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139110-80-8,MFCD03791324
Catalog No.:AA001A8N

139110-80-8 | Zanamivir

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Purity
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1mg
98%
in stock  
$8.00   $6.00
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5mg
98%
in stock  
$19.00   $14.00
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25mg
98%(HPLC)
in stock  
$59.00   $42.00
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100mg
98%(HPLC)
in stock  
$145.00   $102.00
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250mg
98%
in stock  
$193.00   $135.00
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1g
95%
in stock  
$594.00   $416.00
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5g
95%
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$2,007.00   $1,405.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001A8N
Chemical Name:
Zanamivir
CAS Number:
139110-80-8
Molecular Formula:
C12H20N4O7
Molecular Weight:
332.3098
MDL Number:
MFCD03791324
SMILES:
NN=CN[C@H]1C=C(O[C@H]([C@@H]1NC(=O)C)[C@@H]([C@@H](CO)O)O)C(=O)O
Properties
Computed Properties
 
Complexity:
518  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
6  
XLogP3:
-3.2  

Downstream Synthesis Route
1184-90-3   
sodium5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonate 
  139110-80-8 

[1]CarbohydrateResearch,1994,vol.259,p.301-305

[1]JournaloftheChemicalSociety.PerkintransactionsI,1995,p.1173-1180

[1]JournaloftheChemicalSociety.PerkintransactionsI,1995,p.1173-1180

139110-80-8   
5-acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-L-arabino-hept-2-enonicacid 

[1]JournaloftheChemicalSociety.PerkintransactionsI,1995,p.1181-1188

[1]Patent:WO2010/61182,2010,A2.Locationinpatent:Page/Pagecolumn15

[2]Patent:US2011/257418,2011,A1.Locationinpatent:Page/Pagecolumn8

[3]JournaloftheChemicalSociety.PerkintransactionsI,1995,p.1173-1180

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Title: Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza.

Journal: Expert review of anti-infective therapy 20111001

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Journal: PLoS pathogens 20111001

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Journal: PLoS pathogens 20111001

Title: In vitro selection of influenza B viruses with reduced sensitivity to neuraminidase inhibitors.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110901

Title: Online monitoring of flu in Belgium.

Journal: Influenza and other respiratory viruses 20110901

Title: Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection.

Journal: The Journal of infectious diseases 20110901

Title: Estimating effect of antiviral drug use during pandemic (H1N1) 2009 outbreak, United States.

Journal: Emerging infectious diseases 20110901

Title: Increased extent of and risk factors for pandemic (H1N1) 2009 and seasonal influenza among children, Israel.

Journal: Emerging infectious diseases 20110901

Title: Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets.

Journal: PLoS pathogens 20110901

Title: Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry.

Journal: Analytica chimica acta 20110826

Title: Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo.

Journal: PLoS currents 20110807

Title: Comparison of the efficacies of amantadine treatment of swine-origin influenza virus A H1N1 and seasonal influenza H1N1 and H3N2 in Japan (2008-2009).

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110801

Title: Assessing the ecotoxicologic hazards of a pandemic influenza medical response.

Journal: Environmental health perspectives 20110801

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Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110801

Title: Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients.

Journal: Haematologica 20110801

Title: Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child.

Journal: Emerging infectious diseases 20110801

Title: Influenza vaccination, diagnosis, and treatment in children.

Journal: Pediatric emergency care 20110801

Title: Influenza: epidemiology, clinical features, therapy, and prevention.

Journal: Seminars in respiratory and critical care medicine 20110801

Title: First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea.

Journal: Chonnam medical journal 20110801

Title: Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies.

Journal: Vaccine 20110722

Title: Use of intravenous neuraminidase inhibitors during the 2009 pandemic: results from population-based surveillance.

Journal: JAMA 20110713

Title: Neuraminidase inhibitor R-125489--a promising drug for treating influenza virus: steered molecular dynamics approach.

Journal: Biochemical and biophysical research communications 20110708

Title: Characterization and in vitro evaluation of intestinal absorption of liposomes encapsulating zanamivir.

Journal: Current drug delivery 20110701

Title: Failure of combination oral oseltamivir and inhaled zanamivir antiviral treatment in ventilator- and ECMO-treated critically ill patients with pandemic influenza A (H1N1)v.

Journal: Scandinavian journal of infectious diseases 20110701

Title: Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A.

Journal: Respiratory care 20110701

Title: Computational analysis and modeling the effectiveness of 'Zanamivir' targeting neuraminidase protein in pandemic H1N1 strains.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20110701

Title: Mixed influenza A and B infections complicate the detection of influenza viruses with altered sensitivities to neuraminidase inhibitors.

Journal: Antiviral research 20110701

Title: Rapid discrimination of oseltamivir-resistant 275Y and -susceptible 275H substitutions in the neuraminidase gene of pandemic influenza A/H1N1 2009 virus by duplex one-step RT-PCR assay.

Journal: Journal of medical virology 20110701

Title: Intravenous zanamivir in critically ill patients due to pandemic 2009 (H1N1) influenza A virus.

Journal: Singapore medical journal 20110701

Title: Structural basis for Streptococcus pneumoniae NanA inhibition by influenza antivirals zanamivir and oseltamivir carboxylate.

Journal: Journal of molecular biology 20110617

Title: Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20110609

Title: Comparison of the clinical symptoms and the effectiveness of neuraminidase inhibitors for patients with pandemic influenza H1N1 2009 or seasonal H1N1 influenza in the 2007-2008 and 2008-2009 seasons.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110601

Title: Safety of influenza immunizations and treatment during pregnancy: the Vaccines and Medications in Pregnancy Surveillance System.

Journal: American journal of obstetrics and gynecology 20110601

Title: Evaluation of the antiviral drug susceptibility of influenza viruses in Italy from 2004/05 to 2009/10 epidemics and from the recent 2009 pandemic.

Journal: Antiviral research 20110601

Title: Outcome of pandemic H1N1 pneumonia: clinical and radiological findings for severity assessment.

Journal: The Korean journal of internal medicine 20110601

Title: Follow-up after acute respiratory distress syndrome caused by influenza a (H1N1) virus infection.

Journal: Clinics (Sao Paulo, Brazil) 20110601

Title: Pandemic Influenza A (H1N1): knowledge among senior health workers at a secondary health care institution in Southwest, Nigeria.

Journal: African health sciences 20110601

Title: [Influenza A, pregnancy and neuraminidase inhibitors].

Journal: Medicina clinica 20110528

Title: Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity.

Journal: Thorax 20110501

Title: Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes.

Journal: Bioorganic & medicinal chemistry 20110501

Title: Combinations of protein-chemical complex structures reveal new targets for established drugs.

Journal: PLoS computational biology 20110501

Title: [A case of corpus callosum splenium encephalopathy and 2009 influenza A/H1N1].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20110501

Title: Shortening ventilatory support with a protocol based on daily extubation screening and noninvasive ventilation in selected patients.

Journal: Clinics (Sao Paulo, Brazil) 20110501

Title: Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization.

Journal: Annals of biomedical engineering 20110401

Title: A prediction rule to identify severe cases among adult patients hospitalized with pandemic influenza A (H1N1) 2009.

Journal: Journal of Korean medical science 20110401

Title: H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients.

Journal: Emerging infectious diseases 20110401

Title: Influenza neuraminidase-inhibiting antibodies are induced in the presence of zanamivir.

Journal: Vaccine 20110321

Title: Clinical experience in adults and children treated with intravenous peramivir for 2009 influenza A (H1N1) under an Emergency IND program in the United States.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110315

Title: Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus.

Journal: Journal of pharmaceutical sciences 20110301

Title: Feasibility of diagnosing influenza within 24 hours of symptom onset in children 1-3 years of age.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110301

Title: Peri-operative novel 2009 H1N1 influenza virus infection successfully treated with oseltamivir and zanamivir in a lung transplant recipient.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110301

Title: Antivirals in treatment of H1N1 infection: are they really effective?

Journal: European journal of pediatrics 20110301

Title: Neuraminidase-inhibitor resistance testing for pandemic influenza A (H1N1) 2009 in Ontario, Canada.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110301

Title: Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus, Japan, 2009-2010.

Journal: Emerging infectious diseases 20110301

Title: Prophylaxis and therapy of viral infections in pediatric patients treated for malignancy.

Journal: Pediatric reports 20110224

Title: Resistance to neuraminidase inhibitors.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110215

Title: Frequency of drug-resistant viruses and virus shedding in pediatric influenza patients treated with neuraminidase inhibitors.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110215

Title: Assessment of the effects of renal impairment on the pharmacokinetic profile of laninamivir, a novel neuraminidase inhibitor, after a single inhaled dose of its Prodrug, CS-8958.

Journal: Journal of clinical pharmacology 20110201

Title: Successful salvage therapy with inhaled zanamivir in a patient with peramivir-resistant pandemic influenza A (H1N1) 2009 virus.

Journal: Scandinavian journal of infectious diseases 20110201

Title: Resistance and virulence mutations in patients with persistent infection by pandemic 2009 A/H1N1 influenza.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110201

Title: Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110201

Title: Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States.

Journal: Emerging infectious diseases 20110201

Title: Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico.

Journal: Emerging infectious diseases 20110201

Title: [Favorable outcome of acute respiratory failure caused by H1N1 virus infection in critical patients].

Journal: Revista espanola de anestesiologia y reanimacion 20110201

Title: Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP).

Journal: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 20110121

Title: Molecular modeling of swine influenza A/H1N1, Spanish H1N1, and avian H5N1 flu N1 neuraminidases bound to Tamiflu and Relenza.

Journal: PLoS currents 20110103

Title: Top-hits for H1N1pdm Identified by Virtual Screening Using Ensemble-based Docking.

Journal: PLoS currents 20110103

Title: Novel swine--origin influenza A: the 2009 H1N1 influenza virus.

Journal: Indian journal of pediatrics 20110101

Title: Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review.

Journal: The Journal of infection 20110101

Title: Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Genotypic and phenotypic resistance of pandemic A/H1N1 influenza viruses circulating in Germany.

Journal: Antiviral research 20110101

Title: Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit.

Journal: The Journal of infectious diseases 20110101

Title: Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors.

Journal: The Journal of infectious diseases 20110101

Title: Intensive care unit admission for pandemic (H1N1) 2009, Reunion Island, 2009.

Journal: Emerging infectious diseases 20110101

Title: The nonadaptive nature of the H1N1 2009 Swine Flu pandemic contrasts with the adaptive facilitation of transmission to a new host.

Journal: BMC evolutionary biology 20110101

Title: Fatal cases of 2009 pandemic influenza A (H1N1) in Korea.

Journal: Journal of Korean medical science 20110101

Title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center.

Journal: BMC pulmonary medicine 20110101

Title: Identification of critical residues of influenza neuraminidase in viral particle release.

Journal: Virology journal 20110101

Title: Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009.

Journal: PloS one 20110101

Title: Quantification of the anti-influenza drug zanamivir in plasma using high-throughput HILIC-MS/MS.

Journal: Bioanalysis 20110101

Title: Detection of resistance mutations to antivirals oseltamivir and zanamivir in avian influenza A viruses isolated from wild birds.

Journal: PloS one 20110101

Title: Optimizing tactics for use of the U.S. antiviral strategic national stockpile for pandemic influenza.

