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124436-59-5,MFCD00866965
Catalog No.:AA000LXU

124436-59-5 | Pirodavir

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Purity
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1mg
95%
in stock  
$43.00   $30.00
- +
5mg
95%
in stock  
$126.00   $88.00
- +
10mg
95%
in stock  
$183.00   $128.00
- +
25mg
95%
in stock  
$245.00   $172.00
- +
50mg
95%
in stock  
$416.00   $292.00
- +
100mg
95%
in stock  
$705.00   $494.00
- +
250mg
95%
in stock  
$1,199.00   $839.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000LXU
Chemical Name:
Pirodavir
CAS Number:
124436-59-5
Molecular Formula:
C21H27N3O3
Molecular Weight:
369.4574
MDL Number:
MFCD00866965
SMILES:
CCOC(=O)c1ccc(cc1)OCCC1CCN(CC1)c1ccc(nn1)C
Properties
Computed Properties
 
Complexity:
446  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
8  
XLogP3:
3.7  

Downstream Synthesis Route

[1]Watson,KeithG.;Brown,ReneeN.;Cameron,Rachel;Chalmers,DavidK.;Hamilton,Stephanie;Jin,Betty;Krippner,GuyY.;Luttick,Angela;McConnell,DarrylB.;Reece,PhillipA.;Ryan,Jane;Stanislawski,PaulineC.;Tucker,SimonP.;Wu,Wen-Yang;Barnard,DaleL.;Sidwell,RobertW.[JournalofMedicinalChemistry,2003,vol.46,#15,p.3181-3184]

[1]Watson,KeithG.;Brown,ReneeN.;Cameron,Rachel;Chalmers,DavidK.;Hamilton,Stephanie;Jin,Betty;Krippner,GuyY.;Luttick,Angela;McConnell,DarrylB.;Reece,PhillipA.;Ryan,Jane;Stanislawski,PaulineC.;Tucker,SimonP.;Wu,Wen-Yang;Barnard,DaleL.;Sidwell,RobertW.[JournalofMedicinalChemistry,2003,vol.46,#15,p.3181-3184]

Literature

Title: Study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses.

Journal: Molecules (Basel, Switzerland) 20110426

Title: Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110201

Title: [Establishment of isolated rabbit airway smooth muscles responsiveness model for the pharmacodynamic study of anti-rhinoviruses drugs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401

Title: Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors.

Journal: Bioorganic & medicinal chemistry 20090115

Title: Isothiazole derivatives as antiviral agents.

Journal: Antiviral chemistry & chemotherapy 20070101

Title: 2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder.

Journal: Bioorganic & medicinal chemistry letters 20050415

Title: In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity.

Journal: Antimicrobial agents and chemotherapy 20040501

Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.

Journal: Journal of medicinal chemistry 20031009

Title: An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.

Journal: Journal of medicinal chemistry 20030717

Title: Synthesis of new 3-methylthio-5-aryl-4-isothiazolecarbonitriles with broad antiviral spectrum.

Journal: Antiviral research 20020801

Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.

Journal: Journal of medicinal chemistry 20020411

Title: The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication.

Journal: Archives of virology 20020401

Title: In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.

Journal: Antimicrobial agents and chemotherapy 19991001

Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.

Journal: Journal of medicinal chemistry 19990408

Title: In vitro studies of the antirhinovirus activity of soluble intercellular adhesion molecule-1.

Journal: Antimicrobial agents and chemotherapy 19920601

Title: In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

Journal: Antimicrobial agents and chemotherapy 19920101

Title: Barnard DL, et al. In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity. Antimicrob Agents Chemother. 2004 May;48(5):1766-72.

Title: Andries K, et al. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviralactivity. Antimicrob Agents Chemother. 1992 Jan;36(1):100-7.

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