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134-58-7,MFCD00056937
Catalog No.:AA0034BV

134-58-7 | 8-Azaguanine

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1g
98%(HPLC)
in stock  
$34.00   $24.00
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5g
95%
in stock  
$99.00   $69.00
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10g
95%
in stock  
$177.00   $124.00
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25g
95%
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$378.00   $264.00
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100g
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$1,275.00   $892.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034BV
Chemical Name:
8-Azaguanine
CAS Number:
134-58-7
Molecular Formula:
C4H4N6O
Molecular Weight:
152.1142
MDL Number:
MFCD00056937
SMILES:
Nc1nc(=O)c2c([nH]1)nn[nH]2
Properties
Properties
 
BP:
289.9 °C at 760 mmHg  
Form:
Solid  
MP:
>300 °C  
Refractive Index:
2.3000 (estimate)  
Storage:
Light sensitive;Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
XLogP3:
-1.5  

Literature

Title: Apoptosis deregulation influences chemoresistance to azaguanine in human leukemic cell lines.

Journal: Cancer investigation 20120601

Title: Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.

Journal: Journal of biomolecular screening 20120601

Title: Study of the interaction between 8-azaguanine and bovine serum albumin using optical spectroscopy and molecular modeling methods.

Journal: Journal of molecular modeling 20120201

Title: CAXII Is a sero-diagnostic marker for lung cancer.

Journal: PloS one 20120101

Title: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20111201

Title: Equilibrative nucleoside transporter 1 (ENT1) is critical for pollen germination and vegetative growth in Arabidopsis.

Journal: Journal of experimental botany 20110801

Title: Metabolic engineering and classic selection of the yeast Candida famata (Candida flareri) for construction of strains with enhanced riboflavin production.

Journal: Metabolic engineering 20110101

Title: Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4.

Journal: PloS one 20110101

Title: Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma.

Journal: PloS one 20110101

Title: Multidrug resistance in breast cancer: from in vitro models to clinical studies.

Journal: International journal of breast cancer 20110101

Title: Changes in lipid and carnitine concentrations following repeated fasting-refeeding in mice.

Journal: Nutrition research and practice 20101201

Title: Detection of pathogenic Leptospira from selected environment in Kelantan and Terengganu, Malaysia.

Journal: Tropical biomedicine 20101201

Title: 3-Benzyl-6-butyl-5-propyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Ethyl 1-benzyl-5-{[(isopropyl-amino)(3-nitro-phen-oxy)methyl-idene]amino}-1H-1,2,3-triazole-4-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: 6-Isopropyl-5-meth-oxy-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: 6-Butyl-5-(4-methyl-phen-oxy)-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: FlaB PCR-based identification of pathogenic leptospiral isolates.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20100201

Title: 6-Butyl-5-(4-methoxy-phen-oxy)-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Intersystem crossing to excited triplet state of aza analogues of nucleic acid bases in acetonitrile.

Journal: The journal of physical chemistry. A 20091105

Title: Development and characterization of HAT-sensitive Ewing tumour cells for immunotherapy.

Journal: Anticancer research 20091101

Title: 6-Isopropyl-3-phenyl-5-(p-tol-yloxy)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one: whole-mol-ecule disorder.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: 3-Benzyl-6-isopropyl-5-phen-oxy-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: 5-(4-Chloro-phen-oxy)-6-isopropyl-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme.

Journal: Nature chemical biology 20090501

Title: Leptospira kmetyi sp. nov., isolated from an environmental source in Malaysia.

Journal: International journal of systematic and evolutionary microbiology 20090401

Title: AtAzg1 and AtAzg2 comprise a novel family of purine transporters in Arabidopsis.

Journal: FEBS letters 20090122

Title: Semi-allogeneic vaccines and tumor-induced immune tolerance.

Journal: Journal of translational medicine 20090101

Title: Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests.

Journal: BMC complementary and alternative medicine 20090101

Title: Leptospira weilii serovar Topaz, a new member of the Tarassovi serogroup isolated from a bovine source in Queensland, Australia.

Journal: International journal of systematic and evolutionary microbiology 20081001

Title: Leptospira wolffii sp. nov., isolated from a human with suspected leptospirosis in Thailand.