Journal: PloS one 20110101

Title: The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses.

Journal: PloS one 20110101

Title: We should not be complacent about our population-based public health response to the first influenza pandemic of the 21st century.

Journal: BMC public health 20110101

Title: Swine-origin influenza a outbreak 2009 at Shinshu University, Japan.

Journal: BMC public health 20110101

Title: A generic system for the expression and purification of soluble and stable influenza neuraminidase.

Journal: PloS one 20110101

Title: Diagnosis and antiviral intervention strategies for mitigating an influenza epidemic.

Journal: PloS one 20110101

Title: Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.

Journal: PloS one 20110101

Title: Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.

Journal: Critical care (London, England) 20110101

Title: Emergence and genetic variation of neuraminidase stalk deletions in avian influenza viruses.

Journal: PloS one 20110101

Title: A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial.

Journal: Trials 20110101

Title: The impact of pandemic influenza H1N1 on health-related quality of life: a prospective population-based study.

Journal: PloS one 20110101

Title: [Effect of Zanamivir substance on infection induced by highly pathogenic avian influenza A/H5N1 in cell cultures].

Journal: Voprosy virusologii 20110101

Title: [Information of the Center for Ecology and Epidemiology of Influenza, D. I. Ivanovsky Research Institute of Virology, Russian Academy of Medical Sciences, on the results of the 2009-2010 influenza and acute respiratory viral infection epidemic season (at week 40 of 2009 to week 22 of 2010) in the world and Russia].

Journal: Voprosy virusologii 20110101

Title: Comparative evaluation of acute respiratory distress syndrome in patients with and without H1N1 infection at a tertiary care referral center.

Journal: Indian journal of anaesthesia 20110101

Title: Hospitalised patients with suspected 2009 H1N1 influenza A in a hospital in Norway, July - December 2009.

Journal: BMC infectious diseases 20110101

Title: Assessing the in vitro fitness of an oseltamivir-resistant seasonal A/H1N1 influenza strain using a mathematical model.

Journal: PloS one 20110101

Title: Can antiviral drugs contain pandemic influenza transmission?

Journal: PloS one 20110101

Title: Reassortment and mutations associated with emergence and spread of oseltamivir-resistant seasonal influenza A/H1N1 viruses in 2005-2009.

Journal: PloS one 20110101

Title: Assessing secondary attack rates among household contacts at the beginning of the influenza A (H1N1) pandemic in Ontario, Canada, April-June 2009: a prospective, observational study.

Journal: BMC public health 20110101

Title: Profiling the chlorogenic acids of Rudbeckia hirta, Helianthus tuberosus, Carlina acaulis and Symphyotrichum novae-angliae leaves by LC-MS(n).

Journal: Phytochemical analysis : PCA 20110101

Title: Defective interfering virus protects elderly mice from influenza.

Journal: Virology journal 20110101

Title: Predictors of the uptake of A (H1N1) influenza vaccine: findings from a population-based longitudinal study in Tokyo.

Journal: PloS one 20110101

Title: The use of Twitter to track levels of disease activity and public concern in the U.S. during the influenza A H1N1 pandemic.

Journal: PloS one 20110101

Title: Systematic review of influenza resistance to the neuraminidase inhibitors.

Journal: BMC infectious diseases 20110101

Title: Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.

Journal: PloS one 20110101

Title: Duration of viral shedding in hospitalized patients infected with pandemic H1N1.

Journal: BMC infectious diseases 20110101

Title: Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression.

Journal: PloS one 20110101

Title: Phylogenetic analysis of an off-seasonal influenza virus A (H3N2) in Niigata, Japan, 2010.

Journal: Japanese journal of infectious diseases 20110101

Title: Clinico-epidemiological features of the hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in Saurashtra region, India (September, 2009 to February, 2010).

Journal: Lung India : official organ of Indian Chest Society 20110101

Title: An insight into the swine-influenza A (H1N1) virus infection in humans.

Journal: Lung India : official organ of Indian Chest Society 20110101

Title: Household transmission of influenza (H1N1-2009) in Japan: age-specificity and reduction of household transmission risk by zanamivir treatment.

Journal: The Journal of international medical research 20110101

Title: Long-term respiratory follow-up of H1N1 infection.

Journal: Virology journal 20110101

Title: Adverse drug reaction profile of oseltamivir in Indian population: A prospective observational study.

Journal: Indian journal of pharmacology 20110101

Title: Avian influenza viruses infect primary human bronchial epithelial cells unconstrained by sialic acid α2,3 residues.

Journal: PloS one 20110101

Title: Rapid detection of the H275Y oseltamivir resistance mutation in influenza A/H1N1 2009 by single base pair RT-PCR and high-resolution melting.

Journal: PloS one 20110101

Title: Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literature.

Journal: Journal of medical case reports 20110101

Title: New respiratory viruses and the elderly.

Journal: The open respiratory medicine journal 20110101

Title: Analysis of CDC social control measures using an agent-based simulation of an influenza epidemic in a city.

Journal: BMC infectious diseases 20110101

Title: Adverse drug reaction profile of oseltamivir in children.

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: [Etiotropic therapy of influenza: lessons from the last pandemic].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20110101

Title: Influenza-associated monophasic neuromyelitis optica.

Journal: Internal medicine (Tokyo, Japan) 20110101

Title: Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells.

Journal: Virology journal 20110101

Title: Selection of predicted siRNA as potential antiviral therapeutic agent against influenza virus.

Journal: Bioinformation 20110101

Title: Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza.

Journal: PloS one 20110101

Title: Pregnancy and virologic response to antiretroviral therapy in South Africa.

Journal: PloS one 20110101

Title: Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example.

Journal: Virology journal 20110101

Title: Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus.

Journal: Virology journal 20110101

Title: Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses.

Journal: PloS one 20110101

Title: Molecular basis of NDM-1, a new antibiotic resistance determinant.

Journal: PloS one 20110101

Title: A molecular and antigenic survey of H5N1 highly pathogenic avian influenza virus isolates from smallholder duck farms in Central Java, Indonesia during 2007-2008.

Journal: Virology journal 20110101

Title: Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards.

Journal: PloS one 20110101

Title: Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro.

Journal: PloS one 20110101

Title: Evaluation of Cynanchum otophyllum glucan sulfate against human immunodeficiency virus and herpes simplex virus as a microbicide agent.

Journal: Indian journal of pharmacology 20110101

Title: Incidence of influenza in healthy adults and healthcare workers: a systematic review and meta-analysis.

Journal: PloS one 20110101

Title: Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37.

Journal: PloS one 20110101

Title: Application of different chemometric tools in QSAR study of azolo-adamantanes against influenza A virus.

Journal: Research in pharmaceutical sciences 20110101

Title: The feasibility of age-specific travel restrictions during influenza pandemics.

Journal: Theoretical biology & medical modelling 20110101

Title: Rapid and specific influenza virus detection by functionalized magnetic nanoparticles and mass spectrometry.

Journal: Journal of nanobiotechnology 20110101

Title: Novel inhibitor design for hemagglutinin against H1N1 influenza virus by core hopping method.

Journal: PloS one 20110101

Title: Synthesis of an antiviral drug precursor from chitin using a saprophyte as a whole-cell catalyst.

Journal: Microbial cell factories 20110101

Title: Oseltamivir and early deterioration leading to death: a proportional mortality study for 2009A/H1N1 influenza.

Journal: The International journal of risk & safety in medicine 20110101

Title: Structural position correlation analysis (SPCA) for protein family.

Journal: PloS one 20110101

Title: Oseltamivir prescription and regulatory actions vis-à-vis abnormal behavior risk in Japan: drug utilization study using a nationwide pharmacy database.

Journal: PloS one 20110101

Title: Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.

Journal: PloS one 20110101

Title: Potent neutralization of influenza A virus by a single-domain antibody blocking M2 ion channel protein.

Journal: PloS one 20110101

Title: Anti-influenza virus effect of aqueous extracts from dandelion.

Journal: Virology journal 20110101

Title: [A prognostic model of the effect of the antiviral drug Relenza on the epidemic of A(H1N1)/2009 influenza].

Journal: Voprosy virusologii 20110101

Title: Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin.

Journal: PloS one 20110101

Title: Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A virus.

Journal: PloS one 20110101

Title: Influenza A(H1N1) Oseltamivir Resistant Viruses in the Netherlands During the Winter 2007/2008.

Journal: The open virology journal 20110101

Title: Bioactive constituents and medicinal importance of genus Alnus.

Journal: Pharmacognosy reviews 20110101

Title: Perspective: emerging challenges in the treatment of influenza and parainfluenza in transplant patients.

Journal: Advances in virology 20110101

Title: Acute encephalopathy in childhood associated with novel influenza a h1n1 virus infection: clinical and neuroimaging findings.

Journal: The Ulster medical journal 20110101

Title: One-pot bio-synthesis: N-acetyl-D-neuraminic acid production by a powerful engineered whole-cell catalyst.

Journal: Scientific reports 20110101

Title: Persistent oseltamivir-resistant pandemic influenza A/H1N1 infection in an adult with cystic fibrosis.

Journal: BMJ case reports 20110101

Title: A Validated HPLC Method for Zanamivir and its Application to In vitro Permeability Study in Caco-2 Culture Model.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Top leads for swine influenza A/H1N1 virus revealed by steered molecular dynamics approach.

Journal: Journal of chemical information and modeling 20101227

Title: Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity.

Journal: Journal of leukocyte biology 20101201

Title: Pandemic (H1N1) 2009 infection in patients with hematologic malignancy.

Journal: Emerging infectious diseases 20101201

Title: Oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korea.

Journal: Emerging infectious diseases 20101201

Title: Hong Kong's experience on the use of extracorporeal membrane oxygenation for the treatment of influenza A (H1N1).

Journal: Hong Kong medical journal = Xianggang yi xue za zhi 20101201

Title: Participatory epidemiology: use of mobile phones for community-based health reporting.

Journal: PLoS medicine 20101201

Title: The changing face of pediatric respiratory tract infections: how human metapneumovirus and human bocavirus fit into the overall etiology of respiratory tract infections in young children.

Journal: The Yale journal of biology and medicine 20101201

Title: [Case of novel influenza A (H1N1) pneumonia with shrinkage of a pulmonary lesion].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20101201

Title: Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Journal: Journal of molecular biology 20101119

Title: Coupling the Petasis condensation to an iron(III) chloride-promoted cascade provides a short synthesis of Relenza congeners.

Journal: Organic letters 20101119

Title: New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Long-acting neuraminidase inhibitor laninamivir octanoate versus oseltamivir for treatment of influenza: A double-blind, randomized, noninferiority clinical trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101115

Title: Surfactant therapy and intravenous zanamivir in severe respiratory failure due to persistent influenza A/H1N1 2009 virus infection.

Journal: American journal of respiratory and critical care medicine 20101115

Title: Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers.

Journal: Journal of clinical pharmacology 20101101

Title: Influenza antiviral prescribing practices during the 2007-08 and 2008-09 influenza seasons in the setting of increased resistance to oseltamivir among circulating influenza viruses.

Journal: Antiviral research 20101101

Title: Selection and viral load kinetics of an oseltamivir-resistant pandemic influenza A (H1N1) virus in an immunocompromised patient during treatment with neuraminidase inhibitors.

