquedeFrance,1898,vol.<3>19,p.138

[46]JournaloftheIndianChemicalSociety,1926,vol.3,p.209

[47]Chem.Zentralbl.,1927,vol.98,#I,p.608

[48]ChemischeBerichte,1944,vol.77/79,p.585,587,588

[49]JournaloftheIndianChemicalSociety,1948,vol.25,p.69,80

[50]JournalofMedicinalChemistry,1963,vol.6,p.751-755

[51]Farmaco,1991,vol.46,#SUPPL.1,p.277-288

[52]JournaloftheIndianChemicalSociety,1985,vol.62,#9,p.654-656

[53]JournalfurPraktischeChemie,1981,vol.323,#1,p.159-163

[54]JournalofMedicinalChemistry,1987,vol.30,#8,p.1497-1502

[55]OrganicMagneticResonance,1984,vol.22,#3,p.199-200

[56]IndianJournalofChemistry,SectionB:OrganicChemistryIncludingMedicinalChemistry,1995,vol.34,#9,p.816-822

[57]ChemicalandPharmaceuticalBulletin,1992,vol.40,#5,p.1170-1176

[58]CollectionofCzechoslovakChemicalCommunications,1993,vol.58,#8,p.1898-1904

[59]JournalofPharmaceuticalSciences,1982,vol.71,#5,p.556-561

[60]JournalofPhysicalChemistry,1995,vol.99,#20,p.8190-8195

[61]ScientiaPharmaceutica,1994,vol.62,#4,p.389-403

[62]LiebigsAnnales,1996,#4,p.439-446

[63]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1996,vol.35,#12,p.1329-1330

[64]SyntheticCommunications,1999,vol.29,#12,p.2069-2078

[65]Arzneimittel-Forschung/DrugResearch,2001,vol.51,#10,p.839-842

[66]EuropeanJournalofMedicinalChemistry,2002,vol.37,#4,p.339-347

[67]Journalofagriculturalandfoodchemistry,2002,vol.50,#12,p.3486-3490

[68]JournaloftheIndianChemicalSociety,2004,vol.81,#4,p.344-345

[69]SouthAfricanJournalofChemistry,2006,vol.59,p.125-128

[70]JournalofOrganicChemistry,2007,vol.72,#18,p.6901-6904

[71]EuropeanJournalofOrganicChemistry,2007,#34,p.5661-5664

[72]Tetrahedron,2008,vol.64,#8,p.1931-1942

[73]MonatsheftefurChemie,2008,vol.139,#6,p.707-716

[74]SyntheticCommunications,2010,vol.40,#6,p.799-807

[75]BioorganicandMedicinalChemistry,2010,vol.18,#6,p.2195-2203

[76]BioorganicandMedicinalChemistry,2010,vol.18,#14,p.5063-5070

[77]Patent:US2007/27180,2007,A1,.Locationinpatent:Page/Pagecolumntitlepage;sheet1;6

