Home Other Building Blocks 1369665-02-0
1369665-02-0,MFCD31544353
Catalog No.:AA01E6JX

1369665-02-0 | Cobimetinib fumarate - Bio-X

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$203.00   $142.00
- +
10mg
99%
1 week  
$241.00   $169.00
- +
50mg
99%
1 week  
$679.00   $475.00
- +
100mg
99%
1 week  
$965.00   $675.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E6JX
Chemical Name:
Cobimetinib fumarate - Bio-X
CAS Number:
1369665-02-0
Molecular Formula:
C46H46F6I2N6O8
Molecular Weight:
1178.6922
MDL Number:
MFCD31544353
SMILES:
C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C(=CC(=O)O)C(=O)O
Properties
Computed Properties
 
Complexity:
743  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
68  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
10  

Literature

Title: Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.

Title: Choo EF, et al. PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts. Cancer Chemother Pharmacol. 2013 Jan;71(1):133-43.

Title: Wong H, et al. Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor. Clin Cancer Res. 2012 Jun 1;18(11):3090-9.

Title: Corazao-Rozas P, et al. Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors. Oncotarget. 2016 Feb 29. doi: 10.18632/oncotarget.7790.

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SDS
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Tags:1369665-02-0 Molecular Formula|1369665-02-0 MDL|1369665-02-0 SMILES|1369665-02-0 Cobimetinib fumarate - Bio-X