Journal: Diagnostic microbiology and infectious disease 20101101

Title: Pandemic (H1N1) 2009 and oseltamivir resistance in hematology/oncology patients.

Journal: Emerging infectious diseases 20101101

Title: Oseltamivir-resistant pandemic (H1N1) 2009 treated with nebulized zanamivir.

Journal: Emerging infectious diseases 20101101

Title: The persistence of influenza infection.

Journal: Emerging infectious diseases 20101101

Title: Efficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial.

Journal: PLoS medicine 20101101

Title: Prone position ventilation, recruitment maneuver and intravenous zanamivir in severe refractory hypoxemia caused by influenza A (H1N1).

Journal: Clinics (Sao Paulo, Brazil) 20101101

Title: Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles.

Journal: Journal of medicinal chemistry 20101028

Title: NNScore: a neural-network-based scoring function for the characterization of protein-ligand complexes.

Journal: Journal of chemical information and modeling 20101025

Title: Reduced effectiveness of oseltamivir in children infected with oseltamivir-resistant influenza A (H1N1) viruses with His275Tyr mutation.

Journal: The Pediatric infectious disease journal 20101001

Title: Influenza in the tropics.

Journal: Current opinion in infectious diseases 20101001

Title: Antivirals for influenza: strategies for use in pediatrics.

Journal: Paediatric drugs 20101001

Title: Pandemic (H1N1) 2009 and seasonal influenza A (H1N1) co-infection, New Zealand, 2009.

Journal: Emerging infectious diseases 20101001

Title: Reflections on pandemic (H1N1) 2009 and the international response.

Journal: PLoS medicine 20101001

Title: Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry.

Journal: PLoS pathogens 20101001

Title: [In vitro and in vivo effects of a long-acting anti-influenza agent CS-8958 (laninamivir octanoate, Inavir) against pandemic (H1N1) 2009 influenza viruses].

Journal: The Japanese journal of antibiotics 20101001

Title: Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective.

Journal: Viruses 20101001

Title: Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus.

Journal: The New England journal of medicine 20100930

Title: Influenza hemagglutinin and neuraminidase membrane glycoproteins.

Journal: The Journal of biological chemistry 20100910

Title: Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses.

Journal: Journal of medicinal chemistry 20100909

Title: Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model.

Journal: Antiviral research 20100901

Title: Comparison of pandemic (H1N1) 2009 and seasonal influenza, Western Australia, 2009.

Journal: Emerging infectious diseases 20100901

Title: Pandemic influenza A (H1N1) in pregnant women: impact of early diagnosis and antiviral treatment.

Journal: Expert review of anti-infective therapy 20100901

Title: [History of pandemic influenza in Japan].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: [Change of strategies for novel and seasonal flu during pregnancy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: [Current anti-influenza virus chemotherapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: [Present and future in development of new anti-influenza drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: [How have we understood and responded clinically to pandemic H1N1 2009?].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: [Influenza A/H1N1v 2009 during pregnancy and breastfeeding: which antiviral to choose?].

Journal: Annales pharmaceutiques francaises 20100901

Title: Treatment options for H5N1: lessons learned from the H1N1 pandemic.

Journal: Postgraduate medicine 20100901

Title: Molecular dynamics simulations suggest that electrostatic funnel directs binding of Tamiflu to influenza N1 neuraminidases.

Journal: PLoS computational biology 20100901

Title: [Influenza A H1N1v treated with extracorporeal membrane oxygenation].

Journal: Ugeskrift for laeger 20100823

Title: [Naturally occurring oseltamivir resistance in influenza A].

Journal: Ugeskrift for laeger 20100809

Title: Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir.

Journal: Molecular pharmaceutics 20100802

Title: Neuraminidase inhibitors for influenza treatment and prevention in healthy adults.

Journal: American family physician 20100801

Title: Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses.

Journal: PLoS pathogens 20100801

Title: Understanding the Influenza A H1N1 2009 Pandemic.

Journal: Sultan Qaboos University medical journal 20100801

Title: Combination chemotherapy for influenza.

Journal: Viruses 20100801

Title: Antiviral strategies for pandemic and seasonal influenza.

Journal: Viruses 20100801

Title: Drugs in development for influenza.

Journal: Drugs 20100730

Title: Severe H1N1 infection in a pediatric liver transplant recipient treated with intravenous zanamivir: efficiency and complications.

Journal: Transplantation 20100727

Title: A medicinal chemist's guide to molecular interactions.

Journal: Journal of medicinal chemistry 20100722

Title: [Impact of avian influenza virus H5N1 neuraminidase mutations on the activity of neuraminidase and the sensibility to neuraminidase inhibitors].

Journal: Zhonghua yi xue za zhi 20100720

Title: Antiviral drug susceptibilities of seasonal human influenza viruses in Lebanon, 2008-09 season.

Journal: Journal of medical virology 20100701

Title: Fatal respiratory events caused by zanamivir nebulization.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100701

Title: Biotechnological production and applications of N-acetyl-D-neuraminic acid: current state and perspectives.

Journal: Applied microbiology and biotechnology 20100701

Title: An unusual cause of fever in a neonate: influenza A (H1N1) virus pneumonia.

Journal: Pediatric pulmonology 20100701

Title: Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia.

Journal: Emerging infectious diseases 20100701

Title: Oseltamivir-resistant pandemic (H1N1) 2009 in patient with impaired immune system.

Journal: Emerging infectious diseases 20100701

Title: Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets.

Journal: PLoS pathogens 20100701

Title: Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets.

Journal: PLoS pathogens 20100701

Title: siRNA for Influenza Therapy.

Journal: Viruses 20100701

Title: In silico identification of the potential drug resistance sites over 2009 influenza A (H1N1) virus neuraminidase.

Journal: Molecular pharmaceutics 20100607

Title: Treatment of severe cases of pandemic (H1N1) 2009 influenza: review of antivirals and adjuvant therapy.

Journal: Recent patents on anti-infective drug discovery 20100601

Title: Targeting pandemic influenza: a primer on influenza antivirals and drug resistance.

Journal: The Journal of antimicrobial chemotherapy 20100601

Title: Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100601

Title: Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.

Journal: Bioorganic & medicinal chemistry 20100601

Title: Reversible splenial lesion associated with novel influenza A (H1N1) viral infection.

Journal: Pediatric neurology 20100601

Title: Oseltamivir-resistant influenza viruses A (H1N1) during 2007-2009 influenza seasons, Japan.

Journal: Emerging infectious diseases 20100601

Title: Peramivir and its use in H1N1 influenza.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100601

Title: Influenza A(H1N1) outbreak in a long-term care facility for severely handicapped residents, Slovenia, March-April 2009.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20100527

Title: Oseltamivir-induced resistant pandemic A/H1N1 influenza virus in a child with cystic fibrosis and Pseudomonas aeruginosa infection.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100501

Title: Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host.

Journal: The Journal of infectious diseases 20100501

Title: Intravenous zanamivir for patients with pneumonitis due to pandemic (H1N1) 2009 influenza virus.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100501

Title: Influenza outbreaks during World Youth Day 2008 mass gathering.

Journal: Emerging infectious diseases 20100501

Title: Possible transmission of pandemic (HIN1) 2009 virus with oseltamivir resistance.

Journal: Emerging infectious diseases 20100501

Title: Early pandemic influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: a clinical virological and epidemiological analysis.

Journal: PLoS medicine 20100501

Title: Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets.

Journal: PLoS pathogens 20100501

Title: Influenza: a virus of our times.

Journal: The Ulster medical journal 20100501

Title: Complexity in influenza virus targeted drug design: interaction with human sialidases.

Journal: Journal of medicinal chemistry 20100408

Title: The use of antiviral agents for the management of severe influenza.

Journal: Critical care medicine 20100401

Title: Clinical management of pandemic 2009 influenza A(H1N1) infection.

Journal: Chest 20100401

Title: Influenza A/H1N1 (2009) infection in pregnancy--an Asian perspective.

Journal: BJOG : an international journal of obstetrics and gynaecology 20100401

Title: Oseltamivir in seasonal influenza: cumulative experience in low- and high-risk patients.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: Oseltamivir in human avian influenza infection.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: Foreword: Oseltamivir for seasonal, avian and pandemic influenza: 10 years of clinical experience.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: Responding to pandemic (H1N1) 2009 influenza: the role of oseltamivir.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: A close-up view of flu.

Journal: The Nurse practitioner 20100401

Title: [Role of neuraminidase inhibitors for the treatment of influenza A virus infections].

Journal: Pathologie-biologie 20100401

Title: Household transmission of pandemic (H1N1) 2009, San Antonio, Texas, USA, April-May 2009.

Journal: Emerging infectious diseases 20100401

Title: Rapid emergence of oseltamivir resistance.

Journal: Emerging infectious diseases 20100401

Title: Safety and immunogenicity of influenza A H1N1 vaccines.

Journal: Expert review of vaccines 20100401

Title: Laboratory capacity building in Asia for infectious disease research: experiences from the South East Asia Infectious Disease Clinical Research Network (SEAICRN).

Journal: PLoS medicine 20100401

Title: Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: Cancer screening and preventative care among long-term cancer survivors in the United Kingdom.

Journal: British journal of cancer 20100330

Title: Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.

Journal: The Cochrane database of systematic reviews 20100317

Title: An efficient method for N-acetyl-D-neuraminic acid production using coupled bacterial cells with a safe temperature-induced system.

Journal: Applied microbiology and biotechnology 20100301

Title: Homology modeling, docking, and molecular dynamics reveal HR1039 as a potent inhibitor of 2009 A(H1N1) influenza neuraminidase.

Journal: Biophysical chemistry 20100301

Title: Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100301

Title: Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100301

Title: Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs.

Journal: Emerging infectious diseases 20100301

Title: Neurologic manifestations of pandemic (H1N1) 2009 virus infection.

Journal: Emerging infectious diseases 20100301

Title: [Influenza A (H1N1): clinical manifestations and prophylactic and therapeutic indications].

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Title: [Clinical review of 1,017 influenza A cases between weeks 30 and 35 weeks in 2009].

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Title: [Research progress of anti-influenza virus agents].

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Title: Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

Journal: Journal of medicinal chemistry 20100225

Title: Neuraminidase inhibitors for preventing and treating influenza in healthy adults.

Journal: The Cochrane database of systematic reviews 20100217

Title: Fatal respiratory events caused by zanamivir nebulization.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100215

Title: Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing.

Journal: Antiviral research 20100201

Title: Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses.

Journal: Antiviral research 20100201

Title: Bifunctional polymeric inhibitors of human influenza A viruses.

Journal: Pharmaceutical research 20100201

Title: Anti-influenza diarylheptanoids from the bark of Alnus japonica.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Administration of neuraminidase inhibitors for the treatment of Japanese patients infected with the novel influenza A (H1N1).

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20100201

Title: Oseltamivir-resistant pandemic (H1N1) 2009 influenza in a severely ill patient: the first Australian case.

Journal: The Medical journal of Australia 20100201

Title: Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses.

Journal: PLoS pathogens 20100201

Title: Glycosidase inhibition: assessing mimicry of the transition state.

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Title: Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza.

Journal: The New England journal of medicine 20100107

Title: Successful applications of computer aided drug discovery: moving drugs from concept to the clinic.

Journal: Current topics in medicinal chemistry 20100101

Title: H1N1 influenza in pregnancy: cause for concern.

