Title: Silicon dioxide nanoparticles induce COX-2 expression through activation of STAT3 signaling pathway in HaCaT cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20181001
Title: Hormesis of mercuric chloride-human serum albumin adduct on N9 microglial cells via the ERK/MAPKs and JAK/STAT3 signaling pathways.
Journal: Toxicology 20180901
Title: IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180601
Title: PKA/CREB and NF-κB pathway regulates AKNA transcription: A novel insight into T-2 toxin-induced inflammation and GH deficiency in GH3 cells.
Journal: Toxicology 20171201
Title: Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801
Title: Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.
Journal: Journal of biochemical and molecular toxicology 20170501
Title: Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway.
Journal: Toxicology and applied pharmacology 20160715
Title: Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways.
Journal: Acta biochimica et biophysica Sinica 20150301
Title: Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells.
Journal: Journal of ovarian research 20150101
Title: Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.
Journal: The Journal of biological chemistry 20141205
Title: Upregulation of the large conductance voltage- and Ca2+-activated K+ channels by Janus kinase 2.
Journal: American journal of physiology. Cell physiology 20140601
Title: Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.
Journal: Genes & cancer 20140501
Title: Developmental defects in zebrafish for classification of EGF pathway inhibitors.
Journal: Toxicology and applied pharmacology 20140115
Title: Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells.
Journal: PloS one 20140101
Title: Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.
Journal: Toxicology and applied pharmacology 20131101
Title: Cooperation of bisphenol A and leptin in inhibition of caspase-3 expression and activity in OVCAR-3 ovarian cancer cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death.
Journal: Cell death & disease 20130801
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.
Journal: Toxicology 20130208
Title: A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.
Journal: PloS one 20130101
Title: Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream (Sparus aurata L.).
Journal: The Journal of experimental biology 20121101
Title: Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.
Journal: Journal of clinical immunology 20121001
Title: Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.
Journal: Shock (Augusta, Ga.) 20121001
Title: Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120901
Title: Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.
Journal: The Journal of clinical investigation 20120702
Title: Interleukin 6 protects H(2)O(2)-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation.
Journal: Cell biochemistry and function 20120701
Title: A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.
Journal: International journal of oncology 20120601
Title: Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601
Title: JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120601
Title: Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.
Journal: Cancer biology & therapy 20120601
Title: Site-specific regulation of ion transport by prolactin in rat colon epithelium.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20120515
Title: Regulation of interferon-inducible proteins by doxorubicin via interferon γ-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells.
Journal: Molecular pharmacology 20120501
Title: The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.
Journal: Basic research in cardiology 20120501
Title: Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity.
Journal: Journal of pineal research 20120401
Title: Up-regulation of the betaine/GABA transporter BGT1 by JAK2.
Journal: Biochemical and biophysical research communications 20120330
Title: Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis.
Journal: Journal of cellular physiology 20120301
Title: Downregulation of the creatine transporter SLC6A8 by JAK2.
Journal: The Journal of membrane biology 20120301
Title: IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.
Journal: Molecular immunology 20120201
Title: The Jak/STAT pathway is involved in synaptic plasticity.
Journal: Neuron 20120126
Title: A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Journal: Toxicology and applied pharmacology 20120115
Title: Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C.
Journal: Developmental and comparative immunology 20120101
Title: Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells.
Journal: Endocrinology 20120101
Title: Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.
Journal: PloS one 20120101
Title: Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.
Journal: PloS one 20120101
Title: The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
Journal: PloS one 20120101
Title: AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.
Journal: Current medicinal chemistry 20120101
Title: MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells.
Journal: PloS one 20120101
Title: STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells.
Journal: PloS one 20120101
Title: Chronic perinatal hypoxia reduces glutamate-aspartate transporter function in astrocytes through the Janus kinase/signal transducer and activator of transcription pathway.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111207
Title: AG490: an inhibitor of hepcidin expression in vivo.
Journal: World journal of gastroenterology 20111207
Title: STAT3 does not regulate acute liver injury after ischemia/reperfusion.
Journal: The Journal of surgical research 20111201
Title: A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.
Journal: Cellular signalling 20111201
Title: Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells.
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20111201
Title: Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke.
Journal: Stroke 20111201
Title: Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell.
Journal: Placenta 20111201
Title: Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.
