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Home Amines 1365802-18-1
1365802-18-1,MFCD28899574
Catalog No.:AA00120Z

1365802-18-1 | 4,4'-(Piperazine-1,4-diylbis(methylene))bis(N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
96%
1 week  
$241.00   $169.00
- +
5mg
96%
1 week  
$606.00   $424.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00120Z
Chemical Name:
4,4'-(Piperazine-1,4-diylbis(methylene))bis(N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide)
CAS Number:
1365802-18-1
Molecular Formula:
C52H48N12O2
Molecular Weight:
873.0167
MDL Number:
MFCD28899574
SMILES:
O=C(c1ccc(cc1)CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C)Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C
Properties
Properties
 
Form:
Solid  
MP:
>213°C (dec.)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
1380  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
66  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
14  
XLogP3:
7  

Literature

Title: Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1;96(3):925-32.

Title: Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9.

Title: Iqbal N, et al. Imatinib: a breakthrough of targeted therapy in cancer. Chemother Res Pract. 2014;2014:357027.

Title: Okuda K, et al. ARG tyrosine kinase activity is inhibited by STI571.Blood. 2001 Apr 15;97(8):2440-8.

Title: Jeanne M Sisk, et al. Coronavirus S Protein-Induced Fusion Is Blocked Prior to Hemifusion by Abl Kinase Inhibitors. J Gen Virol. 2018 May;99(5):619-630.

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SDS
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Tags:1365802-18-1 Molecular Formula|1365802-18-1 MDL|1365802-18-1 SMILES|1365802-18-1 4,4'-(Piperazine-1,4-diylbis(methylene))bis(N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide)