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Title: A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial.
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Title: A phase I study of concurrent weekly topotecan and cisplatin chemotherapy with whole pelvic radiation therapy in locally advanced cervical cancer: a gynecologic oncology group study.
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Title: Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.
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Title: [Studies by means of 1H NMR spectroscopy of complex formation of aromatic biologically active compounds with antibiotic topotecan].
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Title: An unusual presentation of tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: case report and literature review.
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Title: DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.
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Title: Topotecan and cyclophosphamide in adults with relapsed sarcoma.
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Title: Weekly topotecan for recurrent small cell lung cancer - a retrospective Anatolian Medical Oncology Group study.
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Title: The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment.
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Title: EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.
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Title: ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.
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Title: Activity of topotecan given intravenously for 5 days every three weeks in patients with advanced non-small cell lung cancer pretreated with platinum and taxanes: a phase II study.
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Title: A phase I study of topotecan and gemcitabine in advanced solid tumors.
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Title: High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.
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Title: A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results.
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Title: A prospective clinical trial of lenalidomide with topotecan in women with advanced epithelial ovarian carcinoma.
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Title: Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan.
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Title: Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases.
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Title: Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.
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Title: Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts.
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Title: Pharmacokinetic evaluation of gemcitabine hydrochloride for the treatment of cervical cancer.
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Title: Complete response induced by fotemustine given as single agent in a patient with primary central nervous system non-Hodgkin aggressive lymphoma relapsed after high-dose chemotherapy and autologous stem cell support.
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Journal: Gynecologic oncology 20111101
Title: [Molecular determinants of response to topoisomerase I inhibitors].
Journal: Bulletin du cancer 20111101
Title: A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensive-disease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401.
Journal: Lung cancer (Amsterdam, Netherlands) 20111001
Title: Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells.
Journal: Chinese journal of cancer 20111001
Title: Phase II study of topotecan with cisplatin in Japanese patients with small cell lung cancer.
Journal: Anticancer research 20111001
Title: Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases.
Journal: Oncotarget 20111001
Title: Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.
Journal: Oncotarget 20111001
Title: Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110901
Title: Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects.
Journal: Angiogenesis 20110901
Title: Enhanced antitumor activity of low-dose continuous administration schedules of topotecan in prostate cancer.
Journal: Cancer biology & therapy 20110901
Title: Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110901
Title: Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas.
Journal: Cancer research 20110901
Title: Preclinical assessment of strategies for enhancement of metaiodobenzylguanidine therapy of neuroendocrine tumors.
Journal: Seminars in nuclear medicine 20110901
Title: An integrated disease/pharmacokinetic/pharmacodynamic model suggests improved interleukin-21 regimens validated prospectively for mouse solid cancers.
Journal: PLoS computational biology 20110901
Title: ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.
Journal: Journal of the National Cancer Institute 20110817
Title: Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
Journal: Bioorganic & medicinal chemistry 20110815
Title: Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study.
Journal: Cancer 20110815
Title: Phase 1/pharmacology study of intraperitoneal topotecan alone and with cisplatin: potential for consolidation in ovarian cancer.
Journal: Cancer chemotherapy and pharmacology 20110801
Title: Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.
Journal: Journal of neuro-oncology 20110801
Title: Window-of-opportunity trials to evaluate clinical activity of new molecular entities in oncology.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110801
Title: A prospective phase II study of topotecan (Hycamtin®) and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer.
Journal: Gynecologic oncology 20110801
Title: Can weekly topotecan substitute for a multi-day regimen in the treatment of ovarian cancer? Sadly, 10 years later the answer remains unknown.
Journal: Gynecologic oncology 20110801
Title: Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Journal: Archivum immunologiae et therapiae experimentalis 20110801
Title: Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110801
Title: Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan.
Journal: European biophysics journal : EBJ 20110801
Title: Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump.
Journal: Neuro-oncology 20110801
Title: Management strategies for recurrent platinum-resistant ovarian cancer.
Journal: Drugs 20110730
Title: Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.
Journal: Journal of medicinal chemistry 20110728
Title: Treatment for advanced cervical cancer: impact on quality of life.
Journal: Critical reviews in oncology/hematology 20110701
Title: Topotecan and ifosfamide systemic chemotherapy for CNS involvement of solid tumors.
Journal: Journal of neuro-oncology 20110701
Title: Exploring palliative treatment outcomes in women with advanced or recurrent ovarian clear cell carcinoma.
Journal: Gynecologic oncology 20110701
Title: Single nucleotide polypmorphisms in ERCC1 are associated with disease progression, and survival in patients with advanced stage ovarian and primary peritoneal carcinoma; a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20110701
Title: Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells.
Journal: Disease models & mechanisms 20110701
Title: Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma.
Journal: Gynecologic oncology 20110701
Title: Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.
Journal: Molecular cancer therapeutics 20110701
Title: Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography.
Journal: Nuclear medicine and biology 20110701
Title: Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities.
Journal: Chemistry & biodiversity 20110701
Title: Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a.
Journal: Cancer research 20110615
Title: Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
Journal: Investigational new drugs 20110601
Title: A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies.
Journal: Cancer chemotherapy and pharmacology 20110601
Title: Outcomes of small-cell lung cancer patients treated with second-line chemotherapy: a multi-institutional retrospective analysis.
Journal: Lung cancer (Amsterdam, Netherlands) 20110601
Title: Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110601
Title: DNA repair: the culprit for tumor-initiating cell survival?
Journal: Cancer metastasis reviews 20110601
Title: Phase II study of S-1, an oral fluoropyrimidine, in patients with advanced or recurrent cervical cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110601
Title: [Small cell neuroendocrine carcinoma of the bladder: A case report and review of the literature].
Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20110601
Title: Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents.
Journal: European journal of medicinal chemistry 20110601
Title: Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.
Journal: European journal of medicinal chemistry 20110601
Title: Convection-enhanced delivery of topotecan into a PDGF-driven model of glioblastoma prolongs survival and ablates both tumor-initiating cells and recruited glial progenitors.
Journal: Cancer research 20110601
Title: Periocular topotecan for intraocular retinoblastoma.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110601
Title: [Primary drug resistance/sensitivity in vitro and clininical outcome in ovarian cancer patients].
Journal: Ceska gynekologie 20110601
Title: Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study.
Journal: Cancer chemotherapy and pharmacology 20110501
Title: A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.
Journal: Journal of neuro-oncology 20110501
Title: Topotecan for relapsed small cell lung cancer: a systematic review and economic evaluation.
Journal: Cancer treatment reviews 20110501
Title: New emerging drugs targeting the genomic integrity and replication machinery in ovarian cancer.
Journal: Archives of gynecology and obstetrics 20110501
Title: Electrochemical detection of anticancer drug topotecan using nano-acetylene black film.
Journal: Colloids and surfaces. B, Biointerfaces 20110501
Title: Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
Journal: European journal of clinical pharmacology 20110501
Title: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110501
Title: Trabectedin for the treatment of relapsed ovarian cancer.
Journal: Health technology assessment (Winchester, England) 20110501
Title: A phase II study of higher dose weekly topotecan in relapsed small-cell lung cancer.
Journal: Clinical lung cancer 20110501
Title: Early toxicity predicts long-term survival in high-grade glioma.
Journal: British journal of cancer 20110426
Title: The solvolysis of topotecan in alcohols and acetic anhydride.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
Journal: Journal of medicinal chemistry 20110414
Title: Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier.
Journal: Molecular pharmaceutics 20110404
Title: Sialoblastoma- long-term follow-up and remission for a rare salivary malignancy.
Journal: Rare tumors 20110404
Title: Second-line chemotherapy for small-cell lung cancer (SCLC).
Journal: Cancer treatment reviews 20110401
Title: Phase II trial of high-dose topotecan, melphalan and CY with autologous stem cell support for multiple myeloma.
Journal: Bone marrow transplantation 20110401
Title: Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.
Journal: Brain tumor pathology 20110401
Title: Synthesis and antitumor activity of 10-arylcamptothecin derivatives.
Journal: Bioorganic & medicinal chemistry letters 20110401
Title: The use of convection-enhanced delivery with liposomal toxins in neurooncology.
Journal: Toxins 20110401
Title: Resectable pancreatic small cell carcinoma.
Journal: Rare tumors 20110330
Title: 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Journal: Journal of medicinal chemistry 20110324
Title: The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan.
Journal: Cancer 20110315
Title: Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature.
Journal: Archives of gynecology and obstetrics 20110301
Title: A phase II clinical trial of topotecan in Japanese patients with relapsed ovarian carcinoma.
Journal: Japanese journal of clinical oncology 20110301
Title: High-dose carboplatin-irinotecan-temozolomide: treatment option for neuroblastoma resistant to topotecan.
Journal: Pediatric blood & cancer 20110301
Title: Short topotecan-based induction regimen in newly diagnosed high-risk neuroblastoma.
Journal: European journal of cancer (Oxford, England : 1990) 20110301
Title: A phase II study of two topotecan regimens evaluated in recurrent platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer: a Gynecologic Oncology Group Study (GOG 146Q).
Journal: Gynecologic oncology 20110301
Title: Recent advances in anti-angiogenic therapy of cancer.
Journal: Oncotarget 20110301
Title: Multifaceted chemotherapy for trilateral retinoblastoma.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110301
Title: A network meta-analysis of randomized controlled trials of induction treatments in acute myeloid leukemia in the elderly.
Journal: Clinical therapeutics 20110301
Title: Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines.
Journal: Biochemistry 20110208
Title: Feasibility of extension of platinum-free interval with weekly bolus topotecan and subsequent platinum retreatment outcomes in recurrent ovarian cancer.
Journal: Archives of gynecology and obstetrics 20110201
Title: Phase I study of topotecan and cisplatin in patients with small cell lung cancer.
Journal: Japanese journal of clinical oncology 20110201
Title: Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: Physiologically based pharmacokinetic model for topotecan in mice.
Journal: Journal of pharmacokinetics and pharmacodynamics 20110201
Title: Advances in nano drugs for cancer chemotherapy.
Journal: Current cancer drug targets 20110201
Title: [Treatment of small-cell lung cancer].
Journal: Der Internist 20110201
Title: A Blm-Recql5 partnership in replication stress response.
Journal: Journal of molecular cell biology 20110201
Title: Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract.
Journal: Archives of medical science : AMS 20110201
Title: PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis.
Journal: Oncogene 20110127
Title: Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20110125
Title: Randomized phase II trial of single-agent amrubicin or topotecan as second-line treatment in patients with small-cell lung cancer sensitive to first-line platinum-based chemotherapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110120
Title: Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma.
Journal: Cancer 20110115
Title: Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.
Journal: Biochemical pharmacology 20110115
Title: 3-Arylisoquinolines as novel topoisomerase I inhibitors.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Topotecan Weekly Versus Conventional 5-Day Schedule in Patients With Platinum-Resistant Ovarian Cancer: a randomized multicenter phase II trial of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110
Title: Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110101
Title: Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer delays third-line chemotherapy and prolongs the platinum-free interval.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110101
Title: Antiangiogenic combination therapy after local radiotherapy with topotecan radiosensitizer improved quality of life for children with inoperable brainstem gliomas.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20110101
Title: Second high-dose chemotherapy intensification followed by hematopoietic stem cell transplantation applying a novel high-dose topotecan-based regimen in an adult Wilms' tumor patient: case report.
Journal: Anti-cancer drugs 20110101
Title: High-dose cyclophosphamide-irinotecan-vincristine for primary refractory neuroblastoma.
Journal: European journal of cancer (Oxford, England : 1990) 20110101
Title: An open-label, single-arm Phase II study of intravenous weekly (Days 1 and 8) topotecan in combination with carboplatin (Day 1) every 21 days as second-line therapy in patients with platinum-sensitive relapsed ovarian cancer.
Journal: Gynecologic oncology 20110101
Title: Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry.
Journal: Methods in molecular biology (Clifton, N.J.) 20110101
Title: Intracellular and extracellular microRNAs in breast cancer.
Journal: Clinical chemistry 20110101
Title: A phase 1 study of nifurtimox in patients with relapsed/refractory neuroblastoma.
Journal: Journal of pediatric hematology/oncology 20110101
Title: A phase II study of metronomic oral topotecan for recurrent childhood brain tumors.
Journal: Pediatric blood & cancer 20110101
Title: Current therapeutic approaches in metastatic and recurrent ewing sarcoma.
Journal: Sarcoma 20110101
Title: Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma.
Journal: Sarcoma 20110101
Title: Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance.
Journal: PloS one 20110101
Title: The use of endophytes to obtain bioactive compounds and their application in biotransformation process.
Journal: Biotechnology research international 20110101
Title: High-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma--a systematic review.
Journal: PloS one 20110101
Title: Bevacizumab in the treatment of ovarian cancer.
Journal: Biologics : targets & therapy 20110101
Title: Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma.
Journal: BMC biotechnology 20110101
Title: From antiangiogenesis to hypoxia: current research and future directions.
Journal: Cancer management and research 20110101
Title: Characteristics of human Ewing/PNET sarcoma models.
Journal: Annals of Saudi medicine 20110101
Title: Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway.
Journal: PloS one 20110101
Title: An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development.
Journal: Journal of Cancer 20110101
Title: miRNA Biomarkers in Breast Cancer Detection and Management.
Journal: Journal of Cancer 20110101
Title: Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures.
Journal: PloS one 20110101
Title: Review of the management of relapsed small-cell lung cancer with amrubicin hydrochloride.
Journal: Clinical Medicine Insights. Oncology 20110101
Title: Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
Journal: Journal of hematology & oncology 20110101
Title: Camptothecin-based regimens for treatment of ewing sarcoma: past studies and future directions.
Journal: Sarcoma 20110101
Title: Multiple myeloma emerging after prolonged gefitinib treatment for non-small cell lung carcinoma.
Journal: Case reports in oncology 20110101
Title: Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.
Journal: Breast cancer research : BCR 20110101
Title: Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells.
Journal: Oncology research 20110101
Title: In vitro antiproliferative activity of partially purified Trigona laeviceps propolis from Thailand on human cancer cell lines.
Journal: BMC complementary and alternative medicine 20110101
Title: Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease.
Journal: Parasites & vectors 20110101
Title: Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees.
Journal: PloS one 20110101
Title: Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy.
Journal: Journal of translational medicine 20110101
Title: Long-term topotecan therapy in recurrent or persistent ovarian cancer.
Journal: European journal of gynaecological oncology 20110101
Title: New Topoisomerase I mutations are associated with resistance to camptothecin.
Journal: Molecular cancer 20110101
Title: Interpreting clinical assays for histone deacetylase inhibitors.
Journal: Cancer management and research 20110101
Title: Phase II study of the combination carboplatin plus celecoxib in heavily pre-treated recurrent ovarian cancer patients.
Journal: BMC cancer 20110101
Title: Current developments in the therapy of protozoan infections.
Journal: The open medicinal chemistry journal 20110101
Title: Myelodysplastic syndrome and histone deacetylase inhibitors: 'to be or not to be acetylated'?
Journal: Journal of biomedicine & biotechnology 20110101
Title: A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.
Journal: Current chemical genomics 20110101
Title: Transport processes of radiopharmaceuticals and -modulators.
Journal: Radiation oncology (London, England) 20110101
Title: Changes of constituents and activity to apoptosis and cell cycle during fermentation of tea.
Journal: International journal of molecular sciences 20110101
Title: Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum.
Journal: PloS one 20110101
Title: Solitary Internal Mammary Lymph Node Metastases Detected by F-FDG-PET/CT in Ovarian Cancer.
Journal: Case reports in oncology 20110101
Title: Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells.
Journal: PloS one 20110101
Title: Treatment of HIV-related primary central nervous system lymphoma with AZT high dose, HAART, interleukin-2 and foscarnet in three patients.
Journal: European journal of medical research 20110101
Title: The use of erlotinib in daily practice: a study on adherence and patients' experiences.
Journal: BMC cancer 20110101
Title: Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
Journal: PloS one 20110101
Title: Targeted treatment of recurrent platinum-resistant ovarian cancer: current and emerging therapies.
Journal: Cancer management and research 20110101
Title: A Case of High-Grade Neuroendocrine Carcinoma That Improved with Bevacizumab plus Modified FOLFOX6 as the Fourth-Line Chemotherapy.
Journal: Case reports in oncology 20110101
Title: Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors.
Journal: BMC medical genomics 20110101
Title: Sustained platelet-sparing effect of weekly low dose paclitaxel allows effective, tolerable delivery of extended dose dense weekly carboplatin in platinum resistant/refractory epithelial ovarian cancer.
Journal: BMC cancer 20110101
Title: iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states.
Journal: BMC systems biology 20110101
Title: Leaf Extracts of Calocedrus formosana (Florin) Induce G2/M Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Ovarian epithelial-stromal interactions: role of interleukins 1 and 6.
Journal: Obstetrics and gynecology international 20110101
Title: In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs.
Journal: Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 20110101
Title: Clinical therapeutics in pregnancy.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Pegylated liposomal doxorubicin: appraisal of its current role in the management of epithelial ovarian cancer.
Journal: Cancer management and research 20110101
Title: A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells.
Journal: BMC cancer 20110101
Title: Drug therapy for hereditary cancers.
Journal: Hereditary cancer in clinical practice 20110101
Title: Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts.
Journal: Arthritis research & therapy 20110101
Title: Phase II study on weekly bolus topotecan in advanced or recurrent cervical cancer.
Journal: Oncology 20110101
Title: Current and emerging pharmacotherapies for the treatment of relapsed small cell lung cancer.
Journal: Clinical Medicine Insights. Oncology 20110101
Title: A novel preparation method for camptothecin (CPT) loaded folic acid conjugated dextran tumor-targeted nanoparticles.
Journal: International journal of molecular sciences 20110101
Title: Regulation of apoptotic effects by erythrocarpine E, a cytotoxic limonoid from Chisocheton erythrocarpus in HSC-4 human oral cancer cells.
Journal: PloS one 20110101
Title: Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?
Journal: Breast cancer research : BCR 20110101
Title: Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan.
Journal: Oxidative medicine and cellular longevity 20110101
Title: A method for efficient calculation of diffusion and reactions of lipophilic compounds in complex cell geometry.
Journal: PloS one 20110101
Title: Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives.
Journal: PloS one 20110101
Title: Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.
Journal: OncoTargets and therapy 20110101
Title: Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.
Journal: Journal of hematology & oncology 20110101
Title: Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor.
Journal: PloS one 20110101
Title: Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.
Journal: PloS one 20110101
Title: Platinum resistance in breast and ovarian cancer cell lines.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
Journal: PloS one 20110101
Title: Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines.
Journal: BMC cancer 20110101
Title: The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models.
Journal: PloS one 20110101
Title: Fabrication principles and their contribution to the superior in vivo therapeutic efficacy of nano-liposomes remote loaded with glucocorticoids.
Journal: PloS one 20110101
Title: Uterine carcinosarcomas (malignant mixed müllerian tumours): a review with special emphasis on the controversies in management.
Journal: Obstetrics and gynecology international 20110101
Title: The PACOVAR-trial: a phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer.
Journal: BMC cancer 20110101
Title: Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.
Journal: Fluids and barriers of the CNS 20110101
Title: Long survival of primary diffuse leptomeningeal gliomatosis following radiotherapy and temozolomide: case report and literature review.
Journal: European journal of medical research 20110101
Title: Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis.
Journal: Bone marrow research 20110101
Title: Choroid plexus transport: gene deletion studies.
Journal: Fluids and barriers of the CNS 20110101
Title: Reduction of atherosclerotic lesions in rabbits treated with etoposide associated with cholesterol-rich nanoemulsions.
Journal: International journal of nanomedicine 20110101
Title: Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells.
Journal: PloS one 20110101
Title: Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence.
Journal: BMC cancer 20110101
Title: Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: A rare bladder cancer--small cell carcinoma: review and update.
Journal: Orphanet journal of rare diseases 20110101
Title: A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome.
Journal: Journal of hematology & oncology 20110101
Title: Mathematical prognostic biomarker models for treatment response and survival in epithelial ovarian cancer.
Journal: Cancer informatics 20110101
Title: Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective.
Journal: ISRN oncology 20110101
Title: Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer.
Journal: PloS one 20110101
Title: A very rare adult case with neuroblastoma.
Journal: Case reports in oncology 20110101
Title: Targeting hypoxic tumour cells to overcome metastasis.
Journal: BMC cancer 20110101
Title: A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens.
Journal: International journal of nanomedicine 20110101
Title: Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin.
Journal: Journal of ovarian research 20110101
Title: Attenuation of cytotoxic natural product DNA intercalating agents by caffeine.
Journal: Scientia pharmaceutica 20110101
Title: The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals.
Journal: International journal of nanomedicine 20110101
Title: Selective internal radiation therapy for gastrointestinal neuroendocrine tumour liver metastases: a new and effective modality for treatment.
Journal: International journal of hepatology 20110101
Title: Oxaliplatin but not irinotecan impairs posthepatectomy liver regeneration in a murine model.
Journal: International journal of hepatology 20110101
Title: Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101
Title: Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons.
Journal: PloS one 20110101
Title: Clear cell cancer of the uterine corpus: the association of clinicopathologic parameters and treatment on disease progression.
Journal: Journal of oncology 20110101
Title: Radiotherapy and 'new' drugs-new side effects?
Journal: Radiation oncology (London, England) 20110101
Title: Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition.
Journal: Cancer cell international 20110101
Title: Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells.
Journal: PloS one 20110101
Title: Exophthalmos as a first manifestation of small cell lung cancer: a long-term follow-up.
Journal: Case reports in ophthalmology 20110101
Title: Monoclonal antibodies in gynecological cancer: a critical point of view.
Journal: Clinical & developmental immunology 20110101
Title: [Five year-results of chemoresistance testing in cancer patients].
Journal: Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20110101
Title: The state of research into children with cancer across Europe: new policies for a new decade.
Journal: Ecancermedicalscience 20110101
Title: Retinoblastoma: Recent trends A mini review based on published literature.
Journal: Oman journal of ophthalmology 20110101
Title: Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans.
Journal: Journal of amino acids 20110101
Title: Multidrug resistance in breast cancer: from in vitro models to clinical studies.
Journal: International journal of breast cancer 20110101
Title: Cell death signaling and anticancer therapy.
Journal: Frontiers in oncology 20110101
Title: Combined modality approaches in the management of adult glioblastoma.
Journal: Frontiers in oncology 20110101
Title: Glutathione s-transferases in pediatric cancer.
Journal: Frontiers in oncology 20110101
Title: Investigational approaches for mesothelioma.
Journal: Frontiers in oncology 20110101
Title: Outcomes of advanced and recurrent cervical cancer treated with cisplatin and generic topotecan: retrospective analysis in a tertiary care hospital in Thailand.
Journal: Journal of gynecologic oncology 20101230
Title: Cancer and renal insufficiency results of the BIRMA study.
Journal: British journal of cancer 20101207
Title: Multimodality management for 145 cases of Merkel cell carcinoma.
Journal: Medical oncology (Northwood, London, England) 20101201
Title: Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.
Journal: International journal of cancer 20101201
Title: Chemoresistance testing of human ovarian cancer cells and its in vitro model.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20101201
Title: Health-related quality of life outcomes associated with four cisplatin-based doublet chemotherapy regimens for stage IVB recurrent or persistent cervical cancer: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20101201
Title: Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers.
Journal: Cancer biology & therapy 20101201
Title: Camptothecins compared with etoposide in combination with platinum analog in extensive stage small cell lung cancer: systematic review with meta-analysis.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101201
Title: The DAC system and associations with acute leukemias and myelodysplastic syndromes.
Journal: Investigational new drugs 20101201
Title: Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Journal: Molecular cancer therapeutics 20101201
Title: Antagonism of cytotoxic chemotherapy in neuroblastoma cell lines by 13-cis-retinoic acid is mediated by the antiapoptotic Bcl-2 family proteins.
Journal: Molecular cancer therapeutics 20101201
Title: Growth Inhibition and Apoptosis with H31 Metabolites from Marine Bacillus SW31 in Head and Neck Cancer Cells.
Journal: Clinical and experimental otorhinolaryngology 20101201
Title: Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101115
Title: Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Investigating the correlations among the chemical structures, bioactivity profiles and molecular targets of small molecules.
Journal: Bioinformatics (Oxford, England) 20101115
Title: Laser induced fluorescence and photochemical derivatization for trace determination of camptothecin.
Journal: Talanta 20101115
Title: Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.
Journal: British journal of cancer 20101109
Title: A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies.
Journal: Cancer chemotherapy and pharmacology 20101101
Title: Paclitaxel/carboplatin versus topotecan/paclitaxel/carboplatin in patients with FIGO suboptimally resected stage III-IV epithelial ovarian cancer a multicenter, randomized study.
Journal: European journal of cancer (Oxford, England : 1990) 20101101
Title: Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Journal: British journal of cancer 20101101
Title: Double high-dose chemotherapy and stem cell transplantation in adult Wilms' tumor.
Journal: Future oncology (London, England) 20101101
Title: [Application of ATP-tumor chemosensitivity assay in recurrent epithelial ovarian cancer].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20101101
Title: Topoisomerase I inhibitors in the treatment of primary CNS malignancies: an update on recent trends.
Journal: Anti-cancer agents in medicinal chemistry 20101101
Title: Nigericin-mediated liposome loading of topotecan: is nigericin a potential drug release regulator?
Journal: International journal of pharmaceutics 20101031
Title: Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.
Journal: British journal of cancer 20101026
Title: Another confirmation of the inactivity of topotecan in ovarian cancer.
Journal: Journal of the National Cancer Institute 20101020
Title: Advanced ovarian cancer: phase III randomized study of sequential cisplatin-topotecan and carboplatin-paclitaxel vs carboplatin-paclitaxel.
Journal: Journal of the National Cancer Institute 20101020
Title: Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C.
Journal: European journal of pharmacology 20101010
Title: Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells.
Journal: Breast cancer research and treatment 20101001
Title: Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
Journal: Cancer chemotherapy and pharmacology 20101001
Title: Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours.
Journal: European journal of cancer (Oxford, England : 1990) 20101001
Title: Therapy of small cell lung cancer with emphasis on oral topotecan.
Journal: Lung cancer (Amsterdam, Netherlands) 20101001
Title: Sequence-dependent hematologic side effects of topotecan and cisplatin in persistent or recurrent cervical cancer.
Journal: Gynecologic oncology 20101001
Title: Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101001
Title: Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101001
Title: Ewing's sarcoma.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101001
Title: Combining cytotoxic and targeted therapies for lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101001
Title: Optimization of vincristine-topotecan combination--paving the way for improved chemotherapy regimens by nanoliposomes.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20100915
Title: Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776.
Journal: Journal of pharmaceutical and biomedical analysis 20100905
Title: Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer.
Journal: Journal of materials science. Materials in medicine 20100901
Title: A phase I study of weekly topotecan in combination with pemetrexed in patients with advanced malignancies.
Journal: The oncologist 20100901
Title: Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).
Journal: Current drug metabolism 20100901
Title: 7'-Methyl-5'-oxo-2',3'-dihydro-spiro-[1,3-dioxolane-2,1'(5'H)-indolizine]-6'-carbonitrile.
Journal: Acta crystallographica. Section E, Structure reports online 20100901
Title: Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.
Journal: Journal of cachexia, sarcopenia and muscle 20100901
Title: A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.
Journal: Molecular cell 20100827
Title: Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening.
Journal: British journal of cancer 20100824
Title: Dual inhibition of EGFR and mTOR pathways in small cell lung cancer.