Journal: Bioorganic & medicinal chemistry 20111201
Title: Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.
Journal: Circulation research 20111111
Title: The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats.
Journal: Cytokine 20111101
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells.
Journal: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20111001
Title: Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/ PI3K signaling.
Journal: Cellular signalling 20111001
Title: Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111001
Title: [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20111001
Title: Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
Journal: Cancer letters 20110901
Title: Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Journal: American journal of physiology. Cell physiology 20110901
Title: Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.
Journal: International immunopharmacology 20110801
Title: Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801
Title: Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter.
Journal: The Journal of biological chemistry 20110708
Title: Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats.
Journal: Neuroscience letters 20110708
Title: Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in rats.
Journal: Anesthesia and analgesia 20110701
Title: Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells.
Journal: Journal of endodontics 20110601
Title: Stimulation of the glucose carrier SGLT1 by JAK2.
Journal: Biochemical and biophysical research communications 20110506
Title: The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity.
Journal: International journal of molecular medicine 20110501
Title: Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice.
Journal: Journal of ethnopharmacology 20110426
Title: [Effects of blocking activation of IGF-1-Stat3 signaling pathway in guinea pig sclera fibroblast by AG490 on expression of MMP-2 and Integrinβ(1)].
Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20110401
Title: Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.
Journal: Journal of neuro-oncology 20110201
Title: JAK2 is an important signal transducer in IL-33-induced NF-κB activation.
Journal: Cellular signalling 20110201
Title: In vitro leptin treatment of rainbow trout hypothalamus and hindbrain affects glucosensing and gene expression of neuropeptides involved in food intake regulation.
Journal: Peptides 20110201
Title: Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20110201
Title: JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription.
Journal: Journal of cellular biochemistry 20110201
Title: Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.
Journal: Bioorganic & medicinal chemistry 20110115
Title: α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling.
Journal: Molecular pharmacology 20110101
Title: LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.
Journal: Nature cell biology 20110101
Title: Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice.
Journal: Vascular pharmacology 20110101
Title: Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101
Title: Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway.
Journal: Journal of biomedical science 20110101
Title: Non-nuclear activation of signal transducer and activator of transcription 3 by 17β- estradiol in endometrial cancer cells.
Journal: Neoplasma 20110101
Title: Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.
Journal: PloS one 20110101
Title: p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation.
Journal: Cell death and differentiation 20101201
Title: Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways.
Journal: Biochimica et biophysica acta 20101201
Title: [The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1β].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201
Title: [The expression of suppressor of cytokine signaling-1/3 in renal tubular epithelial cells induced by high glucose].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Ethanolamine is a novel STAT-3 dependent cardioprotective agent.
Journal: Basic research in cardiology 20101101
Title: Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore.
Journal: American journal of physiology. Heart and circulatory physiology 20101001
Title: Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.
Journal: Stem cells (Dayton, Ohio) 20101001
Title: Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice.
Journal: Lupus 20100901
Title: Estrogen increases, whereas IL-27 and IFN-gamma decrease, splenocyte IL-17 production in WT mice.
Journal: European journal of immunology 20100901
Title: Blockade of Janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.
Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100901
Title: Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.
Journal: Molecular and cellular endocrinology 20100830
Title: JAK2V617F/STAT5 signaling pathway promotes cell proliferation through activation of Pituitary Tumor Transforming Gene 1 expression.
Journal: Biochemical and biophysical research communications 20100806
Title: Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma.
Journal: International journal of laboratory hematology 20100801
Title: JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.
Journal: Journal of molecular medicine (Berlin, Germany) 20100801
Title: JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.
Journal: British journal of haematology 20100801
Title: Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release.
Journal: Journal of psychopharmacology (Oxford, England) 20100701
Title: Antagonists of growth hormone-releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells.
Journal: The Prostate 20100701
Title: [Helicobacter pylori cytotoxin associated protein CagA regulates gastrin gene promoter activity].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100701
Title: Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100601
Title: Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100501
Title: An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning.
Journal: Experimental physiology 20100501
Title: Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin.
Journal: Oncology reports 20100501
Title: Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.
Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100501
Title: Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts.
Journal: Toxicology and applied pharmacology 20100415
Title: A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors.
Journal: Journal of immunological methods 20100331
Title: Intermediate Ca2+-sensitive K+ channels are necessary for prolactin-induced proliferation in breast cancer cells.
