Home Deuterated Building Blocks 135897-06-2
135897-06-2,MFCD06411452
Catalog No.:AA007N2R

135897-06-2 | SB 218078

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1mg
≥98%
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$202.00   $141.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007N2R
Chemical Name:
SB 218078
CAS Number:
135897-06-2
Molecular Formula:
C24H15N3O3
Molecular Weight:
393.3942
MDL Number:
MFCD06411452
SMILES:
O=c1[nH]c(=O)c2c1c1c3c4c2c2ccccc2n4C2OC(n3c3c1cccc3)CC2
Properties
Computed Properties
 
Complexity:
754  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
2  
XLogP3:
3.8  

Literature

Title: Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131001

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Chk1 and Hsp90 cooperatively regulate phosphorylation of endothelial nitric oxide synthase at serine 1179.

Journal: Free radical biology & medicine 20111215

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.

Journal: Journal of translational medicine 20090101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061101

Title: Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.

Journal: Journal of medicinal chemistry 20030522

Title: An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.

Journal: Cancer research 20000201

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