Catalog No.:AA01DWZ7

1396337-04-4 | N-(5-FLUOROPYRIDIN-2-YL)-6-METHYL-4-(PYRIMIDIN-5-YLOXY)PICOLINAMIDE

Name: Name:N-(5-FLUOROPYRIDIN-2-YL)-6-METHYL-4-(PYRIMIDIN-5-YLOXY)PICOLINAMIDE
Brand: AABLOCKS
SKU: AA01DWZ7
Availability: InStock
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100mg

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$498.00 $349.00

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250mg

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$943.00 $660.00

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$2,279.00 $1,595.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Download SDS

Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01DWZ7

Chemical Name:

N-(5-FLUOROPYRIDIN-2-YL)-6-METHYL-4-(PYRIMIDIN-5-YLOXY)PICOLINAMIDE

CAS Number:

1396337-04-4

Molecular Formula:

C16H12FN5O2

Molecular Weight:

325.2972

MDL Number:

MFCD28386341

SMILES:

Fc1ccc(nc1)NC(=O)c1cc(Oc2cncnc2)cc(n1)C

Properties

Computed Properties

Complexity:

421

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.6

Downstream Synthesis Route

1396337-94-2

21717-96-4

1396337-04-4

[1]TetrahedronLetters,2017,vol.58,p.3554-3558

[2]Patent:WO2012/118563,2012,A2.Locationinpatent:Page/Pagecolumn137

[3]JournalofMedicinalChemistry,2017,vol.60,p.5072-5085

104711-65-1

1396337-04-4

[1]Patent:WO2012/118563,2012,A2

[2]JournalofMedicinalChemistry,2017,vol.60,p.5072-5085

[3]TetrahedronLetters,2017,vol.58,p.3554-3558

Literature

Title: Felts AS, et al. Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem. 2017 Jun 22;60(12):5072-5085.

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SDS