Journal: British journal of cancer 20100824
Title: Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy.
Journal: British journal of cancer 20100824
Title: Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820
Title: Phase II randomized comparison of topotecan plus cyclophosphamide versus topotecan alone in children with recurrent or refractory neuroblastoma: a Children's Oncology Group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820
Title: Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters.
Journal: Biochemical pharmacology 20100815
Title: Free energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition.
Journal: Biophysical journal 20100804
Title: Phase II trial of oral topotecan and intravenous carboplatin with G-CSF support in previously untreated patients with extensive stage small cell lung cancer: A North Central Cancer Treatment Group Study.
Journal: American journal of clinical oncology 20100801
Title: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).
Journal: Ophthalmology 20100801
Title: Altered phospholipid transfer protein gene expression and serum lipid profile by topotecan.
Journal: Biochemical pharmacology 20100801
Title: Impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer.
Journal: American journal of obstetrics and gynecology 20100801
Title: Topotecan and etoposide combination to test neuroblastoma in pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20100801
Title: Topotecan dynamics, tautomerism and reactivity--1H/13C NMR and ESI MS study.
Journal: Magnetic resonance in chemistry : MRC 20100801
Title: Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.
Journal: Assay and drug development technologies 20100801
Title: Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.
Journal: Molecular cancer therapeutics 20100801
Title: [Effect of cisplatin, topotecan, daunorubicin and hydroxyurea on human mesenchymal stem cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20100801
Title: Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma.
Journal: Pediatric blood & cancer 20100715
Title: Experiment on the factors for enhancing the susceptibility of cancer cells to chemotherapeutic drug by ultrasound microbubbles.
Journal: Journal of drug targeting 20100701
Title: Trifluoromethyl-promoted homocamptothecins: synthesis and biological activity.
Journal: European journal of medicinal chemistry 20100701
Title: Pharmacokinetic analysis of topotecan after intra-vitreal injection. Implications for retinoblastoma treatment.
Journal: Experimental eye research 20100701
Title: Cytotoxicity and topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38.
Journal: European journal of medicinal chemistry 20100701
Title: Phase I and pharmacologic study of weekly bolus topotecan for advanced non-small-cell lung cancer.
Journal: Clinical lung cancer 20100701
Title: Phase III study comparing sequential versus alternate administration of cisplatin-etoposide and topotecan as first-line treatment in small cell lung cancer.
Journal: Anticancer research 20100701
Title: Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model.
Journal: British journal of cancer 20100629
Title: Differential impact of high-dose cyclophosphamide, topotecan, and vincristine in clinical subsets of patients with chemoresistant neuroblastoma.
Journal: Cancer 20100615
Title: Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters.
Journal: Molecular pharmaceutics 20100607
Title: A phase I-II trial of weekly topotecan in the treatment of recurrent cervical carcinoma.
Journal: Medical oncology (Northwood, London, England) 20100601
Title: Review role of topotecan in gynaecological cancers: current indications and perspectives.
Journal: Critical reviews in oncology/hematology 20100601
Title: Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I.
Journal: European journal of medicinal chemistry 20100601
Title: A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies.
Journal: Gynecologic oncology 20100601
Title: Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.
Journal: Cancer research 20100601
Title: A phase II trial of carboplatin and weekly topotecan in the first-line treatment of patients with extensive stage small cell lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100601
Title: The war on cancer: have we won the battle but lost the war?
Journal: Oncotarget 20100601
Title: Solvent effects on the valence UV-vis absorption spectra of topotecan anticancer drug in aqueous solution at room temperature: a nanoseconds time-scale TD-DFT/MD computational study.
Journal: The journal of physical chemistry. B 20100527
Title: Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue.
Journal: Journal of neuro-oncology 20100501
Title: High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system.
Journal: Journal of neuro-oncology 20100501
Title: Initial testing of topotecan by the pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20100501
Title: Achievements and unmet needs in the management of advanced ovarian cancer.
Journal: Gynecologic oncology 20100501
Title: Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma.
Journal: Annals of surgical oncology 20100501
Title: Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia.
Journal: Pediatric blood & cancer 20100501
Title: Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities.
Journal: Bioorganic & medicinal chemistry 20100501
Title: Topotecan for the treatment of recurrent and stage IVB carcinoma of the cervix.
Journal: Health technology assessment (Winchester, England) 20100501
Title: [Hematological toxicity of some combined chemotherapy schemes involving aranoza].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100501
Title: [Resistance/sensitivity in vitro in ovarian cancer patients].
Journal: Ceska gynekologie 20100501
Title: Criteria for evaluation of disease extent by (123)I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force.
Journal: British journal of cancer 20100427
Title: Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.
Journal: Biochemical pharmacology 20100415
Title: Topotecan in second-line treatment of small-cell lung cancer--how it works in our daily clinical practice?
Journal: Current drug safety 20100401
Title: Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.
Journal: Cancer chemotherapy and pharmacology 20100401
Title: Episcleral implants for topotecan delivery to the posterior segment of the eye.
Journal: Investigative ophthalmology & visual science 20100401
Title: Phase II of oral gimatecan in patients with recurrent epithelial ovarian, fallopian tube or peritoneal cancer, previously treated with platinum and taxanes.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20100401
Title: Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system.
Journal: Pediatric blood & cancer 20100401
Title: Bridging the gap between cytotoxic and biologic therapy with metronomic topotecan and pazopanib in ovarian cancer.
Journal: Molecular cancer therapeutics 20100401
Title: Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer.
Journal: Molecular cancer therapeutics 20100401
Title: Flow-based cytometric analysis of cell cycle via simulated cell populations.
Journal: PLoS computational biology 20100401
Title: Phytochemicals in cancer prevention and therapy: truth or dare?
Journal: Toxins 20100401
Title: [Immediate versus delayed topotecan after first-line therapy in small cell lung cancer].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20100320
Title: Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors.
Journal: Journal of medicinal chemistry 20100311
Title: Pharmacotherapy options for locally advanced and advanced cervical cancer.
Journal: Drugs 20100305
Title: Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma.
Journal: Bone marrow transplantation 20100301
Title: Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20100301
Title: A phase I study to characterize the safety, tolerability, and pharmacokinetics of topotecan at 4 mg/m2 administered weekly as a 30-minute intravenous infusion in patients with cancer.
Journal: Journal of clinical pharmacology 20100301
Title: The combination of thalidomide, cyclophosphamide and dexamethasone is potentially useful in highly resistant Hodgkin's lymphoma.
Journal: European journal of haematology 20100301
Title: The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs.
Journal: Molecular pharmacology 20100301
Title: A semi-physiological-based pharmacokinetic/pharmacodynamic model to describe the effects of topotecan on b-lymphocyte lineage cells.
Journal: Pharmaceutical research 20100301
Title: Quantification of topotecan by liquid chromatography-mass spectrometry (LC-MS). Application to intestinal transport using rat everted gut sacs.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100301
Title: Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100301
Title: Bilateral superselective ophthalmic artery chemotherapy for bilateral retinoblastoma: tandem therapy.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100301
Title: The clinical effectiveness and cost-effectiveness of topotecan for small cell lung cancer: a systematic review and economic evaluation.
Journal: Health technology assessment (Winchester, England) 20100301
Title: Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.
Journal: British journal of cancer 20100216
Title: Treatment options for small cell lung cancer - do we have more choice?
Journal: British journal of cancer 20100216
Title: Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma.
Journal: Biochemical pharmacology 20100215
Title: Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Journal: Cancer research 20100215
Title: Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer.
Journal: British journal of cancer 20100202
Title: Myelotoxicity of oral topotecan in relation to treatment duration and dosage: a phase I study.
Journal: Anti-cancer drugs 20100201
Title: Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma.
Journal: International journal of oncology 20100201
Title: Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100201
Title: Treatment of cancer with oral drugs: a position statement by the Spanish Society of Medical Oncology (SEOM).
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20100201
Title: Comparison of the efficacy between topotecan- and belotecan-, a new camptothecin analog, based chemotherapies for recurrent epithelial ovarian cancer: a single institutional experience.
Journal: The journal of obstetrics and gynaecology research 20100201
Title: The rationale for the use of non-platinum chemotherapy doublets for metastatic and recurrent cervical carcinoma.
Journal: Clinical advances in hematology & oncology : H&O 20100201
Title: Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I.
Journal: The Biochemical journal 20100115
Title: Development of a highly stable and targetable nanoliposomal formulation of topotecan.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20100104
Title: MicroRNAs as Novel Biomarkers for Breast Cancer.
Journal: Journal of oncology 20100101
Title: Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia: a report from the Eastern Cooperative Oncology Group.
Journal: British journal of haematology 20100101
Title: Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.
Journal: The Journal of pharmacology and experimental therapeutics 20100101
Title: Gefitinib in combination with oral topotecan and cyclophosphamide in relapsed neuroblastoma: pharmacological rationale and clinical response.
Journal: Pediatric blood & cancer 20100101
Title: Clinical relevance of human cancer xenografts as a tool for preclinical assessment: example of in-vivo evaluation of topotecan-based chemotherapy in a panel of human small-cell lung cancer xenografts.
Journal: Anti-cancer drugs 20100101
Title: Prognostic factors for response to cisplatin-based chemotherapy in advanced cervical carcinoma: a Gynecologic Oncology Group Study.
Journal: Gynecologic oncology 20100101
Title: Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin.
Journal: Phytochemistry 20100101
Title: Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia.
Journal: Cancer 20100101
Title: Controversies in the treatment of advanced stages of small cell lung cancer.
Journal: Frontiers of radiation therapy and oncology 20100101
Title: A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group study.
Journal: BMC medicine 20100101
Title: Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.
Journal: PloS one 20100101
Title: Targeting the EGF receptor for ovarian cancer therapy.
Journal: Journal of oncology 20100101
Title: Treatment for recurrent ovarian cancer-at first relapse.
Journal: Journal of oncology 20100101
Title: A current review of targeted therapeutics for ovarian cancer.
Journal: Journal of oncology 20100101
Title: Antivascular therapy for epithelial ovarian cancer.
Journal: Journal of oncology 20100101
Title: miR-21: an oncomir on strike in prostate cancer.
Journal: Molecular cancer 20100101
Title: Targeted therapy in ovarian cancer.
Journal: Journal of oncology 20100101
Title: Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20100101
Title: Endometrial cancer: what is new in adjuvant and molecularly targeted therapy?
Journal: Obstetrics and gynecology international 20100101
Title: Hypoxia-inducible factor-1 as a therapeutic target in endometrial cancer management.
Journal: Obstetrics and gynecology international 20100101
Title: BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.
Journal: Journal of oncology 20100101
Title: Identification of functional modules that correlate with phenotypic difference: the influence of network topology.
Journal: Genome biology 20100101
Title: Small-cell carcinoma of the ovary with breast metastases: a case report.
Journal: Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20100101
Title: PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology 20100101
Title: Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer.
Journal: Journal of hematology & oncology 20100101
Title: Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance.
Journal: BMC cancer 20100101
Title: Quality of life measurement in women with cervical cancer: implications for Chinese cervical cancer survivors.
Journal: Health and quality of life outcomes 20100101
Title: Cytotoxicity of Atriplex confertifolia.
Journal: Journal of toxicology 20100101
Title: MicroRNAs and their target gene networks in breast cancer.
Journal: Breast cancer research : BCR 20100101
Title: Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae).
Journal: BMC plant biology 20100101
Title: Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation.
Journal: PloS one 20100101
Title: Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
Journal: BMC molecular biology 20100101
Title: Peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy.
Journal: Journal of oncology 20100101
Title: Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.
Journal: Breast cancer research : BCR 20100101
Title: [Effect of topotecan as a second line treatment in small cell lung cancer patients. Preliminary report].
Journal: Pneumonologia i alergologia polska 20100101
Title: Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.
Journal: PloS one 20100101
Title: Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies.
Journal: Journal of oncology 20100101
Title: Effects of bevacizumab plus irinotecan on response and survival in patients with recurrent malignant glioma: a systematic review and survival-gain analysis.
Journal: BMC cancer 20100101
Title: Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complex.
Journal: PloS one 20100101
Title: Controversies in the management of endometrial carcinoma.
Journal: Obstetrics and gynecology international 20100101
Title: Anti-angiogenesis therapies: their potential in cancer management.
Journal: OncoTargets and therapy 20100101
Title: Hypoxia-specific targets in cancer therapy: role of splice variants.
Journal: BMC medicine 20100101
Title: Expression of chemoresistance-related genes and heat shock protein 72 in hyperthermic isolated limb perfusion of malignant melanoma: an experimental study.
Journal: Journal of oncology 20100101
Title: Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report.
Journal: Journal of medical case reports 20100101
Title: Personalized therapies in the cancer 'omics' era.
Journal: Molecular cancer 20100101
Title: HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin.
Journal: Journal of experimental & clinical cancer research : CR 20100101
Title: Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations.
Journal: Breast cancer research : BCR 20100101
Title: Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier.
Journal: Cerebrospinal fluid research 20100101
Title: Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent.
Journal: Marine drugs 20100101
Title: Systematic Review of topotecan (Hycamtin) in relapsed small cell lung cancer.
Journal: BMC cancer 20100101
Title: Recent advances in the treatment of acute myeloid leukemia.
Journal: F1000 medicine reports 20100101
Title: Paeonol oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells.
Journal: PloS one 20100101
Title: H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy.
Journal: Journal of nucleic acids 20100101
Title: Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination.
Journal: PloS one 20100101
Title: Fluorescence in situ hybridization in combination with the comet assay and micronucleus test in genetic toxicology.
Journal: Molecular cytogenetics 20100101
Title: Spontaneously Resolving Periocular Erythema and Ciliary Madarosis Following Intra-arterial Chemotherapy for Retinoblastoma.
Journal: Middle East African journal of ophthalmology 20100101
Title: Molecular pathology of retinoblastoma.
Journal: Middle East African journal of ophthalmology 20100101
Title: A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer.
Journal: Radiation oncology (London, England) 20100101
Title: Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Journal: PloS one 20100101
Title: Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review.
Journal: Metal-based drugs 20100101
Title: Chemotherapy in Ewing's sarcoma.
Journal: Indian journal of orthopaedics 20100101
Title: Nano to micro delivery systems: targeting angiogenesis in brain tumors.
Journal: Journal of angiogenesis research 20100101
Title: PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer.
Journal: F1000 biology reports 20100101
Title: Pegylated liposomal doxorubicin in the management of ovarian cancer.
Journal: Therapeutics and clinical risk management 20100101
Title: Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients.
Journal: International journal of nanomedicine 20100101
Title: Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation.
Journal: Molecular cytogenetics 20100101
Title: Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats.
Journal: International journal of nanomedicine 20100101
Title: GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma.
Journal: Stem cells international 20100101
Title: Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer.
Journal: BMC cancer 20100101
Title: Bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer.
Journal: Oncology 20100101
Title: Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.
Journal: Virology journal 20100101
Title: Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers.
Journal: Molecular cancer 20100101
Title: Pulmonary lymphangitic carcinomatosis from squamous cell carcinoma of the cervix.
Journal: World journal of surgical oncology 20100101
Title: AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells.
Journal: Oncology research 20100101
Title: Idiopathic hyperammonemia after chemotherapy with vinorelbine, topotecan, and cisplatin in a patient with acute lymphocytic leukemia.
Journal: Hematology/oncology and stem cell therapy 20100101
Title: Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review.
Journal: Cancer management and research 20100101
Title: Role of bevacizumab therapy in the management of glioblastoma.
Journal: Cancer management and research 20100101
Title: Efficacy and safety of amrubicin hydrochloride for treatment of relapsed small cell lung cancer.
Journal: Cancer management and research 20100101
Title: New developments in treatment of ovarian carcinoma: focus on trabectedin.
Journal: Cancer management and research 20100101
Title: Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
Journal: Advances in pharmacological sciences 20100101
Title: Development and Validation of a RP-Ultra performance liquid chromatographic Method for Quantification of Topotecan Hydrochloride in Bulk and Injection Dosage Form.
Journal: Indian journal of pharmaceutical sciences 20100101
Title: UK Guidelines for the Management of Bone Sarcomas.
Journal: Sarcoma 20100101
Title: Clinical trials and progress with paclitaxel in ovarian cancer.
Journal: International journal of women's health 20100101
Title: Role and timing of hematopoietic cell transplantation for myelodysplastic syndrome.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Primary signet ring cell mucinous ovarian carcinoma: a case report and literature review.
Journal: Case reports in oncology 20100101
Title: Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder.
Journal: Genetics and molecular biology 20100101
Title: Ayurveda and cancer.
Journal: Pharmacognosy research 20100101
Title: Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.
Journal: Pharmacognosy reviews 20100101
Title: Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma.
Journal: British journal of cancer 20091215
Title: Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
Journal: The Journal of pharmacology and experimental therapeutics 20091201
Title: Weekly combination of topotecan and gemcitabine in early recurrent ovarian cancer patients: a French multicenter phase II study.
Journal: Gynecologic oncology 20091201
Title: [Place of autologous and allogeneic hematopoietic stem cell transplantation in ovarian cancer].
Journal: Bulletin du cancer 20091201
Title: Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201
Title: Chemosensitivity of uterine cervical cancer demonstrated by the histoculture drug response assay.
Journal: The Tohoku journal of experimental medicine 20091201
Title: Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Journal: Neoplasia (New York, N.Y.) 20091201
Title: WU Polyomavirus (WUPyV): A Recently Detected Virus Causing Respiratory Disease?
Journal: Viruses 20091201
Title: 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
Journal: Journal of medicinal chemistry 20091126
Title: Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.
Journal: International journal of cancer 20091115
Title: Topotecan-carboplatin-etoposide combination as 1st line treatment in patients with small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20091101
Title: Venous thromboembolism in recurrent ovarian cancer-patients: A systematic evaluation of the North-Eastern German Society of Gynaecologic Oncology Ovarian Cancer Study Group (NOGGO).
Journal: Thrombosis research 20091101
Title: Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience.
Journal: Journal of neuro-oncology 20091101
Title: Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.
Journal: Molecular pharmacology 20091101
Title: A Phase II evaluation of weekly topotecan as a single agent second line therapy in persistent or recurrent carcinoma of the cervix: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20091101
Title: Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091101
Title: Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives.
Journal: Bioorganic & medicinal chemistry 20091101
Title: ABCG2-associated resistance to Hoechst 33342 and topotecan in a murine cell model with constitutive expression of side population characteristics.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20091101
Title: Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis.
Journal: Molecular cancer therapeutics 20091101
Title: Human leukocyte antigen class I expression is an independent prognostic factor in advanced ovarian cancer resistant to first-line platinum chemotherapy.
Journal: British journal of cancer 20091020
Title: Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.
Journal: The Journal of biological chemistry 20091009
Title: Chemotherapy versus best supportive care for extensive small cell lung cancer.
Journal: The Cochrane database of systematic reviews 20091007
Title: Evaluation of the paclitaxel-ifosfamide-cisplatin (TIP) combination in relapsed and/or metastatic cervical cancer.
Journal: British journal of cancer 20091006
Title: Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Journal: Leukemia research 20091001
Title: Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells.
Journal: Investigative ophthalmology & visual science 20091001
Title: Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091001
Title: A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation.
Journal: International journal of radiation oncology, biology, physics 20091001
Title: Chemotherapy: Topotecan or treosulfan--that is the question.
Journal: Nature reviews. Clinical oncology 20091001
Title: Phase II study of combination chemotherapy with etoposide and ifosfamide in patients with heavily pretreated recurrent or persistent epithelial ovarian cancer.
Journal: Journal of Korean medical science 20091001
Title: New advances in the second-line treatment of small cell lung cancer.
Journal: The oncologist 20091001
Title: [Clinical study on regimen cyclophosphamide, Ara-C and topotecan (CAT) in treatment of patients with refractory or relapsed acute myelogenous leukemia].
Journal: Zhongguo shi yan xue ye xue za zhi 20091001
Title: [Medical management of primary central nervous system lymphoma refractory or resistant to standard of care treatment].
Journal: Brain and nerve = Shinkei kenkyu no shinpo 20091001
Title: Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification.
Journal: Journal of medicinal chemistry 20090924
Title: Flow cytometry analysis of neural differentiation markers expression in human glioblastomas may predict their response to chemotherapy.
Journal: Cellular and molecular neurobiology 20090901
Title: Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20090901
Title: The role of transporters in the pharmacokinetics of orally administered drugs.
Journal: Pharmaceutical research 20090901
Title: Effects of concurrent topotecan and radiation on 6-month progression-free survival in the primary treatment of glioblastoma multiforme.
Journal: International journal of radiation oncology, biology, physics 20090901
Title: The reversal of drug-resistance in tumors using a drug-carrying nanoparticular system.
Journal: International journal of molecular sciences 20090901
Title: Weekly topotecan and daily thalidomide in patients with recurrent epithelial ovarian cancer: a report of 2 cases.
Journal: The Journal of reproductive medicine 20090901
Title: Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.
Journal: Interdisciplinary toxicology 20090901
Title: The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells.
Journal: Cancer letters 20090828
Title: Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme.
Journal: British journal of cancer 20090818
Title: The role of apoptotic cell death in the radiosensitising effect of gemcitabine.
Journal: British journal of cancer 20090818
Title: Anti-angiogenic properties of metronomic topotecan in ovarian carcinoma.
Journal: Cancer biology & therapy 20090815
Title: Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells.
Journal: Cancer chemotherapy and pharmacology 20090801
Title: HIF-1alpha modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines.
Journal: Journal of cancer research and clinical oncology 20090801
Title: Topotecan versus treosulfan, an alkylating agent, in patients with epithelial ovarian cancer and relapse within 12 months following 1st-line platinum/paclitaxel chemotherapy. A prospectively randomized phase III trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR).
Journal: Gynecologic oncology 20090801
Title: Topotecan combined with carboplatin in recurrent epithelial ovarian cancer: results of a single-institutional phase II study.
Journal: Gynecologic oncology 20090801
Title: On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Journal: Bioorganic & medicinal chemistry letters 20090801
Title: 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation.
Journal: Bioorganic & medicinal chemistry letters 20090801
Title: Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy.
Journal: Journal of pediatric hematology/oncology 20090801
Title: Hexamethylmelamine as consolidation treatment for patients with advanced epithelial ovarian cancer in complete response after first-line chemotherapy.
Journal: Journal of Korean medical science 20090801
Title: [Effect of topotecan on expression of aquaporin protein 5 and nuclear factor-kappaB in ovarian cancer SKOV3 cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20090801
Title: [Effect of topotecan on MAGE gene expression of HPB-AM cells].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090801
Title: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.
Journal: Cancer research 20090715
Title: Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
Journal: British journal of cancer 20090707
Title: Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20090701
Title: Application of prolonged microdialysis sampling in carboplatin-treated cancer patients.
Journal: Cancer chemotherapy and pharmacology 20090701
Title: Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
Journal: Journal of neuro-oncology 20090701
Title: Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.
Journal: Biomedical chromatography : BMC 20090701
Title: Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090701
Title: Blasting neuroblastoma using optimal control of chemotherapy.
Journal: Mathematical biosciences and engineering : MBE 20090701
Title: Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.
Journal: Molecular cancer therapeutics 20090701
Title: Pros and cons for systemic therapy in recurrent ovarian cancer.
Journal: Anticancer research 20090701
Title: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.
Journal: Cancer letters 20090628
Title: Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628
Title: Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells.
Journal: British journal of cancer 20090616
Title: Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin.
Journal: Bioorganic & medicinal chemistry letters 20090615
Title: Salvage therapy with topotecan in heavily pretreated ovarian cancer patients.
Journal: Journal of cancer research and clinical oncology 20090601
Title: Topotecan in combination with radiotherapy in unresectable glioblastoma: a phase 2 study.
Journal: Journal of neuro-oncology 20090601
Title: Genetic alterations and chemosensitivity profile in newly established human renal collecting duct carcinoma cell lines.
Journal: BJU international 20090601
Title: A phase II study of weekly topotecan and docetaxel in heavily treated patients with recurrent uterine and ovarian cancers.
Journal: Gynecologic oncology 20090601
Title: Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601
Title: DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin.
Journal: Protein science : a publication of the Protein Society 20090601
Title: Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
Journal: Journal of natural products 20090522
Title: Dose escalation methods in phase I cancer clinical trials.
Journal: Journal of the National Cancer Institute 20090520
Title: Use of an anti-vascular endothelial growth factor antibody in a pharmacokinetic strategy to increase the efficacy of intraperitoneal chemotherapy.
Journal: The Journal of pharmacology and experimental therapeutics 20090501
Title: MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy.
Journal: Gynecologic oncology 20090501
Title: The combination topotecan, temozolomide and dexamethasone associated with radiotherapy as treatment of central nervous system myeloma relapse.
Journal: International journal of hematology 20090501
Title: A phase I study of topotecan plus carboplatin for relapsed SCLC: WJTOG trial.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20090501
Title: Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases.
Journal: Acta pharmacologica Sinica 20090501
Title: Novel camptothecin derivatives as topoisomerase I inhibitors.
Journal: Expert opinion on therapeutic patents 20090501
Title: Topotecan-induced long-term remission of an advanced endometrial cancer after treatment with cisplatinum, an anthracycline and paclitaxel.
Journal: Anticancer research 20090501
Title: [Second-line treatment and targeted therapy of advanced lung cancer].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20090501
Title: UV-vis spectra of the anticancer camptothecin family drugs in aqueous solution: specific spectroscopic signatures unraveled by a combined computational and experimental study.
Journal: The journal of physical chemistry. B 20090423
Title: Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.
Journal: British journal of cancer 20090407
Title: A phase I study of periocular topotecan in children with intraocular retinoblastoma.
Journal: Investigative ophthalmology & visual science 20090401
Title: Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
Journal: European journal of medicinal chemistry 20090401
Title: Lack of stability of topotecan in heart tissue homogenates: is it an analytical dilemma or a real phenomenon?
Journal: Biomedical chromatography : BMC 20090401
Title: Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial.
Journal: Gynecologic oncology 20090401
Title: 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
Journal: Bioorganic & medicinal chemistry 20090401
Title: NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis.
Journal: Proteomics 20090401
Title: Recent achievements and future developments in advanced and recurrent cervical cancer: trials of the Gynecologic Oncology Group.
Journal: Seminars in oncology 20090401
Title: Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs.
Journal: Expert opinion on pharmacotherapy 20090401
Title: Three-day topotecan schedule in heavily pretreated recurrent ovarian cancer patients.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20090401
Title: EGFR inhibition using gefitinib is not active in neuroblastoma cell lines.
Journal: Anticancer research 20090401
Title: Triple cytotoxic therapy for advanced ovarian cancer: a failed application, not a failed strategy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090320
Title: Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090320
Title: Extended weekly dose-dense paclitaxel/carboplatin is feasible and active in heavily pre-treated platinum-resistant recurrent ovarian cancer.
Journal: British journal of cancer 20090310
Title: Phase II trial of combined modality therapy with concurrent topotecan plus radiotherapy followed by consolidation chemotherapy for unresectable stage III and selected stage IV non-small-lung cancer.
Journal: International journal of radiation oncology, biology, physics 20090301
Title: Modulation of the physicochemical state of interior agents to prepare controlled release liposomes.
Journal: Colloids and surfaces. B, Biointerfaces 20090301
Title: Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan.
Journal: Environmental and molecular mutagenesis 20090301
Title: Current role and future aspects of topotecan in relapsed ovarian cancer.
Journal: Current medical research and opinion 20090301
Title: Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.