Journal: Obstetrics and gynecology 20100101

Title: Oseltamivir- and amantadine-resistant influenza virus A (H1N1).

Journal: Emerging infectious diseases 20100101

Title: Pandemic (H1N1) 2009 reinfection, Chile.

Journal: Emerging infectious diseases 20100101

Title: Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan.

Journal: Environmental health perspectives 20100101

Title: The truth about Tamiflu? Zanamivir should be inhaled, not nebulised.

Journal: BMJ (Clinical research ed.) 20100101

Title: The first influenza pandemic of the 21st century.

Journal: Annals of Saudi medicine 20100101

Title: Tamiflu: what dermatologists need to know.

Journal: Journal of drugs in dermatology : JDD 20100101

Title: Antiviral prescriptions to U.S. ambulatory care visits with a diagnosis of influenza before and after high level of adamantane resistance 2005-06 season.

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Title: Single assay for simultaneous detection and differential identification of human and avian influenza virus types, subtypes, and emergent variants.

Journal: PloS one 20100101

Title: New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.

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Title: Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase.

Journal: BMC structural biology 20100101

Title: Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity.

Journal: Journal of biomedical science 20100101

Title: Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.

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Title: Selection for resistance to oseltamivir in seasonal and pandemic H1N1 influenza and widespread co-circulation of the lineages.

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Title: Avian influenza--a review for doctors in travel medicine.

Journal: Travel medicine and infectious disease 20100101

Title: A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir.

Journal: Virology journal 20100101

Title: Circulation of human influenza viruses and emergence of Oseltamivir-resistant A(H1N1) viruses in Cameroon, Central Africa.

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Title: Genomic signature and mutation trend analysis of pandemic (H1N1) 2009 influenza A virus.

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Title: Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India.

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Title: Behavioural intentions in response to an influenza pandemic.

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Title: Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice.

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Title: Current advances in anti-influenza therapy.

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Title: Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications.

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Title: [Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient].

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Title: 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.

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Title: Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support.

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Title: Co-lethality studied as an asset against viral drug escape: the HIV protease case.

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Title: To test or to treat? An analysis of influenza testing and antiviral treatment strategies using economic computer modeling.

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Title: OpenFluDB, a database for human and animal influenza virus.

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Title: Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009.

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Title: Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing.

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Title: Molecular characteristics of the human pandemic influenza A virus (H1N1).

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Title: Neuraminidase inhibitors for influenza in healthy adults: what we don't know.

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Title: In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide.

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Title: ETM-ANN approach application for thiobenzamide and quinolizidine derivatives.

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Title: Issues in pharmacotherapy of 2009 H1N1 influenza infection.

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Title: Q&A: H1N1 pandemic influenza--what's new?

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Title: N-acetylglucosamine: production and applications.

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Title: Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in Indian patients.

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Title: French experience of 2009 A/H1N1v influenza in pregnant women.

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Title: Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in an university hospital of Morocco.

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Title: Prevention and treatment of influenza with hyperimmune bovine colostrum antibody.

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Title: Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.

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Title: In vitro inhibitory activity of Alpinia katsumadai extracts against influenza virus infection and hemagglutination.

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Title: Avian influenza A (H9N2): computational molecular analysis and phylogenetic characterization of viral surface proteins isolated between 1997 and 2009 from the human population.

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Title: Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.

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Title: Laninamivir and its prodrug, CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza.

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Title: Exploring cell tropism as a possible contributor to influenza infection severity.

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Title: Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro.

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Title: The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication.

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Title: H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis.

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Title: Iota-carrageenan is a potent inhibitor of influenza A virus infection.

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Title: Influenza pandemic waves under various mitigation strategies with 2009 H1N1 as a case study.

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Title: Prone Positioning and Intravenous Zanamivir may Represent Effective Alternatives for Patients with Severe ARDS Virus A (H1N1) Related Pneumonia in Hospitals with no Access to ECMO.

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Title: Correlates of severe disease in patients admitted with 2009 pandemic influenza A (H1N1) infection in Saurashtra region, India.

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Title: Strategies for the use of oseltamivir and zanamivir during pandemic outbreaks.

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Title: Encephalitis in a child with H1N1 infection: First case report from India.

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Title: Adamantane resistance in seasonal human influenza A viruses from Calgary, Alberta (January 2007 to August 2008).

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Title: Zanamivir for the treatment of avian influenza infections in humans.

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Title: Effects of (L)-cystine and (L)-theanine supplementation on the common cold: a randomized, double-blind, and placebo-controlled trial.

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Title: What Every Cardiologist Should Know about H1N1?

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Title: Epidemiological characteristics and low case fatality rate of pandemic (H1N1) 2009 in Japan.

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Title: Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons.

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Title: Use of oseltamivir in children.

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Title: Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine.

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Title: Broad and potent anti-influenza virus spectrum of epigallocatechin-3-O-gallate-monopalmitate.

Journal: Journal of molecular and genetic medicine : an international journal of biomedical research 20091201

Title: H1N1 influenza in pregnancy: risks, vaccines, and antivirals.

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Title: A(H5N1) Virus Evolution in South East Asia.

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Title: In silico genome analysis and drug efficacy test of influenza A virus (H1N1) 2009.

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Title: Efficacy of neuraminidase (NA) inhibitors against H1N1 strains of different geographical regions: an in silico approach.

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Title: Predispensing of antivirals to high-risk individuals in an influenza pandemic.

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Title: Optimizing tactics for use of the U.S. Antiviral Strategic National Stockpile for Pandemic (H1N1) Influenza, 2009.

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Title: Antiviral drugs for the treatment of influenza: a systematic review and economic evaluation.

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Title: Systematic review: safety and efficacy of extended-duration antiviral chemoprophylaxis against pandemic and seasonal influenza.

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Title: Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)?

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Title: Dynamic behavior of avian influenza A virus neuraminidase subtype H5N1 in complex with oseltamivir, zanamivir, peramivir, and their phosphonate analogues.

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Title: Guidelines on management of human infection with the novel virus influenza A (H1N1)--a report from the Hospital das Clínicas of the University of São Paulo.

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Title: A model-based assessment of oseltamivir prophylaxis strategies to prevent influenza in nursing homes.

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Title: SeqMonitor: influenza analysis pipeline and visualization.

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Title: Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus.

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Title: Summary of the Australasian Society for Infectious Diseases and the Thoracic Society of Australia and New Zealand guidelines: treatment and prevention of H1N1 influenza 09 (human swine influenza) with antiviral agents.

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Title: Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women.

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Title: Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa.

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Title: Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.

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Title: Emerging antiviral targets for influenza A virus.

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Title: Reducing the burden of influenza-associated complications with antiviral therapy.

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Title: Basic rules of influenza: how to combat the H1N1 influenza (swine flu) virus.

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Title: Telephone triage of patients with influenza.

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Title: Past, present, and possible future human infection with influenza virus A subtype H7.

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Title: Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.

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Title: A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase.

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Title: Update: infections with a swine-origin influenza A (H1N1) virus--United States and other countries, April 28, 2009.

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Title: Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009.

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Title: Seasonal influenza surveillance using prescription data for anti-influenza medications.

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Title: Comparison of the effectiveness of Zanamivir and Oseltamivir against influenza A/H1N1, A/H3N2, and B.

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Title: Computational studies of H5N1 influenza virus resistance to oseltamivir.

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Title: Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season.

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Title: Different neuraminidase inhibitor susceptibilities of human H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany from 2001 to 2005/2006.

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Title: Morbidity and mortality associated with nosocomial transmission of oseltamivir-resistant influenza A(H1N1) virus.

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Title: Probing molecular level interaction of oseltamivir with H5N1-NA and model membranes by molecular docking, multinuclear NMR and DSC methods.

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Title: Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation.

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Title: Antiviral resistance of influenza A (H3N2) strains isolated in northern Greece between 2004 and 2007.

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Title: Novel genotypes of H9N2 influenza A viruses isolated from poultry in Pakistan containing NS genes similar to highly pathogenic H7N3 and H5N1 viruses.

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Title: Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.

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Title: Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis.

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Title: Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases.

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Title: Antiviral strategies: the present and beyond.

Journal: Current molecular pharmacology 20090101

Title: Influenza in outpatient ILI case-patients in national hospital-based surveillance, Bangladesh, 2007-2008.

Journal: PloS one 20090101

Title: Influenza A (H1N1) in Rome, Italy in family: three case reports.

Journal: Cases journal 20090101

Title: Are Belgian senior medical students ready to deliver basic medical care in case of a H5N1 pandemic?

Journal: Prehospital and disaster medicine 20090101

Title: Clinical review: primary influenza viral pneumonia.

Journal: Critical care (London, England) 20090101

Title: Influenza a (H1N1) outbreak and challenges for pharmacotherapy.

Journal: Indian journal of physiology and pharmacology 20090101

Title: Novel influenza H1N1 in pregnancy: a report of two cases.

Journal: Infectious diseases in obstetrics and gynecology 20090101

Title: Phylogenetic analysis of surface proteins of novel H1N1 virus isolated from 2009 pandemic.

Journal: Bioinformation 20090101

Title: Seasonal influenza: waiting for the next pandemic.

Journal: Journal of global infectious diseases 20090101

Title: Mitigation approaches to combat the flu pandemic.

Journal: Journal of global infectious diseases 20090101

Title: Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects.

Journal: The National medical journal of India 20090101

Title: Swine flu.

Journal: Journal of infection and public health 20090101

Title: Foreword: this issue of the Seton Hall Law Review presents contributions to Preparing for Pharmaceutical Response to Pandemic Influenza, a two-day Symposium held at Seton hall University School of Law in the fall of 2008.

Journal: Seton Hall law review 20090101

Title: Swine- Origin Influenza A (H1N1) Pandemic Revisited.

Journal: The Libyan journal of medicine 20090101

Title: Antiinfluenza medication kits need work, FDA advisers conclude.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081215

Title: Antiviral drugs for influenza.

Journal: The Medical letter on drugs and therapeutics 20081201

Title: Recommendations for the prevention and treatment of influenza using antiviral drugs based on cost-effectiveness.

Journal: Expert review of pharmacoeconomics & outcomes research 20081201

Title: Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques.

Journal: Antiviral research 20081101

Title: A new and rapid genotypic assay for the detection of neuraminidase inhibitor resistant influenza A viruses of subtype H1N1, H3N2, and H5N1.

Journal: Journal of virological methods 20081101

Title: Widespread oseltamivir resistance in influenza A viruses (H1N1), South Africa.

Journal: Emerging infectious diseases 20081101

Title: Meeting report: risk assessment of tamiflu use under pandemic conditions.

Journal: Environmental health perspectives 20081101

Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

Journal: Journal of medicinal chemistry 20081009

Title: Insights into inflammation and influenza.

Journal: The New England journal of medicine 20081009

Title: Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.

Journal: Antimicrobial agents and chemotherapy 20081001

Title: Antivirals and influenza: frequency of resistance.

Journal: The Pediatric infectious disease journal 20081001

Title: In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses.

Journal: Antiviral research 20080901

Title: Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids.

Journal: Pharmaceutical research 20080901

Title: Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.

Journal: Journal of chemical information and modeling 20080901

Title: Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20080901

Title: Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008.

