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135575-42-7,MFCD28168025
Catalog No.:AA007ZFG

135575-42-7 | Pneumocandin b0

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1mg
98%
in stock  
$6.00   $4.00
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5mg
98%
in stock  
$9.00   $7.00
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10mg
98%
in stock  
$17.00   $12.00
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100mg
98%
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$27.00   $19.00
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1g
98%
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$143.00   $100.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007ZFG
Chemical Name:
Pneumocandin b0
CAS Number:
135575-42-7
Molecular Formula:
C39H61N7O8
Molecular Weight:
755.9437
MDL Number:
MFCD28168025
SMILES:
CCC(CC(CCCCCCCCC(=O)N[C@H]1C[CH][CH]NC(=O)[C@@H]2[CH]CCN2C(=O)[CH]NC(=O)[CH]NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)[C@H](O)C)C[CH]C2)C)C
Properties
Computed Properties
 
Complexity:
1930  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
75  
Hydrogen Bond Acceptor Count:
17  
Hydrogen Bond Donor Count:
15  
Rotatable Bond Count:
20  
Undefined Atom Stereocenter Count:
2  
XLogP3:
0.5  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1992,vol.35,p.194-198

[2]TetrahedronLetters,1992,vol.33,p.4529-4532

[1]JournalofMedicinalChemistry,1992,vol.35,p.194-198

990-91-0    135575-42-7   
C64H89N8O22P 

[1]JournalofMedicinalChemistry,1992,vol.35,p.194-198

2002-24-6    135575-42-7   
C52H85N9O17*ClH 

[1]JournalofMedicinalChemistry,1994,vol.37,p.222-225

[1]JournalofMedicinalChemistry,1992,vol.35,p.194-198

Literature

Title: Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0.

Journal: The Journal of organic chemistry 20070330

Title: Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0.

Journal: Journal of chromatography. A 20060106

Title: Influence of mobile phase composition and thermodynamics on the normal phase chromatography of echinocandins.

Journal: Journal of chromatography. A 20051209

Title: Novel proline hydroxylase activities in the pneumocandin-producing fungus Glarea lozoyensis responsible for the formation of trans 3- and trans 4-hydroxyproline.

Journal: Applied microbiology and biotechnology 20030801

Title: Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis.

Journal: Organic letters 20021128

Title: Effects of amino acid and trace element supplementation on pneumocandin production by Glarea lozoyensis: impact on titer, analogue levels, and the identification of new analogues of pneumocandin B(0).

Journal: Journal of industrial microbiology & biotechnology 20010401

Title: The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro.

Journal: The Journal of antimicrobial chemotherapy 19961001

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry 19951124

Title: New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.

Journal: Antimicrobial agents and chemotherapy 19950601

Title: In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373.

Journal: Antimicrobial agents and chemotherapy 19950501

Title: Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.

Journal: The Journal of antibiotics 19940701

Title: Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.

Journal: Journal of medicinal chemistry 19940121

Title: Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats.

Journal: Antimicrobial agents and chemotherapy 19920901

Title: Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).

Journal: Journal of medicinal chemistry 19920101

Title: Welch CJ, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101(1-2):204-13.

Title: Leonard WR Jr, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. J Org Chem. 2007 Mar 30;72(7):2335-43.

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