Journal: International journal of clinical pharmacology and therapeutics 20090301
Title: Gemcitabine-oxaliplatin combination for ovarian cancer resistant to taxane-platinum treatment: a phase II study from the GINECO group.
Journal: British journal of cancer 20090224
Title: [Comparison of Oral Topotecan/Intravenous Cisplatin (TC) with Intravenous Etoposide/Cisplatin (EP) as First Line Chemotherapy in Untreated Small Cell Lung Cancer Patient.].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20090220
Title: Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
Title: The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: a systematic review and meta-analysis.
Journal: British journal of cancer 20090210
Title: Topotecan enhances immune clearance of gliomas.
Journal: Cancer immunology, immunotherapy : CII 20090201
Title: Phase I trial of weekly topotecan and gemcitabine in patients with solid tumors.
Journal: American journal of clinical oncology 20090201
Title: Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability.
Journal: Anti-cancer agents in medicinal chemistry 20090201
Title: [Effect of different chemotherapy regimens for concurrent chemoradiotherapy on locally advanced non-small cell lung cancer].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20090201
Title: Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.
Journal: Advanced drug delivery reviews 20090131
Title: A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer.
Journal: British journal of cancer 20090127
Title: Synthesis and antitumor activity of novel 20s-camptothecin analogues.
Journal: Bioorganic & medicinal chemistry letters 20090115
Title: Efficacy of topotecan plus vincristine and doxorubicin in children with recurrent/refractory rhabdomyosarcoma.
Journal: Medical oncology (Northwood, London, England) 20090101
Title: Population pharmacokinetics of cyclophosphamide and metabolites in children with neuroblastoma: a report from the Children's Oncology Group.
Journal: Journal of clinical pharmacology 20090101
Title: A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer.
Journal: Gynecologic oncology 20090101
Title: Weekly topotecan as second- or third-line treatment in patients with recurrent or metastatic cervical cancer.
Journal: Medical oncology (Northwood, London, England) 20090101
Title: Treatment of myelodysplastic syndrome with 2 schedules and doses of oral topotecan: a randomized phase 2 trial by the Cancer and Leukemia Group B (CALGB 19803).
Journal: Cancer 20090101
Title: Diflomotecan, a promising homocamptothecin for cancer therapy.
Journal: Expert opinion on investigational drugs 20090101
Title: Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp.
Journal: Neoplasia (New York, N.Y.) 20090101
Title: Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination.
Journal: Theoretical biology & medical modelling 20090101
Title: A literature review of the recent radiotherapy clinical trials in pediatric brain tumors.
Journal: Reviews on recent clinical trials 20090101
Title: Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.
Journal: Molecular cancer 20090101
Title: The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
Journal: Journal of carcinogenesis 20090101
Title: Port-site metastasis after laparoscopic extraperitoneal paraaortic lymphadenectomy for stage IIb squamous cell carcinoma of the cervix.
Journal: Journal of minimally invasive gynecology 20090101
Title: Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals.
Journal: Molecular pharmaceutics 20090101
Title: CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors.
Journal: Molecular cancer 20090101
Title: Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs).
Journal: Methods in molecular biology (Clifton, N.J.) 20090101
Title: Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function.
Journal: PloS one 20090101
Title: Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis.
Journal: PloS one 20090101
Title: Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP.
Journal: Reproductive biology and endocrinology : RB&E 20090101
Title: A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy.
Journal: PloS one 20090101
Title: Outcome of recurrent and metastatic small cell carcinoma of the bladder.
Journal: BMC urology 20090101
Title: Neoadjuvant chemotherapy or primary surgery for stage III/IV ovarian cancer: contribution of diagnostic laparoscopy.
Journal: BMC cancer 20090101
Title: Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin.
Journal: Clinical interventions in aging 20090101
Title: Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial.
Journal: Trials 20090101
Title: Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice.
Journal: Journal of experimental & clinical cancer research : CR 20090101
Title: The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells.
Journal: Radiation oncology (London, England) 20090101
Title: An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.
Journal: Breast cancer research : BCR 20090101
Title: A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.
Journal: Journal of hematology & oncology 20090101
Title: Functional expression of a DNA-topoisomerase IB from Cryptosporidium parvum.
Journal: Journal of biomedicine & biotechnology 20090101
Title: Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy.
Journal: PloS one 20090101
Title: Small-cell prostate carcinoma: A retrospective analysis of five newly reported cases.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20090101
Title: Network-assisted protein identification and data interpretation in shotgun proteomics.
Journal: Molecular systems biology 20090101
Title: Pegylated liposomal doxorubicin in ovarian cancer.
Journal: Therapeutics and clinical risk management 20090101
Title: Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Journal: Genome medicine 20090101
Title: Treatment of recurrent epithelial ovarian cancer.
Journal: Therapeutics and clinical risk management 20090101
Title: Cytometric assessment of DNA damage induced by DNA topoisomerase inhibitors.
Journal: Methods in molecular biology (Clifton, N.J.) 20090101
Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Journal: PloS one 20090101
Title: Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
Journal: PloS one 20090101
Title: BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?
Journal: Journal of ovarian research 20090101
Title: Rhabdomyosarcoma of the posterior chest wall in a newborn: a case report.
Journal: Cases journal 20090101
Title: Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.
Journal: Molecular cancer 20090101
Title: Twenty-seven years of phase III trials for patients with extensive disease small-cell lung cancer: disappointing results.
Journal: PloS one 20090101
Title: Apoptotic and chemotherapeutic properties of iron (III)-salophene in an ovarian cancer animal model.
Journal: Drug design, development and therapy 20090101
Title: Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.
Journal: Molecular cancer 20090101
Title: Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008.
Journal: Health and quality of life outcomes 20090101
Title: A reproducible brain tumour model established from human glioblastoma biopsies.
Journal: BMC cancer 20090101
Title: What lies behind serum urate concentration? Insights from genetic and genomic studies.
Journal: Genome medicine 20090101
Title: InPACdb--Indian plant anticancer compounds database.
Journal: Bioinformation 20090101
Title: Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines.
Journal: Oxidative medicine and cellular longevity 20090101
Title: Bendamustine in the treatment of non-Hodgkin's lymphomas.
Journal: OncoTargets and therapy 20090101
Title: A Novel Docetaxel-Loaded Poly (ε-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment.
Journal: Nanoscale research letters 20090101
Title: Update on the utility of prognostic biomarkers in ovarian cancer.
Journal: F1000 medicine reports 20090101
Title: Current status of maintenance therapy for advanced ovarian cancer.
Journal: International journal of women's health 20090101
Title: Evolving role of cetuximab in the treatment of colorectal cancer.
Journal: Cancer management and research 20090101
Title: Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron.
Journal: Cancer management and research 20090101
Title: A potential novel combination therapy targeting survivin in renal cancer cells: Inhibition of survivin expression by topotecan and hexamethylene bisacetamide.
Journal: Molecular medicine reports 20090101
Title: Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.
Journal: Bioorganic & medicinal chemistry letters 20081215
Title: Thalidomide-induced reversible interstitial pneumonitis in a patient with recurrent ovarian cancer.
Journal: Gynecologic oncology 20081201
Title: Outcomes of the POG 9340/9341/9342 trials for children with high-risk neuroblastoma: a report from the Children's Oncology Group.
Journal: Pediatric blood & cancer 20081201
Title: WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
Journal: DNA repair 20081201
Title: Phase II evaluation of topotecan and navelbine in patients with recurrent ovarian, fallopian tube or primary peritoneal cancer.
Journal: Gynecologic oncology 20081201
Title: Glutamate regulates the activity of topoisomerase I in mouse cerebellum.
Journal: Molecular neurobiology 20081201
Title: ABCG2 Q141K polymorphism is associated with chemotherapy-induced diarrhea in patients with diffuse large B-cell lymphoma who received frontline rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone chemotherapy.
Journal: Cancer science 20081201
Title: Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081201
Title: Management of small-cell lung cancer: incremental changes but hope for the future.
Journal: Oncology (Williston Park, N.Y.) 20081130
Title: Anti-proliferative and pro-apoptotic effect of CPT13, a novel camptothecin analog, on human colon cancer HCT8 cell line.
Journal: Chemico-biological interactions 20081125
Title: Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081120
Title: The role of polyamine architecture on the pharmacological activity of open lactone camptothecin-polyamine conjugates.
Journal: Bioconjugate chemistry 20081119
Title: Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081115
Title: Antitumor efficacy testing in rodents.
Journal: Journal of the National Cancer Institute 20081105
Title: A modified surgical procedure for microdialysis probe implantation in the lateral ventricle of a FVB mouse.
Journal: Journal of pharmaceutical sciences 20081101
Title: Salvage treatment with topotecan in patients with irinotecan-refractory small cell lung cancer.
Journal: Cancer chemotherapy and pharmacology 20081101
Title: Topotecan distribution in an anephric infant with therapy-resistant bilateral Wilms tumor with a novel germline WT1 gene mutation.
Journal: Cancer chemotherapy and pharmacology 20081101
Title: Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells.
Journal: Pharmaceutical research 20081101
Title: Chemotherapy for recurrent cervical cancer.
Journal: Cancer treatment reviews 20081101
Title: Retinoblastoma: what is new in 2007-2008.
Journal: Current opinion in ophthalmology 20081101
Title: Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma).
Journal: Expert opinion on investigational drugs 20081101
Title: Phase II clinical trial of pegylated liposomal doxorubicin (JNS002) in Japanese patients with mullerian carcinoma (epithelial ovarian carcinoma, primary carcinoma of fallopian tube, peritoneal carcinoma) having a therapeutic history of platinum-based chemotherapy: a Phase II Study of the Japanese Gynecologic Oncology Group.
Journal: Japanese journal of clinical oncology 20081101
Title: Interspecies scaling of a camptothecin analogue: human predictions for intravenous topotecan using animal data.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081101
Title: [A case of stage IV breast cancer in which a long-term no change state (NC) was attained by a combination of S-1 and TAM following AC-T as a primary systemic therapy (PST)].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20081101
Title: Future research directions for the treatment of AML.
Journal: Clinical advances in hematology & oncology : H&O 20081101
Title: Adjuvant hysterectomy for treatment of residual disease in patients with cervical cancer treated with radiation therapy.
Journal: British journal of cancer 20081021
Title: Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Journal: Bioorganic & medicinal chemistry 20081015
Title: Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.
Journal: Pharmaceutical research 20081001
Title: Paclitaxel, topotecan, and carboplatin in metastatic endometrial cancinoma: a Hellenic Co-operative Oncology Group (HeCOG) study.
Journal: Gynecologic oncology 20081001
Title: Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84).
Journal: Biochemical pharmacology 20081001
Title: Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.
Journal: Cell cycle (Georgetown, Tex.) 20081001
Title: Experimental treatment of neuroblastoma using [131I]meta-iodobenzylguanidine and topotecan in combination.
Journal: The British journal of radiology 20081001
Title: Symptom assessment in relapsed small cell lung cancer: cross-validation of the patient symptom assessment in lung cancer instrument.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20081001
Title: Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
Journal: Cancer research 20081001
Title: A phase I study of oral topotecan and pegylated liposomal doxorubicin (doxil) in platinum-resistant ovarian and peritoneal cancer.
Journal: American journal of clinical oncology 20081001
Title: A genomic approach to identify molecular pathways associated with chemotherapy resistance.
Journal: Molecular cancer therapeutics 20081001
Title: Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors.
Journal: Molecular cancer therapeutics 20081001
Title: [Down-regulation of TopI by RNA interference reduces the drug-sensitivity of small cell lung cancer cell lines to topotecan].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20081001
Title: Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: application to pharmacokinetic studies.
Journal: Talanta 20080915
Title: 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
Journal: Bioorganic & medicinal chemistry 20080915
Title: Speeding up the evaluation of new agents in cancer.
Journal: Journal of the National Cancer Institute 20080903
Title: Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
Journal: British journal of cancer 20080902
Title: Chemotherapy for recurrent and metastatic cervical cancer.
Journal: Gynecologic oncology 20080901
Title: Tumor heterogeneity in ovarian cancer as demonstrated by in vitro chemoresistance assays.
Journal: Gynecologic oncology 20080901
Title: Novel chemotherapy approaches in chemoradiation protocols.
Journal: Gynecologic oncology 20080901
Title: Trilateral retinoblastoma with pituitary-hypothalamic dysfunction.
Journal: Ophthalmic genetics 20080901
Title: Long-term survival of a patient with small cell lung cancer after nine lines of chemotherapy and radiation.
Journal: Onkologie 20080901
Title: AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.
Journal: Molecular cancer therapeutics 20080901
Title: Imatinib-mediated inactivation of Akt regulates ABCG2 function in head and neck squamous cell carcinoma.
Journal: Archives of otolaryngology--head & neck surgery 20080901
Title: Combined oral cyclophosphamide and bevacizumab in heavily pre-treated ovarian cancer.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20080901
Title: The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells.
Journal: Interdisciplinary toxicology 20080901
Title: Topotecan and carboplatin in patients with platinum-sensitive recurrent ovarian cancer. Results of a multicenter NOGGO: phase I/II study.
Journal: Cancer chemotherapy and pharmacology 20080801
Title: The feasibility of using topotecan, vinorelbine, thiotepa and gemcitabine (TVTG) in adult patients with relapsed/refractory acute lymphoblastic leukaemia/lymphoma.
Journal: Leukemia 20080801
Title: Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.
Journal: Molecular pharmacology 20080801
Title: Topotecan treatment and its toxic effects on hematologic parameters and trace elements.
Journal: Biological trace element research 20080801
Title: Phase 2 study of intraperitoneal topotecan as consolidation chemotherapy in ovarian and primary peritoneal carcinoma.
Journal: Cancer 20080801
Title: Treatment of recurrent or persistent platinum-refractory ovarian, fallopian tube or primary peritoneal cancer with gemcitabine and topotecan: a phase II trial of the Puget Sound Oncology Consortium.
Journal: Gynecologic oncology 20080801
Title: Concomitant and neoadjuvant chemotherapy for cervical cancer.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20080801
Title: Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080801
Title: Optimizing MIBG therapy of neuroendocrine tumors: preclinical evidence of dose maximization and synergy.
Journal: Nuclear medicine and biology 20080801
Title: [Effects of CPUY013, a novel Topo I inhibitor, on human gastric adenocarcinoma BGC823 cells in vitro and in vivo].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080801
Title: A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.
Journal: The Journal of biological chemistry 20080725
Title: Novel hexacyclic camptothecin derivatives. Part 1: synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring.
Journal: Bioorganic & medicinal chemistry letters 20080715
Title: EGFR-targeting drugs in combination with cytotoxic agents: from bench to bedside, a contrasted reality.
Journal: British journal of cancer 20080708
Title: Erufosine, a novel alkylphosphocholine, in acute myeloid leukemia: single activity and combination with other antileukemic drugs.
Journal: Cancer chemotherapy and pharmacology 20080701
Title: Central neurocytoma responsive to topotecan, ifosfamide, carboplatin.
Journal: Pediatric blood & cancer 20080701
Title: Intrathecal chemotherapy delivered by a lumbar-thecal catheter in metastatic medulloblastoma: a case illustration.
Journal: Acta neurochirurgica 20080701
Title: Nonplatinum topotecan combinations versus topotecan alone for recurrent ovarian cancer: results of a phase III study of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080701
Title: Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Journal: Molecular cancer therapeutics 20080701
Title: Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
Journal: Molecular cancer therapeutics 20080701
Title: Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.
Journal: Investigational new drugs 20080601
Title: BCRP/ABCG2 in the placenta: expression, function and regulation.
Journal: Pharmaceutical research 20080601
Title: ATP modulates poly(ADP-ribose) polymerase-1-facilitated topoisomerase I-linked DNA religation in the presence of camptothecin.
Journal: Molecular pharmacology 20080601
Title: Topotecan weekly bolus chemotherapy for relapsed platinum-sensitive ovarian and peritoneal cancers.
Journal: Gynecologic oncology 20080601
Title: Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20080601
Title: Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling.
Journal: Mathematical biosciences 20080601
Title: Prolonged survival with continuous infusion topotecan: a report of 2 cases.
Journal: Journal of pediatric hematology/oncology 20080601
Title: ISG15 as a novel tumor biomarker for drug sensitivity.
Journal: Molecular cancer therapeutics 20080601
Title: The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line.
Journal: Cancer investigation 20080601
Title: [Recent progress in the study on antitumor drugs targeting hypoxia-inducible factor-1].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601
Title: Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib.
Journal: British journal of cancer 20080520
Title: Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.
Journal: British journal of cancer 20080506
Title: Topotecan and cisplatin in combination with concurrent twice-daily chemoradiation in limited disease small cell lung cancer-a Danish Oncological Lung Cancer Group (DOLG) phase II trial.
Journal: Lung cancer (Amsterdam, Netherlands) 20080501
Title: Phase II study of topotecan in combination with dexamethasone, asparaginase, and vincristine in pediatric patients with acute lymphoblastic leukemia in first relapse.
Journal: Cancer 20080501
Title: Listen to their answers! Response behaviour in the measurement of physical and role functioning.
Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20080501
Title: E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: Synthesis and cytotoxic activity of new 9-substituted camptothecins.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: Topoisomerase I inhibitors for the treatment of brain tumors.
Journal: Expert review of anticancer therapy 20080501
Title: Key role of topoisomerase I inhibitors in the treatment of recurrent and refractory epithelial ovarian carcinoma.
Journal: Expert review of anticancer therapy 20080501
Title: A randomized phase II trial of oral topotecan versus docetaxel in the second-line treatment of non-small-cell lung cancer.
Journal: Clinical lung cancer 20080501
Title: Topotecan for ovarian cancer.
Journal: The Cochrane database of systematic reviews 20080416
Title: The effect of PEG coating on in vitro cytotoxicity and in vivo disposition of topotecan loaded liposomes in rats.
Journal: International journal of pharmaceutics 20080402
Title: Symptom burden after autologous stem cell transplantation for multiple myeloma.
Journal: Cancer 20080401
Title: Costs associated with intravenous chemotherapy administration in patients with small cell lung cancer: a retrospective claims database analysis.
Journal: Current medical research and opinion 20080401
Title: A multicenter phase II trial of intrathecal topotecan in patients with meningeal malignancies.
Journal: Neuro-oncology 20080401
Title: Effect of frequently used chemotherapeutic drugs on cytotoxic activity of human cytotoxic T-lymphocytes.
Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20080401
Title: Combination of metronomic gimatecan and CpG-oligodeoxynucleotides against an orthotopic pancreatic cancer xenograft.
Journal: Cancer biology & therapy 20080401
Title: Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.
Journal: Leukemia & lymphoma 20080401
Title: Freeze drying of double emulsions to prepare topotecan-entrapping liposomes featuring controlled release.
Journal: Drug development and industrial pharmacy 20080401
Title: Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia.
Journal: Anti-cancer drugs 20080401
Title: Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study.
Journal: Statistics in medicine 20080330
Title: Next generation topoisomerase I inhibitors: Rationale and biomarker strategies.
Journal: Biochemical pharmacology 20080315
Title: Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.
Journal: British journal of cancer 20080311
Title: Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma.
Journal: Pediatric blood & cancer 20080301
Title: Chemotherapy-induced dermatological toxicity: frequencies and impact on quality of life in women's cancers. Results of a prospective study.
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080301
Title: Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression.
Journal: Molecular pharmacology 20080301
Title: Tolerance and activity of oxaliplatin with protracted topotecan infusion in patients with previously treated ovarian cancer. A phase I study.
Journal: Gynecologic oncology 20080301
Title: Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies.
Journal: Molecular cancer therapeutics 20080301
Title: [Therapeutic and adverse effects of topotecan combined with cisplatin for treatment of advanced squamous cell lung cancer and head and neck cancer].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080301
Title: Management of recurrent small cell lung cancer.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20080301
Title: Tumor targeting using liposomal antineoplastic drugs.
Journal: International journal of nanomedicine 20080301
Title: FLIP as an anti-cancer therapeutic target.
Journal: Yonsei medical journal 20080227
Title: A phase II randomised clinical trial comparing cisplatin, paclitaxel and ifosfamide with cisplatin, paclitaxel and epirubicin in newly diagnosed advanced epithelial ovarian cancer: long-term survival analysis.
Journal: British journal of cancer 20080226
Title: Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080215
Title: Construction of optimized bispecific antibodies for selective activation of the death receptor CD95.
Journal: Cancer research 20080215
Title: Combination of topotecan and etoposide as a salvage treatment for patients with recurrent small cell lung cancer following irinotecan and platinum first-line chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20080201
Title: Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.
Journal: Molecular pharmacology 20080201
Title: A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan.
Journal: Computer methods and programs in biomedicine 20080201
Title: Phase I study of weekly topotecan combined to concurrent external cranial irradiation in adults with glioblastoma multiforme of the brain.
Journal: Oncology reports 20080201
Title: New homocamptothecins: synthesis, antitumor activity, and molecular modeling.
Journal: Bioorganic & medicinal chemistry 20080201
Title: Subconjunctival topotecan in fibrin sealant in the treatment of transgenic murine retinoblastoma.
Journal: Investigative ophthalmology & visual science 20080201
Title: [Chemotherapy for brain tumors in adult patients].
Journal: Der Nervenarzt 20080201
Title: Small-cell lung cancer, getting smaller but still difficult to treat.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080201
Title: Therapeutic options for chronic myeloid leukemia: focus on imatinib (Glivec, Gleevectrade mark).
Journal: Therapeutics and clinical risk management 20080201
Title: A review of topotecan in combination chemotherapy for advanced cervical cancer.
Journal: Therapeutics and clinical risk management 20080201
Title: [New strategies in pediatric ophthalmic oncology].
Journal: Revue medicale suisse 20080116
Title: A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma.
Journal: Cancer 20080115
Title: Favorable response of intraommaya topotecan for leptomeningeal metastasis of neuroblastoma after intravenous route failure.
Journal: Pediatric blood & cancer 20080101
Title: A feasibility study of low-dose, prolonged oral topotecan in patients with advanced ovarian, fallopian tube, or primary peritoneal serous cancer who have attained a complete clinical response following platinum-based chemotherapy.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101
Title: Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors.
Journal: Journal of neuro-oncology 20080101
Title: Prospective evaluation of weekly topotecan in recurrent platinum-resistant epithelial ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101
Title: Phase II multicenter open-label study of karenitecin in previously treated epithelial ovarian and primary peritoneal cancer: a Gynecologic Oncology Group Study.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101
Title: Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma.
Journal: Journal of neuro-oncology 20080101
Title: A Phase I trial of weekly docetaxel and topotecan for solid tumors.
Journal: Acta oncologica (Stockholm, Sweden) 20080101
Title: Weekly topotecan for recurrent platinum resistant ovarian cancer.
Journal: Gynecologic oncology 20080101
Title: Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Journal: The Journal of pharmacology and experimental therapeutics 20080101
Title: A phase II study of topotecan and docetaxel in patients with sensitive relapse small cell lung cancer.
Journal: Acta oncologica (Stockholm, Sweden) 20080101
Title: Prognostic factors in patients treated with taxane-based chemotherapy for recurrent or metastatic endometrial cancer: proposal for a new prognostic model.
Journal: Gynecologic oncology 20080101
Title: Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents.
Journal: The Journal of pharmacy and pharmacology 20080101
Title: Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan.
Journal: International journal of oncology 20080101
Title: Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080101
Title: From plasma membrane to cytoskeleton: a novel function for semaphorin 6A.
Journal: Molecular cancer therapeutics 20080101
Title: Preparation, optimization, and characterization of topotecan loaded PEGylated liposomes using factorial design.
Journal: Drug development and industrial pharmacy 20080101
Title: Binding of topotecan to a nicked DNA oligomer in solution.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
Journal: Molecular cancer 20080101
Title: Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.
Journal: PLoS medicine 20080101
Title: Chemotherapy for advanced, recurrent, and metastatic cervical cancer.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20080101
Title: Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids.
Journal: BMC genomics 20080101
Title: Prostaglandin E2 metabolism in rat brain: Role of the blood-brain interfaces.
Journal: Cerebrospinal fluid research 20080101
Title: A phase II, multicenter trial of weekly topotecan in patients with recurrent platinum-sensitive epithelial cancers of the ovary and peritoneum.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101
Title: First-line randomized trials: revisiting the Ptolemaic universe.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101
Title: Multiple myeloma emerging after chemotherapy for non-small-cell lung cancer.
Journal: Medical oncology (Northwood, London, England) 20080101
Title: Drug waste minimisation and cost-containment in Medical Oncology: two-year results of a feasibility study.
Journal: BMC health services research 20080101
Title: [Imatinib--a possible therapeutic option for cervical carcinoma: results of a preclinical phase I study].
Journal: Gynakologisch-geburtshilfliche Rundschau 20080101
Title: Design, synthesis and development of novel camptothecin drugs.
Journal: Current pharmaceutical design 20080101
Title: Current status of clinical trials for small cell lung cancer.
Journal: Reviews on recent clinical trials 20080101
Title: PPARgamma in Neuroblastoma.
Journal: PPAR research 20080101
Title: FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate.
Journal: World journal of surgical oncology 20080101
Title: Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major.
Journal: BMC microbiology 20080101
Title: Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells.
Journal: PloS one 20080101
Title: Cell killing and resistance in pre-operative breast cancer chemotherapy.
Journal: BMC cancer 20080101
Title: Cervical lymphadenopathy - an unusual presentation of carcinoma of the cervix: a case report.
Journal: Journal of medical case reports 20080101
Title: Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy.
Journal: BMC gastroenterology 20080101
Title: Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line.
Journal: Journal of translational medicine 20080101
Title: EGFR and HER2 expression in primary cervical cancers and corresponding lymph node metastases: implications for targeted radiotherapy.
Journal: BMC cancer 20080101
Title: Activity of chemotherapy in mucinous ovarian cancer with a recurrence free interval of more than 6 months: results from the SOCRATES retrospective study.
Journal: BMC cancer 20080101
Title: Neuropsychological testing and biomarkers in the management of brain metastases.
Journal: Radiation oncology (London, England) 20080101
Title: Extrapulmonary small cell carcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans.
Journal: World journal of surgical oncology 20080101
Title: Small-cell lung cancer: an unusual therapeutic approach with more than 10-year overall survival. Case report and review of the literature.
Journal: Tumori 20080101
Title: Intestinal permeability and toxicity of second-line therapeutic agents in ovarian cancer.
Journal: Tumori 20080101
Title: Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance.
Journal: BMC cancer 20080101
Title: Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study.
Journal: BMC cancer 20080101
Title: Alternate serotype adenovector provides long-term therapeutic gene expression in the eye.
Journal: Molecular vision 20080101
Title: Next-generation anthracycline for the management of small cell lung cancer: focus on amrubicin.
Journal: Drug design, development and therapy 20080101
Title: Topotecan in the treatment of relapsed small cell lung cancer.
Journal: OncoTargets and therapy 20080101
Title: A review on plant-derived natural products and their analogs with anti-tumor activity.
Journal: Indian journal of pharmacology 20080101
Title: Primary central nervous system lymphomas: salvage treatment after failure to high-dose methotrexate.
Journal: Cancer letters 20071218
Title: A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.
Journal: British journal of cancer 20071217
Title: [Evaluation of second-line chemotherapies most often used in recurrent epithelial ovarian cancer].
Journal: Orvosi hetilap 20071209
Title: Activity of endovesical gemcitabine in BCG-refractory bladder cancer patients: a translational study.
Journal: British journal of cancer 20071203
Title: Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP).