Journal: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 20080808

Title: Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080801

Title: Editorial commentary: viral susceptibility and the choice of influenza antivirals.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080801

Title: Modifying clinical practices to manage influenza in children effectively.

Journal: The Pediatric infectious disease journal 20080801

Title: Oseltamivir prescribing in pharmacy-benefits database, United States, 2004-2005.

Journal: Emerging infectious diseases 20080801

Title: Zanamivir: new indication. Influenza: in children as in adults, symptom relief or vaccination.

Journal: Prescrire international 20080801

Title: Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.

Journal: Journal of medicinal chemistry 20080710

Title: Enzymatic properties of the neuraminidase of seasonal H1N1 influenza viruses provide insights for the emergence of natural resistance to oseltamivir.

Journal: PLoS pathogens 20080701

Title: Statement on influenza vaccination for the 2008-2009 season. An Advisory Committee Statement (ACS).

Journal: Canada communicable disease report = Releve des maladies transmissibles au Canada 20080701

Title: [Neuraminidase inhibitors in prophylaxis and treatment of influenza].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080701

Title: Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.

Journal: Nature 20080626

Title: Understanding of known drug-target interactions in the catalytic pocket of neuraminidase subtype N1.

Journal: Proteins 20080601

Title: PA subunit of RNA polymerase as a promising target for anti-influenza virus agents.

Journal: Antiviral research 20080601

Title: Major issues and challenges of influenza pandemic preparedness in developing countries.

Journal: Emerging infectious diseases 20080601

Title: [Bird flu: what the intensivist must know].

Journal: Medicina intensiva 20080501

Title: Human metapneumovirus infection in immunocompromised child.

Journal: Emerging infectious diseases 20080501

Title: Molecular strategies to inhibit the replication of RNA viruses.

Journal: Antiviral research 20080401

Title: Current and future antiviral therapy of severe seasonal and avian influenza.

Journal: Antiviral research 20080401

Title: Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice.

Journal: Biological & pharmaceutical bulletin 20080401

Title: Prevention of influenza: recommendations for influenza immunization of children, 2007-2008.

Journal: Pediatrics 20080401

Title: Determination of oseltamivir quality by colorimetric and liquid chromatographic methods.

Journal: Emerging infectious diseases 20080401

Title: Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses.

Journal: PLoS pathogens 20080401

Title: Lessons learned from the 2007-2008 cold and flu season: what worked and what was worthless.

Journal: Urologic nursing 20080401

Title: Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses.

Journal: Biotechnology letters 20080301

Title: Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080301

Title: Influenza.

Journal: Canadian family physician Medecin de famille canadien 20080301

Title: [Analysis of decrease in sensitivity in influenza A (H5N1) avian and human strains to neuraminidase inhibitors].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20080301

Title: Synthetic efforts for stereo structure determination of cytotoxic marine natural product pericosines as metabolites of Periconia sp. from sea hare.

Journal: International journal of molecular sciences 20080301

Title: [Influenza].

Journal: La Revue du praticien 20080227

Title: Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble.

Journal: Chemical biology & drug design 20080201

Title: Cost-effectiveness of antiviral stockpiling and near-patient testing for potential influenza pandemic.

Journal: Emerging infectious diseases 20080201

Title: [Influenza in children: what should be considered in prevention and treatment?].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20080201

Title: Amantadine and rimantadine for influenza A in children and the elderly.

Journal: The Cochrane database of systematic reviews 20080123

Title: A comparison of the effectiveness of zanamivir and oseltamivir for the treatment of influenza A and B.

Journal: The Journal of infection 20080101

Title: Medical management of influenza infection.

Journal: Annual review of medicine 20080101

Title: Detection of human influenza A (H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20080101

Title: Mutations of neuraminidase implicated in neuraminidase inhibitors resistance.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20080101

Title: Whatever happened to bird flu?

Journal: Reviews in medical virology 20080101

Title: Coutilization of glucose and glycerol enhances the production of aromatic compounds in an Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system.

Journal: Microbial cell factories 20080101

Title: Pandemic influenza and pregnant women.

Journal: Emerging infectious diseases 20080101

Title: Proposed lead molecules against Hemagglutinin of avian influenza virus (H5N1).

Journal: Bioinformation 20080101

Title: Cost-effectiveness and value of information analyses of neuraminidase inhibitors for the treatment of influenza.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

Title: Do pediatricians manage influenza differently than internists?

Journal: BMC pediatrics 20080101

Title: Impact of emerging antiviral drug resistance on influenza containment and spread: influence of subclinical infection and strategic use of a stockpile containing one or two drugs.

Journal: PloS one 20080101

Title: The metabolism and transplacental transfer of oseltamivir in the ex vivo human model.

Journal: Infectious diseases in obstetrics and gynecology 20080101

Title: Bench-to-bedside review: rare and common viral infections in the intensive care unit--linking pathophysiology to clinical presentation.

Journal: Critical care (London, England) 20080101

Title: Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay.

Journal: Virology journal 20080101

Title: Influenza A H5N1 clade 2.3.4 virus with a different antiviral susceptibility profile replaced clade 1 virus in humans in northern Vietnam.

Journal: PloS one 20080101

Title: Oseltamivir is adequately absorbed following nasogastric administration to adult patients with severe H5N1 influenza.

Journal: PloS one 20080101

Title: Avian Influenza: a global threat needing a global solution.

Journal: Asia Pacific family medicine 20080101

Title: Current research on drugs and vaccines for fighting bird flu.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20071201

Title: Neuraminidase inhibitor drug susceptibility differs between influenza N1 and N2 neuraminidase following mutagenesis of two conserved residues.

Journal: Antiviral research 20071201

Title: The war against influenza: discovery and development of sialidase inhibitors.

Journal: Nature reviews. Drug discovery 20071201

Title: Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread.

Journal: PLoS computational biology 20071201

Title: Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic.

Journal: Infectious disorders drug targets 20071201

Title: [Influenza in children].

Journal: La Revue du praticien 20071115

Title: [Countermeasures for newly-emerging influenza].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20071110

Title: Characterization of human H1N1 influenza virus variants selected in vitro with zanamivir in the presence of sialic acid-containing molecules.

Journal: Virus research 20071101

Title: [Antiviral treatment of influenza in humans].

Journal: Therapeutische Umschau. Revue therapeutique 20071101

Title: Neuraminidase inhibitor resistance in influenza viruses.

Journal: Journal of medical virology 20071001

Title: The role of oseltamivir in the treatment and prevention of influenza in children.

Journal: Expert opinion on drug metabolism & toxicology 20071001

Title: Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds.

Journal: Carbohydrate research 20070903

Title: Neuraminidase inhibitor susceptibility of porcine H3N2 influenza A viruses isolated in Germany between 1982 and 1999.

Journal: Antiviral research 20070901

Title: Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir).

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: Influenza: the virus and prophylaxis with inactivated influenza vaccine in 'at risk' groups, including COPD patients.

Journal: International journal of chronic obstructive pulmonary disease 20070901

Title: Reduced sensitivity of influenza A (H5N1) to oseltamivir.

Journal: Emerging infectious diseases 20070901

Title: Avian influenza: should China be alarmed?

Journal: Yonsei medical journal 20070831

Title: Efficacy and safety of inhaled zanamivir in the prevention of influenza in community-dwelling, high-risk adult and adolescent subjects: a 28-day, multicenter, randomized, double-blind, placebo-controlled trial.

Journal: Clinical therapeutics 20070801

Title: John F. Enders lecture 2006: antivirals for influenza.

Journal: The Journal of infectious diseases 20070715

Title: Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007.

Journal: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 20070713

Title: The bird flu: a new emerging pandemic threat and its pharmacological intervention.

Journal: International journal of health sciences 20070701

Title: Zanamivir treatment is equally effective for both influenza A and influenza B.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070615

Title: Determination of zanamivir in rat and monkey plasma by positive ion hydrophilic interaction chromatography (HILIC)/tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Title: Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention.

Journal: Trends in pharmacological sciences 20070601

Title: The Diskus: a review of its position among dry powder inhaler devices.

Journal: International journal of clinical practice 20070601

Title: Zanamivir for the prevention of influenza in adults and children age 5 years and older.

Journal: Therapeutics and clinical risk management 20070601

Title: Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir.

Journal: Antiviral research 20070501

Title: Transparent development of the WHO rapid advice guidelines.

Journal: PLoS medicine 20070501

Title: Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.

Journal: PLoS medicine 20070501

Title: Monitoring of neuraminidase inhibitor resistance among clinical influenza virus isolates in Japan during the 2003-2006 influenza seasons.

Journal: Releve epidemiologique hebdomadaire 20070427

Title: [Threat from newly emerging influenza].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070410

Title: Antiviral therapy and prophylaxis for influenza in children.

Journal: Pediatrics 20070401

Title: Influenza: evolving strategies in treatment and prevention.

Journal: Seminars in respiratory and critical care medicine 20070401

Title: Influenza antiviral susceptibility monitoring activities in relation to national antiviral stockpiles in Europe during the winter 2006/2007 season.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20070401

Title: Study of drug resistance of chicken influenza A virus (H5N1) from homology-modeled 3D structures of neuraminidases.

Journal: Biochemical and biophysical research communications 20070316

Title: Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity.

Journal: Bioorganic & medicinal chemistry letters 20070315

Title: Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.

Journal: Antiviral research 20070301

Title: Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice.

Journal: Antimicrobial agents and chemotherapy 20070301

Title: [Zanamivir for prevention of influenza and in children].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20070301

Title: Drug-induced linear immunoglobulin A bullous dermatosis mimicking Stevens-Johnson syndrome: a case report.

Journal: Cutis 20070301

Title: Occasional review: influenza in COPD: pathogenesis, prevention, and treatment.

Journal: International journal of chronic obstructive pulmonary disease 20070301

Title: Prevention and control of influenza in persons with chronic obstructive pulmonary disease.

Journal: International journal of chronic obstructive pulmonary disease 20070301

Title: Influenza infection and COPD.

Journal: International journal of chronic obstructive pulmonary disease 20070301

Title: [Antiviral agents for influenza].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070227

Title: Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005.

Journal: Antiviral research 20070201

Title: Oseltamivir: new indication. Prevention of influenza in at-risk children: vaccination is best.

Journal: Prescrire international 20070201

Title: Neuraminidase inhibitors for preventing and treating influenza in children.

Journal: The Cochrane database of systematic reviews 20070124

Title: Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials.

Journal: American journal of epidemiology 20070115

Title: How influenza's neuraminidase promotes virulence and creates localized lung mucosa immunodeficiency.

Journal: Cellular & molecular biology letters 20070101

Title: [Neuraminidase inhibitors and risk of H5N1 influenza].

Journal: Annales pharmaceutiques francaises 20070101

Title: Potential risks associated with the proposed widespread use of Tamiflu.

Journal: Environmental health perspectives 20070101

Title: Questioning aerosol transmission of influenza.

Journal: Emerging infectious diseases 20070101

Title: Graphical representation and numerical characterization of H5N1 avian flu neuraminidase gene sequence.

Journal: Journal of chemical information and modeling 20070101

Title: Clinical review: update of avian influenza A infections in humans.

Journal: Critical care (London, England) 20070101

Title: Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection.

Journal: Respiratory research 20070101

Title: Avian influenza: an osteopathic component to treatment.

