Home Carboxes 131-01-1
131-01-1,MFCD00078228
Catalog No.:AA01CBDZ

131-01-1 | Yohimban-16-carboxylic acid,17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$213.00   $149.00
- +
10mg
95%
in stock  
$348.00   $243.00
- +
25mg
95%
in stock  
$695.00   $486.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CBDZ
Chemical Name:
Yohimban-16-carboxylic acid,17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-
CAS Number:
131-01-1
Molecular Formula:
C32H38N2O8
Molecular Weight:
578.6527
MDL Number:
MFCD00078228
SMILES:
COC(=O)[C@@H]1[C@@H](OC)[C@@H](C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c1[nH]c1c2cccc1)OC(=O)c1cc(OC)c(c(c1)OC)OC
NSC Number:
72138
Properties
Computed Properties
 
Complexity:
953  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
4.1  

Literature

Title: [Application of recording SK2 current in human atrial myocytes by perforated patch clamp techniques with the mix of beta-escin and amphotericin B].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20120501

Title: Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.

Journal: Life sciences 20100508

Title: Calcium sensitization induced by sodium fluoride in permeabilized rat mesenteric arteries.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20100201

Title: Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation.

Journal: BMC immunology 20100101

Title: Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1).

Journal: International journal of peptides 20100101

Title: Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response.

Journal: Journal of nucleic acids 20100101

Title: Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001

Title: Beta-escin, a natural triterpenoid saponin from Chinese horse chestnut seeds, depresses HL-60 human leukaemia cell proliferation and induces apoptosis.

Journal: The Journal of pharmacy and pharmacology 20080901

Title: Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor.

Journal: Pflugers Archiv : European journal of physiology 20080501

Title: Intracellular calcium stores in beta-escin skinned rat and guinea-pig bladders.

Journal: European journal of pharmacology 20070702

Title: Acylation with diangeloyl groups at C21-22 positions in triterpenoid saponins is essential for cytotoxicity towards tumor cells.

Journal: Biochemical pharmacology 20070201

Title: The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm.

Journal: Plant cell reports 20061001

Title: Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders.

Journal: British journal of pharmacology 20060601

Title: Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells.

Journal: Molecular cancer therapeutics 20060601

Title: Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current.

Journal: Journal of cardiovascular electrophysiology 20060501

Title: Synthesis of deserpidine from reserpine.

Journal: Journal of natural products 20051101

Title: Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

Journal: The Journal of biological chemistry 20050325

Title: Ca2+-independent hypoxic vasorelaxation in porcine coronary artery.

Journal: The Journal of physiology 20050201

Title: Inhibition by cytoplasmic nucleotides of a new cation channel in freshly isolated human and rat type II pneumocytes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20041201

Title: Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons.

Journal: Journal of neuroscience methods 20041015

Title: Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMP-independent decrease in calcium sensitivity of myofilaments.

Journal: Cell calcium 20040801

Title: Perforated patch recording of L-type calcium current with beta-escin in guinea pig ventricular myocytes.

Journal: Acta pharmacologica Sinica 20031101

Title: Dependence of Ca2+-induced contraction on ATP in alpha-toxin-permeabilized preparations of rat femoral artery.

Journal: Journal of pharmacological sciences 20031001

Title: Characterization of alpha-soluble N-ethylmaleimide-sensitive fusion attachment protein in alveolar type II cells: implications in lung surfactant secretion.

Journal: American journal of respiratory cell and molecular biology 20030901

Title: Lowdenic acid: a new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp.

Journal: Journal of natural products 20030901

Title: Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.

Journal: The Journal of clinical investigation 20030815

Title: Troponin I inhibitory peptide suppresses the force generation in smooth muscle by directly interfering with cross-bridge formation.

Journal: Biochemical and biophysical research communications 20030725

Title: Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics.

Journal: Cell calcium 20030701

Title: CaM kinase IIalpha mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope.

Journal: Journal of cell science 20030115

Title: Pyrrolizidine alkaloids from Lithospermum canescens Lehm.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: [Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

Title: Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells.

Journal: British journal of pharmacology 20020401

Title: Extensive skinning of cell membrane diminishes the force-inhibiting effect of okadaic acid on smooth muscles of Guinea pig hepatic portal vein.

Journal: The Japanese journal of physiology 20020401

Title: Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010901

Title: Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010501

Title: Inhibition of capacitative calcium entry is not obligatory for relaxation of the mouse anococcygeus by the NO/cyclic GMP signalling pathway.

Journal: British journal of pharmacology 20010201

Title: Protein kinase C suppresses spontaneous, transient, outwards K+ currents through modulation of the Na/Ca exchanger in guinea-pig gastric myocytes.

Journal: Pflugers Archiv : European journal of physiology 20010101

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68(11):1629-31.

Title: Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3221-5.

Title: Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35(14):2558-62.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:131-01-1 Molecular Formula|131-01-1 MDL|131-01-1 SMILES|131-01-1 Yohimban-16-carboxylic acid,17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-