Journal: Journal of pharmaceutical sciences 20071201
Title: Mathematical modeling of topotecan pharmacokinetics and toxicodynamics in mice.
Journal: Journal of pharmacokinetics and pharmacodynamics 20071201
Title: Increased phosphorylation of caveolin-1 in the spinal cord of irradiated rats.
Journal: Journal of veterinary science 20071201
Title: Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factors.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20071201
Title: Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
Journal: Molecular cancer therapeutics 20071201
Title: Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.
Journal: Molecular cancer therapeutics 20071201
Title: In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.
Journal: Molecular cancer therapeutics 20071201
Title: Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation.
Journal: International journal of nanomedicine 20071201
Title: Topotecan: An evolving option in the treatment of relapsed small cell lung cancer.
Journal: Therapeutics and clinical risk management 20071201
Title: Palonosetron as an anti-emetic and anti-nausea agent in oncology.
Journal: Therapeutics and clinical risk management 20071201
Title: Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071120
Title: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.
Journal: British journal of cancer 20071119
Title: Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115
Title: Population pharmacokinetic analysis of topotecan in pediatric cancer patients.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071115
Title: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.
Journal: The EMBO journal 20071114
Title: Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
Journal: The EMBO journal 20071114
Title: Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship.
Journal: Cancer chemotherapy and pharmacology 20071101
Title: Treatment of recurrent ovarian cancer relapsing 6-12 months post platinum-based chemotherapy.
Journal: Critical reviews in oncology/hematology 20071101
Title: Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.
Journal: Biomedical chromatography : BMC 20071101
Title: Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101
Title: Psychometric validation of the Patient Symptom Assessment in Lung Cancer instrument for small cell lung cancer.
Journal: Current medical research and opinion 20071101
Title: The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
Journal: British journal of pharmacology 20071101
Title: P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071101
Title: Prolonged response to oral gefitinib, cyclophosphamide, and topotecan in heavily pretreated relapsed stage 4 neuroblastoma: a case report.
Journal: Journal of pediatric hematology/oncology 20071101
Title: Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.
Journal: Anti-cancer agents in medicinal chemistry 20071101
Title: Integrated computational strategies for UV/vis spectra of large molecules in solution.
Journal: Chemical Society reviews 20071101
Title: The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study.
Journal: British journal of cancer 20071022
Title: Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071020
Title: UVC inhibits HIF-1alpha protein translation by a DNA damage- and topoisomerase I-independent pathway.
Journal: Oncogene 20071018
Title: First-into-man phase I and pharmacokinetic study of XR5944.14, a novel agent with a unique mechanism of action.
Journal: British journal of cancer 20071008
Title: The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Journal: Oncology reports 20071001
Title: Chemotherapy for recurrent cervical cancer.
Journal: Gynecologic oncology 20071001
Title: The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation.
Journal: Cancer research 20071001
Title: Antiangiogenic activity of thalidomide in combination with fludarabine, carboplatin, and topotecan for high-risk acute myelogenous leukemia.
Journal: Leukemia & lymphoma 20071001
Title: Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells.
Journal: Molecular cancer therapeutics 20071001
Title: Cancer antigen 125 in ovarian cancer surveillance: a decision analysis model.
Journal: Current oncology (Toronto, Ont.) 20071001
Title: Optimal chemotherapy treatment for women with recurrent ovarian cancer.
Journal: Current oncology (Toronto, Ont.) 20071001
Title: Recent advances with topotecan in the treatment of lung cancer.
Journal: The oncologist 20071001
Title: [Clinical study of topotecan and cisplatin as first line chemotherapy in epithelial ovarian cancer].
Journal: Zhonghua fu chan ke za zhi 20071001
Title: [Prognosis of locally advanced non small cell lung cancer treated with three dimentional conformal radiotherapy].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20071001
Title: Decitabine in the treatment of myelodysplastic syndromes.
Journal: Therapeutics and clinical risk management 20071001
Title: Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.
Journal: The Journal of biological chemistry 20070914
Title: Markov-modeling for the administration of platinum analogues and paclitaxel as first-line chemotherapy as well as topotecan and liposomal doxorubicin as second-line chemotherapy with epithelial ovarian carcinoma.
Journal: Journal of cancer research and clinical oncology 20070901
Title: Topotecan, cyclophosphamide, and etoposide (TCE) in the treatment of high-risk neuroblastoma. Results of a phase-II trial.
Journal: Journal of cancer research and clinical oncology 20070901
Title: Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070901
Title: Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride].
Journal: The Journal of pharmacology and experimental therapeutics 20070901
Title: Differential gene expression in anticancer drug- and TRAIL-mediated apoptosis in renal cell carcinomas.
Journal: Apoptosis : an international journal on programmed cell death 20070901
Title: Putative chemosensitivity predictive genes in colorectal cancer cell lines for anticancer agents.
Journal: Oncology reports 20070901
Title: Deletion of the short arm of chromosome 1 (del 1p) is a strong predictor of poor outcome in myeloma patients undergoing an autotransplant.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20070901
Title: A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070901
Title: A prospective phase II study of induction carboplatin and vinorelbine followed by concomitant topotecan and accelerated radiotherapy (ART) in locally advanced non-small cell lung cancer (NSCLC).
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070901
Title: Multi-disciplinary treatment of a rare pelvic cavity ependymoma.
Journal: Yonsei medical journal 20070831
Title: Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells.
Journal: Journal of molecular biology 20070824
Title: Does consolidation with autologous stem cell transplantation improve the outcome of children with metastatic or relapsed Ewing sarcoma?
Journal: Pediatric blood & cancer 20070801
Title: Chemical radiosensitizers for use in radiotherapy.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20070801
Title: Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Journal: Molecular pharmacology 20070801
Title: UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium.
Journal: Gynecologic oncology 20070801
Title: Topotecan vitreous levels after periocular or intravenous delivery in rabbits: an alternative for retinoblastoma chemotherapy.
Journal: Investigative ophthalmology & visual science 20070801
Title: Camptothecin: therapeutic potential and biotechnology.
Journal: Current pharmaceutical biotechnology 20070801
Title: The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity.
Journal: Molecular cancer therapeutics 20070801
Title: Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185.
Journal: Current oncology (Toronto, Ont.) 20070801
Title: Current status of second-line treatment and novel therapies for small cell lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070801
Title: Torque and dynamics of linking number relaxation in stretched supercoiled DNA.
Journal: Physical review. E, Statistical, nonlinear, and soft matter physics 20070801
Title: Topotecan is active against Wilms' tumor: results of a multi-institutional phase II study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070720
Title: Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Journal: Biochemical pharmacology 20070715
Title: Antitumour drugs impede DNA uncoiling by topoisomerase I.
Journal: Nature 20070712
Title: Management of metastatic cervical cancer: review of the literature.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070710
Title: A phase I/II trial of topotecan and radiation therapy for brain metastases in patients with solid tumors.
Journal: International journal of radiation oncology, biology, physics 20070701
Title: Addition of topotecan to standard cisplatin/etoposide combination in patients with extended stage small cell lung carcinoma.
Journal: Lung cancer (Amsterdam, Netherlands) 20070701
Title: A multi-center phase II study of weekly topotecan as second-line therapy for small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20070701
Title: Contribution of modelling chemotherapy-induced hematological toxicity for clinical practice.
Journal: Critical reviews in oncology/hematology 20070701
Title: Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: Treatment of retinoblastoma: current status and future perspectives.
Journal: Current treatment options in neurology 20070701
Title: Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070701
Title: Phase II trial of paclitaxel-topotecan-etoposide followed by consolidation chemoradiotherapy for limited-stage small cell lung cancer: CALGB 30002.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070701
Title: Update in the management of ovarian and cervical carcinoma.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20070701
Title: Antiproliferation in human EA.hy926 endothelial cells and inhibition of VEGF expression in PC-3 cells by topotecan.
Journal: Die Pharmazie 20070701
Title: Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.
Journal: Bioorganic & medicinal chemistry 20070615
Title: Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin.
Journal: Cancer chemotherapy and pharmacology 20070601
Title: Weekly administration of topotecan-paclitaxel as second-line treatment in ovarian cancer.
Journal: Cancer chemotherapy and pharmacology 20070601
Title: Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
Journal: The Journal of pharmacology and experimental therapeutics 20070601
Title: A phase I study of paclitaxel, topotecan, cisplatin and Filgrastim in patients with newly diagnosed advanced ovarian epithelial malignancies: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20070601
Title: A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070601
Title: Topotecan for the treatment of small-cell lung cancer.
Journal: Expert review of anticancer therapy 20070601
Title: Gam1-associated alterations of drug responsiveness through activation of apoptosis.
Journal: Molecular cancer therapeutics 20070601
Title: Canadian recommendations for the treatment of glioblastoma multiforme.
Journal: Current oncology (Toronto, Ont.) 20070601
Title: Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.
Journal: The Yale journal of biology and medicine 20070601
Title: Cetuximab in the management of colorectal cancer.
Journal: Biologics : targets & therapy 20070601
Title: Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070520
Title: A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.
Journal: British journal of cancer 20070507
Title: Effects of standard chemotherapy on tumor growth and regulation of multidrug resistance genes and proteins in childhood rhabdomyosarcoma.
Journal: Pediatric surgery international 20070501
Title: The incidence and impact of thrombocytopenia in myelodysplastic syndromes.
Journal: Cancer 20070501
Title: The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
Journal: British journal of pharmacology 20070501
Title: Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells.
Journal: Oncology reports 20070501
Title: [A randomized study comparing topotecan plus cisplatin versus etoposide plus carboplatin for previously untreated small cell lung cancer].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20070420
Title: Upfront window trial of topotecan in previously untreated children and adolescents with poor prognosis metastatic osteosarcoma: children's Cancer Group (CCG) 7943.
Journal: Cancer 20070415
Title: Hypoxia suppresses glutamate transport in astrocytes.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070411
Title: High-dose cyclophosphamide inhibition of humoral immune response to murine monoclonal antibody 3F8 in neuroblastoma patients: broad implications for immunotherapy.
Journal: Pediatric blood & cancer 20070401
Title: Efficacy and toxicity of weekly topotecan in recurrent epithelial ovarian and primary peritoneal cancer.
Journal: Gynecologic oncology 20070401
Title: Replication-deficient adenovirus induces host topoisomerase I activity: implications for adenovirus-mediated gene expression.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20070401
Title: Pegylated liposomal doxorubicin HCL (PLD; Caelyx/Doxil): experience with long-term maintenance in responding patients with recurrent epithelial ovarian cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070401
Title: Exatecan in pretreated adult patients with advanced soft tissue sarcoma: results of a phase II--study of the EORTC Soft Tissue and Bone Sarcoma Group.
Journal: European journal of cancer (Oxford, England : 1990) 20070401
Title: ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.
Journal: Anti-cancer drugs 20070401
Title: Chemotherapy for relapsed small cell lung cancer: a systematic review and practice guideline.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070401
Title: [TP53 and RB tumor suppressor pathways collaborate in retinoblastoma genesis].
Journal: Medecine sciences : M/S 20070401
Title: Phenoxodiol-Topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects.
Journal: Cancer biology & therapy 20070401
Title: Temozolomide as salvage treatment in primary brain lymphomas.
Journal: British journal of cancer 20070326
Title: Phase I North Central Cancer Treatment Group Trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer.
Journal: International journal of radiation oncology, biology, physics 20070315
Title: A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia.
Journal: British journal of cancer 20070312
Title: Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours.
Journal: British journal of cancer 20070312
Title: A phase II trial of weekly topotecan for patients with secondary platinum-resistant recurrent epithelial ovarian carcinoma following the failure of second-line therapy.
Journal: Gynecologic oncology 20070301
Title: Imatinib mesylate potentiates topotecan antitumor activity in rhabdomyosarcoma preclinical models.
Journal: International journal of cancer 20070301
Title: Levels of soluble HLA-I and beta2M in patients with acute myeloid leukemia and advanced myelodysplastic syndrome: association with clinical behavior and outcome of induction therapy.
Journal: Leukemia 20070301
Title: Treatment options for relapsed small-cell lung cancer.
Journal: Anti-cancer drugs 20070301
Title: Synergistic effect of survivin-specific small interfering RNA and topotecan in renal cancer cells: topotecan enhances liposome-mediated transfection by increasing cellular uptake.
Journal: International journal of oncology 20070301
Title: ABCG2: determining its relevance in clinical drug resistance.
Journal: Cancer metastasis reviews 20070301
Title: Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Journal: Molecular cancer therapeutics 20070301
Title: Determination of the optimal combination chemotherapy regimen for treatment of platinum-resistant ovarian cancer in nude mouse model.
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20070301
Title: Long-term outcome after prophylactic lamivudine treatment on hepatitis B virus reactivation in non-Hodgkin's lymphoma.
Journal: Yonsei medical journal 20070227
Title: Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070215
Title: A phase I trial of oxaliplatin and topotecan in recurrent ovarian carcinoma.
Journal: Gynecologic oncology 20070201
Title: Effects of topotecan treatment on nasal, buccal, and lingual mucosa in the rabbit: light and transmission electron microscopic evaluation.
Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20070201
Title: Topotecan in the management of cervical cancer.
Journal: Expert opinion on pharmacotherapy 20070201
Title: Chemotherapy resistance and oncogene expression in non-small cell lung cancer.
Journal: The Journal of thoracic and cardiovascular surgery 20070201
Title: Topotecan and etoposide in the treatment of relapsed high-risk neuroblastoma: results of a phase 2 trial.
Journal: Journal of pediatric hematology/oncology 20070201
Title: Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
Journal: Journal of natural products 20070201
Title: New Agents in Clinical Oncology. 24 November 2006, London, UK.
Journal: IDrugs : the investigational drugs journal 20070201
Title: New, expanded, and modified use of approved antineoplastic agents in ovarian cancer.
Journal: The oncologist 20070201
Title: Effective combination chemotherapy of carboplatin and paclitaxel in the treatment of a recurrent small-cell lung cancer patient.
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070201
Title: Amrubicin for the treatment of small cell lung cancer: does effectiveness cross the Pacific?
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070201
Title: Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial.
Journal: British journal of cancer 20070115
Title: Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts.
Journal: Neuro-oncology 20070101
Title: The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Journal: Molecular pharmacology 20070101
Title: Randomised phase II study comparing topotecan/carboplatin administration for 5 versus 3 days in the treatment of extensive-stage small-cell lung cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070101
Title: Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.
Journal: Pharmacological research 20070101
Title: Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer.
Journal: Expert opinion on drug safety 20070101
Title: Interferon beta-mediated vessel stabilization improves delivery and efficacy of systemically administered topotecan in a murine neuroblastoma model.
Journal: Journal of pediatric surgery 20070101
Title: Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes.
Journal: International journal of medical sciences 20070101
Title: Early changes in CA125 after treatment with pegylated liposomal doxorubicin or topotecan do not always reflect best response in recurrent ovarian cancer patients.
Journal: The oncologist 20070101
Title: Clinical radionuclide therapy dosimetry: the quest for the 'Holy Gray'.
Journal: European journal of nuclear medicine and molecular imaging 20070101
Title: Effectiveness of weekly topotecan in patients with recurrent epithelial ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Early CA-125 fluctuations in patients with recurrent ovarian cancer receiving chemotherapy.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Systemic anticancer therapy in gynecological cancer patients with renal dysfunction.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Topotecan more effective than supportive care.
Journal: The Lancet. Oncology 20070101
Title: A phase II clinical trial of topotecan and carboplatin in patients with newly diagnosed advanced epithelial ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine.
Journal: Breast cancer research : BCR 20070101
Title: relocating job wise? A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor.
Journal: Theoretical biology & medical modelling 20070101
Title: Cyclophosphamide 'metronomic' chemotherapy for palliative treatment of a young patient with advanced epithelial ovarian cancer.
Journal: BMC cancer 20070101
Title: Differences of chemoresistance assay between invasive micropapillary/low-grade serous ovarian carcinoma and high-grade serous ovarian carcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas.
Journal: PloS one 20070101
Title: Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a systematic review.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: [Interest of cystatin C for individual dosing of anticancer drugs cleared by the kidneys].
Journal: Therapie 20070101
Title: Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas.
Journal: BMC cancer 20070101
Title: ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
Journal: BMC cell biology 20070101
Title: Duration of chemotherapy with topotecan influences survival in recurrent ovarian cancer: a meta-analysis.
Journal: Anticancer research 20070101
Title: External influences and priority-setting for anti-cancer agents: a case study of media coverage in adjuvant trastuzumab for breast cancer.
Journal: BMC cancer 20070101
Title: Numerical modelling of label-structured cell population growth using CFSE distribution data.
Journal: Theoretical biology & medical modelling 20070101
Title: STEALTH liposomal CKD-602, a topoisomerase I inhibitor, improves the therapeutic index in human tumor xenograft models.
Journal: Anticancer research 20070101
Title: Radiotherapeutic alternatives for previously irradiated recurrent gliomas.
Journal: BMC cancer 20070101
Title: Automated recognition of cell phenotypes in histology images based on membrane- and nuclei-targeting biomarkers.
Journal: BMC medical imaging 20070101
Title: Phase I/II study of IV topotecan in combination with whole brain radiation for the treatment of brain metastases.
Journal: Medical oncology (Northwood, London, England) 20070101
Title: [Small cell lung cancer--state of the art and future perspectives].
Journal: Revista portuguesa de pneumologia 20070101
Title: Modern management of small-cell lung cancer.
Journal: Drugs 20070101
Title: Impact of imatinib on the pharmacokinetics and in vivo efficacy of etoposide and/or ifosfamide.
Journal: BMC pharmacology 20070101
Title: A novel camptothecin analog with enhanced antitumor activity.
Journal: Anticancer research 20070101
Title: Topotecan in cervical cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: Bone metastasis from ovarian cancer.
Journal: Journal of cancer research and therapeutics 20070101
Title: Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer.
Journal: BMC bioinformatics 20070101
Title: Serial intense chemotherapy combining topotecan, etoposide, carboplatin and cyclophosphamide (TECC) followed by autologous hematopoietic stem cell support in patients with high risk soft tissue sarcoma (STS).
Journal: Klinische Padiatrie 20070101
Title: Optimal management strategies for rhabdomyosarcoma in children.
Journal: Paediatric drugs 20070101
Title: Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer.
Journal: BMC cancer 20070101
Title: [Small cell lung cancer].
Journal: Wiener klinische Wochenschrift 20070101
Title: Breast tumour angiogenesis.
Journal: Breast cancer research : BCR 20070101
Title: Activity of bortezomib in adult de novo and relapsed acute myeloid leukemia.
Journal: Anticancer research 20070101
Title: Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101
Title: Haematological evaluation of weekly therapy with topotecan for the treatment of recurrent ovarian cancer resistant to platinum-based therapy.
Journal: Oncology 20070101
Title: [Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20061220
Title: ABCG2 expression, function, and promoter methylation in human multiple myeloma.
Journal: Blood 20061201
Title: A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells.
Journal: Journal of pharmaceutical sciences 20061201
Title: Microwave expedited synthesis of 5-aminocamptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1alpha.
Journal: Bioorganic & medicinal chemistry letters 20061201
Title: Phase I and pharmacologic study of sequential topotecan-carboplatin-etoposide in patients with extensive stage small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20061201
Title: Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry.
Journal: Journal of veterinary science 20061201
Title: Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells.
Journal: Biological chemistry 20061201
Title: Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061201
Title: Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.
Journal: Cancer research 20061201
Title: Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20061201
Title: [Routine chemotherapeutic drug treatment effectiveness predictive molecules and chemotherapeutic drug selection].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061201
Title: Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus.
Journal: Journal of natural products 20061201
Title: A review of topoisomerase inhibition in lung cancer.
Journal: Cancer biology & therapy 20061201
Title: New methods for direct delivery of chemotherapy for treating brain tumors.
Journal: The Yale journal of biology and medicine 20061201
Title: Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring.
Journal: Cancer research 20061115
Title: Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors.
Journal: Pediatric blood & cancer 20061101
Title: Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study.
Journal: Pediatric blood & cancer 20061101
Title: BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer.
Journal: Cancer chemotherapy and pharmacology 20061101
Title: Sequence dependence of hematologic toxicity using carboplatin and topotecan for primary therapy of advanced epithelial ovarian cancer: a phase I study of the Gynecologic Oncology Group.
Journal: Gynecologic oncology 20061101
Title: Phase II evaluation of a 3-day infusion of topotecan in patients with recurrent ovarian or primary peritoneal cancer.
Journal: Gynecologic oncology 20061101
Title: Three sequential chemotherapy doublets for the treatment of newly diagnosed advanced müllerian malignancies: the modified triple doublet regimen.
Journal: Gynecologic oncology 20061101
Title: Diffuse alveolar damage after a single dose of topotecan in a patient with pulmonary fibrosis and small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20061101
Title: Aberrant promoter methylation of the ABCG2 gene in renal carcinoma.
Journal: Molecular and cellular biology 20061101
Title: Microtransponders, the miniature RFID electronic chips, as platforms for cell growth in cytotoxicity assays.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20061101
Title: Intrathecal topotecan in adult patients with neoplastic meningitis.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061101
Title: Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate.
Journal: Anti-cancer drugs 20061101
Title: A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
Journal: Journal of natural products 20061101
Title: Cerebral and parotid metachronous metastases from an ovarian carcinoma.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20061101
Title: [Small cell lung cancer (CPC). Second line treatment].
Journal: Revue des maladies respiratoires 20061101
Title: Phase II trial of paclitaxel, carboplatin, and topotecan with G-CSF support in previously untreated patients with extensive stage small cell lung cancer: Southwest Oncology Group 9914.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20061101
Title: Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327).
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20061101
Title: Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer: a systematic review and practice guideline.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20061101
Title: [Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061101
Title: Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas.
Journal: British journal of cancer 20061023
Title: Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines.
Journal: British journal of cancer 20061009
Title: Front-line paclitaxel and topotecan chemotherapy in advanced or metastatic non-small-cell lung cancer: a phase II trial.
Journal: Cancer chemotherapy and pharmacology 20061001
Title: CA-125 response in patients with recurrent ovarian or primary peritoneal cancer treated with pegylated liposomal doxorubicin or topotecan.
Journal: Gynecologic oncology 20061001
Title: Activity of 9-nitro-camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia.
Journal: Cancer 20061001
Title: Potential use of the adenosine triphosphate cell viability assay in endometrial cancer.
Journal: Journal of the Society for Gynecologic Investigation 20061001
Title: Topoisomerase I inhibitors: camptothecins and beyond.
Journal: Nature reviews. Cancer 20061001
Title: Antitumor activity of nifurtimox observed in a patient with neuroblastoma.
Journal: Journal of pediatric hematology/oncology 20061001
Title: New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children.
Journal: Future oncology (London, England) 20061001
Title: Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Journal: Molecular cancer therapeutics 20061001
Title: Papillary serous carcinoma of peritoneum: presentation of 2 cases.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20061001
Title: Topotecan in combination with cisplatin for the treatment of stage IVB, recurrent, or persistent cervical cancer.
Journal: Oncology (Williston Park, N.Y.) 20061001
Title: Assessment of supra-additive effects of cytotoxic drugs and low dose rate irradiation in an in vitro model for hepatocellular carcinoma.
Journal: Canadian journal of physiology and pharmacology 20061001
Title: Population pharmacokinetic-pharmacodynamic model for neutropenia with patient subgroup identification: comparison across anticancer drugs.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060915
Title: A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer.
Journal: British journal of cancer 20060904
Title: Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan.
Journal: Cancer chemotherapy and pharmacology 20060901
Title: Effect of a novel vacuolar-H+-ATPase inhibitor on cell and tumor response to camptothecins.
Journal: The Journal of pharmacology and experimental therapeutics 20060901
Title: Phase I dose escalation study of pegylated liposomal doxorubicin (Caelyx) in combination with topotecan in patients with advanced malignancies.
Journal: Investigational new drugs 20060901
Title: Chemotherapy for recurrent cervical carcinoma.
Journal: Current opinion in oncology 20060901
Title: Topotecan therapy in patients with relapsed small-cell lung cancer and poor performance status.
Journal: Clinical lung cancer 20060901
Title: Pegylated liposomal doxorubicin in ovarian cancer.
Journal: International journal of nanomedicine 20060901
Title: Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
Journal: International journal of nanomedicine 20060901
Title: [Treatment of epithelial ovarian cancer].
Journal: Orvosi hetilap 20060827
Title: Synthesis and cytotoxic activity of polyamine analogues of camptothecin.
Journal: Journal of medicinal chemistry 20060824
Title: Copper-topotecan complexation mediates drug accumulation into liposomes.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20060810
Title: In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.
Journal: British journal of cancer 20060807
Title: Is it time for some new approaches for treating advanced ovarian cancer?
Journal: Journal of the National Cancer Institute 20060802
Title: Randomized phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a gynecologic cancer intergroup trial of the AGO-OVAR and GINECO.
Journal: Journal of the National Cancer Institute 20060802
Title: Phase-I study of a new schedule based on increasing days of topotecan administration associated with dose individualisation.
Journal: Cancer chemotherapy and pharmacology 20060801
Title: Sequential prolonged oral topotecan and prolonged oral etoposide as second-line therapy in ovarian or peritoneal carcinoma: a phase I Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20060801
Title: Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
Journal: Cancer biology & therapy 20060801
Title: A phase I and pharmacological study of amrubicin and topotecan in patients of small-cell lung cancer with relapsed or extensive-disease small-cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20060801
Title: Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
Journal: Molecular cancer therapeutics 20060801
Title: Sequential doxorubicin and topotecan in relapsed/refractory aggressive non-Hodgkin's lymphoma: results of CALGB 59906.
Journal: Leukemia & lymphoma 20060801
Title: Important differences between topoisomerase-I and -II targeting agents.
Journal: Cancer biology & therapy 20060801
Title: Progressive epithelial ovarian carcinoma. Prognostic factors and clinical management.
Journal: Danish medical bulletin 20060801
Title: Pooled analysis of phase II window studies in children with contemporary high-risk metastatic rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060720
Title: HIF-1 and tumour radiosensitivity.
Journal: British journal of cancer 20060703
Title: Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples.
Journal: Histology and histopathology 20060701
Title: Prospective trial on topotecan salvage therapy in primary CNS lymphoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060701
Title: Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model.
Journal: Neuro-oncology 20060701
Title: Convection-enhanced delivery in the treatment of malignant glioma.
Journal: Neurological research 20060701
Title: Second-line treatment of small-cell lung cancer.
Journal: Current oncology reports 20060701
Title: Oral second-line chemotherapy for advanced non-small-cell lung cancer: the bottom line.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620
Title: Phase III study comparing oral topotecan to intravenous docetaxel in patients with pretreated advanced non-small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620
Title: Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin.
Journal: British journal of cancer 20060619
Title: Second-line chemotherapy in small cell lung cancer in a modified administration of topotecan combined with paclitaxel: a phase II study.
Journal: Cancer chemotherapy and pharmacology 20060601
Title: A phase I study of 3-day topotecan and cisplatin in elderly patients with small-cell lung cancer.
Journal: Cancer chemotherapy and pharmacology 20060601
Title: Efficacy of a toxicity-adjusted topotecan therapy in recurrent small cell lung cancer.
Journal: The European respiratory journal 20060601
Title: Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice.
Journal: European journal of clinical investigation 20060601
Title: Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
Journal: Pharmacogenetics and genomics 20060601
Title: Optimal therapy for platinum-resistant recurrent ovarian cancer: doxorubicin, gemcitabine or topotecan?