[78]ChineseChemicalLetters,2010,vol.21,#4,p.412-416

[79]Patent:WO2011/32277,2011,A1,.Locationinpatent:Page/Pagecolumn86

[80]Chemistry-AnAsianJournal,2010,vol.5,#10,p.2258-2265

[81]BioorganicandMedicinalChemistryLetters,2011,vol.21,#21,p.6476-6481

[82]HeterocyclicCommunications,2011,vol.17,#5-6,p.181-185

[83]LettersinDrugDesignandDiscovery,2011,vol.8,#9,p.758-762

[84]LettersinDrugDesignandDiscovery,2011,vol.8,#9,p.758-762

[85]EuropeanJournalofMedicinalChemistry,2012,vol.52,p.70-81

[86]JournalofChemicalSciences,2012,vol.124,#2,p.463-468

[87]JournalofPhotochemistryandPhotobiologyA:Chemistry,2012,vol.241,p.13-20

[88]Synlett,2012,vol.23,#12,p.1797-1800

[89]ChineseJournalofChemistry,2012,vol.30,#6,p.1339-1344

[90]Tetrahedron,2012,vol.68,#34,p.6892-6901

[91]JournalofChemicalResearch,2012,vol.36,#7,p.393-395

[92]EuropeanJournalofMedicinalChemistry,2012,vol.54,p.403-412

[93]JournalofHeterocyclicChemistry,2012,vol.49,#4,p.959-964

[94]JournalofPhotochemistryandPhotobiologyB:Biology,2012,vol.115,p.25-34

[95]Synlett,2012,vol.23,#18,p.2609-2614,6

[96]TetrahedronLetters,2012,vol.53,#50,p.6761-6764

[97]MedicinalChemistryResearch,2013,vol.22,#2,p.818-831

[98]BioorganicandMedicinalChemistryLetters,2013,vol.23,#7,p.2031-2034

[99]ChemicalCommunications,2013,vol.49,#43,p.4890-4892

[100]JournalofOrganicChemistry,2013,vol.78,#11,p.5314-5327

[101]Tetrahedron,2013,vol.69,#31,p.6392-6398

[102]JournalofOrganicChemistry,2013,vol.78,#12,p.6276-6280

[103]OrganicandBiomolecularChemistry,2013,vol.11,#27,p.4546-4550

[104]EuropeanJournalofMedicinalChemistry,2013,vol.65,p.102-111

[105]AngewandteChemie-InternationalEdition,2013,vol.52,#44,p.11632-11636

[106]Angew.Chem.,2013,vol.125,#44,p.11846-11850,5

[107]ChemMedChem,2014,vol.9,#1,p.177-188

[108]AdvancedSynthesisandCatalysis,2013,vol.355,#18,p.3570-3574

[1]Tetrahedron,2007,vol.63,#1,p.155-159

[1]SyntheticCommunications,2008,vol.38,#10,p.1629-1637

Downstream Synthesis Route

[1]JustusLiebigsAnnalenderChemie,1902,vol.324,p.93    ChemischesZentralblatt,1902,vol.73,p.1294

[1]JournaloftheAmericanChemicalSociety,1949,vol.71,p.2050,2052    JournaloftheAmericanChemicalSociety,1950,vol.72,p.3795

4903-09-7    122-00-9   
3-chloro-4-methoxy-4'-methyl-<i>trans</i>-chalcone 

[1]JournaloftheChemicalSociety,1937,p.1798,1804

60632-40-8    122-00-9   
2-bromo-4-hydroxy-5-methoxy-4'-methyl-<i>trans</i>(?)-chalcone 

[1]JournalofOrganicChemistry,1938,vol.3,p.265,269

[1]ChemicalCommunications,2017,vol.54,p.449-451

[2]JournaloftheAmericanChemicalSociety,2010,vol.132,p.11431-11433

[3]HelveticaChimicaActa,2010,vol.93,p.1261-1273

[4]OrganicandBiomolecularChemistry,2019,vol.17,p.6985-6988

[5]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1984,vol.23,p.1098-1102

[6]JournaloftheChemicalSociety,1934,p.852

[7]GazzettaChimicaItaliana,1891,vol.21I,p.98

[8]ChemischeBerichte,1920,vol.53,p.81

[9]Patent:US4264507,1981,A

[10]Patent:US4287201,1981,A

[11]Patent:WO2006/129257,2006,A2.Locationinpatent:Page/Pagecolumn21

[12]BioorganicandMedicinalChemistryLetters,2018,vol.28,p.3441-3445

[13]Patent:WO2019/99564,2019,A1.Locationinpatent:Page/Pagecolumn88

[14]Patent:WO2019/99578,2019,A1.Locationinpatent:Page/Pagecolumn123

Literature

Title: Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives.

Journal: Journal of agricultural and food chemistry 20120411

Title: Theoretical and experimental studies on selective oxidation of aromatic ketone by performic acid.

Journal: The journal of physical chemistry. A 20120322

Title: Total synthesis of (+)-erogorgiaene using lithiation-borylation methodology, and stereoselective synthesis of each of its diastereoisomers.

Journal: Journal of the American Chemical Society 20111026

Title: Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants.

Journal: Journal of agricultural and food chemistry 20110608

Title: Syntheses and structures of ruthenium(II) N,S-heterocyclic carbene diphosphine complexes and their catalytic activity towards transfer hydrogenation.

Journal: Chemistry, an Asian journal 20110606

Title: [Broader substrate specifity of Candida parapsilosis SCR II for catalyzing acetophenone derivatives by site-directed mutagenesis].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20110601

Title: (2E)-3-(3-Bromo-4-meth-oxy-phen-yl)-1-(4-methyl-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110401

Title: 2,2-Dichloro-1-(4-methyl-phen-yl)ethanone.