Journal: The Journal of membrane biology 20100301
Title: [Inhibitor of tyrosine phosphorylation AG490 inhibits the proliferation of Jurkat T cells].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100301
Title: Effects of AG490 on lens epithelial cell death induced by H(2)O(2).
Journal: Japanese journal of ophthalmology 20100301
Title: STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100216
Title: Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.
Journal: Cancer letters 20100201
Title: Leptin excites proopiomelanocortin neurons via activation of TRPC channels.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100127
Title: Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes.
Journal: Regulatory peptides 20100108
Title: IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.
Journal: Immunology letters 20100104
Title: Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma.
Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100101
Title: The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.
Journal: The American journal of pathology 20100101
Title: Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.
Journal: PloS one 20100101
Title: Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro.
Journal: Journal of experimental & clinical cancer research : CR 20100101
Title: Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells.
Journal: The Journal of international medical research 20100101
Title: Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells.
Journal: Biochemical and biophysical research communications 20091218
Title: Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway.
Journal: International journal of radiation oncology, biology, physics 20091201
Title: Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.
Journal: The Journal of biological chemistry 20091127
Title: STAT1/2 is involved in the inhibition of cell growth induced by U0126 in HeLa cells.
Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20091115
Title: Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway.
Journal: Journal of ethnopharmacology 20091112
Title: Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.
Journal: Cardiovascular research 20091101
Title: Histamine induces human beta-defensin-3 production in human keratinocytes.
Journal: Journal of dermatological science 20091101
Title: IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Journal: Anticancer research 20091101
Title: NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.
Journal: Toxicology and applied pharmacology 20091015
Title: Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells.
Journal: Digestive diseases and sciences 20091001
Title: Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats.
Journal: American journal of physiology. Renal physiology 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).
Journal: Biology of the cell 20090923
Title: 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.
Journal: Cancer research 20090915
Title: Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3.
Journal: Cell research 20090901
Title: Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.
Journal: Immunology 20090901
Title: Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.
Journal: Journal of medicinal chemistry 20090827
Title: Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.
Journal: Journal of cellular biochemistry 20090801
Title: Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.
Journal: American journal of physiology. Cell physiology 20090801
Title: Serenoa repens induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of STAT 3 signaling.
Journal: Oncology reports 20090801
Title: The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.
Journal: Investigative ophthalmology & visual science 20090701
Title: The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.
Journal: International immunopharmacology 20090701
Title: [Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion].
Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20090701
Title: Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer.
Journal: British journal of cancer 20090616
Title: Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.
Journal: The international journal of neuropsychopharmacology 20090601
Title: Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines.
Journal: International journal of molecular medicine 20090601
Title: Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527
Title: Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells.
Journal: Chemico-biological interactions 20090515
Title: The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice.
Journal: The Journal of biological chemistry 20090508
Title: Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.
Journal: Investigative ophthalmology & visual science 20090501
Title: A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.
Journal: Biochemical and biophysical research communications 20090501
Title: STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.
Journal: Molecular immunology 20090501
Title: Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis.
Journal: Arthritis and rheumatism 20090501
Title: Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501
Title: Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.
Journal: Oncogene 20090409
Title: IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.
Journal: Atherosclerosis 20090401
Title: Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
Journal: Journal of molecular endocrinology 20090401
Title: STAT3 induces muscle stem cell differentiation by interaction with myoD.
Journal: Cytokine 20090401
Title: Myricetin directly targets JAK1 to inhibit cell transformation.
Journal: Cancer letters 20090308
Title: Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Journal: The Journal of allergy and clinical immunology 20090301
Title: Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality.
Journal: The Journal of trauma 20090301
Title: Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB.
Journal: Brain research 20090223
Title: Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity.
Journal: Kidney international 20090101
Title: IL-12-dependent activation of ERK1/2 in human T lymphoblasts.
Journal: Immunobiology 20090101
Title: Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z.
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20090101
Title: Oxidative stress induces PKR-dependent apoptosis via IFN-gamma activation signaling in Jurkat T cells.
Journal: Biochemical and biophysical research communications 20081219
Title: Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors.
Journal: Biochemical and biophysical research communications 20081212
Title: Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages.
Journal: Biochimica et biophysica acta 20081201
Title: AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways.
