Home Other Building Blocks 1260251-31-7
1260251-31-7,MFCD25976869
Catalog No.:AA000QP3

1260251-31-7 | Birinapant

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$82.00   $57.00
- +
5mg
99% (HPLC)
in stock  
$186.00   $130.00
- +
10mg
99% (HPLC)
in stock  
$270.00   $189.00
- +
25mg
99% (HPLC)
in stock  
$500.00   $350.00
- +
50mg
98%
in stock  
$650.00   $455.00
- +
100mg
98%
in stock  
$1,118.00   $783.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000QP3
Chemical Name:
Birinapant
CAS Number:
1260251-31-7
Molecular Formula:
C42H56F2N8O6
Molecular Weight:
806.9408
MDL Number:
MFCD25976869
SMILES:
CC[C@@H](C(=O)N1C[C@H](C[C@H]1Cc1c([nH]c2c1ccc(c2)F)c1[nH]c2c(c1C[C@@H]1C[C@@H](CN1C(=O)[C@@H](NC(=O)[C@@H](NC)C)CC)O)ccc(c2)F)O)NC(=O)[C@@H](NC)C
Properties
Computed Properties
 
Complexity:
1350  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
58  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
15  
XLogP3:
3.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MEDIVIRAB-US2011/3877,2011,A1Locationinpatent:Page/Pagecolumn15

[2]CurrentPatentAssignee:TETRALOGICPHARMACEUTICALSCORP-WO2013/49350,2013,A1Locationinpatent:Paragraph0074;0075;0076

[3]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[1]CurrentPatentAssignee:TETRALOGICPHARMACEUTICALSCORP-WO2013/49350,2013,A1

[2]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[3]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[4]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[5]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[6]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[7]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[8]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[9]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[1]CurrentPatentAssignee:TETRALOGICPHARMACEUTICALSCORP-WO2013/49350,2013,A1

[2]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[3]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[4]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[5]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[1]CurrentPatentAssignee:TETRALOGICPHARMACEUTICALSCORP-WO2013/49350,2013,A1

[2]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[3]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[4]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[5]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[1]CurrentPatentAssignee:TETRALOGICPHARMACEUTICALSCORP-WO2013/49350,2013,A1

[2]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[3]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[4]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

[5]Deng,Yijun;Xie,Qiuzhe;LaPorte,MatthewG.;Chasnoff,AnnaT.A.;Mortensen,MarkA.;Patra,Debasis;Putrelo,SethA.;Antonovich,RobertS.;Cao,Hong;Yan,Jun;Cooper,ArthurJ.;Rippin,SusanR.;Alexander,MatthewD.;Kumar,PavanTirunahari;Hendi,MuktaS.;Lee,Yu-Hua;Haimowitz,Thomas;Condon,StephenM.[OrganicProcessResearchandDevelopment,2016,vol.20,#2,p.242-252]

Literature

Title: Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Journal: Molecular cancer therapeutics 20140401

Title: Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140115

Title: The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20130401

Title: Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.

Journal: Breast cancer research and treatment 20130101

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