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123464-89-1,MFCD08703110
Catalog No.:AA000KLF

123464-89-1 | PNU-282987

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Purity
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1mg
98%
in stock  
$11.00   $8.00
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10mg
98%
in stock  
$32.00   $22.00
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25mg
98%
in stock  
$52.00   $36.00
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250mg
98%
in stock  
$197.00   $138.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000KLF
Chemical Name:
PNU-282987
CAS Number:
123464-89-1
Molecular Formula:
C14H18Cl2N2O
Molecular Weight:
301.2115
MDL Number:
MFCD08703110
SMILES:
O=C(c1ccc(cc1)Cl)N[C@H]1CN2CCC1CC2.Cl
Properties
Computed Properties
 
Complexity:
307  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  

Downstream Synthesis Route

[1]Bodnar,AliceL.;Cortes-Burgos,LuzA.;Cook,KarenK.;Dinh,DacM.;Groppi,VincentE.;Hajos,Mihaly;Higdon,NicoleR.;Hoffmann,WilliamE.;Hurst,RaymondS.;Myers,JasonK.;Rogers,BruceN.;Wall,TheronM.;Wolfe,MarkL.;Wong,Erik[JournalofMedicinalChemistry,2005,vol.48,#4,p.905-908]

[1]CurrentPatentAssignee:SANOFI-US5206246,1993,A

[1]CurrentPatentAssignee:SANOFI-US5206246,1993,A

Literature

Title: Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

Title: Dong Jun Yu, et al. Effect of ischemic preconditioning combined with α7 nAchR agonists on limb ischemia-reperfusion lung injury in rat. Biomed Res. 2017; Special Issue: ISSN 0970.

Title: Li F, et al. The protective effect of PNU-282987, a selective α7 nicotinic acetylcholine receptor agonist, on the hepatic ischemia-reperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor κB activation in mice. Shock. 2013 Feb;39(2):197-203.

Title: Stuckenholz V, et al. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. J Parkinsons Dis. 2013;3(2):161-72.

Title: Mesa-Gresa P, et al. Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987. Behav Processes. 2014 Mar;103:117-24.

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SDS
Tags:123464-89-1 Molecular Formula|123464-89-1 MDL|123464-89-1 SMILES|123464-89-1 PNU-282987