Journal: Molecules and cells 20081130
Title: JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro.
Journal: Journal of neuroimmunology 20081115
Title: Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation.
Journal: International immunopharmacology 20081101
Title: Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081101
Title: High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response.
Journal: Obesity (Silver Spring, Md.) 20081101
Title: [Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal cerebral ischemia/reperfusion injury in rats].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081101
Title: Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.
Journal: Molecular cancer research : MCR 20081101
Title: Cloning and characterization of 5'-untranslated region of porcine beta casein gene (CSN2).
Journal: Domestic animal endocrinology 20081001
Title: Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.
Journal: European journal of haematology 20081001
Title: Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons.
Journal: Histochemistry and cell biology 20081001
Title: Regulating RISK: a role for JAK-STAT signaling in postconditioning?
Journal: American journal of physiology. Heart and circulatory physiology 20081001
Title: A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490.
Journal: Anti-cancer agents in medicinal chemistry 20081001
Title: Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion.
Journal: Basic research in cardiology 20080901
Title: Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080801
Title: [Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways].
Journal: Zhonghua xin xue guan bing za zhi 20080801
Title: Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.
Journal: Journal of medicinal chemistry 20080724
Title: Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080715
Title: Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning.
Journal: Cardiovascular research 20080701
Title: Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.
Journal: Endocrinology 20080701
Title: The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin.
Journal: American journal of physiology. Heart and circulatory physiology 20080701
Title: Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA.
Journal: FEMS immunology and medical microbiology 20080701
Title: Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells.
Journal: Neoplasia (New York, N.Y.) 20080701
Title: Potential role of JAK2 in cerebral vasospasm after experimental subarachnoid hemorrhage.
Journal: Brain research 20080612
Title: Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.
Journal: The American journal of cardiology 20080602
Title: Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury.
Journal: American journal of physiology. Renal physiology 20080601
Title: [Interferon-alpha upregulates thymidine phosphorylase expression via JAK-STAT transcriptional activation and mRNA stabilization in human hepatocellular carcinoma SMMC-7721 cells].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080601
Title: Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway.
Journal: Life sciences 20080507
Title: Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
Title: Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation.
Journal: The Annals of thoracic surgery 20080401
Title: Possible involvement of prolactin in the synthesis of lactoferrin in bovine mammary epithelial cells.
Journal: Bioscience, biotechnology, and biochemistry 20080401
Title: Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3.
Journal: The Journal of biological chemistry 20080321
Title: Mao (Ephedra sinica Stapf) protects against D-galactosamine and lipopolysaccharide-induced hepatic failure.
Journal: Cytokine 20080301
Title: The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines.
Journal: Cancer investigation 20080301
Title: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.
Journal: Neoplasia (New York, N.Y.) 20080301
Title: Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas.
Journal: Blood 20080201
Title: Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.
Journal: The Journal of pharmacology and experimental therapeutics 20080201
Title: [Effects of Yisui Jiedu Recipe on JAK2-STAT5 signal transduction pathway in bone marrow hematopoietic cells from patients with myelodysplastic syndrome-refractory anemia].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080201
Title: Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB.
Journal: Cytokine 20080201
Title: Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.
Journal: The Journal of biological chemistry 20080118
Title: Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080101
Title: Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.
Journal: American journal of physiology. Heart and circulatory physiology 20080101
Title: Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20080101
Title: [The molecular mechanism of survivin expression in activated human peripheral lymphocytes].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20080101
Title: [Effect of Janus kinase inhibitor AG490 on invasion and metastasis of human breast cancer cells].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101
Title: Postreceptor crosstalk on PI3K/Akt between GH and insulin in non-catch-up growth rats born small for gestational age.
Journal: Hormone research 20080101
Title: Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.
Journal: Journal of nephrology 20080101
Title: Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line.
Journal: Cancer letters 20071218
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.
Journal: Cancer research 20071201
Title: Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells.
Journal: Biochemical and biophysical research communications 20071123
Title: Jak2 dampens the induction by IL-1beta of prostaglandin endoperoxide H synthase 2 expression in human orbital fibroblasts: evidence for divergent influence on the prostaglandin E2 biosynthetic pathway.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20071115
Title: AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.
Journal: Cancer letters 20071108
Title: JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions.
Journal: Experimental eye research 20071101
Title: S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.
