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Home Other Building Blocks 1365267-27-1
1365267-27-1,MFCD25976868
Catalog No.:AA009IAF

1365267-27-1 | X-376

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
99%
in stock  
$322.00   $225.00
- +
25mg
99%
in stock  
$640.00   $448.00
- +
50mg
99%
in stock  
$1,029.00   $720.00
- +
100mg
99%
in stock  
$1,382.00   $968.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009IAF
Chemical Name:
X-376
CAS Number:
1365267-27-1
Molecular Formula:
C25H25Cl2FN6O3
Molecular Weight:
547.4088
MDL Number:
MFCD25976868
SMILES:
CN1CCN(CC1)C(=O)c1ccc(cc1)NC(=O)c1nnc(c(c1)O[C@@H](c1c(Cl)ccc(c1Cl)F)C)N
Properties
Computed Properties
 
Complexity:
784  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route

[1]Patent:WO2012/48259,2012,A2

[1]CurrentPatentAssignee:BETTAPHARMACEUTICALSCOLTD-WO2012/48259,2012,A2

[1]Patent:WO2012/48259,2012,A2

[1]CurrentPatentAssignee:BETTAPHARMACEUTICALSCOLTD-WO2012/48259,2012,A2

[1]CurrentPatentAssignee:BETTAPHARMACEUTICALSCOLTD-WO2012/48259,2012,A2

Literature

Title: Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors.

Journal: Cancer research 20110715

Title: Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31.

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SDS
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Tags:1365267-27-1 Molecular Formula|1365267-27-1 MDL|1365267-27-1 SMILES|1365267-27-1 X-376