Journal: Expert opinion on pharmacotherapy 20060601
Title: American Association for Cancer Research--97th annual meeting.
Journal: IDrugs : the investigational drugs journal 20060601
Title: Phase II NCCTG trial of oral topotecan and paclitaxel with G-CSF (filgrastim) support in patients with previously untreated extensive-stage small cell lung cancer.
Journal: American journal of clinical oncology 20060601
Title: Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
Journal: Journal of natural products 20060601
Title: Promoting best gynecologic oncology practice: a role for the Society of Gynecologic Oncologists of Canada.
Journal: Current oncology (Toronto, Ont.) 20060601
Title: Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20060530
Title: A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20060515
Title: Phase II study of irinotecan combined with carboplatin in previously untreated small-cell lung cancer.
Journal: British journal of cancer 20060508
Title: 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
Journal: Bioorganic & medicinal chemistry 20060501
Title: Reponses to topoisomerase-I inhibitors in extensive small-cell lung cancer: chance or chromosomes?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060501
Title: Open-label, multicenter, randomized, phase III study comparing oral topotecan/cisplatin versus etoposide/cisplatin as treatment for chemotherapy-naive patients with extensive-disease small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060501
Title: Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.
Journal: Cancer research 20060501
Title: Ewing's sarcoma family of tumors: current management.
Journal: The oncologist 20060501
Title: Topotecan continuous infusion: CA-125 responses including patients pretreated with other schedules of topotecan.
Journal: The oncologist 20060501
Title: Second-line treatment for advanced-stage non-small-cell lung cancer: current and future options.
Journal: Clinical lung cancer 20060501
Title: A phase II study of gemcitabine and immunotherapy in renal cancer: preliminary results and review of the literature.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060501
Title: Topoisomerase I, II alpha and II beta mRNA expression in peripheral blood mononuclear cells of patients with solid tumor: preliminary results.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060501
Title: Development and validation of limited sampling models for topotecan lactone pharmacokinetic studies in children.
Journal: Cancer chemotherapy and pharmacology 20060401
Title: Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations.
Journal: International journal of cancer 20060401
Title: Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model.
Journal: Gynecologic oncology 20060401
Title: Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells.
Journal: Blood 20060401
Title: Concurrent chemoradiotherapy and adjuvant chemotherapy with Topotecan for patients with glioblastoma multiforme.
Journal: Journal of neuro-oncology 20060401
Title: A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.
Journal: Journal of neuro-oncology 20060401
Title: Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060401
Title: Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.
Journal: Neuro-oncology 20060401
Title: Phase I study of high-dose topotecan with haematopoietic stem cell support in the treatment of ovarian carcinomas: the ITOV 01 protocol.
Journal: Bone marrow transplantation 20060401
Title: Chemotherapy in the management of cervical carcinoma.
Journal: Clinical advances in hematology & oncology : H&O 20060401
Title: A study of variable hydration states in topotecan hydrochloride.
Journal: Journal of pharmaceutical and biomedical analysis 20060318
Title: Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells.
Journal: Biochemical pharmacology 20060314
Title: Experimental designs for phase I and phase I/II dose-finding studies.
Journal: British journal of cancer 20060313
Title: Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.
Journal: Cancer letters 20060308
Title: Clinical results and quality of life analysis for the MVAC combination (methotrexate, vinblastine, doxorubicin, and cisplatin) in carcinoma of the uterine cervix: A Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20060301
Title: Phase II study of topotecan and thalidomide in patients with high-risk myelodysplastic syndromes.
Journal: Leukemia & lymphoma 20060301
Title: Pegfilgrastim administered in a single fixed dose is effective in inducing neutrophil count recovery after paclitaxel and topotecan chemotherapy in patients with relapsed aggressive non-Hodgkin's lymphoma.
Journal: Leukemia & lymphoma 20060301
Title: Long-term follow-up results of the combination of topotecan and cytarabine and other intensive chemotherapy regimens in myelodysplastic syndrome.
Journal: Cancer 20060301
Title: Role of ABCG2 as a biomarker for predicting resistance to CPT-11/SN-38 in lung cancer.
Journal: Cancer science 20060301
Title: Topotecan, pegylated liposomal doxorubicin hydrochloride and paclitaxel for second-line or subsequent treatment of advanced ovarian cancer: a systematic review and economic evaluation.
Journal: Health technology assessment (Winchester, England) 20060301
Title: [Medical treatment of metastatic or recurrent cancer of the cervix].
Journal: Bulletin du cancer 20060301
Title: [Inhibition effect of topotecan on human myelodysplastic syndrome cells in vitro and in vivo].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060301
Title: Topotecan and paclitaxel in previously treated patients with relapsed small cell lung cancer: phase II trial of the North Central Cancer Treatment Group.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20060301
Title: Comparison of efficacy and toxicity profile between intraperitoneal and intravenous topotecan in human ovarian cancer xenografts.
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060218
Title: Effects of drug combinations on smooth muscle cell proliferation: an isobolographic analysis.
Journal: European journal of pharmacology 20060217
Title: Prolonged topotecan infusion with cisplatin in the first-line treatment of ovarian cancer: an NYGOG and ECOG study.
Journal: Gynecologic oncology 20060201
Title: Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.
Journal: Molecular pharmacology 20060201
Title: DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060201
Title: Topotecan, thiotepa, and carboplatin for neuroblastoma: failure to prevent relapse in the central nervous system.
Journal: Bone marrow transplantation 20060201
Title: ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Journal: Cell proliferation 20060201
Title: Prevalence of in vitro extreme chemotherapy resistance in resected nonsmall-cell lung cancer.
Journal: The Annals of thoracic surgery 20060201
Title: Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201
Title: Optimizing therapy in previously treated non-small cell lung cancer.
Journal: Seminars in oncology 20060201
Title: The hematologic response to anti-apoptotic cytokine therapy: results of pentoxifylline, ciprofloxacin, and dexamethasone treatment for patients with myelodysplastic syndrome.
Journal: Journal of Korean medical science 20060201
Title: A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Journal: Molecular cancer therapeutics 20060201
Title: Risk assessment of human myelotoxicity of anticancer drugs: a predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay.
Journal: Die Pharmazie 20060201
Title: [Is small cell lung cancer an orphan disease?].
Journal: Revue de pneumologie clinique 20060201
Title: [From ASCO and WCLC 2005 to clinical practice: 'conventional' treatments].
Journal: Revue de pneumologie clinique 20060201
Title: Combination chemotherapy with carboplatin, capecitabine and epirubicin (ECarboX) as second- or third-line treatment in patients with relapsed ovarian cancer: a phase I/II trial.
Journal: British journal of cancer 20060116
Title: A phase I and pharmacokinetic study of novel taxane BMS-188797 and cisplatin in patients with advanced solid tumours.
Journal: British journal of cancer 20060116
Title: SCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel-irinotecan as first-line therapy for ovarian cancer.
Journal: British journal of cancer 20060116
Title: SCOTROC 2A: carboplatin followed by docetaxel or docetaxel-gemcitabine as first-line chemotherapy for ovarian cancer.
Journal: British journal of cancer 20060116
Title: Phase I study of the combination of topotecan and irinotecan in children with refractory solid tumors.
Journal: Cancer chemotherapy and pharmacology 20060101
Title: Combination of topotecan and cisplatin in relapsed patients with small cell lung cancer: a phase II study of the hellenic cooperative oncology group (HeCOG).
Journal: Cancer chemotherapy and pharmacology 20060101
Title: A phase I trial of gemcitabine and topotecan in previously treated ovarian or peritoneal cancer: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20060101
Title: Pharmacokinetics, pharmacodynamics and adherence to oral topotecan in myelodysplastic syndromes: a Cancer and Leukemia Group B study.
Journal: Cancer chemotherapy and pharmacology 20060101
Title: Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy.
Journal: Gynecologic oncology 20060101
Title: Topotecan can compensate for protracted radiation treatment time effects in high grade glioma xenografts.
Journal: Journal of neuro-oncology 20060101
Title: Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.
Journal: Trends in pharmacological sciences 20060101
Title: Second- and third-line treatments in non-small cell lung cancer.
Journal: Current treatment options in oncology 20060101
Title: Rubitecan.
Journal: Expert opinion on investigational drugs 20060101
Title: Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101
Title: Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: the Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study.
Journal: BMC cancer 20060101
Title: Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo.
Journal: Molecular cancer therapeutics 20060101
Title: Phase I/II study of tandem cycles of high-dose chemotherapy followed by autologous hematopoietic stem cell support in women with advanced ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Phase II study of the combination of pegylated liposomal doxorubicin and topotecan in platinum-resistant ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Ethnicity is a factor to be considered before dose planning in ovarian cancer patients to be treated with topotecan.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Topotecan is a substrate for multidrug resistance associated protein 4.
Journal: Current drug metabolism 20060101
Title: Early patterns of verbal memory impairment in children treated for medulloblastoma.
Journal: Neuropsychology 20060101
Title: Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.
Journal: BMC cell biology 20060101
Title: Topotecan and liposomal doxorubicin in recurrent ovarian cancer: is sequence important?
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Is there a role for neoadjuvant chemotherapy in the treatment of stage IV serous endometrial carcinoma?
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Recurrent ovarian cancer metastatic to the sternum, costae, and thoracic wall after prolonged treatment with platinum-based chemotherapy: a case report and review of the literature.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile.
Journal: Drug safety 20060101
Title: Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer.
Journal: Neoplasia (New York, N.Y.) 20060101
Title: Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment.
Journal: BMC cancer 20060101
Title: Cytokines, GM-CSF and IFNgamma administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin.
Journal: Journal of translational medicine 20060101
Title: Treatment of non-small cell lung cancer with intensity-modulated radiation therapy in combination with cetuximab: the NEAR protocol (NCT00115518).
Journal: BMC cancer 20060101
Title: Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.
Journal: Molecular cancer 20060101
Title: Radiosensitizers in cervical cancer. Cisplatin and beyond.
Journal: Radiation oncology (London, England) 20060101
Title: Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors.
Journal: Radiation oncology (London, England) 20060101
Title: Topotecan in the treatment of brain metastases. A phase II study of GOIM (Gruppo Oncologico dell'Italia Meridionale).
Journal: Anticancer research 20060101
Title: Signatures of human regulatory T cells: an encounter with old friends and new players.
Journal: Genome biology 20060101
Title: Review camptothecin: current perspectives.
Journal: Current medicinal chemistry 20060101
Title: Safety of a 3-weekly schedule of carboplatin plus pegylated liposomal doxorubicin as first line chemotherapy in patients with ovarian cancer: preliminary results of the MITO-2 randomized trial.
Journal: BMC cancer 20060101
Title: Pharmacokinetic considerations in the treatment of CNS tumours.
Journal: Clinical pharmacokinetics 20060101
Title: New agents for intrathecal administration.
Journal: Cancer investigation 20060101
Title: Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer.
Journal: Cancer cell international 20060101
Title: New molecular mechanisms of action of camptothecin-type drugs.
Journal: Anticancer research 20060101
Title: Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells.
Journal: BMC cancer 20060101
Title: Topotecan, Ara-C, cisplatin and prednisolone (Toposhap) for patients with refractory and relapsing lymphomas: Results of a phase II trial.
Journal: Acta haematologica 20060101
Title: Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.
Journal: Molecular cancer 20060101
Title: A phase I study of dose-dense topotecan given upfront to standard therapy in patients with small cell lung cancer.
Journal: Clinical drug investigation 20060101
Title: Topotecan as a second-line therapy in patients with ovarian and primary peritoneal cancer: initial response and long-term follow-up.
Journal: European journal of gynaecological oncology 20060101
Title: Combinational effect of topotecan and octreotide on murine leukemia cells in vivo and in vitro.
Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20060101
Title: Drug approved for late-stage cervical cancer.
Journal: FDA consumer 20060101
Title: Improving Outcomes After Relapse in Ewing's Sarcoma: Analysis of 114 Patients From a Single Institution.
Journal: Sarcoma 20060101
Title: Transcriptional upregulation of breast cancer resistance protein by 17beta-estradiol in ERalpha-positive MCF-7 breast cancer cells.
Journal: Oncology 20060101
Title: Brain metastasis--evidence based management.
Journal: Journal of cancer research and therapeutics 20060101
Title: Colorectal cancer: from epidemiology to current treatment.
Journal: The Libyan journal of medicine 20060101
Title: The co-transfection of p16(INK4a) and p14(ARF) genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity.
Journal: Colloids and surfaces. B, Biointerfaces 20051220
Title: Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
Journal: Bioorganic & medicinal chemistry 20051215
Title: Topotecan as a radiosensitizer in the treatment of children with malignant diffuse brainstem gliomas: results of a French Society of Paediatric Oncology Phase II Study.
Journal: Cancer 20051215
Title: A phase I/II trial of weekly topotecan and carboplatin in potentially platinum-sensitive relapsed ovarian and peritoneal carcinoma.
Journal: Gynecologic oncology 20051201
Title: Topotecan plus ifosfamide in patients with platinum refractory advanced/metastatic non-small cell lung cancer: a phase II trial.
Journal: Oncology reports 20051201
Title: The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Ayurveda and traditional Chinese medicine: a comparative overview.
Journal: Evidence-based complementary and alternative medicine : eCAM 20051201
Title: Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Journal: Haematologica 20051201
Title: Phase I study of docetaxel and topotecan in patients with advanced malignancies.
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20051201
Title: Front-line paclitaxel and irinotecan combination chemotherapy in advanced non-small-cell lung cancer: a phase I-II trial.
Journal: British journal of cancer 20051114
Title: New hints on the Ph-driven tautomeric equilibria of the topotecan anticancer drug in aqueous solutions from an integrated spectroscopic and quantum-mechanical approach.
Journal: Journal of the American Chemical Society 20051109
Title: Augmenting tumor sensitivity to topotecan by transient hypoxia.
Journal: Cancer chemotherapy and pharmacology 20051101
Title: Non-enrolment of ovarian cancer patients in clinical trials: reasons and background.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20051101
Title: Plant-based anticancer molecules: a chemical and biological profile of some important leads.
Journal: Bioorganic & medicinal chemistry 20051101
Title: Human multidrug resistance associated protein 4 confers resistance to camptothecins.
Journal: Pharmaceutical research 20051101
Title: Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20051101
Title: Gynecologic oncology group trials of chemotherapy for metastatic and recurrent cervical cancer.
Journal: Current oncology reports 20051101
Title: [131I]meta-iodobenzylguanidine and topotecan combination treatment of tumors expressing the noradrenaline transporter.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051101
Title: Sequential versus alternating administration of cisplatin/etoposide and topotecan as first-line treatment in extensive-stage small-cell lung cancer: preliminary results of a Phase III Trial of the Hellenic Oncology Research Group.
Journal: Clinical lung cancer 20051101
Title: Topotecan in the treatment of elderly patients with relapsed small-cell lung cancer.
Journal: Clinical lung cancer 20051101
Title: [131I]MIBG and topotecan: a rationale for combination therapy for neuroblastoma.
Journal: Cancer letters 20051018
Title: A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.
Journal: British journal of cancer 20051017
Title: The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan.
Journal: Biochemical pharmacology 20051015
Title: Topotecan combination chemotherapy in two new rodent models of retinoblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051015
Title: Second-line treatment with irinotecan plus cisplatin vs cisplatin of patients with advanced non-small-cell lung cancer pretreated with taxanes and gemcitabine: a multicenter randomised phase II study.
Journal: British journal of cancer 20051003
Title: Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).
Journal: Cancer chemotherapy and pharmacology 20051001
Title: High-dose melphalan is an effective salvage therapy in acute myeloid leukaemia patients with refractory relapse and relapse after autologous stem cell transplantation.
Journal: Annals of hematology 20051001
Title: Phase II study of topotecan and cyclophosphamide in patients with relapsed and refractory multiple myeloma.
Journal: Leukemia research 20051001
Title: Hypoxia inducible factor-1: a novel target for cancer therapy.
Journal: Anti-cancer drugs 20051001
Title: Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.
Journal: Cancer research 20051001
Title: Topotecan in platinum-resistant epithelial ovarian cancer.
Journal: Chemotherapy 20051001
Title: Use of preclinical models to improve treatment of retinoblastoma.
Journal: PLoS medicine 20051001
Title: Hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung cancer: an integrated analysis.
Journal: The oncologist 20051001
Title: Topotecan as second-line therapy for ovarian cancer: dosage versus toxicity.
Journal: The oncologist 20051001
Title: Topotecan: weighing in when there are many options.
Journal: The oncologist 20051001
Title: Paclitaxel/carboplatin/etoposide versus paclitaxel/topotecan for extensive-stage small cell lung cancer: a Minnie Pearl Cancer Research Network randomized, prospective phase II trial.
Journal: The oncologist 20051001
Title: In-vitro cytotoxicity, in-vivo biodistribution and anti-tumour effect of PEGylated liposomal topotecan.
Journal: The Journal of pharmacy and pharmacology 20051001
Title: Single-agent topotecan as first-line chemotherapy in women with metastatic breast cancer: final results of eastern cooperative oncology group trial E8193.
Journal: Clinical breast cancer 20051001
Title: Fluorescence detection combined with either HPLC or HPTLC for pharmaceutical quality control in a hospital chemotherapy production unit: application to camptothecin derivatives.
Journal: Journal of pharmaceutical and biomedical analysis 20050915
Title: One- and two-stage designs for stratified phase II clinical trials.
Journal: Statistics in medicine 20050915
Title: Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
Title: Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract.
Journal: Biochemical pharmacology 20050901
Title: Conservation of in vitro drug resistance patterns in epithelial ovarian carcinoma.
Journal: Gynecologic oncology 20050901
Title: Potential activity of paclitaxel, vinorelbine and gemcitabine in anaplastic thyroid carcinoma.
Journal: Journal of cancer research and clinical oncology 20050901
Title: Activity of novel cytotoxic agents in lung cancer: epothilones and topoisomerase I inhibitors.
Journal: Clinical lung cancer 20050901
Title: Modern management of recurrent ovarian carcinoma. A systematic approach to a chronic disease.
Journal: Oncology (Williston Park, N.Y.) 20050901
Title: Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.
Journal: Current drug discovery technologies 20050901
Title: Plants as a source of anti-cancer agents.
Journal: Journal of ethnopharmacology 20050822
Title: [Topotecan in combination with cisplatin in the treatment of recurrent small cell lung cancer].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20050820
Title: Phase I study of combined pegylated liposomal doxorubicin with protracted daily topotecan for ovarian cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050815
Title: New drugs target hypoxia response in tumors.
Journal: Journal of the National Cancer Institute 20050803
Title: Single nucleotide polymorphisms modify the transporter activity of ABCG2.
Journal: Cancer chemotherapy and pharmacology 20050801
Title: Phase-I dose escalation and sequencing study of docetaxel and continuous infusion topotecan in patients with advanced malignancies.
Journal: Cancer chemotherapy and pharmacology 20050801
Title: Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: opposite effect of siRNA in combination with different drugs.
Journal: Molecular pharmacology 20050801
Title: Phase II evaluation of topotecan in carcinosarcoma of the uterus: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20050801
Title: Weekly topotecan in heavily pretreated patients with recurrent epithelial ovarian carcinoma.
Journal: Gynecologic oncology 20050801
Title: A randomised phase II study of the efficacy and safety of intravenous topotecan in combination with either cisplatin or etoposide in patients with untreated extensive disease small-cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20050801
Title: Brain metastases in metastatic non-small cell lung cancer responding to single-agent gefitinib: a case report.
Journal: Anti-cancer drugs 20050801
Title: Gefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family protein.
Journal: Cancer research 20050801
Title: Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.
Journal: Cancer science 20050801
Title: Quality of life outcomes from a randomized phase III trial of cisplatin with or without topotecan in advanced carcinoma of the cervix: a Gynecologic Oncology Group Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050720
Title: Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050720
Title: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Journal: Cancer research 20050715
Title: Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer.
Journal: British journal of cancer 20050711
Title: A phase I clinical trial of continual alternating etoposide and topotecan in refractory solid tumours.
Journal: British journal of cancer 20050711
Title: Chemotherapy dosing in the setting of liver dysfunction.
Journal: Oncology (Williston Park, N.Y.) 20050701
Title: Improved response in high-risk neuroblastoma with protracted topotecan administration using a pharmacokinetically guided dosing approach.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050620
Title: Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Topotecan and etoposide as first-line therapy for extensive disease small cell lung cancer: a phase II trial of a platinum-free regimen.
Journal: Lung cancer (Amsterdam, Netherlands) 20050601
Title: Randomized phase II study comparing topotecan/cisplatin administration for 5 days versus 3 days in the treatment of extensive stage small cell lung cancer (SCLC).
Journal: Lung cancer (Amsterdam, Netherlands) 20050601
Title: Effect of ABCG2 genotype on the oral bioavailability of topotecan.
Journal: Cancer biology & therapy 20050601
Title: DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.
Journal: Molecular and cellular biology 20050601
Title: Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells.
Journal: Cancer research 20050601
Title: Management of leptomeningeal malignancy.
Journal: Expert opinion on pharmacotherapy 20050601
Title: High dose chemotherapy and transplantation of hematopoietic progenitors from murine D3 embryonic stem cells.
Journal: Journal of chemotherapy (Florence, Italy) 20050601
Title: Advances in the management of epithelial ovarian cancer.
Journal: The Journal of reproductive medicine 20050601
Title: Preclinical relevance of dosing time for the therapeutic index of gemcitabine-cisplatin.
Journal: British journal of cancer 20050509
Title: Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver.
Journal: Molecular pharmacology 20050501
Title: The effect of quercetin on topotecan cytotoxicity in MCF-7 and MDA-MB 231 human breast cancer cells.
Journal: The Journal of surgical research 20050501
Title: Chronomodulation of topotecan or X-radiation treatment increases treatment efficacy without enhancing acute toxicity.
Journal: International journal of radiation oncology, biology, physics 20050501
Title: Phase I trial of intravenous cisplatin-topotecan chemotherapy for three consecutive days in patients with advanced solid tumors: parallel topotecan escalation in two fixed platinum dosing schemes.
Journal: Chemotherapy 20050501
Title: Cell cycle effects of topotecan alone and in combination with irradiation.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20050501
Title: Emerging drugs for ovarian cancer.
Journal: Expert opinion on emerging drugs 20050501
Title: In vitro and in vivo studies of different liposomes containing topotecan.
Journal: Archives of pharmacal research 20050501
Title: Simple and sensitive high performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of topotecan in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
Title: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.
Journal: British journal of cancer 20050425
Title: Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin.
Journal: Bioorganic & medicinal chemistry letters 20050415
Title: Serum cystatin C is a better marker of topotecan clearance than serum creatinine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050415
Title: Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Journal: Journal of medicinal chemistry 20050407
Title: Sequential topotecan and oral etoposide in recurrent ovarian carcinoma pretreated with platinum-taxane. Results from a multicenter phase I/II study.
Journal: Cancer 20050401
Title: CA125 Nadir values as a prognostic factor in epithelial ovarian cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401
Title: Open-label simultaneous radio-chemotherapy of glioblastoma multiforme with topotecan in adults.
Journal: Clinical neurology and neurosurgery 20050401
Title: [Effect of bone marrow stromal cells on the apoptotic sensitivity of HL-60 and HL-60/VCR cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20050401
Title: Feasibility of dosimetry-based high-dose 131I-meta-iodobenzylguanidine with topotecan as a radiosensitizer in children with metastatic neuroblastoma.
Journal: Cancer biotherapy & radiopharmaceuticals 20050401
Title: Phase I/II study of oral etoposide plus GM-CSF as second-line chemotherapy in platinum-pretreated patients with advanced ovarian cancer.
Journal: British journal of cancer 20050328
Title: Randomized trial of two intravenous schedules of the topoisomerase I inhibitor liposomal lurtotecan in women with relapsed epithelial ovarian cancer: a trial of the national cancer institute of Canada clinical trials group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050320
Title: Hypersensitivity in DNA mismatch repair-deficient colon carcinoma cells to DNA polymerase reaction inhibitors.
Journal: Cancer letters 20050318
Title: Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301
Title: A phase I study of intraperitoneal topotecan in combination with intravenous carboplatin and paclitaxel in advanced ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20050301
Title: Expression of p53 and p21 in primary glioblastomas.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050301
Title: Alternative administration of camptothecin analogues.
Journal: Expert opinion on drug delivery 20050301
Title: Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile.
Journal: British journal of cancer 20050227
Title: High-performance liquid chromatographic assay for the determination of total and free topotecan in the presence and absence of anti-topotecan antibodies in mouse plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Title: In vivo efficacy of STI571 in xenografted human small cell lung cancer alone or combined with chemotherapy.
Journal: International journal of cancer 20050220
Title: Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
Journal: Cancer research 20050215
Title: MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215
Title: 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Journal: Journal of medicinal chemistry 20050210
Title: Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.
Journal: Gynecologic oncology 20050201
Title: The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.
Journal: Nature medicine 20050201
Title: Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies.
Journal: Cancer research 20050201
Title: A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma.
Journal: Journal of neuro-oncology 20050201
Title: Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models.
Journal: Neoplasia (New York, N.Y.) 20050201
Title: A randomised phase II trial of docetaxel vs docetaxel and irinotecan in patients with stage IIIb-IV non-small-cell lung cancer who failed first-line treatment.
Journal: British journal of cancer 20050117
Title: Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2.
Journal: Cancer research 20050115
Title: Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells.
Journal: Advanced drug delivery reviews 20050102
Title: Panniculitis induced by a chemotherapy regimen consisting of topotecan and cyclophosphamide.
Journal: Pediatric blood & cancer 20050101
Title: Role of pegylated liposomal doxorubicin in ovarian cancer.
Journal: Gynecologic oncology 20050101
Title: Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis.
Journal: Cell cycle (Georgetown, Tex.) 20050101
Title: Efficacy of topotecan treatment on antioxidant enzymes and TBA-RS levels in submandibular glands of rabbits: an experimental study.
Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20050101
Title: Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis.
Journal: Clinical pharmacokinetics 20050101
Title: Phase I/II trial of simultaneous whole-brain irradiation and dose-escalating topotecan for brain metastases.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050101
Title: Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck.
Journal: Expert opinion on pharmacotherapy 20050101
Title: Toxicity of the topoisomerase I inhibitors.
Journal: Expert opinion on drug safety 20050101
Title: In vitro effects of topotecan and ionizing radiation on TRAIL/Apo2L-mediated apoptosis in malignant glioma.
Journal: Journal of neuro-oncology 20050101
Title: High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.
Journal: Journal of neuro-oncology 20050101
Title: Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population.
Journal: American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20050101
Title: Future options for first-line therapy of advanced ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: The effects of topotecan on lipid peroxidation and antioxidant enzyme levels in rabbit liver tissue.
Journal: Redox report : communications in free radical research 20050101
Title: Topotecan in heavily pretreated patients with recurrent ovarian, peritoneal, and fallopian tube carcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: Current concepts of treatment strategies in advanced or recurrent ovarian cancer.
Journal: Oncology 20050101
Title: Cancer cell adaptation to chemotherapy.
Journal: BMC cancer 20050101
Title: Brain metastases in breast cancer--an in vitro study to evaluate new systemic chemotherapeutic options.
Journal: Anticancer research 20050101
Title: Activity of chemotherapy in mucinous epithelial ovarian cancer: a retrospective study.
Journal: Anticancer research 20050101
Title: Recent developments in the clinical activity of topoisomerase-1 inhibitors.