Journal: Osteopathic medicine and primary care 20070101

Title: Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

Journal: Antiviral therapy 20070101

Title: General practitioners' management of influenza with or without neuraminidase inhibitors.

Journal: The European journal of general practice 20070101

Title: PocketPicker: analysis of ligand binding-sites with shape descriptors.

Journal: Chemistry Central journal 20070101

Title: Recent anti-influenza strategies in multivalent sialyloligosaccharides and sialylmimetics approaches.

Journal: Current medicinal chemistry 20070101

Title: Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus.

Journal: PloS one 20070101

Title: Neuraminidase inhibitors and their role in avian and pandemic influenza.

Journal: Antiviral therapy 20070101

Title: M2 protein-a proton channel of influenza A virus.

Journal: Current pharmaceutical design 20070101

Title: A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination.

Journal: PloS one 20070101

Title: Strategies of development of antiviral agents directed against influenza virus replication.

Journal: Current pharmaceutical design 20070101

Title: Antivirals for the treatment and prevention of epidemic and pandemic influenza.

Journal: Influenza and other respiratory viruses 20070101

Title: Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061215

Title: Pharmacokinetics and dosage adjustment of oseltamivir and zanamivir in patients with renal failure.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061201

Title: Antiviral agents active against influenza A viruses.

Journal: Nature reviews. Drug discovery 20061201

Title: Antivirals in the management of an influenza pandemic.

Journal: The Medical journal of Australia 20061120

Title: A nanoscale study of particle friction in a pharmaceutical system.

Journal: International journal of pharmaceutics 20061115

Title: Evolution of the susceptibility to antiviral drugs of A/H3N2 influenza viruses isolated in France from 2002 to 2005.

Journal: Vaccine 20061110

Title: Scientific lessons from the first influenza pandemic of the 20th century.

Journal: Vaccine 20061110

Title: Which agents should we use to treat and prevent influenza in 2006-2007?

Journal: Cleveland Clinic journal of medicine 20061101

Title: Antiviral management of seasonal and pandemic influenza.

Journal: The Journal of infectious diseases 20061101

Title: Prevention and treatment of influenza in high-risk groups: children, pregnant women, immunocompromised hosts, and nursing home residents.

Journal: The Journal of infectious diseases 20061101

Title: Antiviral drugs prophylaxis and treatment of influenza.

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Title: Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro.

Journal: The Journal of antimicrobial chemotherapy 20061001

Title: [Treatment of influenza virus infection with anti-virals].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061001

Title: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

Journal: Nature 20060907

Title: Symptomatic predictors of influenza virus positivity in children during the influenza season.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060901

Title: Safety of neuraminidase inhibitors for influenza.

Journal: Expert opinion on drug safety 20060901

Title: Possible case scenarios and logistic issues in H5N1 pandemic.

Journal: Respirology (Carlton, Vic.) 20060901

Title: State plans for containment of pandemic influenza.

Journal: Emerging infectious diseases 20060901

Title: [Various sides of influenza. Part II--epidemiology, influenza surveillance and prophylaxis].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060901

Title: [Avian influenza pandemic prevention - current research].

Journal: Revue medicale suisse 20060823

Title: Neuraminidase inhibitors for preventing and treating influenza in healthy adults.

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Title: Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use.

Journal: Antimicrobial agents and chemotherapy 20060701

Title: Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.

Journal: Biochemical and biophysical research communications 20060609

Title: Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors.

Journal: Medical microbiology and immunology 20060601

Title: Non-voluntary licensing of antivirals under patent: options the Australian Government should consider in light of a potential bird flu pandemic.

Journal: Journal of law and medicine 20060501

Title: [Role of influenza virus sialidase].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20060501

Title: Human cell lines used in a micro neutralization test for measuring influenza-neutralizing antibodies.

Journal: Scandinavian journal of immunology 20060401

Title: In vitro efficacies of oseltamivir carboxylate and zanamivir against equine influenza A viruses.

Journal: The Journal of veterinary medical science 20060401

Title: Roles of neuraminidase in the initial stage of influenza virus infection.

Journal: Microbes and infection 20060401

Title: Human influenza surveillance: the demand to expand.

Journal: Emerging infectious diseases 20060401

Title: Oseltamivir resistance in influenza A (H5N1) infection.

Journal: The New England journal of medicine 20060330

Title: Increased antiviral medication sales before the 2005-06 influenza season--New York City.

Journal: MMWR. Morbidity and mortality weekly report 20060317

Title: [What do your patients want to know now? The most frequent questions about avian influenza].

Journal: MMW Fortschritte der Medizin 20060302

Title: Pandemics, avian influenza A (H5N1), and a strategy for pharmacists.

Journal: Pharmacotherapy 20060301

Title: [Neuraminidase inhibitors are effective in influenza---if administered quickly after the debut or as prophylaxis to infected persons].

Journal: Lakartidningen 20060301

Title: A QSAR study on influenza neuraminidase inhibitors.

Journal: Bioorganic & medicinal chemistry 20060215

Title: Influenza diagnosis and treatment in veterans with spinal cord injury.

Journal: Archives of physical medicine and rehabilitation 20060201

Title: Antiviral drugs in influenza: an adjunct to vaccination in some situations.

Journal: Prescrire international 20060201

Title: [Epidemiology, clinical picture, prevention and treatment of Avian influenza].

Journal: Georgian medical news 20060201

Title: Review says oseltamivir and zanamivir should be kept for epidemics of flu.

Journal: BMJ (Clinical research ed.) 20060128

Title: Antivirals for influenza in healthy adults: systematic review.

Journal: Lancet (London, England) 20060128

Title: High levels of adamantane resistance among influenza A (H3N2) viruses and interim guidelines for use of antiviral agents--United States, 2005-06 influenza season.

Journal: MMWR. Morbidity and mortality weekly report 20060120

Title: Anti-influenza virus activity of peramivir in mice with single intramuscular injection.

Journal: Antiviral research 20060101

Title: Vaccines and antiviral drugs in pandemic preparedness.

Journal: Emerging infectious diseases 20060101

Title: Pandemic influenza threat and preparedness.

Journal: Emerging infectious diseases 20060101

Title: Combating influenza with antiviral therapy in the pediatric population.

Journal: Pharmacotherapy 20060101

Title: [Nosocomial outbreak of influenza in high-risk hematological patients. Efficacy of control measures and the use of zanamivir].

Journal: Enfermedades infecciosas y microbiologia clinica 20060101

Title: In vitro inhibition of human influenza A virus replication by chloroquine.

Journal: Virology journal 20060101

Title: Influenza virus inhibitors available for the chemotherapy and/or chemoprophylaxis of influenza virus infections.

Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20060101

Title: Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice.

Journal: Respiratory research 20060101

Title: A 'small-world-like' model for comparing interventions aimed at preventing and controlling influenza pandemics.

Journal: BMC medicine 20060101

Title: [Antiviral etiotropic chemicals: efficacy against influenza A viruses A subtype H5N1].

Journal: Voprosy virusologii 20060101

Title: A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.

Journal: PloS one 20060101

Title: Neuraminidase inhibitors reduce nitric oxide production in influenza virus-infected and gamma interferon-activated RAW 264.7 macrophages.

Journal: Pharmacological reports : PR 20060101

Title: Another option for flu prevention.

Journal: FDA consumer 20060101

Title: [Significance of virological diagnostics for the effective treatment of hospitalized patients infected with influenza virus].

Journal: Pneumonologia i alergologia polska 20060101

Title: Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds.

Journal: Antiviral therapy 20060101

Title: Molecular drug targets and structure based drug design: A holistic approach.

Journal: Bioinformation 20060101

Title: Oseltamivir resistance--disabling our influenza defenses.

Journal: The New England journal of medicine 20051222

Title: Consideration of use of neuraminidase inhibitors such as oseltamivir and zanamivir in IgA nephropathy.

Journal: Kidney international 20051201

Title: Star role for bacteria in controlling flu pandemic?

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Title: [Antiviral agents in influenza--current recommendations. Anti-influenza agents are not a substitution for but a complement to vaccination].

Journal: Lakartidningen 20051201

Title: Neuraminidase inhibitors as antiviral agents.

Journal: Current drug targets. Infectious disorders 20051201

Title: [Influenza prevention in your practice (interview by Waldtraud Paukstadt)].

Journal: MMW Fortschritte der Medizin 20051117

Title: Avian flu: isolation of drug-resistant H5N1 virus.

Journal: Nature 20051020

Title: Sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice.

Journal: Antiviral research 20051001

Title: One-bead-one-inhibitor-one-substrate screening of neuraminidase activity.

Journal: Chembiochem : a European journal of chemical biology 20051001

Title: Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors.

Journal: The Pediatric infectious disease journal 20051001

Title: Use of antiviral agents and other measures in an influenza pandemic.

Journal: The Netherlands journal of medicine 20051001

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Title: Influenza treatment with neuraminidase inhibitors: cost-effectiveness and cost-utility in healthy adults in the United Kingdom.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20050901

Title: Threat of pandemic brings flu drug back to life.

Journal: Nature medicine 20050901

Title: Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice.

Journal: The Journal of infectious diseases 20050815

Title: Cost-benefit of stockpiling drugs for influenza pandemic.

Journal: Emerging infectious diseases 20050801

Title: Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.

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Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

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Title: Avian flu special: what's in the medicine cabinet?

Journal: Nature 20050526

Title: Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Journal: Journal of medicinal chemistry 20050421

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Journal: Expert review of anti-infective therapy 20050401

Title: Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations.

Journal: The Journal of antimicrobial chemotherapy 20050201

Title: A side effect of neuraminidase inhibitor in a patient with liver cirrhosis.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20050201

Title: [Antivirals for influenza].

Journal: Bulletin de l'Academie nationale de medecine 20050201

Title: Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance.

Journal: Treatments in respiratory medicine 20050101

Title: Replicative homeostasis II: influence of polymerase fidelity on RNA virus quasispecies biology: implications for immune recognition, viral autoimmunity and other 'virus receptor' diseases.

Journal: Virology journal 20050101

Title: Antiviral agents for influenza: a comparison of cost-effectiveness data.

Journal: PharmacoEconomics 20050101

Title: H5N1.

Journal: Genome biology 20050101

Title: Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population.

Journal: Journal of the American Medical Directors Association 20050101

Title: Inhaled zanamivir versus placebo for the prevention of influenza outbreaks in an unvaccinated long-term care population.

Journal: Journal of the American Medical Directors Association 20050101

Title: Neuraminidase inhibitor susceptibility network position statement: antiviral resistance in influenza A/H5N1 viruses.

Journal: Antiviral therapy 20050101

Title: Pharmacoeconomics of antiviral therapy for influenza in a Japanese hospital setting.

Journal: Clinical drug investigation 20050101

Title: Therapy of hearing disorders - conservative procedures.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: [Zanamivir, oseltamivir].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041201

Title: Influenza.

Journal: Clinical evidence 20041201

Title: [Super pathogenic avian influenza].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110

Title: Prevention of influenza in the general population: recommendation statement from the Canadian Task Force on Preventive Health Care.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20041109

Title: Vaccines for women age 50 and older.

Journal: Emerging infectious diseases 20041101

Title: Antiviral treatment and prophylaxis of influenza in primary care: German recommendations.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20041001

Title: Avian influenza should be ruffling our feathers.