Journal: Acta crystallographica. Section E, Structure reports online 20110201

Title: Screening of microorganisms producing cold-active oxidoreductases to be applied in enantioselective alcohol oxidation. An Antarctic survey.

Journal: Marine drugs 20110101

Title: 4-Phenyl-2,6-bis-(4-tol-yl)pyridine.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: (E)-1-(4-Methyl-phen-yl)ethanone [8-(trifluoro-meth-yl)quinolin-4-yl]hydrazone.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: (E)-3-[4-(Dimethyl-amino)phen-yl]-1-(4-methyl-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: 3-Dimethyl-amino-1-(4-methyl-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: Metal-free carbon-carbon bond-forming reductive coupling between boronic acids and tosylhydrazones.

Journal: Nature chemistry 20090901

Title: Site-isolation and recycling of PdCl(2) using PDMS thimbles.

Journal: The Journal of organic chemistry 20090703

Title: Synthesis, spectral, thermal and anti-fungal studies of organotin(IV) thiohydrazone complexes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090501

Title: N-(2,4-Dinitro-phen-yl)-N'-(1-p-tolyl-ethyl-idene)hydrazine.

Journal: Acta crystallographica. Section E, Structure reports online 20090401

Title: 1,3,5-Tri-p-tolyl-pentane-1,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: (E)-3-(3-Bromo-phen-yl)-1-(4-methyl-phenyl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20081101

Title: (E)-3-(4-Methyl-phen-yl)-3-[3-(4-methyl-phen-yl)-1H-pyrazol-1-yl]-2-propenal.

Journal: Acta crystallographica. Section E, Structure reports online 20081101

Title: 1-[(E)-2-Formyl-1-(4-methyl-phen-yl)ethen-yl]-3-(4-methyl-phen-yl)pyrazole-4-carbaldehyde.

Journal: Acta crystallographica. Section E, Structure reports online 20081001

Title: Characterization of the most odor-active compounds in an American Bourbon whisky by application of the aroma extract dilution analysis.

Journal: Journal of agricultural and food chemistry 20080723

Title: Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.

Journal: Bioorganic & medicinal chemistry 20080201

Title: (2E)-1-(4-Methyl-phen-yl)-3-(2,3,5-trichloro-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression.

Journal: Bioorganic & medicinal chemistry 20070215

Title: Comprehensive two-dimensional gas chromatographic analysis of commercial lemon-flavored beverages.

Journal: Journal of separation science 20061001

Title: Liquid-chromatographic separation and determination of process-related impurities, including a regio-specific isomer of celecoxib on reversed-phase C18 column dynamically coated with hexamethyldisilazane.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060901

Title: Potent inhibitory effects of black tea theaflavins on off-odor formation from citral.

Journal: Journal of agricultural and food chemistry 20060419

Title: In vitro effects of essential oils from Ostericum koreanum against antibiotic-resistant Salmonella spp.

Journal: Archives of pharmacal research 20050701

Title: Combined ruthenium(II) and lipase catalysis for efficient dynamic kinetic resolution of secondary alcohols. Insight into the racemization mechanism.

Journal: Journal of the American Chemical Society 20050622

Title: Formation mechanism of p-methylacetophenone from citral via a tert-alkoxy radical intermediate.

Journal: Journal of agricultural and food chemistry 20040908

Title: Antioxidant activity of plant extracts on the inhibition of citral off-odor formation.

Journal: Molecular nutrition & food research 20040901

Title: Development of new synthetic methods with aryl 1-chlorovinyl sulfoxides.

Journal: Chemical record (New York, N.Y.) 20040101

Title: Keto-enol/enolate equilibria in the N-acetylamino-p-methylacetophenone system. Effect of a beta-nitrogen substituent.

Journal: Journal of the American Chemical Society 20010919

Title: Api AM, et al. RIFM fragrance ingredient safety assessment, 4'-methylacetophenone, CAS Registry Number 122-00-9. Food Chem Toxicol. 2018 Dec;122 Suppl 1:S75-S83.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:122-00-9 Molecular Formula|122-00-9 MDL|122-00-9 SMILES|122-00-9 4'-Methylacetophenone |Organic_Building_Blocks