Journal: Cancer chemotherapy and biological response modifiers 20050101
Title: p53 Gene status and response to topotecan-containing chemotherapy in advanced ovarian carcinoma.
Journal: Oncology 20050101
Title: Effect of chemotherapy on the mutation frequency of ovarian cancer cells at the HPRT locus.
Journal: Anticancer research 20050101
Title: Anthracyclines, proteasome activity and multi-drug-resistance.
Journal: BMC cancer 20050101
Title: Phase I trial of an all-oral combination chemotherapy regimen: topotecan and capecitabine in solid tumor patients.
Journal: The Journal of oncology management : the official journal of the American College of Oncology Administrators 20050101
Title: Addition of 5-fluorouracil to doxorubicin-paclitaxel sequence increases caspase-dependent apoptosis in breast cancer cell lines.
Journal: Breast cancer research : BCR 20050101
Title: Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells.
Journal: Breast cancer research : BCR 20050101
Title: Efficacy and tolerability of lower-dose topotecan in recurrent ovarian cancer: a retrospective case review.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application.
Journal: Cancer investigation 20050101
Title: ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.
Journal: Cancer cell international 20050101
Title: A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with Carboplatin and Etoposide in extensive stage small cell lung cancer.
Journal: Cancer investigation 20050101
Title: Epigenetics of cervical cancer. An overview and therapeutic perspectives.
Journal: Molecular cancer 20050101
Title: The effect of Topotecan on oxidative stress in MCF-7 human breast cancer cell line.
Journal: Acta biochimica Polonica 20050101
Title: First-line therapy with gemcitabine and paclitaxel in locally, recurrent or metastatic breast cancer: a phase II study.
Journal: BMC cancer 20050101
Title: Breast cancer resistance protein-mediated topotecan resistance in ovarian cancer cells.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: Randomized single-agents trials in recurrent epithelial ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: Gemcitabine in patients with ovarian cancer.
Journal: Cancer treatment reviews 20050101
Title: Phase I clinical trial of topotecan and pegylated liposomal doxorubicin.
Journal: Cancer investigation 20050101
Title: The value of serum and tissular expression of CA 125 antigen, in evaluation of the response to second line chemotherapy for the relapsed ovarian carcinoma.
Journal: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 20050101
Title: Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.
Journal: The Journal of biological chemistry 20041224
Title: HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.
Journal: Cancer research 20041215
Title: Nucleoside analogs and antimetabolite therapies for myelodysplastic syndrome.
Journal: Best practice & research. Clinical haematology 20041201
Title: Heterogeneous cell response to topotecan in a CFSE-based proliferation test.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20041201
Title: Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.
Journal: Journal of neurochemistry 20041201
Title: Retrospective analysis of weekly topotecan as salvage therapy in relapsed ovarian cancer.
Journal: Gynecologic oncology 20041201
Title: Phase II study of weekly topotecan in patients with recurrent or persistent epithelial ovarian cancer.
Journal: Gynecologic oncology 20041201
Title: Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041201
Title: In regard to Bogart et al.: 70 Gy thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage non-small-cell lung cancer: Analysis of cancer and leukemia group B study 39808 (Int J Radiat Oncol Biol Phys 2004;59:460-468).
Journal: International journal of radiation oncology, biology, physics 20041201
Title: Mechanism-based models for topotecan-induced neutropenia.
Journal: Clinical pharmacology and therapeutics 20041201
Title: The use of topotecan for relapsed ovarian cancer in accordance with the National Institute for Clinical Excellence Guidance 2001: the Nottingham experience.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20041201
Title: Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference.
Journal: Molecular cancer therapeutics 20041201
Title: The ex vivo characterization of XR5944 (MLN944) against a panel of human clinical tumor samples.
Journal: Molecular cancer therapeutics 20041201
Title: Treatment of patients with advanced lung cancer and poor performance status.
Journal: Clinical lung cancer 20041201
Title: Liposomal anthracycline treatment for ovarian cancer.
Journal: Seminars in oncology 20041201
Title: Pharmacoeconomics of liposomal anthracycline therapy.
Journal: Seminars in oncology 20041201
Title: Emerging therapeutic and supportive care approaches for the myelodisplastic syndromes.
Journal: Reviews in clinical and experimental hematology 20041201
Title: Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Phase II clinical trial of capecitabine and gemcitabine chemotherapy in patients with metastatic renal carcinoma.
Journal: British journal of cancer 20041115
Title: Recurrent ovarian cancer: how important is it to treat to disease progression?
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041115
Title: Multiple binding modes of the camptothecin family to DNA oligomers.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041105
Title: Review of the use of topotecan in ovarian carcinoma.
Journal: Expert opinion on pharmacotherapy 20041101
Title: Recent advances in primary CNS lymphoma.
Journal: Current opinion in oncology 20041101
Title: Role of pegylated liposomal doxorubicin (PLD) in epithelial ovarian cancer.
Journal: Journal of chemotherapy (Florence, Italy) 20041101
Title: Topotecan induced nail pigmentation.
Journal: The Journal of dermatology 20041101
Title: [Effect of palliative chemotherapy with topoisomerase inhibitor on the quality of life and survival of patients with advanced colorectal carcinoma].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20041101
Title: Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
Journal: Journal of medicinal chemistry 20041021
Title: A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer.
Journal: British journal of cancer 20041018
Title: Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1-5 of a 3-weekly cycle in patients with advanced solid tumours.
Journal: British journal of cancer 20041018
Title: Should CA-125 response criteria be preferred to response evaluation criteria in solid tumors (RECIST) for prognostication during second-line chemotherapy of ovarian carcinoma?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041015
Title: Response to paclitaxel, topotecan, and topotecan-cyclophosphamide in children with untreated disseminated neuroblastoma treated in an upfront phase II investigational window: a pediatric oncology group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041015
Title: A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041015
Title: Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
Journal: British journal of cancer 20041004
Title: Monoclonal gammopathy of undetermined significance (MGUS) in patients with solid tumors: effects of chemotherapy on the monoclonal protein.
Journal: Annals of hematology 20041001
Title: The role of chemotherapy in locally advanced, metastatic and recurrent cervical cancer.
Journal: Critical reviews in oncology/hematology 20041001
Title: Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer.
Journal: Gynecologic oncology 20041001
Title: Phase 2 trial of prolonged administration of oral topotecan in platinum/taxane-refractory ovarian, fallopian tube, and primary peritoneal cancers.
Journal: Gynecologic oncology 20041001
Title: Weekly topotecan for recurrent endometrial cancer: a case series and review of the literature.
Journal: Gynecologic oncology 20041001
Title: Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts.
Journal: Cancer research 20041001
Title: Camptothecin, over four decades of surprising findings.
Journal: Phytochemistry 20041001
Title: A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041001
Title: Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
Journal: Journal of experimental therapeutics & oncology 20041001
Title: Sequential intraperitoneal topotecan and oral etoposide chemotherapy in recurrent platinum-resistant ovarian carcinoma: results of a phase II trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040915
Title: No topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan.
Journal: British journal of cancer 20040913
Title: Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line.
Journal: British journal of cancer 20040913
Title: Weekly administration of topotecan and paclitaxel in pretreated advanced cancer patients: a phase I/II study.
Journal: Cancer chemotherapy and pharmacology 20040901
Title: Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF.
Journal: Journal of pharmaceutical sciences 20040901
Title: Topotecan versus paclitaxel in second-line therapy: a lost opportunity for quality-of-life evaluation?
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040901
Title: The treatment of neoplastic meningitis.
Journal: Expert opinion on pharmacotherapy 20040901
Title: Topotecan disposition in an anephric child.
Journal: Journal of pediatric hematology/oncology 20040901
Title: Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening.
Journal: Journal of immunological methods 20040901
Title: Gefitinib reverses breast cancer resistance protein-mediated drug resistance.
Journal: Molecular cancer therapeutics 20040901
Title: Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration.
Journal: Clinical colorectal cancer 20040901
Title: Advanced ovarian cancer: a clinical update on first-line treatment, recurrent disease, and new agents.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20040901
Title: A phase II feasibility study of carboplatin followed by sequential weekly paclitaxel and gemcitabine as first-line treatment for ovarian cancer.
Journal: British journal of cancer 20040816
Title: Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer.
Journal: British journal of cancer 20040816
Title: Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040815
Title: Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.
Journal: Cancer research 20040815
Title: Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin.
Journal: Bioorganic & medicinal chemistry letters 20040802
Title: Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group).
Journal: British journal of cancer 20040802
Title: Phase I/II trial of topotecan given as continuous infusion in combination with oxaliplatin in 5-FU-pretreated patients with colorectal cancer.
Journal: Cancer chemotherapy and pharmacology 20040801
Title: Is stabilization of disease a useful indicator for survival in second-line treatment of ovarian carcinoma pre-treated with Paclitaxel-Platinum?
Journal: Gynecologic oncology 20040801
Title: Phase II study of sequential doublets: topotecan and carboplatin, followed by paclitaxel and carboplatin, in patients with newly diagnosed advanced ovarian cancer.
Journal: Gynecologic oncology 20040801
Title: [Synthesis and antitumor activity of 20-O-linked camptothecin ester derivatives].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801
Title: Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo.
Journal: Carcinogenesis 20040701
Title: The telomeric region is excluded from nucleosomal fragmentation during apoptosis, but the bulk nuclear chromatin is randomly degraded.
Journal: Cell death and differentiation 20040701
Title: Combined topoisomerase I inhibition for the treatment of metastatic colon cancer.
Journal: Anti-cancer drugs 20040701
Title: Topotecan compared with no therapy after response to surgery and carboplatin/paclitaxel in patients with ovarian cancer: Multicenter Italian Trials in Ovarian Cancer (MITO-1) randomized study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040701
Title: The role of topotecan for extending the platinum-free interval in recurrent ovarian cancer: an in vitro model.
Journal: Gynecologic oncology 20040701
Title: Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs.
Journal: Gynecologic oncology 20040701
Title: [A case of brain metastasis of small cell lung cancer improved with nogitecan hydrochloride (topotecan) after prophylactic irradiation].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040701
Title: Topotecan-induced bronchiolitis.
Journal: Southern medical journal 20040701
Title: A non-parametric approach to the design and analysis of two-dimensional dose-finding trials.
Journal: Statistics in medicine 20040630
Title: A phase I study of sequential administration of escalating doses of intravenous paclitaxel, oral topotecan, and fixed-dose oral etoposide in patients with solid tumors.
Journal: Cancer 20040615
Title: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.
Journal: Cancer research 20040615
Title: Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks.
Journal: British journal of cancer 20040614
Title: A phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumours.
Journal: British journal of cancer 20040614
Title: Mechanisms of camptothecin resistance by human topoisomerase I mutations.
Journal: Journal of molecular biology 20040611
Title: A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.
Journal: Mathematical biosciences 20040601
Title: A phase II study of timed sequential therapy of acute myelogenous leukemia (AML) for patients over the age of 60: two cycle timed sequential therapy with topotecan, ara-C and mitoxantrone in adults with poor-risk AML.
Journal: Leukemia research 20040601
Title: Analysis of 96 patients with advanced ovarian carcinoma treated with high-dose chemotherapy and autologous stem cell transplantation.
Journal: Bone marrow transplantation 20040601
Title: 70 Gy thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage small-cell lung cancer: analysis of Cancer and Leukemia Group B study 39808.
Journal: International journal of radiation oncology, biology, physics 20040601
Title: Topotecan in patients with advanced neuroendocrine tumors: a phase II study with significant hematologic toxicity.
Journal: American journal of clinical oncology 20040601
Title: Survival following the documentation of platinum and taxane resistance in ovarian cancer: a single institution experience involving multiple phase 2 clinical trials.
Journal: Gynecologic oncology 20040601
Title: Phase I trial of escalating doses of topotecan in combination with a fixed dose of pegylated liposomal doxorubicin in women with müllerian malignancies.
Journal: Gynecologic oncology 20040601
Title: Topoisomerase I inhibitors in the combined-modality therapy of lung cancer.
Journal: Oncology (Williston Park, N.Y.) 20040601
Title: Response of relapsed or refractory primary central nervous system lymphoma (PCNSL) to topotecan.
Journal: Neurology 20040525
Title: An evaluation of transmembrane ion gradient-mediated encapsulation of topotecan within liposomes.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20040518
Title: Phase I evaluation of docetaxel and topotecan for patients with advanced solid tumors.
Journal: Cancer 20040515
Title: Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin, and cyclophosphamide.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040515
Title: Topotecan and ifosfamide as salvage treatment in advanced ovarian cancer.
Journal: Gynecologic oncology 20040501
Title: Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts.
Journal: European journal of cancer (Oxford, England : 1990) 20040501
Title: Decreased nucleotide excision repair activity and alterations of topoisomerase IIalpha are associated with the in vivo resistance of a P388 leukemia subline to F11782, a novel catalytic inhibitor of topoisomerases I and II.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040501
Title: Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Journal: Journal of natural products 20040501
Title: Ifosfamide/carboplatin/etoposide (ICE) as front-line, topotecan/cyclophosphamide as second-line and oral temozolomide as third-line treatment for advanced neuroblastoma over one year of age.
Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement 20040501
Title: [Homocamptothecins--novel promising anticancer drugs as inhibitors of topoisomerase I].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040501
Title: Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040415
Title: A window on reality?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040415
Title: Oral topotecan in children with recurrent or progressive high-grade glioma: a Phase I/II study by the German Society for Pediatric Oncology and Hematology.
Journal: Cancer 20040415
Title: Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.
Journal: Cancer research 20040415
Title: Cytostatic and cytotoxic effects of topotecan decoded by a novel mathematical simulation approach.
Journal: Cancer research 20040415
Title: A phase I study of Topotecan, as a radiosensitizer, for thoracic malignancies.
Journal: Lung cancer (Amsterdam, Netherlands) 20040401
Title: Costs of treatment and outcomes associated with second-line therapy and greater for relapsed ovarian cancer.
Journal: Gynecologic oncology 20040401
Title: A phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer.
Journal: Gynecologic oncology 20040401
Title: Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20040401
Title: Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.
Journal: Cancer research 20040401
Title: A fludarabine, topotecan, and cytarabine regimen is active in patients with refractory acute myelogenous leukemia.
Journal: Leukemia research 20040401
Title: [Structure-activity relationship analysis].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040401
Title: Hematological response of topotecan in tumor-bearing rats: modeling of the time course of different cellular populations.
Journal: Pharmaceutical research 20040401
Title: Phase I/II clinical study of topotecan and cytarabine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia and acute myeloid leukemia.
Journal: Leukemia & lymphoma 20040401
Title: High-dose topotecan, melphalan and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of multiple myeloma.
Journal: Leukemia & lymphoma 20040401
Title: Targeted therapies in myelodysplastic syndromes: ASH 2003 review.
Journal: Seminars in hematology 20040401
Title: Subcellular localization of the camptothecin analogues, topotecan and gimatecan.
Journal: Biochemical pharmacology 20040315
Title: Prophylactic treatment of known ifosfamide-induced encephalopathy for chemotherapy with high-dose ifosfamide?
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20040301
Title: Comparison of the X-radiation, drug and ultraviolet-radiation responses of clones isolated from a human colorectal tumor cell line.
Journal: Radiation research 20040301
Title: Quality of life evaluations in patients with ovarian cancer during chemotherapy treatment.
Journal: Gynecologic oncology 20040301
Title: Phase I and pharmacokinetic study of topotecan administered orally once daily for 5 days for 2 consecutive weeks to pediatric patients with refractory solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040301
Title: Camptothecins in clinical development.
Journal: Expert opinion on investigational drugs 20040301
Title: VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040301
Title: Evolving role of topotecan in treating small-cell lung cancer.
Journal: Clinical lung cancer 20040301
Title: [The mechanism of topotecan resistance in ovarian cancer cell line].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040301
Title: Activity of topotecan in retinoblastoma.
Journal: Ophthalmic genetics 20040301
Title: A phase II study of sequential carboplatin, paclitaxel and topotecan in patients with previously untreated advanced ovarian cancer.
Journal: British journal of cancer 20040223
Title: N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx.
Journal: British journal of cancer 20040223
Title: Mode of binding of camptothecins to double helix oligonucleotides.
Journal: Organic & biomolecular chemistry 20040221
Title: 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
Journal: Bioorganic & medicinal chemistry 20040215
Title: Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Journal: Cancer research 20040215
Title: Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene.
Journal: Cancer research 20040215
Title: Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
Journal: Cancer research 20040215
Title: Targeting topoisomerase I to inhibit hypoxia inducible factor 1.
Journal: Cell cycle (Georgetown, Tex.) 20040201
Title: Phase II study of topotecan and paclitaxel for patients with previously untreated extensive stage small-cell lung cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040201
Title: Phase II study of topotecan and paclitaxel for recurrent, persistent, or metastatic cervical carcinoma.
Journal: Gynecologic oncology 20040201
Title: Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Synergistic cytotoxicity of pyrazoloacridine with doxorubicin, etoposide, and topotecan in drug-resistant tumor cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Recurrent ovarian cancer.
Journal: Onkologie 20040201
Title: Dose finding study for combination treatment with topotecan and gemcitabine of patients with recurrent ovarian cancer after failure of first-line chemotherapy with Paclitaxel and platinum.
Journal: Onkologie 20040201
Title: Factors affecting pharmacokinetic variability of oral topotecan: a population analysis.
Journal: British journal of cancer 20040126
Title: Do CA125 response criteria overestimate tumour response in second-line treatment of epithelial ovarian carcinoma?
Journal: British journal of cancer 20040126
Title: An in vitro model to optimize dose scheduling of multimodal radioimmunotherapy and chemotherapy: effects of p53 expression.
Journal: International journal of cancer 20040110
Title: Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.
Journal: Journal of the National Cancer Institute 20040107
Title: Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein.
Journal: Leukemia 20040101
Title: A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with advanced ovarian, tubal or peritoneal cancer resistant to platinum, taxane and topotecan.
Journal: Cancer chemotherapy and pharmacology 20040101
Title: Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic.
Journal: International journal of cancer 20040101
Title: Phase II study of low-dose topotecan in myelodysplastic syndromes: a Hoosier Oncology Group (HOG) study.
Journal: Leukemia research 20040101
Title: Long-term survival in a phase III, randomised study of topotecan versus paclitaxel in advanced epithelial ovarian carcinoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040101
Title: Use of erythropoietin in cancer patients: assessment of oncologists' practice patterns in the United States and other countries.
Journal: The American journal of medicine 20040101
Title: A phase II study of topotecan and cyclophosphamide with G-CSF in patients with advanced small cell lung cancer.
Journal: Cancer biology & therapy 20040101
Title: Camptothecin analogs (irinotecan or topotecan) plus high-dose cyclophosphamide as preparative regimens for antibody-based immunotherapy in resistant neuroblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040101
Title: Topotecan in small cell lung cancer: first or second line?
Journal: Cancer biology & therapy 20040101
Title: In vitro chemoresistance and biomarker profiles are unique for histologic subtypes of epithelial ovarian cancer.
Journal: Gynecologic oncology 20040101
Title: Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors.
Journal: Pediatric blood & cancer 20040101
Title: Multidrug resistance in cancer chemotherapy and xenobiotic protection mediated by the half ATP-binding cassette transporter ABCG2.
Journal: Current medicinal chemistry. Anti-cancer agents 20040101
Title: Topotecan dosing guidelines in ovarian cancer: reduction and management of hematologic toxicity.
Journal: The oncologist 20040101
Title: The role of topotecan in the treatment of brain metastases.
Journal: The oncologist 20040101
Title: Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis.
Journal: Molecular cancer research : MCR 20040101
Title: Topotecan in the treatment of relapsed small cell lung cancer patients with poor performance status.
Journal: The oncologist 20040101
Title: High-dose chemotherapy with autologous stem cell rescue as first line of treatment in young children with medulloblastoma and supratentorial primitive neuroectodermal tumors.
Journal: Journal of neuro-oncology 20040101
Title: [Ovarian cancer--therapeutic options after the failure of the first line of treatment].
Journal: Ginekologia polska 20040101
Title: The incidence of port-site metastases in gynecologic cancers.
Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons 20040101
Title: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2).
Journal: BMC medicine 20040101
Title: Topotecan as a continuous infusion over 14 days in recurrent ovarian cancer patients.
Journal: Anticancer research 20040101
Title: Inhibitory effect of genistein and daidzein on ovarian cancer cell growth.
Journal: Anticancer research 20040101
Title: DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells.
Journal: BMC cancer 20040101
Title: Weekly topotecan in a heavily pretreated patient with peritoneal papillary serous adenocarcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20040101
Title: Phase I/II study of first-line irinotecan combined with 5-fluorouracil and folinic acid Mayo Clinic schedule in patients with advanced colorectal cancer.
Journal: BMC cancer 20040101
Title: Cancer of the endometrium: current aspects of diagnostics and treatment.
Journal: World journal of surgical oncology 20040101
Title: Topotecan-induced alterations in the amount and stability of human DNA topoisomerase I in solid tumor cell lines.
Journal: Anticancer research 20040101
Title: Effect of association of temozolomide with other chemotherapic agents on cell growth inhibition in glioma cell lines.
Journal: Oncology research 20040101
Title: Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20040101
Title: Effective knock down of very high ABCG2 expression by a hammerhead ribozyme.
Journal: Anticancer research 20040101
Title: Topotecan, Ara-C, cisplatin and prednisolone (TOPOSHAP) for patients with refractory and relapsing lymphomas: results of a phase I trial.
Journal: Acta haematologica 20040101
Title: Role of primary surgery in advanced ovarian cancer.
Journal: World journal of surgical oncology 20040101
Title: Phase I trial of topotecan in combination with gemcitabine in refractory solid tumor patients.
Journal: Cancer investigation 20040101
Title: How should we manage patients with 'platinum-sensitive' recurrent ovarian cancer?
Journal: Cancer investigation 20040101
Title: Update on Gynecologic Oncology Group (GOG) trials in ovarian cancer.
Journal: Cancer investigation 20040101
Title: Ovarian cancer: review of the National Institute for Clinical Excellence (NICE) guidance recommendations.
Journal: Cancer investigation 20040101
Title: Foreword--new directions for topotecan in lung cancer treatment.
Journal: The oncologist 20040101
Title: Topotecan in the treatment of recurrent small cell lung cancer: an update.
Journal: The oncologist 20040101
Title: Quality-of-life considerations in patients with advanced lung cancer: effect of topotecan on symptom palliation and quality of life.
Journal: The oncologist 20040101
Title: Emerging role of weekly topotecan in recurrent small cell lung cancer.
Journal: The oncologist 20040101
Title: Topotecan in the first-line treatment of small cell lung cancer.
Journal: The oncologist 20040101
Title: Update on the role of topotecan in the treatment of non-small cell lung cancer.
Journal: The oncologist 20040101
Title: [Status report on the chemotherapy of ovarian cancer at special cancer centers in Hungary (2002-2003)].
Journal: Magyar onkologia 20040101
Title: Establishment of a 7-ethyl-10-hydroxy-camptothecin-resistant small cell lung cancer cell line.
Journal: Anticancer research 20040101
Title: Progress in treatment of small-cell lung cancer: role of CPT-11.
Journal: British journal of cancer 20031215
Title: Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.
Journal: International journal of cancer 20031210
Title: A phase II study of topotecan with vincristine and doxorubicin in children with recurrent/refractory neuroblastoma.
Journal: Cancer 20031201
Title: Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines.
Journal: British journal of cancer 20031201
Title: Chemotherapy for ovarian cancer: yesterday, today and tomorrow.
Journal: British journal of cancer 20031201
Title: Primary ovarian cancer chemotherapy: current standards of care.
Journal: British journal of cancer 20031201
Title: Resistance to chemotherapy in advanced ovarian cancer: mechanisms and current strategies.
Journal: British journal of cancer 20031201
Title: Docetaxel: promising and novel combinations in ovarian cancer.
Journal: British journal of cancer 20031201
Title: Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Journal: Cancer research 20031201
Title: [Antisense oligonucleotide reverses topotecan-resistant ovarian cancer cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20031201
Title: [Chemosensitivity testing of topotecan as second-line agent in chemotherapy of ovarian cancer].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20031201
Title: Treatment advances in ovarian cancer.
Journal: Cancer nursing 20031201
Title: A phase II trial of capecitabine (Xeloda) in recurrent ovarian cancer.
Journal: British journal of cancer 20031117
Title: Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.
Journal: British journal of cancer 20031117
Title: Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions.
Journal: Bioorganic & medicinal chemistry letters 20031103
Title: Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeutics.
Journal: British journal of cancer 20031103
Title: A phase II study of topotecan in patients with anaplastic oligodendroglioma or anaplastic mixed oligoastrocytoma.
Journal: Investigational new drugs 20031101
Title: An open label, non-comparative phase II study of topotecan as salvage treatment for patients with soft tissue sarcoma.
Journal: Investigational new drugs 20031101
Title: A phase II trial of three sequential doublets for the treatment of advanced müllerian malignancies.
Journal: Gynecologic oncology 20031101
Title: A phase II study to determine the efficacy and tolerability of intravenous ZD9331 in heavily pretreated patients with ovarian cancer.
Journal: Gynecologic oncology 20031101
Title: The role of breast cancer resistance protein in acute lymphoblastic leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031101
Title: Phase I study of topotecan in combination with concurrent radiotherapy in adults with glioblastoma.
Journal: Journal of neuro-oncology 20031101
Title: [Topotecan-based combined chemotherapy for refractory or relapsed hematologic malignancies].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20031101
Title: Chemotherapy for newly diagnosed and relapsed advanced ovarian cancer.
Journal: Seminars in oncology nursing 20031101
Title: [Economic assessment of Caelyx versus topotecan in advanced ovarian cancer].
Journal: Bulletin du cancer 20031101
Title: Clinical use of rituximab in haematological malignancies.
Journal: British journal of cancer 20031020
Title: Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells.
Journal: British journal of cancer 20031020
Title: Mechanisms of resistance to topoisomerase I-targeting drugs.
Journal: Oncogene 20031020
Title: Phase II evaluation of three-day topotecan in recurrent platinum-sensitive ovarian carcinoma: a gynecologic oncology group study.
Journal: Cancer 20031015
Title: Phase II study of liposomal doxorubicin and gemcitabine in the salvage treatment of ovarian cancer.
Journal: British journal of cancer 20031006
Title: Phase II study of docetaxel and topotecan combination chemotherapy in patients with advanced head and neck cancer.
Journal: Cancer chemotherapy and pharmacology 20031001
Title: Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031001
Title: Sequential dose-dense paclitaxel followed by topotecan in untreated extensive-stage small-cell lung cancer: a Spanish Lung Cancer Group phase II study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20031001
Title: A new multidrug reinduction protocol with topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine for relapsed or refractory acute leukemia.
Journal: Leukemia 20031001
Title: Apoptotic pathways of epothilone BMS 310705.
Journal: Gynecologic oncology 20031001
Title: Cost-minimisation analysis of pegylated liposomal doxorubicin hydrochloride versus topotecan in the treatment of patients with recurrent epithelial ovarian cancer in Spain.
Journal: British journal of cancer 20030915
Title: Phase I study of oral topotecan in hematological malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030915
Title: The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
Journal: Cancer chemotherapy and pharmacology 20030901
Title: The topoisomerase I inhibitor topotecan increases the sensitivity of prostate tumor cells to TRAIL/Apo-2L-induced apoptosis.
