Home Amines 138-37-4
138-37-4,MFCD00013005
Catalog No.:AA003K2Y

138-37-4 | 4-Aminomethylbenzenesulfonamide, HCl

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003K2Y
Chemical Name:
4-Aminomethylbenzenesulfonamide, HCl
CAS Number:
138-37-4
Molecular Formula:
C7H11ClN2O2S
Molecular Weight:
222.6924
MDL Number:
MFCD00013005
SMILES:
NCc1ccc(cc1)S(=O)(=O)N.Cl
Properties
Properties
 
Form:
Solid  
MP:
261-263 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
224  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  

Downstream Synthesis Route
129363-88-8    138-37-4   
1-(4-sulfamoyl-benzyl)-pyrrole-2,5-dicarboxylicaciddiethylester 

[1]JustusLiebigsAnnalenderChemie,1951,vol.571,p.44,55

[1]Pharmazie,1971,vol.26,p.469-473

138-37-4    23926-60-5   
L-2-Acetylamino-2-carbethoxyethan-N-homosulfanilylamidosulfonamid 

[1]Pharmazie,1971,vol.26,p.469-473

[1]JournalofMedicinalChemistry,1993,vol.36,p.126-133

138-37-4   
sodium3,5-bis(bis((ethoxycarbonyl)methyl)aminomethyl)benzoate 
  662165-89-1 

[1]ChemicalCommunications,2003,p.2328-2329

Literature

Title: Silver debate continue.

Journal: Journal of wound care 20110601

Title: Comparison between topical honey and mafenide acetate in treatment of auricular burn.

Journal: American journal of otolaryngology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant?

Journal: Burns : journal of the International Society for Burn Injuries 20100201

Title: The diversity of wound presentation associated with freon contact frostbite injury.

Journal: Journal of burn care & research : official publication of the American Burn Association 20100101

Title: Understanding and managing burn pain: Part 2.

Journal: The American journal of nursing 20090501

Title: Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG).

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20090401

Title: Comparison of therapeutic antibiotic treatments on tissue-engineered human skin substitutes.

Journal: Tissue engineering. Part A 20080501

Title: Effects of commonly used topical antimicrobial agents on Acinetobacter baumannii: an in vitro study.

Journal: Military medicine 20080101

Title: Allergic contact dermatitis to mafenide acetate: a case series and review of the literature.

Journal: Journal of drugs in dermatology : JDD 20070801

Title: Comparative evaluation of silver-containing antimicrobial dressings and drugs.

Journal: International wound journal 20070601

Title: Management of bioburden with a burn gel that targets nociceptors.

Journal: Journal of wound care 20070401

Title: Seven years' experience with Integra as a reconstructive tool.

Journal: Journal of burn care & research : official publication of the American Burn Association 20070101

Title: Controlling methicillin resistant Staphyloccocus aureus and Pseudomonas aeruginosa wound infections with a novel biomaterial.

Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20070101

Title: Managing extracavitary prosthetic vascular graft infections: a pathway to success.

Journal: Annals of plastic surgery 20061201

Title: Vibrational analyses of sulfamoyl halides NH2SO2X (X is F, Cl and Br).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound.

Journal: Surgery 20060501

Title: Adjuvant dressing for negative pressure wound therapy in burns.

Journal: Ostomy/wound management 20060101

Title: Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism.

Journal: Pharmacological research 20051201

Title: Survival benefit conferred by topical antimicrobial preparations in burn patients: a historical perspective.

Journal: The Journal of trauma 20040401

Title: Comparative evaluation of topical antiseptic/antimicrobial treatment on aspects of wound repair in the porcine model.

Journal: Ostomy/wound management 20020901

Title: Using mafenide acetate in acute and chronic wounds.

Journal: Ostomy/wound management 20020901

Title: Dressings for burn injury in a military conflict--change of practice based on current evidence.

Journal: Journal of the Royal Army Medical Corps 20020901

Title: Mafenide acetate allergy presenting as recurrent chondritis.

Journal: Annals of plastic surgery 20020201

Title: Off-label drug use in WOC nursing: issues related to use of mafenide acetate to treat infected chronic wounds.

Journal: Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 20010901

Title: An in vivo comparison of topical agents on wound repair.

Journal: Plastic and reconstructive surgery 20010901

Title: The use of 5% mafenide acetate solution in the postgraft treatment of necrotizing fasciitis.

Journal: The Journal of burn care & rehabilitation 20010101

Title: Does the addition of nystatin to 5% mafenide acetate and genitourinary irrigant solutions interfere with their antimicrobial activity? Assessment by two topical antimicrobial test assay systems.

Journal: The Journal of burn care & rehabilitation 20010101

Title: Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue.

Journal: Prehospital and disaster medicine 20010101

Title: Ashkan Afshari, et al. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39(5):736-738.

Title: Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324.

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