Home Other Building Blocks 1346704-33-3
1346704-33-3,MFCD25563250
Catalog No.:AA009C9D
1346704-33-3 | GSK 343
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Purity
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1mg
98+%
in stock  
$33.00
- +
5mg
98+%
in stock  
$57.00
- +
10mg
98+%
in stock  
$91.00
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25mg
98+%
in stock  
$164.00
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  • Technical Information
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Technical Information
Catalog Number:
AA009C9D
Chemical Name:
GSK 343
CAS Number:
1346704-33-3
Molecular Formula:
C31H39N7O2
Molecular Weight:
541.6871
MDL Number:
MFCD25563250
IUPAC Name:
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide
InChI:
InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChI Key:
ULNXAWLQFZMIHX-UHFFFAOYSA-N
SMILES:
CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2c1cnn2C(C)C)c1ccnc(c1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
986  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
541.317g/mol
Formal Charge:
0
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
541.7g/mol
Monoisotopic Mass:
541.317g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
95.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  

Synonyms
 
GSK343 
GSK343 
compound 6 [PMID 24900432] 
GTPL8240 
SCHEMBL14716863 
AOB3680 
EX-A244 
SYN5151 
BCP07777 
2449AH 
BDBM50400778 
MFCD25563250 
1346704-33-3 
ZINC95564006 
AKOS025405231 
CS-1626 
NCGC00351480-11 
AK175558 
AS-16513 
BC600349 
GSK343, >=98% (HPLC) 
HY-13500 
QC-11809 
GSK 343 
AB0199866 
FT-0767292 
S7164 
J3.544.025I 
J-006589 
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide 
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide 
D02TVQ 
ACN-053701 
A3449 
GSK-343 
A13114 
C586265 
1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide 
CHEMBL2204995 
C31H39N7O2 
1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide 
N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide 
Literature

Title: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Journal: Nature communications 20140101

Title: Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.

Journal: Cell cycle (Georgetown, Tex.) 20130701

Title: Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

Journal: ACS medicinal chemistry letters 20121213

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