Home Amines 13484-95-2
13484-95-2,MFCD18427078
Catalog No.:AA009ED3

13484-95-2 | 2(1H)-Pyrimidinone, 4-amino-5-hydroxy- (9CI)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
3 weeks  
$513.00   $359.00
- +
10g
3 weeks  
$2,750.00   $1,925.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009ED3
Chemical Name:
2(1H)-Pyrimidinone, 4-amino-5-hydroxy- (9CI)
CAS Number:
13484-95-2
Molecular Formula:
C4H5N3O2
Molecular Weight:
127.1014
MDL Number:
MFCD18427078
SMILES:
Nc1nc(=O)[nH]cc1O
Properties
Computed Properties
 
Complexity:
206  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
XLogP3:
-1.3  

Literature

Title: Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.

Journal: Human molecular genetics 20121115

Title: Profiling cytosine oxidation in DNA by LC-MS/MS.

Journal: Chemical research in toxicology 20120917

Title: Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities.

Journal: DNA repair 20120901

Title: DNA glycosylases: in DNA repair and beyond.

Journal: Chromosoma 20120201

Title: Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin.

Journal: PloS one 20120101

Title: The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site.

Journal: Biochemistry 20111129

Title: Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA.

Journal: Journal of molecular biology 20110819

Title: New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.

Journal: PloS one 20110101

Title: RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease.

Journal: PloS one 20110101

Title: Direct detection and sequencing of damaged DNA bases.

Journal: Genome integrity 20110101

Title: Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates.

Journal: Cardiovascular toxicology 20100901

Title: The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Journal: DNA repair 20100204

Title: Early Steps in the DNA Base Excision Repair Pathway of a Fission Yeast Schizosaccharomyces pombe.

Journal: Journal of nucleic acids 20100101

Title: Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.

Journal: Journal of nucleic acids 20100101

Title: African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA.

Journal: Virology 20090720

Title: Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.

Journal: Carcinogenesis 20090701

Title: Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats.

Journal: FEMS immunology and medical microbiology 20090701

Title: Up-regulation of myocardial DNA base excision repair activities in experimental heart failure.

Journal: Mutation research 20090618

Title: The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide.

Journal: PLoS pathogens 20090501

Title: Excision of the oxidatively formed 5-hydroxyhydantoin and 5-hydroxy-5-methylhydantoin pyrimidine lesions by Escherichia coli and Saccharomyces cerevisiae DNA N-glycosylases.

Journal: Biochimica et biophysica acta 20090101

Title: Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.

Journal: Biochemistry 20080708

Title: Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA.

Journal: Chemical research in toxicology 20080601

Title: Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil, with standard DNA bases at the BSSE-free DFT and MP2 theory levels.

Journal: Organic & biomolecular chemistry 20070521

Title: Oligonucleotide transformation for the study of mutagenic specificities of DNA lesions in yeast.

Journal: Nucleic acids symposium series (2004) 20070101

Title: Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break.

Journal: Radiation research 20061101

Title: Collisionally activated dissociation of protonated 2'-deoxycytidine, 2'-deoxyuridine, and their oxidatively damaged derivatives.

Journal: Journal of the American Society for Mass Spectrometry 20061001

Title: Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.

Journal: Journal of the American Chemical Society 20060927

Title: DNA oxidation in Alzheimer's disease.

Journal: Antioxidants & redox signaling 20060101

Title: DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency.

Journal: Biochemistry 20051101

Title: Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients.

Journal: Blood 20050615

Title: Electrochemical detection of lesions in DNA.

Journal: Bioconjugate chemistry 20050101

Title: Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145.

Journal: Carcinogenesis 20040801

Title: Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.

Journal: Journal of the American Chemical Society 20040602

Title: Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts.

Journal: The Journal of biological chemistry 20040430

Title: Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.

Journal: The Journal of biological chemistry 20030905

Title: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.

Journal: Biochemistry 20030506

Title: Oxidative DNA base modifications and polycyclic aromatic hydrocarbon DNA adducts in squamous cell carcinoma of larynx.

Journal: Free radical research 20030301

Title: Repair of oxidative cytosine damage by DNA glycosylases.

Journal: Nucleic acids research. Supplement (2001) 20030101

Title: Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo.

Journal: Biochemical and biophysical research communications 20020830

Title: Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.

Journal: The Journal of biological chemistry 20020823

Title: Biological consequences of free radical-damaged DNA bases.

Journal: Free radical biology & medicine 20020701

Title: Gender differences in steady-state levels of oxidative damage to DNA in healthy individuals.

Journal: Free radical research 20020201

Title: Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines.

Journal: The EMBO journal 20011115

Title: Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA.

Journal: Biochemistry 20010605

Title: 6-hydroxydopamine increases hydroxyl free radical production and DNA damage in rat striatum.

Journal: Neuroreport 20010508

Title: Repair and mutagenic potential of oxaluric acid, a major product of singlet oxygen-mediated oxidation of 8-oxo-7,8-dihydroguanine.

Journal: Chemical research in toxicology 20010101

Title: New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

Journal: The Journal of biological chemistry 19940722

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 13484-95-2
Tags:13484-95-2 Molecular Formula|13484-95-2 MDL|13484-95-2 SMILES|13484-95-2 2(1H)-Pyrimidinone, 4-amino-5-hydroxy- (9CI)