Journal: International journal of systematic and evolutionary microbiology 20081001

Title: Human leptospirosis caused by a new, antigenically unique Leptospira associated with a Rattus species reservoir in the Peruvian Amazon.

Journal: PLoS neglected tropical diseases 20080401

Title: Enhancement of hybridoma formation, clonability and cell proliferation in a nanoparticle-doped aqueous environment.

Journal: BMC biotechnology 20080101

Title: Gene targeting in adult rhesus macaque fibroblasts.

Journal: BMC biotechnology 20080101

Title: CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture.

Journal: Pathophysiology : the official journal of the International Society for Pathophysiology 20070501

Title: 8-Azaguanine reporter of purine ionization states in structured RNAs.

Journal: Journal of the American Chemical Society 20070321

Title: Semi-allogeneic vaccine for T-cell lymphoma.

Journal: Journal of translational medicine 20070101

Title: Interactions of calf spleen purine nucleoside phosphorylase with formycin B and its aglycone - spectroscopic and kinetic studies.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

Journal: Journal of medicinal chemistry 20061214

Title: Expression of the E. coli fpg protein in CHO cells lowers endogenous oxypurine clustered damage levels and decreases accumulation of endogenous Hprt mutations.

Journal: Environmental and molecular mutagenesis 20060601

Title: Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Journal: Molecular neurodegeneration 20060101

Title: Identification of pathogenic Leptospira species by conventional or real-time PCR and sequencing of the DNA gyrase subunit B encoding gene.

Journal: BMC microbiology 20060101

Title: Structure of human PNP complexed with ligands.

Journal: Acta crystallographica. Section D, Biological crystallography 20050701

Title: Spectroscopic and kinetic studies of interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and its 9-(2-phosphonylmethoxyethyl) derivative.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: A unique strain of Leptospira isolated from a patient with pulmonary haemorrhages in the Andaman Islands: a proposal of serovar portblairi of serogroup Sehgali.

Journal: Epidemiology and infection 20040801

Title: [A study on inclusion complexes of cyclodextrin with three anticancer xanthines by fluorescence].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040701

Title: Estimation of guanine deaminase using guanosine as a 'prosubstrate'.

Journal: Analytical biochemistry 20040115

Title: Interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and a bisubstrate analogue inhibitor: implications for the reaction mechanism.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: Spectroscopy behavior of 6-Mercaptopurine, Azathiopurine, and 8-Azaguanine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031101

Title: Chemical composition of some components of the arrestment pheromone of the black-legged tick, Ixodes scapularis (Acari: Ixodidae) and their use in tick control.

Journal: Journal of medical entomology 20031101

Title: Structure and the energy of base pairing in non-natural bases of nucleic acids: the azaguanine-cytosine and azaadenine-thymine base pairs.

Journal: Bioorganic chemistry 20031001

Title: Genetic engineering of Escherichia coli for production of tetrahydrobiopterin.

Journal: Metabolic engineering 20031001

Title: Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis.

Journal: World journal of gastroenterology 20030515

Title: The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.

Journal: BMC biochemistry 20030101

Title: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.

Journal: BMC microbiology 20030101

Title: Fusion of mature dendritic cells and human T-lymphotropic virus type I infected T cells: its efficiency as an antigen-presenting cell.

Journal: Virology 20020915

Title: [Riboflavin overproduction in 4-aminopyrazole[3,4-d]pyrimidine-treated yeast Pichia guilliermondii].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20020101

Title: The mouse guanylate kinase double mutant E72Q/D103N is a functional adenylate kinase.

Journal: Protein engineering 20011101

Title: The superiority of organically cultivated vegetables to general ones regarding antimutagenic activities.

Journal: Mutation research 20010920

Title: GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I.

Journal: Archives of biochemistry and biophysics 20010401

Title: Behavioural and chemoreceptor cell responses of the tick, Ixodes ricinus, to its own faeces and faecal constituents.

Journal: Experimental & applied acarology 20010101

Title: Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.

Journal: Research in virology 19970101

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

Title: Dourado M, et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology. 2007 May;14(1):3-10.

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