Journal: The Lancet. Infectious diseases 20041001

Title: What is the best antiviral agent for influenza infection?

Journal: American family physician 20041001

Title: Influenza among U.K. pilgrims to hajj, 2003.

Journal: Emerging infectious diseases 20041001

Title: In vitro generation and characterisation of an influenza B variant with reduced sensitivity to neuraminidase inhibitors.

Journal: Antiviral research 20040901

Title: A reverse genetics study of resistance to neuraminidase inhibitors in an influenza A/H1N1 virus.

Journal: Antiviral therapy 20040801

Title: Medical economics in the field of influenza--past, present and future.

Journal: Virus research 20040701

Title: A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza viruses.

Journal: Virus research 20040701

Title: Surveillance of influenza isolates for susceptibility to neuraminidase inhibitors during the 2000-2002 influenza seasons.

Journal: Virus research 20040701

Title: Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs.

Journal: Virus research 20040701

Title: Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac42en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone.

Journal: Organic letters 20040624

Title: Influenza outbreaks in aged-care facilities: staff vaccination and the emerging use of antiviral therapy.

Journal: The Medical journal of Australia 20040621

Title: Neuraminidase inhibitors for treatment of influenza.

Journal: American family physician 20040615

Title: Biotech business Down Under.

Journal: Nature 20040603

Title: Antiviral drugs in current clinical use.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040601

Title: Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host.

Journal: The Journal of antimicrobial chemotherapy 20040501

Title: Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline?

Journal: Current opinion in pulmonary medicine 20040501

Title: Influenza-induced tachypnea is prevented in immune cotton rats, but cannot be treated with an anti-inflammatory steroid or a neuraminidase inhibitor.

Journal: Virology 20040501

Title: [Treatment for viral respiratory infections: Principles of action, strategies, and future prospects].

Journal: Der Internist 20040401

Title: Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

Journal: Antiviral research 20040401

Title: Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs.

Journal: Emerging infectious diseases 20040401

Title: Guidelines for preventing health-care--associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee.

Journal: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 20040326

Title: Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.

Journal: Bioorganic & medicinal chemistry letters 20040322

Title: [Strategies in the diagnosis and treatment of patients with avian influenza].

Journal: Zhonghua yi xue za zhi 20040302

Title: Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040301

Title: A new millennium conundrum: how to use a powerful class of influenza anti-neuraminidase drugs (NAIs) in the community.

Journal: The Journal of antimicrobial chemotherapy 20040201

Title: An evaluation of the impact of NICE guidance on GP prescribing.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20040201

Title: Controlling influenza by inhibiting the virus's neuraminidase.

Journal: Current drug targets 20040201

Title: [Neuraminidase inhibitors oseltamivir and zanamivir: new means of defence against influenza].

Journal: Nederlands tijdschrift voor geneeskunde 20040110

Title: Phenotypic drug susceptibility assay for influenza virus neuraminidase inhibitors.

Journal: Clinical and diagnostic laboratory immunology 20040101

Title: Influenza infection of the embryonated hen's egg/an alternative model for in vivo evaluation of antiviral compounds.

Journal: Arzneimittel-Forschung 20040101

Title: Antiviral therapy for influenza : a clinical and economic comparative review.

Journal: Drugs 20040101

Title: Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations.

Journal: Journal of medicinal chemistry 20031218

Title: [English meta-analysis on zanamivir and oseltamivir. Knowledge of effects of influenza agents still not sufficient].

Journal: Lakartidningen 20031211

Title: Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.

Journal: Chemical & pharmaceutical bulletin 20031201

Title: Influenza.

Journal: Clinical evidence 20031201

Title: Assessment of development of resistance to antivirals in the ferret model of influenza virus infection.

Journal: The Journal of infectious diseases 20031101

Title: [Clinical characteristic of the elderly in influenza infection].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20031101

Title: [Influenza virus infection in children].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20031101

Title: [Criteria for the use of anti-influenza agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20031101

Title: [Neuraminidase inhibitor, anti-influenzal agent--mechanism of action, and how to use clinically].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20031101

Title: Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model.

Journal: Pediatric pulmonology 20031001

Title: Management of influenza symptoms in healthy adults.

Journal: Journal of general internal medicine 20031001

Title: Neuraminidase inhibitors slightly beneficial for shortening flu symptoms.

Journal: The Journal of family practice 20031001

Title: Nosocomial influenza in children.

Journal: The Journal of hospital infection 20031001

Title: Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy.

Journal: Annals of internal medicine 20030902

Title: Summaries for patients. Cost-effective management of flu in adults older than 65 years of age.

Journal: Annals of internal medicine 20030902

Title: Emergence of amantadine-resistant influenza A viruses: epidemiological study.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20030901

Title: Clinical features of influenza a virus infection in older hospitalized persons.

Journal: Journal of the American Geriatrics Society 20030801

Title: Influenza therapy.

Journal: Southern medical journal 20030801

Title: Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents.

Journal: Bioorganic & medicinal chemistry 20030703

Title: Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials.

Journal: BMJ (Clinical research ed.) 20030607

Title: We need to determine who benefits most from flu treatments.

Journal: BMJ (Clinical research ed.) 20030607

Title: Oseltamivir: new preparation. An antiviral agent with little impact on influenza.

Journal: Prescrire international 20030601

Title: New application method of zanamivir with a straw.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20030601

Title: A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding.

Journal: Antiviral research 20030601

Title: Review of the use of neuraminidase inhibitors for prophylaxis of influenza.

Journal: Communicable disease and public health 20030601

Title: Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza.

Journal: Antiviral therapy 20030601

Title: [Influenza in global aspect].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

Title: The role of antivirals in the control of influenza.

Journal: Vaccine 20030501

Title: Pandemic influenza and healthcare demand in the Netherlands: scenario analysis.

Journal: Emerging infectious diseases 20030501

Title: Zanamivir in the treatment of influenza.

Journal: Expert opinion on pharmacotherapy 20030501

Title: Compared protective effect of nasal immunoprophylaxis using a new human monoclonal IgM antibody, human polyclonal antibodies, F(ab')2, amantadine, and zanamivir for prophylaxis of influenza A virus pneumonia in mice.

Journal: Military medicine 20030301

Title: Semi-quantitative detection of viral RNA in influenza A virus-infected mice for evaluation of antiviral compounds.

Journal: Antiviral research 20030301

Title: Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.

Journal: Bioorganic & medicinal chemistry letters 20030224

Title: Antiviral drugs in the immunocompetent host: part II. Treatment of influenza and respiratory syncytial virus infections.

Journal: American family physician 20030215

Title: Logistic issues and potential prescribing costs associated with use of neuraminidase inhibitors for the treatment of influenza in primary care.

Journal: Journal of the Royal Society of Medicine 20030201

Title: Influenza diagnosis and treatment in children: a review of studies on clinically useful tests and antiviral treatment for influenza.

Journal: The Pediatric infectious disease journal 20030201

Title: [Influenza].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: [Antiviral agents for influenza].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: [Treatment of influenza in children].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20030201

Title: Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Journal: Biochemistry 20030128

Title: [Oral neuraminidase inhibitor and an early warning system. New weapons against influenza].

Journal: MMW Fortschritte der Medizin 20030123

Title: The treatment of influenza with antiviral drugs.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20030107

Title: Neuraminidase inhibitors in pediatric patients: potential place in influenza therapy.

Journal: Paediatric drugs 20030101

Title: Bedside rapid flu test and zanamivir prescription in healthy working adults: a cost-benefit analysis.

Journal: PharmacoEconomics 20030101

Title: Influenza vaccination and antiviral therapy: is there a role for concurrent administration in the institutionalised elderly?

Journal: Drugs & aging 20030101

Title: Treatment and prevention of influenza: Swedish recommendations.

Journal: Scandinavian journal of infectious diseases 20030101

Title: Zanamivir: a significant reduction in viral load during treatment in military conscripts with influenza.

Journal: Scandinavian journal of infectious diseases 20030101

Title: Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030101

Title: [Influenza].

Journal: Revista da Sociedade Brasileira de Medicina Tropical 20030101

Title: Neuraminidase inhibitors for preventing and treating influenza in children.

Journal: The Cochrane database of systematic reviews 20030101

Title: Assaying susceptibility of avian and other influenza A viruses to zanamivir: comparison of fluorescent and chemiluminescent neuraminidase assays.

Journal: Avian diseases 20030101

Title: Systematic review and economic decision modelling for the prevention and treatment of influenza A and B.

Journal: Health technology assessment (Winchester, England) 20030101

Title: Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer.

Journal: Reproductive biology and endocrinology : RB&E 20030101

Title: Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia.

Journal: Communicable diseases intelligence quarterly report 20030101

Title: Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households.

Journal: The Journal of infectious diseases 20021201

Title: Problems of case and disease management in outpatient treatment of influenza.

Journal: Medical microbiology and immunology 20021201

Title: Neuraminidase inhibitors in the management of influenza--experience of an outpatient practice.

Journal: Medical microbiology and immunology 20021201

Title: Efficacy and safety of zanamivir in patients with influenza--impact of age, severity of infections and specific risk factors.

Journal: Medical microbiology and immunology 20021201

Title: Drug under test: influenza--Relenza in daily practice. Experience during the influenza season 1999/2000.

Journal: Medical microbiology and immunology 20021201

Title: [Patient assessment for zanamivir therapy (second report) -- a survey of patients with influenza who were prescribed zanamivir during the 2001/2002 season in Japan].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20021201

Title: Oseltamivir for influenza.

Journal: Drug and therapeutics bulletin 20021201

Title: [New diagnostic possibilities and medications. Fit for influenza?].

Journal: MMW Fortschritte der Medizin 20021128

Title: Risk for respiratory events in a cohort of patients receiving inhaled zanamivir: a retrospective study.

Journal: Clinical therapeutics 20021101

Title: The effect of zanamivir treatment on influenza complications: a retrospective cohort study.

Journal: Clinical therapeutics 20021101

Title: Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy.

Journal: International journal of pharmaceutics 20021024

Title: Characterization of 2 influenza A(H3N2) clinical isolates with reduced susceptibility to neuraminidase inhibitors due to mutations in the hemagglutinin gene.

Journal: The Journal of infectious diseases 20021015

Title: [Neuraminidase inhibitor permitted. The first pill against influenza].

Journal: MMW Fortschritte der Medizin 20021010

Title: Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds.

Journal: Journal of virological methods 20021001

Title: Utility of zanamivir for chemoprophylaxis of concomitant influenza A and B in a complex continuing care population.

Journal: Infection control and hospital epidemiology 20021001

Title: Current strategies for management of influenza in the elderly population.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020915

Title: Influenza prevention 2002-2003.

Journal: The Medical letter on drugs and therapeutics 20020902

Title: Cost-effectiveness of newer treatment strategies for influenza.

Journal: The American journal of medicine 20020901

Title: Economic analysis of influenza vaccination and antiviral treatment for healthy working adults.

Journal: Annals of internal medicine 20020820

Title: Summaries for patients. Influenza vaccination or antiviral treatment for healthy working adults: an economic analysis.

Journal: Annals of internal medicine 20020820

Title: Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.

Journal: Bioorganic & medicinal chemistry letters 20020805

Title: Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.

Journal: Bioorganic & medicinal chemistry letters 20020805

Title: Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.