Journal: The Journal of biological chemistry 20071019
Title: Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.
Journal: Immunology and cell biology 20071001
Title: Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.
Journal: Journal of hepatology 20071001
Title: Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.
Journal: Glia 20071001
Title: Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.
Journal: American journal of physiology. Heart and circulatory physiology 20070801
Title: Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity.
Journal: The Journal of reproduction and development 20070801
Title: Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.
Journal: American journal of physiology. Heart and circulatory physiology 20070801
Title: PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.
Journal: The European journal of neuroscience 20070801
Title: Olanzapine increases RGS7 protein expression via stimulation of the Janus tyrosine kinase-signal transducer and activator of transcription signaling cascade.
Journal: The Journal of pharmacology and experimental therapeutics 20070701
Title: Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway.
Journal: Endocrinology 20070701
Title: Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.
Journal: Journal of cardiovascular pharmacology 20070701
Title: Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation.
Journal: Cancer research 20070601
Title: Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
Journal: Journal of leukocyte biology 20070501
Title: Raloxifene plus 17beta-estradiol inhibits proliferation of primary cultured vascular smooth muscle cells and human mammary endothelial cells via the janus kinase/signal transducer and activator of transcription3 cascade.
Journal: European journal of pharmacology 20070430
Title: A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.
Journal: Oncogene 20070412
Title: GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.
Journal: Biogerontology 20070401
Title: JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.
Journal: Journal of leukocyte biology 20070401
Title: Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.
Journal: American journal of physiology. Cell physiology 20070301
Title: Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons.
Journal: Experimental neurology 20070301
Title: Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.
Journal: The Journal of endocrinology 20070301
Title: Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth.
Journal: The Journal of biological chemistry 20070209
Title: Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells.
Journal: Journal of hepatology 20070101
Title: Constitutive phosphorylation of Janus kinase 2 in the GL15 glioblastoma derived human cell line.
Journal: Oncology reports 20070101
Title: Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotides.
Journal: Autophagy 20070101
Title: Modulation of protein tyrosine phosphatase 1B by erythropoietin in UT-7 cell line.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome.
Journal: American journal of nephrology 20070101
Title: Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells.
Journal: Folia biologica 20070101
Title: Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.
Journal: Vascular pharmacology 20061201
Title: Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.
Journal: Cancer science 20061201
Title: [Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061201
Title: Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells.
Journal: Biochemical pharmacology 20061130
Title: Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061101
Title: Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation.
Journal: Acta pharmacologica Sinica 20061101
Title: Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.
Journal: Cytokine 20061101
Title: Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells.
Journal: Cell and tissue research 20061001
Title: Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.
Journal: Biology of reproduction 20061001
Title: Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.
Journal: Cancer research 20061001
Title: [Effects of a JAK inhibitor, AG490, on proliferation and survivin expression of breast cancer cell line MDA-MB-231].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061001
Title: Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).
Journal: International journal of cancer 20060915
Title: Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion.
Journal: American journal of physiology. Cell physiology 20060901
Title: All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060901
Title: JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia.
Journal: Journal of neurochemistry 20060901
Title: STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.
Journal: Kidney international 20060801
Title: Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway.
Journal: Kidney international 20060801
Title: Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways.
Journal: Clinical and experimental immunology 20060701
Title: Janus kinase 2: a critical target in chronic myelogenous leukemia.
Journal: Cancer research 20060701
Title: STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.
Journal: Biochemical pharmacology 20060628
Title: American Association for Cancer Research--97th annual meeting.
Journal: IDrugs : the investigational drugs journal 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival.
Journal: Cellular signalling 20060401
Title: CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2.
Journal: Cellular signalling 20060401
Title: Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells.
Journal: International journal of cancer 20060315
Title: Pancreatitis-associated protein I suppresses NF-kappa B activation through a JAK/STAT-mediated mechanism in epithelial cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060315
Title: Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer.
Journal: Cancer research 20060315
Title: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Journal: Molecular and cellular endocrinology 20060309
Title: Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production.
Journal: Molecular pharmacology 20060301
Title: Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes.
Journal: Molecular and cellular biochemistry 20060301
Title: Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.
Journal: Cardiovascular research 20060215
Title: Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
Journal: FEBS letters 20060206
Title: Activation of JAK/STAT signalling in neurons following spinal cord injury in mice.
