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Home Other Heterocycles 138401-24-8
138401-24-8,MFCD06658242
Catalog No.:AA0018NI

138401-24-8 | 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]biphenyl-2-carbonitrile

Pack Size
Purity
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Price(USD)
Quantity
  
100mg
98%(HPLC)
in stock  
$39.00   $27.00
- +
1g
98%(HPLC)
in stock  
$108.00   $76.00
- +
5g
>97.0%(N)
in stock  
$309.00   $216.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0018NI
Chemical Name:
4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]biphenyl-2-carbonitrile
CAS Number:
138401-24-8
Molecular Formula:
C25H27N3O
Molecular Weight:
385.5014
MDL Number:
MFCD06658242
SMILES:
CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1C#N)CCCC2
Properties
Computed Properties
 
Complexity:
661  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
4.7  

Downstream Synthesis Route

[1]AdvancedSynthesisandCatalysis,2010,vol.352,p.3255-3266

[2]Patent:WO2008/107799,2008,A2.Locationinpatent:Page/Pagecolumn8

[3]JournalofMedicinalChemistry,1993,vol.36,p.3371-3380

[4]Patent:WO2005/51943,2005,A1.Locationinpatent:Page/Pagecolumn7;8

[5]Patent:US2010/234614,2010,A1.Locationinpatent:Page/Pagecolumn3

[6]Patent:WO2007/13101,2007,A1.Locationinpatent:Page/Pagecolumn8

[7]Patent:WO2007/13101,2007,A1.Locationinpatent:Page/Pagecolumn9

[8]Patent:WO2007/13101,2007,A1.Locationinpatent:Page/Pagecolumn9

[9]Patent:WO2007/13101,2007,A1.Locationinpatent:Page/Pagecolumn8

[10]Patent:WO2007/13101,2007,A1.Locationinpatent:Page/Pagecolumn8

[1]Satyanarayana,Bollikonda;Sumalatha,Yasareni;Sridhar,Chaganti;Venkatraman,Sundaram;Reddy,PadiPratap[HeterocyclicCommunications,2006,vol.12,#5,p.323-328]

[2]CurrentPatentAssignee:ZHUHAIRUNDUPHARMACEUTICALCOLTD-CN108840860,2018,ALocationinpatent:Paragraph0026-0034

[3]Locationinpatent:experimentalpartKumar,ManianRajesh;Park,Kyungho;Lee,Sunwoo[AdvancedSynthesisandCatalysis,2010,vol.352,#18,p.3255-3266]

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2006/41147,2006,A1Locationinpatent:Page/Pagecolumn3;5

[5]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-WO2005/51943,2005,A1Locationinpatent:Page/Pagecolumn8;9;11

[6]CurrentPatentAssignee:ZHUHAIRUNDUPHARMACEUTICALCOLTD-CN109748905,2019,ALocationinpatent:Paragraph0099;0100;0101;0109

[7]CurrentPatentAssignee:PIRAMALENTERPRISESLIMITED-WO2013/171643,2013,A1Locationinpatent:Page/Pagecolumn9

[8]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2008/107799,2008,A2Locationinpatent:Page/Pagecolumn8-10

[9]CurrentPatentAssignee:ALEMBICLTD-US2007/99973,2007,A1Locationinpatent:Page/Pagecolumn12-13

[10]CurrentPatentAssignee:ALEMBICLTD-WO2007/49293,2007,A1Locationinpatent:Page/Pagecolumn20-21;22;23

[11]CurrentPatentAssignee:CADILAPHARMACEUTICALSLIMITED-EP1918288,2008,A1Locationinpatent:Page/Pagecolumn3-4

[12]Ye,Ping;Sargent,Katie;Stewart,Ethan;Liu,Ji-Feng;Yohannes,Daniel;Yu,Libing[JournalofOrganicChemistry,2006,vol.71,#8,p.3137-3140]

[13]Bernhart,ClaudeA.;Perreaut,PierreM.;Ferrari,BernardP.;Muneaux,YvetteA.;Assens,Jean-LouisA.;etal.[JournalofMedicinalChemistry,1993,vol.36,#22,p.3371-3380]

[14]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-WO2007/122508,2007,A2Locationinpatent:Page/Pagecolumn18-19

[15]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-WO2005/51929,2005,A1Locationinpatent:Page/Pagecolumn17

[16]CurrentPatentAssignee:VIATRISINC-WO2007/20659,2007,A2Locationinpatent:Page/Pagecolumn5

[17]CurrentPatentAssignee:HETERODRUGSLIMITED-WO2009/72137,2009,A2Locationinpatent:Page/Pagecolumn9-10

[18]CurrentPatentAssignee:HETERODRUGSLIMITED-US2010/234614,2010,A1Locationinpatent:Page/Pagecolumn4

[19]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn9

[20]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn10

[21]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn10

[22]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn10

[23]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn11

[24]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn11

[25]CurrentPatentAssignee:JUBILANTPHARMOVALTD-WO2007/13101,2007,A1Locationinpatent:Page/Pagecolumn11

[26]CurrentPatentAssignee:DIVI'SLABORATORIESLIMITED-US2011/275828,2011,A1Locationinpatent:Page/Pagecolumn2

[27]CurrentPatentAssignee:LGCHEMCO.,LTD.-WO2012/148148,2012,A2Locationinpatent:Page/Pagecolumn13-14

[28]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-WO2007/122508,2007,A2Locationinpatent:Page/Pagecolumn3-4;20

[29]CurrentPatentAssignee:HETERODRUGSLIMITED-US2022/127238,2022,A1Locationinpatent:Paragraph0081-0084;0086-0090;0091-0095

(2'-cyano-biphenyl-4-ylmethyl)-carbamicacidtert-butylester 
  60421-23-0    109-52-4    138401-24-8 

[1]JournalofOrganicChemistry,2006,vol.71,p.3137-3140

[1]JournalofOrganicChemistry,2006,vol.71,p.3137-3140

[1]HeterocyclicCommunications,2006,vol.12,p.323-328

Literature

Title: Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.

Journal: Bioorganic & medicinal chemistry 20071201

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Tags:138401-24-8 Molecular Formula|138401-24-8 MDL|138401-24-8 SMILES|138401-24-8 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]biphenyl-2-carbonitrile