Journal: Cancer chemotherapy and pharmacology 20030901
Title: Breast cancer resistance protein exports sulfated estrogens but not free estrogens.
Journal: Molecular pharmacology 20030901
Title: Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030901
Title: Individualised dosing strategy for high-dose carboplatin in patients with germ cell cancer.
Journal: British journal of cancer 20030901
Title: Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil.
Journal: British journal of cancer 20030901
Title: Clinical experience with topotecan in relapsed ovarian cancer.
Journal: Gynecologic oncology 20030901
Title: First-line treatment regimens and the role of consolidation therapy in advanced ovarian cancer.
Journal: Gynecologic oncology 20030901
Title: The role of topotecan in the treatment of advanced cervical cancer.
Journal: Gynecologic oncology 20030901
Title: Treatment options for endometrial cancer: experience with topotecan.
Journal: Gynecologic oncology 20030901
Title: Weekly topotecan in the management of ovarian cancer.
Journal: Gynecologic oncology 20030901
Title: Optimal sequencing in the treatment of recurrent ovarian cancer.
Journal: Gynecologic oncology 20030901
Title: Workshop: options for therapy in ovarian cancer.
Journal: Gynecologic oncology 20030901
Title: [Current status of camptothecin derivatives as natural antitumor agents].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030901
Title: Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Journal: Bioorganic & medicinal chemistry letters 20030818
Title: Phase I study of cisplatin, irinotecan, and epirubicin administered every 3 weeks in patients with advanced solid tumours.
Journal: British journal of cancer 20030818
Title: Molecular mechanisms underlying the interaction between ZD1839 ('Iressa') and cisplatin/5-fluorouracil.
Journal: British journal of cancer 20030804
Title: [Topotecan for pediatric patients with resistant and recurrent solid tumors].
Journal: Anales de pediatria (Barcelona, Spain : 2003) 20030801
Title: Amifostine pretreatment for protection against topotecan-induced hematologic toxicity: results of a multicenter phase III trial in patients with advanced gynecologic malignancies.
Journal: Gynecologic oncology 20030801
Title: Oral topotecan for refractory and relapsed neuroblastoma: a retrospective analysis.
Journal: Journal of pediatric hematology/oncology 20030801
Title: Expression and functional analyses of breast cancer resistance protein in lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Title: CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Title: Clinical and cellular pharmacology in relation to solid tumours of childhood.
Journal: Cancer treatment reviews 20030801
Title: Clinical trials of newer regimens for treating ovarian cancer: the rationale for Gynecologic Oncology Group Protocol GOG 182-ICON5.
Journal: Gynecologic oncology 20030801
Title: Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors.
Journal: Anti-cancer drugs 20030801
Title: The role of topotecan in treating small cell lung cancer: second-line treatment.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Topotecan as first-line therapy for small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Single-agent chemotherapy for non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Combination chemotherapy with topotecan for non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Weekly topotecan in the management of lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Options for first- and second-line therapy in small cell lung cancer--a workshop discussion.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Enhanced effectiveness of last generation antiblastic compounds vs. cisplatin on malignant pleural mesothelioma cell lines.
Journal: European journal of pharmacology 20030725
Title: Alveolar soft-part sarcoma responding to interferon alpha-2b.
Journal: British journal of cancer 20030721
Title: New designs for phase 2 clinical trials.
Journal: Blood 20030715
Title: Survival-signaling pathway as a promising target for cancer chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20030701
Title: Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer.
Journal: Anti-cancer drugs 20030701
Title: Influence of the cisplatin hydration schedule on topotecan pharmacokinetics.
Journal: European journal of cancer (Oxford, England : 1990) 20030701
Title: Sequencing topotecan and etoposide plus cisplatin to overcome topoisomerase I and II resistance: a pharmacodynamically based Phase I trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Title: Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Title: Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Title: A case of paraneoplastic nephrotic syndrome in a patient with ovarian carcinoma.
Journal: Yonsei medical journal 20030630
Title: The camptothecins.
Journal: Lancet (London, England) 20030628
Title: Oral melphalan as a treatment for platinum-resistant ovarian cancer.
Journal: British journal of cancer 20030616
Title: Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.
Journal: British journal of cancer 20030616
Title: Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.
Journal: British journal of cancer 20030616
Title: Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.
Journal: Cancer research 20030615
Title: Topotecan in the treatment of acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy.
Journal: Journal of neurovirology 20030601
Title: Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma: Eastern Cooperative Oncology Group Study E3E93.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030601
Title: Treatment of relapsed small-cell lung cancer--a focus on the evolving role of topotecan.
Journal: Lung cancer (Amsterdam, Netherlands) 20030601
Title: Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.
Journal: Cancer research 20030601
Title: Hematological side-effect profiles of individualized chemotherapy regimen for recurrent ovarian cancer.
Journal: Anti-cancer drugs 20030601
Title: Second-line chemotherapy for ovarian cancer.
Journal: The Lancet. Oncology 20030601
Title: Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030601
Title: A phase I study of topotecan/paclitaxel alternating with etoposide/cisplatin and thoracic irradiation in patients with limited small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030601
Title: Randomized phase II study of daily versus continuous-infusion schedules of topotecan in the treatment of extensive-stage small cell lung cancers.
Journal: American journal of clinical oncology 20030601
Title: A new therapeutical approach: topotecan plus gemcitabine in the treatment of patients with relapsed ovarian cancer after failure of first-line chemotherapy with paclitaxel and platinum.
Journal: The journal of obstetrics and gynaecology research 20030601
Title: Cost-minimization analysis of pegylated liposomal doxorubicin versus topotecan for the treatment of ovarian cancer in Italy.
Journal: Clinical therapeutics 20030601
Title: Phase II study to topotecan and cisplatin in advanced hepatocellular carcinoma.
Journal: The Korean journal of internal medicine 20030601
Title: Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Journal: Journal of medicinal chemistry 20030522
Title: The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells.
Journal: Life sciences 20030516
Title: Alternating chemotherapy with etoposide plus cisplatin and topotecan plus paclitaxel in patients with untreated, extensive-stage small cell lung carcinoma: a phase II trial of the North Central Cancer Treatment Group.
Journal: Cancer 20030515
Title: Combined-modality therapy of locally advanced cervical cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030515
Title: Developmental chemotherapy and management of recurrent ovarian cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030515
Title: Genotoxicity of two anticancer drugs, gemcitabine and topotecan, in mouse bone marrow in vivo.
Journal: Mutation research 20030509
Title: Phase II study of docetaxel in patients with relapsed or refractory malignant lymphoma.
Journal: British journal of cancer 20030506
Title: The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells.
Journal: International journal of oncology 20030501
Title: Toxicity patterns of cytotoxic drugs.
Journal: Investigational new drugs 20030501
Title: ZD9331 in combination with topotecan: phase I and II experience.
Journal: Anti-cancer drugs 20030501
Title: Emerging treatments for ovarian cancer.
Journal: Expert opinion on emerging drugs 20030501
Title: Tracking the cell cycle origins for escape from topotecan action by breast cancer cells.
Journal: British journal of cancer 20030422
Title: Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models.
Journal: Biochemical pharmacology 20030415
Title: Induction of long-term remission of a relapsed childhood B-acute lymphoblastic leukemia with rituximab chimeric anti-CD20 monoclonal antibody and autologous stem cell transplantation.
Journal: Journal of pediatric hematology/oncology 20030401
Title: [Drug-resistant proteins in breast cancer: recent progress in multidrug resistance].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030401
Title: Phase I trial of carboplatin and paclitaxel with escalating doses of oral topotecan in patients with solid tumors.
Journal: American journal of clinical oncology 20030401
Title: Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins.
Journal: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20030401
Title: Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug.
Journal: Statistics in medicine 20030330
Title: Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy.
Journal: British journal of cancer 20030324
Title: Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.
Journal: British journal of cancer 20030324
Title: Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315
Title: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.
Journal: Cancer research 20030315
Title: A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome.
Journal: Cancer 20030301
Title: Red blood cells: a neglected compartment in topotecan pharmacokinetic analysis.
Journal: Anti-cancer drugs 20030301
Title: [Second-line Hycamtin in the treatment of lung cancer].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20030301
Title: [A symphony for the camptothecins].
Journal: Bulletin du cancer 20030301
Title: Emerging role of topotecan in first-line therapy of small-cell lung cancer.
Journal: Clinical lung cancer 20030301
Title: Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205
Title: A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
Title: A phase II multicenter study of combined topotecan and gemcitabine as first line chemotherapy for advanced non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20030201
Title: Three-consecutive-day topotecan is an active regimen for recurrent epithelial ovarian cancer.
Journal: Gynecologic oncology 20030201
Title: Chemotherapy for small cell lung cancer.
Journal: Seminars in oncology 20030201
Title: Chemotherapy for malignant pleural mesothelioma: past results and recent developments.
Journal: British journal of cancer 20030127
Title: Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
Journal: Journal of medicinal chemistry 20030116
Title: Commentary: topoisomerases as targets in acute leukemia: I, II, I plus II or none?
Journal: Leukemia research 20030101
Title: A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia.
Journal: Leukemia research 20030101
Title: Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs.
Journal: Critical reviews in oncology/hematology 20030101
Title: Evaluation of the nutritional and inflammatory status in cancer patients for the risk assessment of severe haematological toxicity following chemotherapy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030101
Title: Sequential administration of cisplatin-etoposide followed by topotecan in patients with extensive stage small cell lung cancer. A multicenter phase II study.
Journal: Lung cancer (Amsterdam, Netherlands) 20030101
Title: Phase I clinical trial of intrathecal topotecan in patients with neoplastic meningitis.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030101
Title: Boosting bioavailability to topotecan: what do we gain?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030101
Title: Recent advances in traditional plant drugs and orchids.
Journal: Acta pharmacologica Sinica 20030101
Title: Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.
Journal: Molecular cancer therapeutics 20030101
Title: European organization for research and treatment of cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030101
Title: The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours.
Journal: Cancer detection and prevention 20030101
Title: Phase I study of paclitaxel and topotecan for the first-line treatment of extensive-stage small cell lung cancer.
Journal: The oncologist 20030101
Title: A phase I study of topotecan as a radiosensitizer for brainstem glioma of childhood: first report of the Children's Cancer Group-0952.
Journal: Neuro-oncology 20030101
Title: [Preclinical studies of concomitant chemoradiation].
Journal: Medicina (Kaunas, Lithuania) 20030101
Title: Current therapies in ovarian cancer.
Journal: Cancer investigation 20030101
Title: The use of continuous infusion topotecan in persistent and recurrent ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20030101
Title: A pilot study of topotecan in the treatment of serous carcinoma of the uterus.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20030101
Title: Modeling plasma and saliva topotecan concentration time course using a population approach.
Journal: Oncology research 20030101
Title: High-dose daunorubicin as liposomal compound (Daunoxome) in elderly patients with acute lymphoblastic leukemia.
Journal: The hematology journal : the official journal of the European Haematology Association 20030101
Title: p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer.
Journal: Anticancer research 20030101
Title: Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma.
Journal: BMC cancer 20030101
Title: Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.
Journal: Cell cycle (Georgetown, Tex.) 20030101
Title: Prolonged stabilization of platinum/paclitaxel-refractory ovarian cancer with topotecan: a case report and review of the literature.
Journal: Clinical and experimental obstetrics & gynecology 20030101
Title: Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone.
Journal: Anticancer research 20030101
Title: DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis.
Journal: Cell cycle (Georgetown, Tex.) 20030101
Title: Combined therapy with topotecan and gemcitabine in patients with inoperable or metastatic non-small cell lung cancer.
Journal: Cancer investigation 20030101
Title: Interaction of clinically important human DNA topoisomerase I poison, topotecan, with double-stranded DNA.
Journal: Biopolymers 20030101
Title: Clinical studies of camptothecin and derivatives.
Journal: The Alkaloids. Chemistry and biology 20030101
Title: A phase II study of topotecan in patients with relapsed small-cell lung cancer.
Journal: Clinical lung cancer 20030101
Title: Topotecan in relapsed small-cell lung cancer: can good things come in small packages?
Journal: Clinical lung cancer 20030101
Title: Improving first-line therapy of advanced ovarian cancer - the AGO Ovarian Cancer Study Group perspective.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20030101
Title: The role of anthracyclines in second-line therapy of ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20030101
Title: [Interaction of topotecan-a DNA topoisomerase I inhibitor-with dual-stranded polydeoxyribonucleotides. V. Topotecan is able to cause single- and double-strand breaks in ring superhelical DNA in the absence of enzyme].
Journal: Molekuliarnaia biologiia 20030101
Title: New agents in the treatment of small-cell lung cancer: focus on gemcitabine.
Journal: Clinical lung cancer 20030101
Title: Tumor-specific dose scheduling of bimodal radioimmunotherapy and chemotherapy.
Journal: Anticancer research 20030101
Title: Role of weekly paclitaxel in the treatment of advanced ovarian cancer.
Journal: Critical reviews in oncology/hematology 20021227
Title: Low levels of ABCG2 expression in adult AML blast samples.
Journal: Blood 20021215
Title: Action models for the antitumor drug camptothecin: formation of alkali-labile complex with DNA and inhibition of human DNA topoisomerase I.
Journal: Journal of biomolecular structure & dynamics 20021201
Title: Mylotarg combined with topotecan and cytarabine in patients with refractory acute myelogenous leukemia.
Journal: Cancer chemotherapy and pharmacology 20021201
Title: A phase II trial of topotecan in patients with advanced, persistent, or recurrent endometrial carcinoma: a gynecologic oncology group study.
Journal: Gynecologic oncology 20021201
Title: Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021201
Title: Treatment of diffuse alveolar hemorrhage after allogeneic bone marrow transplant with recombinant factor VIIa.
Journal: Bone marrow transplantation 20021201
Title: Prolonged infusional topotecan and accelerated hyperfractionated 3d-conformal radiation in patients with newly diagnosed glioblastoma--a phase I study.
Journal: Journal of neuro-oncology 20021201
Title: New drugs for the treatment of cancer, 1990-2001.
Journal: The Israel Medical Association journal : IMAJ 20021201
Title: [Preliminary study of apoptosis of human hepatocarcinoma cell line HepG2 induced by topotecan].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20021201
Title: ZD0473 combined with other chemotherapeutic agents for the treatment of solid malignancies.
Journal: European journal of cancer (Oxford, England : 1990) 20021201
Title: The mechanism of topoisomerase I poisoning by a camptothecin analog.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20021126
Title: Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
Journal: Journal of medicinal chemistry 20021107
Title: A phase II study of topotecan plus gemcitabine in the treatment of patients with relapsed ovarian cancer after failure of first-line chemotherapy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20021101
Title: Unexpected pleural effusions in 3 pediatric patients treated with STI-571.
Journal: Journal of pediatric hematology/oncology 20021101
Title: A phase I study of weekly topotecan and Paclitaxel in previously treated epithelial ovarian carcinoma patients.
Journal: Gynecologic oncology 20021101
Title: [Own experiences in salvage chemotherapy of ovarian cancer--a preliminary report].
Journal: Ginekologia polska 20021101
Title: Oral cancer treatment: developments in chemotherapy and beyond.
Journal: British journal of cancer 20021021
Title: Treatment of paediatric pontine glioma with oral trophosphamide and etoposide.
Journal: British journal of cancer 20021021
Title: [Evaluation of topotecan combined with cisplatin in the treatment of small cell lung cancer].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20021020
Title: The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer.
Journal: Biochemical pharmacology 20021015
Title: Efficacy of low-dose topotecan in second-line treatment for patients with epithelial ovarian carcinoma.
Journal: Cancer 20021015
Title: First-line chemotherapy for ovarian cancer - the controversy continues.
Journal: British journal of cancer 20021007
Title: Platinum drugs in the treatment of non-small-cell lung cancer.
Journal: British journal of cancer 20021007
Title: A Phase I-II study of sequential administration of topotecan and oral etoposide (toposiomerase I and II inhibitors) in the treatment of patients with small cell lung carcinoma.
Journal: Cancer 20021001
Title: Cisplatin-etoposide alternating with topotecan in patients with extensive stage small cell lung cancer (SCLC). A multicenter phase II study.
Journal: Lung cancer (Amsterdam, Netherlands) 20021001
Title: A comparative economic analysis of pegylated liposomal doxorubicin versus topotecan in ovarian cancer in the USA and the UK.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20021001
Title: Tumor lysis syndrome in extensive-stage small-cell lung cancer.
Journal: American journal of clinical oncology 20021001
Title: Preclinical activity of an i.v. formulation of rubitecan in IDD-P against human solid tumor xenografts.
Journal: Anti-cancer drugs 20021001
Title: DNA topoisomerases in cancer chemotherapy: using enzymes to generate selective DNA damage.
Journal: Current opinion in investigational drugs (London, England : 2000) 20021001
Title: Detection of topoisomerase inhibitor-induced DNA strand breaks and apoptosis by the alkaline comet assay.
Journal: Mutation research 20020926
Title: Irinotecan in patients with relapsed or cisplatin-refractory germ cell cancer: a phase II study of the German Testicular Cancer Study Group.
Journal: British journal of cancer 20020923
Title: A Phase II trial of topotecan and gemcitabine in patients with previously treated, advanced nonsmall cell lung carcinoma.
Journal: Cancer 20020915
Title: A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.
Journal: British journal of cancer 20020909
Title: DNA topoisomerase I and II expression in drug resistant germ cell tumours.
Journal: British journal of cancer 20020909
Title: Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
Journal: British journal of cancer 20020909
Title: Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
Journal: British journal of cancer 20020909
Title: Ovarian cancer: progress and continuing controversies in management.
Journal: European journal of cancer (Oxford, England : 1990) 20020901
Title: Response to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation. a multicentre phase II study.
Journal: European journal of cancer (Oxford, England : 1990) 20020901
Title: Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents.
Journal: Molecular pharmacology 20020901
Title: Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma.
Journal: Urological research 20020901
Title: Topotecan preceded by oxaliplatin using a 3 week schedule: a phase I study in advanced cancer patients.
Journal: European journal of cancer (Oxford, England : 1990) 20020901
Title: Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis.
Journal: Cancer 20020901
Title: SWOG-9510: evaluation of topotecan in hormone refractory prostate cancer: a Southwest Oncology Group study.
Journal: The Prostate 20020901
Title: Part II: chemotherapy for epithelial ovarian cancer-treatment of recurrent disease.
Journal: The Lancet. Oncology 20020901
Title: Combined effect of topotecan and irradiation on the survival and the induction of chromosome aberrations in vitro.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20020901
Title: VIII International Conference on malignant lymphoma. June 12-15, 2002 Lugano, Switzerland.
Journal: Clinical lymphoma 20020901
Title: Weekly gemcitabine plus Epirubicin as effective chemotherapy for advanced pancreatic cancer: a multicenter phase II study.
Journal: British journal of cancer 20020827
Title: Carboplatin and topotecan combination and myelosuppression.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020815
Title: Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection.
Journal: British journal of cancer 20020812
Title: Sequence-dependent synergism between the new generation platinum agent ZD0473 and paclitaxel in cisplatin-sensitive and -resistant human ovarian carcinoma cell lines.
Journal: European journal of cancer (Oxford, England : 1990) 20020801
Title: BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia.
Journal: Leukemia 20020801
Title: Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801
Title: Phase I trial of topotecan plus vinorelbine with/without filgrastim (G-CSF) in patients with refractory malignancies.
Journal: American journal of clinical oncology 20020801
Title: Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Journal: Cancer research 20020801
Title: Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020801
Title: Treating relapsed epithelial ovarian cancer with luteinizing hormone-releasing agonist (goserelin) after failure of chemotherapy.
Journal: The Israel Medical Association journal : IMAJ 20020801
Title: Simple and efficient liposomal encapsulation of topotecan by ammonium sulfate gradient: stability, pharmacokinetic and therapeutic evaluation.
Journal: Anti-cancer drugs 20020801
Title: Phase II study of sequential topotecan and etoposide in patients with intermediate grade non-Hodgkin's lymphoma: a National Cancer Institute of Canada Clinical Trials Group study.
Journal: Leukemia & lymphoma 20020801
Title: [Gemicitabine in the treatment of epithelial ovarian cancer].
Journal: Bulletin du cancer 20020801
Title: Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugs.
Journal: Fundamental & clinical pharmacology 20020801
Title: Phase II study of topotecan plus cranial radiation for glioblastoma multiforme: results of Radiation Therapy Oncology Group 9513.
Journal: International journal of radiation oncology, biology, physics 20020715
Title: Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38.
Journal: British journal of cancer 20020715
Title: Epithelial ovarian cancer: second and third line chemotherapy (review).
Journal: International journal of oncology 20020701
Title: A phase I dose-escalating study of DaunoXome, liposomal daunorubicin, in metastatic breast cancer.
Journal: British journal of cancer 20020701
Title: Boosting bioavailability of topotecan: what do we gain?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020701
Title: Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020701
Title: Novel mutation of topoisomerase I in rendering cells resistant to camptothecin.
Journal: Cancer research 20020701
Title: Urinary and fecal excretion of topotecan in patients with malignant solid tumours.
Journal: Cancer chemotherapy and pharmacology 20020701
Title: Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: determination of efficacy and possible mechanisms of resistance.
Journal: International journal of cancer 20020701
Title: Topotecan-induced celluitis-like fixed drug eruption.
Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20020701
Title: Clinical and economic benefits of irinotecan in combination with 5-fluorouracil and folinic acid as first line treatment of metastatic colorectal cancer.
Journal: British journal of cancer 20020605
Title: Topotecan is anti-angiogenic in experimental hepatoblastoma.
Journal: Journal of pediatric surgery 20020601
Title: Phase I clinical and pharmacokinetic study of combination chemotherapy with topotecan and ifosfamide in patients with progressive or relapsed solid tumors.
Journal: Journal of cancer research and clinical oncology 20020601
Title: Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents.
Journal: Cancer chemotherapy and pharmacology 20020601
Title: Phase I studies of nogitecan hydrochloride for Japanese.
Journal: International journal of clinical oncology 20020601
Title: Troxacitabine-based therapy of refractory leukemia.
Journal: Expert review of anticancer therapy 20020601
Title: Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan.
Journal: Current cancer drug targets 20020601
Title: C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.
Journal: Molecular cancer therapeutics 20020601
Title: Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice.
Journal: British journal of cancer 20020520
Title: [New drugs in bronchial cancer].
Journal: Presse medicale (Paris, France : 1983) 20020511
Title: Intraperitoneal adenovirus-mediated suicide gene therapy in combination with either topotecan or paclitaxel in nude mice with human ovarian cancer.
Journal: Cancer gene therapy 20020501
Title: Phase II evaluation of 3-day topotecan with cyclophosphamide in the treatment of recurrent ovarian cancer.
Journal: Gynecologic oncology 20020501
Title: Topotecan-induced topoisomerase IIalpha expression increases the sensitivity of the CML cell line K562 to subsequent etoposide plus mitoxantrone treatment.
Journal: Cancer chemotherapy and pharmacology 20020501
Title: Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.
Journal: Clinical pharmacology and therapeutics 20020501
Title: No evidence that amifostine influences the plasma pharmacokinetics of topotecan in ovarian cancer patients.
Journal: European journal of clinical pharmacology 20020501
Title: Paclitaxel, carboplatin, and topotecan in the treatment of patients with small cell lung cancer: a phase II trial of the Minnie Pearl Cancer Research Network.
Journal: Cancer 20020501
Title: [A case of recurrent small cell lung cancer with symptoms improved by nogitecan hydrochloride].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020501
Title: Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue.
Journal: Cancer chemotherapy and pharmacology 20020501
Title: [Lung carcinoma. An unusual case of survival].
Journal: Recenti progressi in medicina 20020501
Title: [Nogitecan hydrochloride].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020501
Title: Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (T-EM) and correlation with topoisomerase II levels.
Journal: Leukemia & lymphoma 20020501
Title: [Early results of topotecan therapy in patients with recurrent ovarian cancer].
Journal: Orvosi hetilap 20020421
Title: A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.
Journal: Cancer research 20020415
Title: Phase II trial of topotecan and cisplatin in persistent or recurrent squamous and nonsquamous carcinomas of the cervix.
Journal: Gynecologic oncology 20020401
Title: Phase I study of alternating doublets of topotecan/carboplatin and paclitaxel/carboplatin in patients with newly diagnosed, advanced ovarian cancer.
Journal: Gynecologic oncology 20020401
Title: Phase I study of topotecan and radiation therapy in advanced cervical cancer.
Journal: Gynecologic oncology 20020401
Title: Performance status rather than age is the key prognostic factor in second-line treatment of elderly patients with epithelial ovarian carcinoma.
Journal: Cancer 20020401
Title: Combination of topotecan and oxaliplatin in inoperable hepatocellular cancer patients.
Journal: American journal of clinical oncology 20020401
Title: Lung cancer: a review.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020401
Title: Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance.
Journal: Biochemical pharmacology 20020401
Title: Recurrent ovarian cancer as chronic disease.
Journal: Oncology (Williston Park, N.Y.) 20020401
Title: Epithelial ovarian cancer.
Journal: Current treatment options in oncology 20020401
Title: Pegylated liposomal doxorubicin (Caelyx) in recurrent ovarian cancer.
Journal: Cancer treatment reviews 20020401
Title: [Killing and proapoptotic effects of topoisomerase I inhibitor on K562 cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20020401
Title: [Phase II clinical study of topotecan hydrochloride in patients with recurrent advanced ovarian cancer].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20020401
Title: Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
Journal: Molecular cancer therapeutics 20020401
Title: Dear doctor: we really are not sure what dose of capecitabine you should prescribe for your patient.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315
Title: Protracted intermittent schedule of topotecan in children with refractory acute leukemia: a pediatric oncology group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315
Title: Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.
Journal: Cancer research 20020315
Title: Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells.
Journal: Cytokine 20020307
Title: Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer.
Journal: British journal of cancer 20020304
Title: Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway.
Journal: International journal of cancer 20020301
Title: Chemotherapy and pregnancy.
Journal: Clinical obstetrics and gynecology 20020301
Title: Distinct response of experimental neuroblastoma to combination antiangiogenic strategies.
Journal: Journal of pediatric surgery 20020301
Title: Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination.
Journal: Mutagenesis 20020301
Title: Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Title: A phase I clinical trial of sequentially administered doxorubicin and topotecan in refractory solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Title: Structural identification and biological activity of 7-methyl-10,11-ethylenedioxy-20(S)-camptothecin, a photodegradant of lurtotecan.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Title: Fas/CD95-mediated apoptosis in human glioblastoma cells: a target for sensitisation to topoisomerase I inhibitors.
Journal: Biochemical pharmacology 20020301
Title: Topotecan and the development of scleroderma or a scleroderma-like illness.
Journal: Arthritis and rheumatism 20020301
Title: Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance.
Journal: Japanese journal of cancer research : Gann 20020301
Title: Preclinical and phase I study of oxaliplatin and topotecan in combination in human cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20020301
Title: Topotecan in combination with carboplatin: phase I trial evaluation of two treatment schedules.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20020301
Title: Neutrophilic eccrine hidradenitis secondary to topotecan.
Journal: The Journal of dermatological treatment 20020301
Title: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.
Journal: Biochemical pharmacology 20020215
Title: Differential response of tumor cells and normal fibroblasts to fractionated combined treatment with topotecan and ionizing radiation.
Journal: International journal of radiation biology 20020201
Title: Phase I/II clinical trial of concurrent radiochemotherapy in combination with topotecan for the treatment of brain metastases.