Journal: Journal of neurochemistry 20060201
Title: Signal transducer and activator of transcription 6 down-regulates toll-like receptor-4 expression of a monocytic cell line.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201
Title: Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells.
Journal: Cancer letters 20060118
Title: The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.
Journal: Journal of molecular medicine (Berlin, Germany) 20060101
Title: Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060101
Title: Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
Journal: Molecular cancer therapeutics 20060101
Title: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.
Journal: Retrovirology 20060101
Title: The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells.
Journal: Anticancer research 20060101
Title: Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.
Journal: The international journal of biochemistry & cell biology 20060101
Title: JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.
Journal: Mediators of inflammation 20060101
Title: TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death.
Journal: Anticancer research 20060101
Title: LIF upregulates expression of NK-1R in NHBE cells.
Journal: Mediators of inflammation 20060101
Title: Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line.
Journal: Diabetes research and clinical practice 20051201
Title: STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.
Journal: The Biochemical journal 20051201
Title: Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons.
Journal: Endocrinology 20051201
Title: Divergent action of calcium channel blockers on ATP-binding cassette protein expression.
Journal: Journal of cardiovascular pharmacology 20051201
Title: Jak2 tyrosine kinase prevents angiotensin II-mediated inositol 1,4,5 trisphosphate receptor degradation.
Journal: Vascular pharmacology 20051101
Title: Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.
Journal: Neuron 20051020
Title: Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.
Journal: British journal of pharmacology 20051001
Title: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.
Journal: The American journal of pathology 20051001
Title: Prevention of acute lung allograft rejection in rat by the janus kinase 3 inhibitor, tyrphostin AG490.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001
Title: A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia.
Journal: The Biochemical journal 20050901
Title: Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells.
Journal: Endocrinology 20050901
Title: The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells.
Journal: International journal of oncology 20050901
Title: Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Journal: Brain : a journal of neurology 20050701
Title: Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2.
Journal: Journal of leukocyte biology 20050701
Title: Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.
Journal: The Journal of biological chemistry 20050701
Title: Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling.
Journal: Bioorganic & medicinal chemistry 20050701
Title: Targeting Stat3 in cancer therapy.
Journal: Anti-cancer drugs 20050701
Title: JAK-STAT signaling pathway in pulmonary arterial smooth muscle cells is activated by hypoxia.
Journal: Cell biology international 20050701
Title: Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma.
Journal: Oncogene 20050623
Title: Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.
Journal: Nagoya journal of medical science 20050601
Title: Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells.
Journal: Journal of neuro-oncology 20050501
Title: Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.
Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050501
Title: Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue.
Journal: Circulation 20050419
Title: IFNgamma and TNFalpha synergistically induce neurite outgrowth on PC12 cells.
Journal: Neuroscience letters 20050411
Title: JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells.
Journal: Journal of cellular physiology 20050401
Title: Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.
Journal: Biochemical and biophysical research communications 20050401
Title: Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050401
Title: KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway.
Journal: Oncogene 20050317
Title: Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050315
Title: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.
Journal: Carcinogenesis 20050301
Title: Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia.
Journal: Leukemia & lymphoma 20050301
Title: Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216
Title: Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
Journal: Circulation research 20050204
Title: AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway.
Journal: Journal of neurochemistry 20050201
Title: [Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20050201
Title: Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.
Journal: Molecular cancer 20050101
Title: [Influence on the cytokines expression on hepatic tissue by inhibition the signal pathway of inflammatory mediators following extensive hepatectomy in rats].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20050101
Title: EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20041201
Title: Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis.
Journal: Kidney international 20041201
Title: Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201
Title: Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin.
Journal: Molecular cancer therapeutics 20041201
Title: Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.
Journal: Blood 20041115
Title: Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20041115
Title: STAT3 induces anti-hepatitis C viral activity in liver cells.
Journal: Biochemical and biophysical research communications 20041112
Title: The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.
Journal: European journal of immunology 20041101
Title: Janus kinase 2 signaling in the angiotensin II-dependent activation of StAR expression.
Journal: Endocrine research 20041101
Title: The androgen receptor co-activator CBP is up-regulated following androgen withdrawal and is highly expressed in advanced prostate cancer.
Journal: The Journal of pathology 20041001
Title: STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression.
