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122306-11-0
Catalog No.:AA00170I

122306-11-0 | Naspm

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Purity
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5mg
96%
1 week  
$203.00   $142.00
- +
10mg
96%
1 week  
$257.00   $180.00
- +
50mg
96%
1 week  
$781.00   $547.00
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100mg
96%
1 week  
$1,336.00   $935.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00170I
Chemical Name:
Naspm
CAS Number:
122306-11-0
Molecular Formula:
C22H34N4O
Molecular Weight:
370.5316
SMILES:
NCCCNCCCCNCCCNC(=O)Cc1cccc2c1cccc2
Properties
Computed Properties
 
Complexity:
391  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
14  
XLogP3:
2  

Literature

Title: Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons.

Journal: Archives of toxicology 20180101

Title: Enhancing VTA Ca(v)1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Journal: Molecular psychiatry 20171201

Title: TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury.

Journal: Experimental neurology 20121201

Title: PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822

Title: Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.

Journal: Brain research 20120411

Title: Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning.

Journal: Molecular brain 20120101

Title: Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity.

Journal: Frontiers in molecular neuroscience 20120101

Title: The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain.

Journal: Frontiers in molecular neuroscience 20120101

Title: Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

Journal: Frontiers in molecular neuroscience 20120101

Title: AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor.

Journal: Neurochemistry international 20111101

Title: Inhibition of Ca2+-activated large-conductance K+ channel activity alters synaptic AMPA receptor phenotype in mouse cerebellar stellate cells.

Journal: Journal of neurophysiology 20110701

Title: Tumor necrosis factor-α (TNF-α) augments AMPA-induced Purkinje neuron toxicity.

Journal: Brain research 20110422

Title: Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110413

Title: Synaptic mechanism for the sustained activation of oculomotor integrator circuits in the rat prepositus hypoglossi nucleus: contribution of Ca2+-permeable AMPA receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101124

Title: Involvement of AMPA/kainate-excitotoxicity in MK801-induced neuronal death in the retrosplenial cortex.

Journal: Neuroscience 20100825

Title: Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

Journal: Journal of medicinal chemistry 20100812

Title: Differences in glutamate-mediated calcium responses in the ventral cochlear nucleus and inferior colliculus of the developing rat.

Journal: Hearing research 20100801

Title: Synaptic contribution of Ca2+-permeable and Ca2+-impermeable AMPA receptors on isolated carp retinal horizontal cells and their modulation by Zn2+.

Journal: Brain research 20100304

Title: Ca2+-permeable AMPA receptors mediate induction of test pulse depression of naive synapses in rat visual cortical slices at early postnatal stage.

Journal: Neuroscience 20100203

Title: Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate.

Journal: Toxicology and applied pharmacology 20091015

Title: Effects of 1-naphthyl acetyl spermine on dendrite formation by cultured cerebellar Purkinje cells.

Journal: Neuroscience letters 20091002

Title: Death and survival of heterozygous Lurcher Purkinje cells in vitro.

Journal: Developmental neurobiology 20090701

Title: Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction.

Journal: Psychopharmacology 20090301

Title: Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

Title: Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins gamma2, gamma3, gamma4, and gamma8.

Journal: Neuroscience 20090112

Title: Pharmacological characterization, localization, and regulation of ionotropic glutamate receptors in skate horizontal cells.

Journal: Visual neuroscience 20090101

Title: Distance-dependent homeostatic synaptic scaling mediated by a-type potassium channels.

Journal: Frontiers in cellular neuroscience 20090101

Title: Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081217

Title: Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent current.

Journal: Neuropharmacology 20081201

Title: Long-range axonal calcium sweep induces axon retraction.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080430

Title: Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat.

Journal: The Journal of physiology 20080115

Title: Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?

Journal: PloS one 20080101

Title: Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells.

Journal: Brain : a journal of neurology 20071001

Title: The delta2 'ionotropic' glutamate receptor functions as a non-ionotropic receptor to control cerebellar synaptic plasticity.

Journal: The Journal of physiology 20071001

Title: Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.

Journal: Experimental neurology 20071001

Title: GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis.

Journal: Journal of neurochemistry 20070801

Title: Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Evidence for Ca(2+)-permeable AMPA receptors in the olfactory bulb.

Journal: American journal of physiology. Cell physiology 20060301

Title: Mode of action of novel polyamines increasing the permeability of bacterial outer membrane.

Journal: International journal of antimicrobial agents 20040701

Title: Ca2+ ion permeability and single-channel properties of the metabotropic slow EPSC of rat Purkinje neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040407

Title: Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus.

Journal: Neuroscience letters 20030130

Title: GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity.

Journal: Journal of neurophysiology 20020901

Title: Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020215

Title: Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.

Journal: Journal of medicinal chemistry 20011025

Title: Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20011008

Title: Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

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