Journal: Bioorganic & medicinal chemistry letters 20020805

Title: Development of a novel influenza A antiviral assay.

Journal: Journal of virological methods 20020801

Title: The management of influenza in people of working age.

Journal: Occupational medicine (Oxford, England) 20020801

Title: Management of viral infections in immunocompromised cancer patients.

Journal: Swiss medical weekly 20020713

Title: Analysis of the desialidation process of the haemagglutinin protein of influenza B virus: the host-dependent desialidation step.

Journal: The Journal of general virology 20020701

Title: In vitro selection and characterization of influenza A (A/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675.

Journal: Journal of virology 20020601

Title: Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza.

Journal: Expert opinion on investigational drugs 20020601

Title: Susceptibility of recent Canadian influenza A and B virus isolates to different neuraminidase inhibitors.

Journal: Antiviral research 20020601

Title: Gateways to Clinical Trials. June 2002.

Journal: Methods and findings in experimental and clinical pharmacology 20020601

Title: [A revolutionary change in the diagnosis and treatment of influenza].

Journal: Uirusu 20020601

Title: Influenza.

Journal: Clinical evidence 20020601

Title: Structural studies of the resistance of influenza virus neuramindase to inhibitors.

Journal: Journal of medicinal chemistry 20020523

Title: Role of phosphatidylserine exposure and sugar chain desialylation at the surface of influenza virus-infected cells in efficient phagocytosis by macrophages.

Journal: The Journal of biological chemistry 20020517

Title: Neuraminidase inhibitors as antivirals.

Journal: Vaccine 20020515

Title: Evidence-based emergency medicine/systematic review abstract. Use of the neuraminidase inhibitor class of antiviral drugs for treatment of healthy adults with an acute influenza-like illness.

Journal: Annals of emergency medicine 20020501

Title: Exploitation of the Herpes simplex virus translocating protein VP22 to carry influenza virus proteins into cells for studies of apoptosis: direct confirmation that neuraminidase induces apoptosis and indications that other proteins may have a role.

Journal: Archives of virology 20020501

Title: Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP).

Journal: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 20020412

Title: In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication.

Journal: Antimicrobial agents and chemotherapy 20020401

Title: Challenges and options in the management of viral infections after stem cell transplantation.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20020401

Title: Antiviral therapy of influenza.

Journal: Seminars in pediatric infectious diseases 20020401

Title: Highlights in the development of new antiviral agents.

Journal: Mini reviews in medicinal chemistry 20020401

Title: Syncytium formation and HIV-1 replication are both accentuated by purified influenza and virus-associated neuraminidase.

Journal: The Journal of biological chemistry 20020322

Title: [Pneumonia diagnosis in the practice on the test-bench: how much diagnosis is necessary?].

Journal: Deutsche medizinische Wochenschrift (1946) 20020315

Title: Accumulation of defective neuraminidase (NA) genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA.

Journal: The Journal of infectious diseases 20020301

Title: Influenza in the acute hospital setting.

Journal: The Lancet. Infectious diseases 20020301

Title: Neuraminidase inhibitors for the treatment and prevention of influenza.

Journal: Expert opinion on pharmacotherapy 20020201

Title: Dry powder inhaler: influence of humidity on topology and adhesion studied by AFM.

Journal: International journal of pharmaceutics 20020131

Title: Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay.

Journal: Antiviral research 20020101

Title: Zanamivir: an update of its use in influenza.

Journal: Drugs 20020101

Title: Influenza in the nursing home.

Journal: American family physician 20020101

Title: Patient perspective on zanamivir in the treatment of influenza.

Journal: International journal of clinical practice 20020101

Title: The use of zanamivir to treat influenza A and B infection after allogeneic stem cell transplantation.

Journal: Bone marrow transplantation 20020101

Title: Zanamivir for the treatment of influenza in adults: a systematic review and economic evaluation.

Journal: Health technology assessment (Winchester, England) 20020101

Title: Antiviral therapy for influenza virus infections.

Journal: Seminars in pediatric infectious diseases 20020101

Title: Zanamivir is an effective treatment for influenza in children undergoing therapy for acute lymphoblastic leukemia.

Journal: Scandinavian journal of infectious diseases 20020101

Title: Antivirals for influenza: what is their role in the older patient?

Journal: Drugs & aging 20020101

Title: Neuraminidase inhibitors in patients with underlying airways disease.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: Spotlight on zanamivir in influenza.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: Creating an integrated public sector? Labour's plans for the modernisation of the English health care system.

Journal: International journal of integrated care 20020101

Title: Perspectives on antiviral use during pandemic influenza.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Zanamivir: from drug design to the clinic.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Treatment of influenza with neuraminidase inhibitors: virological implications.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Clinical effectiveness and cost effectiveness of zanamivir (Relenza): translating the evidence into clinical practice, a National Institute for Clinical Excellence view.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Zanamivir: an alternative translation.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.

Journal: Journal of medicinal chemistry 20011206

Title: Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201.

Journal: Antiviral research 20011201

Title: Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.

Journal: Antimicrobial agents and chemotherapy 20011201

Title: Management of influenza in patients with asthma or chronic obstructive pulmonary disease.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011201

Title: Zanamivir: a second look. Still no tangible impact on influenza.

Journal: Prescrire international 20011201

Title: Are we ready for the next flu pandemic?

Journal: The Lancet. Infectious diseases 20011201

Title: Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture.

Journal: Virus research 20011105

Title: Vaccines for pneumonia and new antiviral therapies.

Journal: The Medical clinics of North America 20011101

Title: Rapid pharmacotherapeutic intervention for an influenza A outbreak in the Canadian Arctic: lessons from the Sanikiluaq experience.

Journal: International journal of circumpolar health 20011101

Title: Synthesis of influenza neuraminidase inhibitors.

Journal: Current opinion in drug discovery & development 20011101

Title: Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses.

Journal: Antimicrobial agents and chemotherapy 20011001

Title: ACIP releases guidelines on the prevention and control of influenza. Advisory Committee on Immunization Practices.

Journal: American family physician 20011001

Title: Therapeutic options for the management of influenza.

Journal: Current opinion in pharmacology 20011001

Title: Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza.

Journal: Archives of internal medicine 20010924

Title: The effect of zanamivir treatment on the early immune response to influenza vaccination.

Journal: Vaccine 20010914

Title: Virology. The origin and control of pandemic influenza.

Journal: Science (New York, N.Y.) 20010907

Title: [Patient assessment for zanamivir therapy--a survey of patients with influenza who were prescribed zanamivir during the 2000/2001 season in Japan].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20010901

Title: Unprepared for an influenza pandemic.

Journal: Lancet (London, England) 20010825

Title: Antiviral drugs: current state of the art.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801

Title: Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections.

Journal: The Medical journal of Australia 20010716

Title: Elderly people's technique in using dry powder inhalers. Zanamivir and unreason seem to go together.

Journal: BMJ (Clinical research ed.) 20010707

Title: Adverse cutaneous reactions to influenza vaccinations and chemotherapy.

Journal: International journal of dermatology 20010701

Title: Advances in pharmacology. New treatments for influenza: neuraminidase inhibitors.

Journal: Medicine and health, Rhode Island 20010601

Title: Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Journal: Journal of medicinal chemistry 20010412

Title: Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.

Journal: Antimicrobial agents and chemotherapy 20010401

Title: Managing influenza: amantadine, rimantadine and beyond.

Journal: International journal of clinical practice 20010401

Title: Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.

Journal: Bioorganic & medicinal chemistry letters 20010312

Title: Comparison of elderly people's technique in using two dry powder inhalers to deliver zanamivir: randomised controlled trial.

Journal: BMJ (Clinical research ed.) 20010310

Title: Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities.

Journal: Antimicrobial agents and chemotherapy 20010301

Title: Zanamivir and oseltamivir: two new options for the treatment and prevention of influenza.

Journal: Clinical therapeutics 20010301

Title: Position statement: global neuraminidase inhibitor susceptibility network.

Journal: Antiviral research 20010301

Title: Does the availability of a neuraminidase inhibitor impair influenza vaccination? A report from Austria.

Journal: Vaccine 20010227

Title: The failings of NICE. Latest decision on zanamivir will not end postcode prescribing.

Journal: BMJ (Clinical research ed.) 20010224

Title: The failings of NICE. 'Spinning' is not nice.

Journal: BMJ (Clinical research ed.) 20010224

Title: Zanamivir to prevent influenza.

Journal: The New England journal of medicine 20010215

Title: Zanamivir to prevent influenza.

Journal: The New England journal of medicine 20010215

Title: [New preparations against influenza].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20010210

Title: Utility of zanamivir for chemoprophylaxis of concomitant influenza A and B in a complex continuing-care population.

Journal: Canada communicable disease report = Releve des maladies transmissibles au Canada 20010201

Title: Why not [symbol: see text]zanamivir?

Journal: Drug and therapeutics bulletin 20010201

Title: [Efficacy of inhaled zanamivir in the treatment and prevention of influenza].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20010201

Title: Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials.

Journal: Archives of internal medicine 20010122

Title: Neuraminidase inhibitors: zanamivir and oseltamivir.

Journal: The Annals of pharmacotherapy 20010101

Title: Prophylactic and symptomatic treatment of influenza. Current and developing options.

Journal: Postgraduate medicine 20010101

Title: [What is current opinion of antiviral therapy for the flu in 2001?].

Journal: La Revue de medecine interne 20010101

Title: Zanamivir: a rational approach to influenza B.

Journal: Scandinavian journal of infectious diseases 20010101

Title: Oseltamivir: a review of its use in influenza.

Journal: Drugs 20010101

Title: Cost-effectiveness analysis of inhaled zanamivir in the treatment of influenza A and B in high-risk patients.

Journal: PharmacoEconomics 20010101

Title: Prophylaxis and treatment of influenza virus infection.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101

Title: Impact of patient characteristics on the risk of influenza/ILI-related complications.

Journal: BMC health services research 20010101

Title: Antiviral drugs with extra-cellular sites of action.

Journal: Reviews in medical virology 20010101

Title: Zanamivir: a review of clinical safety in individuals at high risk of developing influenza-related complications.

Journal: Drug safety 20010101

Title: The anti-influenza virus agent 4-GU-DANA (zanamivir) inhibits cell fusion mediated by human parainfluenza virus and influenza virus HA.

Journal: Journal of virology 20001201

Title: In vitro and in vivo assay systems for study of influenza virus inhibitors.

Journal: Antiviral research 20001001

Title: BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

Journal: Journal of medicinal chemistry 20000921

Title: Chemoprophylaxis of influenza A virus infections, with single doses of zanamivir, demonstrates that zanamivir is cleared slowly from the respiratory tract.

Journal: Antimicrobial agents and chemotherapy 19991101

Title: A novel approach to antiviral therapy for influenza.

Journal: The Journal of antimicrobial chemotherapy 19991101

Title: Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain.

Journal: European journal of medicinal chemistry 19990101

Title: Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice.

Journal: The Journal of infectious diseases 19981201

Title: Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.

Journal: Antimicrobial agents and chemotherapy 19981201

Title: Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.

Journal: Journal of medicinal chemistry 19980312

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Tags:139110-80-8 Molecular Formula|139110-80-8 MDL|139110-80-8 SMILES|139110-80-8 Zanamivir