Journal: The Journal of biological chemistry 20040820
Title: Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20040813
Title: CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.
Journal: FEBS letters 20040716
Title: Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Journal: Journal of the American Society of Nephrology : JASN 20040601
Title: Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction.
Journal: The Biochemical journal 20040515
Title: Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.
Journal: British journal of haematology 20040501
Title: FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production.
Journal: Circulation research 20040430
Title: Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.
Journal: American journal of physiology. Renal physiology 20040401
Title: The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.
Journal: The Journal of pharmacology and experimental therapeutics 20040401
Title: Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
Journal: Molecular cancer therapeutics 20040401
Title: Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.
Journal: Life sciences 20040312
Title: Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors.
Journal: Investigative ophthalmology & visual science 20040301
Title: The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.
Journal: The Journal of endocrinology 20040301
Title: Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.
Journal: The Journal of biological chemistry 20040227
Title: Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes.
Journal: FEBS letters 20040227
Title: IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.
Journal: Biochemical and biophysical research communications 20040206
Title: AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1.
Journal: Molecular cancer therapeutics 20040201
Title: Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia.
Journal: Glia 20040115
Title: Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines.
Journal: Molecular cancer therapeutics 20040101
Title: Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells.
Journal: American journal of nephrology 20040101
Title: Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.
Journal: The Journal of biological chemistry 20031226
Title: Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.
Journal: British journal of haematology 20031201
Title: Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.
Journal: Cardiovascular research 20031101
Title: Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Journal: Science (New York, N.Y.) 20031031
Title: PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.
Journal: Biochemical and biophysical research communications 20031024
Title: Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.
Journal: Journal of medicinal chemistry 20031023
Title: Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20031001
Title: Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes.
Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20031001
Title: A critical role for Stat3 signaling in immune tolerance.
Journal: Immunity 20030901
Title: Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.
Journal: International archives of allergy and immunology 20030901
Title: Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma.
Journal: Oncogene 20030821
Title: Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes.
Journal: Biochemical and biophysical research communications 20030808
Title: Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia.
Journal: Blood 20030715
Title: Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030715
Title: Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.
Journal: The Journal of biological chemistry 20030516
Title: Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.
Journal: Hypertension (Dallas, Tex. : 1979) 20030501
Title: Inhibitors that target protein kinases for the treatment of ovarian carcinoma.
Journal: American journal of obstetrics and gynecology 20030501
Title: Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.
Journal: Experimental hematology 20030401
Title: Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20030314
Title: Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.
Journal: Molecular endocrinology (Baltimore, Md.) 20030301
Title: [Role of Janus kinase/signal transducer and activator of transcription pathway in mediating mRNA expression of high mobility group box1 protein in the liver in septic rats].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20030301
Title: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.
Journal: Blood 20030215
Title: Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia.
Journal: Blood 20030201
Title: CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.
Journal: Blood 20030101
Title: Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030101
Title: Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors.
Journal: Anticancer research 20030101
Title: Gamma interferon-induced nitric oxide production in mouse CD5+ B1-like cell line and its association with apoptotic cell death.
Journal: Microbiology and immunology 20030101
Title: Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells.
Journal: Oncogene 20021205
Title: Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells.
Journal: Diabetes 20021201
Title: Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.
Journal: Molecular endocrinology (Baltimore, Md.) 20021201
Title: Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.
Journal: The Journal of biological chemistry 20021122
Title: Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.
Journal: Oncogene 20021031
Title: JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells.
Journal: The Journal of biological chemistry 20021025
Title: Jak2 is involved in c-Myc induction by Bcr-Abl.
Journal: Oncogene 20021017
Title: Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.
Journal: American journal of respiratory cell and molecular biology 20020901
Title: Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.
Journal: Molecular cancer therapeutics 20020901
Title: IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation.
Journal: Cytokine 20020807
Title: Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation.
Journal: American journal of physiology. Cell physiology 20020701
Title: Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.
Journal: Oncogene 20020627
Title: Leukemia inhibitory factor relaxes arteries through endothelium-dependent mechanism.
Journal: Biochemical and biophysical research communications 20020607
Title: Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
Journal: The Journal of biological chemistry 20020517
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.
Journal: Cellular signalling 20020401
Title: IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.
Journal: Biochemical and biophysical research communications 20020322
Title: Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists.