Journal: European journal of cancer (Oxford, England : 1990) 20020201
Title: Individual adaptive dosing of topotecan in ovarian cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020201
Title: The role of gemcitabine-based doublets in the management of ovarian carcinoma.
Journal: Seminars in oncology 20020201
Title: Developmental chemotherapy in advanced ovarian cancer: incorporation of newer cytotoxic agents in a phase III randomized trial of the Gynecologic Oncology Group (GOG-0182).
Journal: Seminars in oncology 20020201
Title: Future directions in the treatment of ovarian cancer.
Journal: Seminars in oncology 20020201
Title: [Developed new agents for lung cancer].
Journal: Nihon Geka Gakkai zasshi 20020201
Title: Clinical trials using irinotecan.
Journal: Journal of pediatric hematology/oncology 20020201
Title: Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942.
Journal: Journal of pediatric hematology/oncology 20020201
Title: Phase II trial of topotecan by continuous infusion in patients with advanced soft tissue sarcomas, a SWOG study. Southwest Oncology Group.
Journal: Investigational new drugs 20020201
Title: Novel doublets in extensive-stage small-cell lung cancer: a randomized phase II study of topotecan plus cisplatin or paclitaxel (CALGB 9430).
Journal: Clinical lung cancer 20020201
Title: Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Journal: Journal of medicinal chemistry 20020131
Title: Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein.
Journal: The Journal of biological chemistry 20020125
Title: Cell-based assays for identification of novel double-strand break-inducing agents.
Journal: Journal of the National Cancer Institute 20020116
Title: X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.
Journal: Cancer research 20020115
Title: S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function.
Journal: The Journal of biological chemistry 20020111
Title: Weekly cisplatin and daily oral etoposide is highly effective in platinum pretreated ovarian cancer.
Journal: British journal of cancer 20020107
Title: Determination of topotecan in human whole blood and unwashed erythrocytes by high-performance liquid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020105
Title: The use of oral cytotoxic and cytostatic drugs in cancer treatment.
Journal: European journal of cancer (Oxford, England : 1990) 20020101
Title: A randomised trial of oral versus intravenous topotecan in patients with relapsed epithelial ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20020101
Title: Modulation of cisplatin pharmacodynamics by Cremophor EL: experimental and clinical studies.
Journal: European journal of cancer (Oxford, England : 1990) 20020101
Title: Phase I study of combination topotecan and carboplatin in pediatric solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020101
Title: Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20020101
Title: A phase II study of topotecan in non-Hodgkin's lymphoma: an Ohio State University phase II research consortium study.
Journal: Cancer investigation 20020101
Title: Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study.
Journal: Anti-cancer drugs 20020101
Title: Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer.
Journal: Drugs & aging 20020101
Title: New approaches to the treatment of myelodysplasia.
Journal: The oncologist 20020101
Title: An HIV treatment the world may never see.
Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20020101
Title: Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Journal: Journal of the Society for Gynecologic Investigation 20020101
Title: Chemotherapy for recurrent epithelial ovarian cancer previously treated with platinum--a systematic review of the evidence from randomized trials.
Journal: European journal of gynaecological oncology 20020101
Title: Effect of topotecan infusion duration on hematologic toxicity in recurrent ovarian carcinoma.
Journal: Medical oncology (Northwood, London, England) 20020101
Title: Is there a preferred combination chemotherapy regimen for metastastic non-small cell lung cancer?
Journal: The oncologist 20020101
Title: [Interaction of topotecan, DNA topoisomerase I inhibitor, with double-stranded polydeoxyribonucleotides. III. Binding at the minor groove].
Journal: Molekuliarnaia biologiia 20020101
Title: Topotecan in the treatment of refractory neuroblastoma and other malignant tumors in childhood - a phase-II-study.
Journal: Klinische Padiatrie 20020101
Title: Impact of topotecan-based chemotherapy on the immune system of advanced ovarian cancer patients: an immunophenotypic study.
Journal: Oncology reports 20020101
Title: Weekly topotecan: an alternative to topotecan's standard daily x 5 schedule?
Journal: The oncologist 20020101
Title: Phase I study of sequential administration of topotecan and 5-fluorouracil in patients with advanced malignancies.
Journal: Cancer investigation 20020101
Title: DNA binding induces conformational transition within human DNA topoisomerase I in solution.
Journal: Biopolymers 20020101
Title: The role of topotecan as second-line therapy in patients with recurrent ovarian cancer.
Journal: European journal of gynaecological oncology 20020101
Title: Camptothecins: a review of their chemotherapeutic potential.
Journal: Drugs 20020101
Title: Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS-related Kaposi's sarcoma.
Journal: Drugs 20020101
Title: Update on the role of topotecan in the treatment of recurrent ovarian cancer.
Journal: The oncologist 20020101
Title: Management of treatment-related toxicity in advanced ovarian cancer.
Journal: The oncologist 20020101
Title: Alternate dosing schedules for topotecan in the treatment of recurrent ovarian cancer.
Journal: The oncologist 20020101
Title: Update on the treatment of cervical and uterine carcinoma: focus on topotecan.
Journal: The oncologist 20020101
Title: Emerging role of topotecan in front-line treatment of carcinoma of the ovary.
Journal: The oncologist 20020101
Title: Current status and perspectives in the development of camptothecins.
Journal: Current pharmaceutical design 20020101
Title: Intralesional topotecan in advanced ovarian cancer: a clinical report, based on a preclinical study.
Journal: Oncology reports 20020101
Title: [Interaction of topotecan, DNA topoisomerase I inhibitor, with double-stranded polydeoxyribonucleotides. 4. Topotecan binds preferably to the GC base pairs of DNA].
Journal: Molekuliarnaia biologiia 20020101
Title: Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells.
Journal: Journal of experimental therapeutics & oncology 20020101
Title: Oral cytotoxic drugs.
Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] 20020101
Title: Multiple myeloma and its treatment.
Journal: Clinical journal of oncology nursing 20020101
Title: Early detection and successful treatment of drug-induced pneumonitis with corticosteroids.
Journal: Cancer investigation 20020101
Title: A dose-escalation study of weekly topotecan, cisplatin, and gemcitabine front-line therapy in patients with inoperable non-small cell lung cancer.
Journal: The oncologist 20020101
Title: Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview.
Journal: The oncologist 20020101
Title: [4th National Conference of the Italian Association of Medical Oncology. From research to clinical practice: the role of topotecan in oncology].
Journal: Tumori 20020101
Title: Topoisomerase I interactive agents.
Journal: Cancer chemotherapy and biological response modifiers 20020101
Title: First-line chemotherapy with topotecan and etoposide in advanced small cell lung cancer. A phase II study.
Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20020101
Title: Comparison of idarubicin + ara-C-, fludarabine + ara-C-, and topotecan + ara-C-based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts.
Journal: Blood 20011215
Title: Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20011201
Title: The Cockayne syndrome group B DNA repair protein as an anti-cancer target.
Journal: International journal of oncology 20011201
Title: Model for time dependency of cytotoxic effect of CHS 828 in vitro suggests two different mechanisms of action.
Journal: The Journal of pharmacology and experimental therapeutics 20011201
Title: Salivary and plasma pharmacokinetics of topotecan in patients with metastatic epithelial ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20011201
Title: Novel use of an established agent: Topotecan is anti-angiogenic in experimental Wilms tumor.
Journal: Journal of pediatric surgery 20011201
Title: A phase I/II study of topotecan in combination with carboplatin in recurrent epithelial ovarian cancer.
Journal: Gynecologic oncology 20011201
Title: Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.
Journal: Gynecologic oncology 20011201
Title: Treatment of advanced ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20011201
Title: Phase III data on Caelyx in ovarian cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20011201
Title: Topoisomerase I inhibitors combination chemotherapy in non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20011201
Title: Idarubicin, cytarabine, and topotecan in patients with refractory or relapsed acute myelogenous leukemia and high-risk myelodysplastic syndrome.
Journal: American journal of hematology 20011201
Title: Acute toxicity and changes in quality of life during a combined radio-chemotherapy of glioblastomas with topotecan (Hycamtin).
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20011201
Title: The role of half-transporters in multidrug resistance.
Journal: Journal of bioenergetics and biomembranes 20011201
Title: Quantitation of camptothecin and related compounds.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20011125
Title: Analytical approaches for traditional chinese medicines exhibiting antineoplastic activity.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20011125
Title: Design and optimization of 20-O-linked camptothecin glycoconjugates as anticancer agents.
Journal: Journal of medicinal chemistry 20011122
Title: Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells.
Journal: Biochemical and biophysical research communications 20011109
Title: Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions.
Journal: International journal of pediatric otorhinolaryngology 20011101
Title: The differentiation inducers phenylacetate and phenylbutyrate modulate camptothecin sensitivity in colon carcinoma cells in vitro by intracellular acidification.
Journal: International journal of oncology 20011101
Title: Improved therapeutic index of lower dose topotecan chemotherapy in recurrent ovarian cancer.
Journal: Gynecologic oncology 20011101
Title: A dose-escalating study of weekly bolus topotecan in previously treated ovarian cancer patients.
Journal: Gynecologic oncology 20011101
Title: Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.
Journal: Molecular pharmacology 20011101
Title: Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia.
Journal: British journal of haematology 20011101
Title: A phase I and pharmacokinetic study of intraperitoneal topotecan.
Journal: British journal of cancer 20011101
Title: Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan.
Journal: Medical and pediatric oncology 20011101
Title: A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20011101
Title: [Single topotecan or in combination with other chemotherapeutic agents for 18 recurrent advanced ovarian cancer patients].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20011101
Title: A new method to evaluate in vitro myelotoxicity of antitumour agents in the first steps of drug development.
Journal: Pharmacology & toxicology 20011101
Title: Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.
Journal: Molecular cancer therapeutics 20011101
Title: Second-line chemotherapy for small-cell lung cancer: a review.
Journal: Clinical lung cancer 20011101
Title: High-dose chemotherapy in high-risk myelodysplastic syndrome: covariate-adjusted comparison of five regimens.
Journal: Cancer 20011015
Title: Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011015
Title: Downregulation of topoisomerase I in differentiating human intestinal epithelial cells.
Journal: International journal of cancer 20011015
Title: A dose escalation study of topotecan in combination with epirubicin in pretreated patients with small-cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20011001
Title: Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011001
Title: Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.
Journal: Cancer research 20011001
Title: Schedule-dependent activity of topotecan in OVCAR-3 ovarian carcinoma xenograft: pharmacokinetic and pharmacodynamic evaluation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
Title: A new case of isolated del(12)(q15q22) in myelodysplastic syndrome.
Journal: Cancer genetics and cytogenetics 20011001
Title: Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia.
Journal: Bone marrow transplantation 20011001
Title: Dose and schedule-finding study of oral topotecan and weekly cisplatin in patients with recurrent ovarian cancer.
Journal: British journal of cancer 20011001
Title: Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity.
Journal: Journal of medicinal chemistry 20010927
Title: Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Journal: Cancer research 20010915
Title: High-dose topotecan, melphalan, and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of advanced ovarian cancer.
Journal: Gynecologic oncology 20010901
Title: Body-surface area-based dosing does not increase accuracy of predicting cisplatin exposure.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010901
Title: Therapeutic options for acute myelogenous leukemia.
Journal: Cancer 20010901
Title: A Phase I-II study of 96-hour infusional topotecan and paclitaxel for patients with recurrent Müllerian tumors.
Journal: Cancer 20010901
Title: Chemotherapy as treatment of primary and recurrent small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20010901
Title: Synergistic interaction between topotecan and microtubule-interfering agents.
Journal: Cancer chemotherapy and pharmacology 20010901
Title: Topotecan combined with myeloablative doses of thiotepa and carboplatin for neuroblastoma, brain tumors, and other poor-risk solid tumors in children and young adults.
Journal: Bone marrow transplantation 20010901
Title: Topotecan-filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells.
Journal: Bone marrow transplantation 20010901
Title: Recent advances in the treatment of epithelial ovarian cancer.
Journal: Expert opinion on investigational drugs 20010901
Title: Resistance to topoisomerase poisons due to loss of DNA mismatch repair.
Journal: International journal of cancer 20010815
Title: A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.
Journal: Cancer research 20010815
Title: Clonal heterogeneity of p53 mutations in ovarian cancer.
Journal: International journal of oncology 20010801
Title: Phase I clinical trial of weekly combined topotecan and irinotecan.
Journal: American journal of clinical oncology 20010801
Title: Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor.
Journal: Journal of pediatric surgery 20010801
Title: Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010801
Title: Pharmacodynamic model of topotecan-induced time course of neutropenia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010801
Title: A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex.
Journal: Molecular carcinogenesis 20010801
Title: Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20010801
Title: Management of small cell lung cancer.
Journal: Expert review of anticancer therapy 20010801
Title: Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines.
Journal: International journal of cancer 20010715
Title: Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010715
Title: A phase I trial of topotecan and gemcitabine administered weekly for 3 consecutive weeks to patients with advanced tumors.
Journal: Cancer 20010715
Title: CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release.
Journal: Oncogene 20010712
Title: Topotecan selectively enhances the radioresponse of human small-cell lung carcinoma and glioblastoma multiforme xenografts in nude mice.
Journal: International journal of radiation oncology, biology, physics 20010701
Title: UCN-01 dose-dependent inhibition of normal hyperproliferative cells in mice.
Journal: International journal of oncology 20010701
Title: Interaction between novel anticancer agents and radiation in non-small cell lung cancer cell lines.
Journal: Lung cancer (Amsterdam, Netherlands) 20010701
Title: Effective dosing of topotecan with carboplatin in relapsed ovarian cancer: a phase I/II study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010701
Title: Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice.
Journal: Cancer chemotherapy and pharmacology 20010701
Title: Topoisomerase I inhibitors in the treatment of head and neck cancer.
Journal: Oncology (Williston Park, N.Y.) 20010701
Title: Advances in the management of epithelial ovarian cancer.
Journal: The Journal of reproductive medicine 20010701
Title: Paclitaxel plus topotecan treatment for patients with relapsed or refractory aggressive non-Hodgkin's lymphoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010701
Title: Surgery, radiotherapy, and chemotherapy for esophageal carcinoma.
Journal: Current opinion in gastroenterology 20010701
Title: Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan.
Journal: International journal of oncology 20010601
Title: Temporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance.
Journal: American journal of clinical oncology 20010601
Title: Topotecan chemotherapy in patients with breast cancer and brain metastases: results of a pilot study.
Journal: Onkologie 20010601
Title: Oligodendroglial ganglioglioma with anaplastic features arising from the thalamus.
Journal: Pediatric neurosurgery 20010601
Title: Sensitivity to topoisomerase I inhibitors and cisplatin is associated with epidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines.
Journal: Cancer chemotherapy and pharmacology 20010601
Title: Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20010601
Title: Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010515
Title: Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.
Journal: Cancer research 20010515
Title: Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Journal: Journal of medicinal chemistry 20010510
Title: Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20010501
Title: Repetitive high-dose topotecan, carboplatin, and paclitaxel with peripheral blood progenitor cell support in previously untreated ovarian cancer: results of a Phase I study.
Journal: Gynecologic oncology 20010501
Title: Phase II trial of topotecan, carboplatin, and paclitaxel as front-line therapy in suboptimal advanced epithelial ovarian cancer.
Journal: Gynecologic oncology 20010501
Title: A weekly regimen of cisplatin, paclitaxel and topotecan with granulocyte-colony stimulating factor support for patients with extensive disease small cell lung cancer: a phase II study.
Journal: British journal of cancer 20010501
Title: Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010501
Title: A Phase II study of topotecan in patients with squamous cell carcinoma of the cervix: a gynecologic oncology group study.
Journal: Gynecologic oncology 20010501
Title: Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V.
Journal: Journal of pediatric hematology/oncology 20010501
Title: Role of topoisomerase I inhibitors in small-cell lung cancer.
Journal: Clinical lung cancer 20010501
Title: Topoisomerase I inhibitors in the combined modality therapy of lung cancer.
Journal: Clinical lung cancer 20010501
Title: Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593--a phase III trial of the Eastern Cooperative Oncology Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415
Title: Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Journal: Cancer research 20010415
Title: A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma.
Journal: Blood 20010401
Title: Clinical evidence for topotecan-paclitaxel non--cross-resistance in ovarian cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010401
Title: Determination of topotecan by ELISA.
Journal: Biological & pharmaceutical bulletin 20010401
Title: Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.
Journal: Cancer research 20010401
Title: Unusual potency of BN 80915, a novel fluorinated E-ring modified camptothecin, toward human colon carcinoma cells.
Journal: Cancer research 20010401
Title: Radiosensitization of tumor-targeted radioimmunotherapy with prolonged topotecan infusion in human breast cancer xenografts.
Journal: Cancer research 20010401
Title: Topotecan given as a 21-day infusion in the treatment of advanced ovarian cancer.
Journal: British journal of cancer 20010401
Title: Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401
Title: The association of topotecan and cytarabine in the treatment of secondary or relapsed acute myeloid leukemia.
Journal: Haematologica 20010401
Title: Antitumor activity of XR5944, a novel and potent topoisomerase poison.
Journal: Anti-cancer drugs 20010401
Title: New agents for induction and postremission therapy of acute myeloid leukemia.
Journal: Leukemia 20010401
Title: Treatment of patients with metastatic germ cell tumors relapsing after high-dose chemotherapy.
Journal: World journal of urology 20010401
Title: Phase I dose escalation study of topotecan combined with alternating schedules of paclitaxel and carboplatin in advanced solid tumors.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010401
Title: Paclitaxel-based three-drug combinations for the treatment of small cell lung cancer: a review of the Sarah Cannon Cancer Center experience.
Journal: Seminars in oncology 20010401
Title: Phase ii comparator study of oral versus intravenous topotecan in patients with chemosensitive small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010315
Title: Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20010312
Title: Topoisomerase I targeting agents in small-cell lung cancer.
Journal: Current oncology reports 20010301
Title: Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Journal: Cancer research 20010301
Title: Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Journal: Gene therapy 20010301
Title: Development, characterization and therapy of a disseminated model of childhood neuroblastoma in SCID mice.
Journal: Cancer chemotherapy and pharmacology 20010301
Title: Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues.
Journal: Expert opinion on pharmacotherapy 20010301
Title: The epidermal growth factor receptor as a target for cancer therapy.
Journal: Endocrine-related cancer 20010301
Title: [Evaluation of quality of life in patients with advanced colorectal cancer treated with topotecan].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010301
Title: [Clinical study of topotecan in the treatment of small cell lung cancer and recurrent ovarian cancer].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20010301
Title: The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS-I Through IRS-IV Studies as Background for the Current IRS-V Treatment Protocols.
Journal: Sarcoma 20010301
Title: Phase I study of topotecan plus cranial radiation for glioblastoma multiforme: results of Radiation Therapy Oncology Group Trial 9507.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215
Title: Phase I trial of multiple cycles of high-dose carboplatin, paclitaxel, and topotecan with peripheral-blood stem-cell support as front-line therapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215
Title: P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.
Journal: Cancer research 20010215
Title: Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.
Journal: Bioorganic & medicinal chemistry letters 20010212
Title: Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.
Journal: Biochemical and biophysical research communications 20010209
Title: Topotecan concomitant with primary brachytherapy radiation in patients with cervical carcinoma: a phase I trial.
Journal: Gynecologic oncology 20010201
Title: Evaluation of topotecan and etoposide for non-Hodgkin lymphoma: correlation of topoisomerase-DNA complex formation with clinical response.
Journal: Cancer 20010201
Title: Selective drug resistant human osteosarcoma cell lines.
Journal: Clinical orthopaedics and related research 20010201
Title: P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line.
Journal: Cancer research 20010201
Title: Lack of efficacy of topotecan in the treatment of metastatic or recurrent squamous carcinoma of the head and neck: an Eastern Cooperative Oncology Group Trial (E3393).
Journal: American journal of clinical oncology 20010201
Title: Clear cell carcinoma of the ovary: a remarkable case.
Journal: American journal of clinical oncology 20010201
Title: Modulation of camptothecin analogs in the treatment of cancer: a review.
Journal: Anti-cancer drugs 20010201
Title: Altretamine is an effective palliative therapy of patients with recurrent epithelial ovarian cancer.
Journal: Japanese journal of clinical oncology 20010201
Title: Glioma cell sensitivity to topotecan: the role of p53 and topotecan-induced DNA damage.
Journal: European journal of pharmacology 20010119
Title: The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
Journal: Cancer research 20010115
Title: ICE bioassay. Isolating in vivo complexes of enzyme to DNA.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: an intergroup rhabdomyosarcoma study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010101
Title: Response and toxicity to topotecan in sensitive ovarian cancer cases with small residual disease after first-line treatment with carboplatinum and paclitaxel.
Journal: Gynecologic oncology 20010101
Title: Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan.
Journal: Biochemical pharmacology 20010101
Title: Fludarabine, cytarabine and topotecan (FLAT) as induction therapy for acute myeloid leukemia in the elderly: a preliminary report.
Journal: Haematologica 20010101
Title: Topotecan and gemcitabine in platinum/paclitaxel-resistant ovarian cancer.
Journal: Oncology 20010101
Title: The role of systemic chemotherapy in the treatment of brain metastases from small-cell lung cancer.
Journal: Critical reviews in oncology/hematology 20010101
Title: Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010101
Title: Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction.
Journal: Cancer chemotherapy and pharmacology 20010101
Title: Treatment of extensive stage small cell lung cancer.
Journal: Cancer treatment and research 20010101
Title: The effect of increasing topotecan infusion from 30 minutes to 4 hours on the duration of exposure in cerebrospinal fluid.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010101
Title: Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer.
Journal: Cancer chemotherapy and pharmacology 20010101
Title: Current treatment for ovarian cancer.
Journal: Expert opinion on pharmacotherapy 20010101
Title: Advances in chemotherapy for small cell lung cancer: single-agent activity of newer agents.
Journal: Cancer journal (Sudbury, Mass.) 20010101
Title: [Interaction of topotecan--a DNA topoisomerase inhibitor--with dual-stranded polydeoxyribonucleotides. I. Dimerization of topotecan in solution].
Journal: Molekuliarnaia biologiia 20010101
Title: [Interaction of topotecan--a DNA topoisomerase I inhibitor--with dual-stranded polydeoxyribonucleotides. II. Formation of a complex containing several DNA molecules in the presence of topotecan].
Journal: Molekuliarnaia biologiia 20010101
Title: A phase I-II trial of topotecan and gemcitabine in patients with previously treated, advanced non-small cell lung cancer (LOA-3).
Journal: Cancer investigation 20010101
Title: Overview of the treatment of infant central nervous system tumors: medulloblastoma as a model.
Journal: Journal of pediatric hematology/oncology 20010101
Title: Developmental chemotherapy in advanced ovarian cancer: incorporation of topoisomerase-I inhibitors and perspective of the Gynecologic Oncology Group.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20010101
Title: The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis.
Journal: Arthritis research 20010101
Title: Phase I and pharmacologic study of sequential topotecan, carboplatin, and etoposide.
Journal: Lung cancer (Amsterdam, Netherlands) 20010101
Title: Novel therapies in lung cancer management. An update on the role of topotecan.
Journal: Oncology 20010101
Title: Current standards of care in small-cell and non-small-cell lung cancer.
Journal: Oncology 20010101
Title: New advances in lung cancer chemotherapy: topotecan and the role of topoisomerase I inhibitors.
Journal: Oncology 20010101
Title: A phase I trial of a 5-day schedule of intravenous topotecan and etoposide in previously untreated patients with small-cell lung cancer.
Journal: Oncology 20010101
Title: Feasibility of oral topotecan plus intravenous paclitaxel in advanced non-small-cell lung cancer.
Journal: Oncology 20010101
Title: Is cisplatin required for the treatment of non-small-cell lung cancer? Experience and preliminary results of a phase I/II trial with topotecan and vinorelbine.
Journal: Oncology 20010101
Title: Feasibility of oral topotecan in previously untreated patients with small-cell lung cancer ineligible for standard therapy.
Journal: Oncology 20010101
Title: Preliminary results of combined therapy with topotecan and carboplatin in advanced non-small-cell lung cancer.
Journal: Oncology 20010101
Title: Future role of topotecan in the treatment of lung cancer.
Journal: Oncology 20010101
Title: Topoisomerase I interactive agents.
Journal: Cancer chemotherapy and biological response modifiers 20010101
Title: Intravenous bolus topotecan in patients with myelodysplastic syndrome.
Journal: Leukemia & lymphoma 20010101
Title: A rapid and systematic review of the clinical effectiveness and cost-effectiveness of topotecan for ovarian cancer.
Journal: Health technology assessment (Winchester, England) 20010101
Title: A phase I clinical trial of topotecan given every 2 weeks in patients with refractory solid tumors.
Journal: Oncology 20010101
Title: Controversies in the management of brain metastases: the role of chemotherapy.
Journal: Forum (Genoa, Italy) 20010101
Title: Serous papillary adenocarcinomas of the ovary display heterogeneity in their response to chemotherapy.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20010101
Title: The development of camptothecin analogs in childhood cancers.
Journal: The oncologist 20010101
Title: Therapeutic management of refractory or relapsed primary central nervous system lymphomas.
Journal: Annals of hematology 20010101
Title: Topotecan (Hycamtin) responsiveness in human renal carcinoma cell lines of the clear cell and papillary types.
Journal: Anticancer research 20010101
Title: Long time therapy with topotecan in patients with recurrence of ovarian carcinoma.
Journal: Anticancer research 20010101
Title: Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan.
Journal: European journal of gynaecological oncology 20010101
Title: Nursing considerations for managing topotecan-related hematologic side effects.
Journal: Clinical journal of oncology nursing 20010101
Title: [3rd National Congress of Medical Oncology. Issues in Gynecologic Oncology. Naples, November 7, 2000].
Journal: Tumori 20010101
Title: The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
Journal: Journal of medicinal chemistry 20001019
Title: Phase II trial of topotecan in patients with advanced, persistent, or recurrent uterine leiomyosarcomas: a Gynecologic Oncology Group Study.
Journal: American journal of clinical oncology 20000801
Title: Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20000701
Title: Phase II study of oral topotecan in advanced non-small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20000301
Title: An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
Journal: Cancer research 20000201
Title: Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan.
Journal: Leukemia 20000101
Title: Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Journal: Antimicrobial agents and chemotherapy 19991201
Title: Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
Journal: Cancer research 19991201
Title: Topotecan - A novel topoisomerase I inhibitor: pharmacology and clinical experience.
Journal: Oncology 19990101
Title: [Topotecan: a new field of use].
Journal: Tumori 19990101
Title: Continuous infusion of low-dose topotecan: pharmacokinetics and pharmacodynamics during a phase II study in patients with small cell lung cancer.
Journal: Anti-cancer drugs 19980601
Title: Topotecan inhibits human immunodeficiency virus type 1 infection through a topoisomerase-independent mechanism in a cell line with altered topoisomerase I.
Journal: Antimicrobial agents and chemotherapy 19970501
Title: An overview of the clinical pharmacology of topotecan.
Journal: Seminars in oncology 19970201
Title: Phase II trial to topotecan in hepatocellular carcinoma: a Southwest Oncology Group study.
Journal: Investigational new drugs 19970101
Title: Clinical pharmacokinetics of topotecan.
Journal: Clinical pharmacokinetics 19960801
Title: Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Journal: Journal of medicinal chemistry 19930903
Title: Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin.
Journal: Cancer research 19930615
Title: Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930301
Title: Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells.
Title: Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.
