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1221485-83-1,MFCD22572738
Catalog No.:AA009CBZ

1221485-83-1 | Skepinone-L

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$131.00   $92.00
- +
5mg
98%
in stock  
$216.00   $152.00
- +
10mg
98%
in stock  
$322.00   $225.00
- +
25mg
98%
in stock  
$588.00   $412.00
- +
50mg
98%
in stock  
$906.00   $634.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CBZ
Chemical Name:
Skepinone-L
CAS Number:
1221485-83-1
Molecular Formula:
C24H21F2NO4
Molecular Weight:
425.4246
MDL Number:
MFCD22572738
SMILES:
OC[C@H](COc1ccc2c(c1)C(=O)c1ccc(cc1CC2)Nc1ccc(cc1F)F)O
Properties
Computed Properties
 
Complexity:
608  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
4.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:C-A-I-RBIOSCIENCESGMBH-US2012/115862,2012,A1Locationinpatent:Page/Pagecolumn21

[1]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[1]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[2]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[1]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[2]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[1]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

[2]Gong,Mengdie;Tu,Mingyan;Sun,Hongxia;Li,Lu;Zhu,Lili;Li,Honglin;Zhao,Zhenjiang;Li,Shiliang[Molecules,2022,vol.27,#1]

Literature

Title: C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20160101

Title: Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

Journal: Journal of medicinal chemistry 20120628

Title: Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

Journal: Nature chemical biology 20111225

Title: Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143.

Title: Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55(12), 5868-5877.

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