Journal: European journal of pharmacology 20020308
Title: Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation of Janus kinase 2 and p44/42 mitogen-activated protein kinase.
Journal: Cellular signalling 20020301
Title: STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.
Journal: Kidney international 20020301
Title: Acute stimulation of glucose uptake by leptin in l6 muscle cells.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020301
Title: Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020215
Title: Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.
Journal: Nitric oxide : biology and chemistry 20020201
Title: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.
Journal: European journal of biochemistry 20020201
Title: Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.
Journal: Hypertension (Dallas, Tex. : 1979) 20020101
Title: Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia.
Journal: British journal of haematology 20020101
Title: [Inhibition of constitutively activated Jak3 and induction of apoptosis in NALM-6 cell line].
Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101
Title: Neuroprotective effects of leptin in vivo and in vitro.
Journal: Neuroreport 20011221
Title: Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein.
Journal: Free radical biology & medicine 20011201
Title: Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells.
Journal: British journal of pharmacology 20011201
Title: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells.
Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20011201
Title: Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Title: Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.
Journal: Oncogene 20011129
Title: HTLV-1 cell lines differ in constitutively activated signaling pathways that can be altered by cytokine exposure.
Journal: Virology 20011110
Title: The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome.
Journal: Leukemia 20011101
Title: PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase.
Journal: Molecular endocrinology (Baltimore, Md.) 20011101
Title: Role of STAT3 in ischemic preconditioning.
Journal: Journal of molecular and cellular cardiology 20011101
Title: Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.
Journal: Oncogene 20011011
Title: Activation of the transcription factor NF-kappaB by the erythropoietin receptor: structural requirements and biological significance.
Journal: Cellular signalling 20010901
Title: JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures.
Journal: Journal of neuroscience research 20010901
Title: Constitutive activation of STAT transcription factors in acute myelogenous leukemia.
Journal: European journal of haematology 20010801
Title: JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion.
Journal: Circulation 20010717
Title: Hydrogen peroxide is a novel inducer of connective tissue growth factor.
Journal: Biochemical and biophysical research communications 20010622
Title: IL-6 upregulates its own receptor on some human myeloma cell lines.
Journal: Cytokine 20010621
Title: Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010615
Title: Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.
Journal: Blood 20010601
Title: Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
Journal: Journal of hypertension 20010601
Title: TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Journal: Leukemia 20010601
Title: [The effect of AG490 on NK activity and lymphocyte transformation of PBMC].
Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010601
Title: Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.
Journal: Oncogene 20010503
Title: SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.
Journal: Nature genetics 20010501
Title: Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells.
Journal: Leukemia 20010501
Title: Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.
Journal: Experimental hematology 20010501
Title: Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.
Journal: Blood 20010401
Title: Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010315
Title: Characterization of a rat uterine cell line, U(III) cells: prolactin (PRL) expression and endogenous regulation of PRL-dependent genes; estrogen receptor beta, alpha(2)-macroglobulin, and decidual PRL involving the Jak2 and Stat5 pathway.
Journal: Endocrinology 20010301
Title: Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010301
Title: Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301
Title: Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
Journal: The Journal of clinical investigation 20010201
Title: LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42.
Journal: Nitric oxide : biology and chemistry 20010201
Title: New dermatological agents for the treatment of psoriasis.
Journal: Journal of medicinal chemistry 20010201
Title: Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells.
Journal: Journal of cellular biochemistry 20010101
Title: Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.
Journal: Transplantation proceedings 20010101
Title: Modulation of primary T cell responses and tolerance induction by tyrphostin AG490.
Journal: Transplantation proceedings 20010101
Title: Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.
Journal: Journal of vascular research 20010101
Title: IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells.
Journal: BMC cancer 20010101
Title: Naphthyl ketones: a new class of Janus kinase 3 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20000320
Title: Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
Journal: Biochemistry 19951121
Title: Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Journal: Journal of medicinal chemistry 19910601
1210492-11-7 | 1-(4-chlorophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid | AA019X2U | MFCD00068873
1803607-65-9 | methyl 3-(2-aminopropan-2-yl)-1,2-oxazole-5-carboxylate hydrochloride | AA01BBZC | MFCD28714682
138227-63-1 | 1-Piperidinecarboxylic acid, 4-(4-aminophenoxy)-, 1,1-dimethylethyl ester | AA00189D | MFCD04115023