Home Aldehydes 14003-96-4
14003-96-4,MFCD12027255
Catalog No.:AA001BVV

14003-96-4 | 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

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1mg
98%
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$19.00   $14.00
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5mg
98%
in stock  
$40.00   $28.00
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10mg
98%
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$64.00   $45.00
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25mg
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$96.00   $68.00
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50mg
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$145.00   $102.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001BVV
Chemical Name:
7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde
CAS Number:
14003-96-4
Molecular Formula:
C11H8O4
Molecular Weight:
204.1788
MDL Number:
MFCD12027255
SMILES:
O=Cc1c(O)ccc2c1oc(=O)cc2C
Properties
Properties
 
Form:
Solid  
MP:
189-190℃ (ethanol )  
Refractive Index:
1.641  
Solubility:
DMSO: soluble5mg/mL, clear (warmed)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
321  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.5  

Literature

Title: Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.

Journal: Journal of medicinal chemistry 20140522

Title: Synthesis, spectroscopic characterization and biological evaluation studies of Schiff's base derived from naphthofuran-2-carbohydrazide with 8-formyl-7-hydroxy-4-methyl coumarin and its metal complexes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121201

Title: 8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzenesulfonate.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: Synthesis, physico-chemical investigations of Co(II), Ni(II) and Cu(II) complexes and their in vitro microbial, cytotoxic, DNA cleavage studies.

Journal: Journal of enzyme inhibition and medicinal chemistry 20100601

Title: DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: synthesis, spectral characterization, and electrochemical studies.

Journal: Journal of enzyme inhibition and medicinal chemistry 20100201

Title: Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

Journal: European journal of medicinal chemistry 20090701

Title: Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090601

Title: Synthesis, spectral characterization and in vitro biological studies of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090401

Title: Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.

Journal: European journal of medicinal chemistry 20081201

Title: Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.

Journal: Journal of medicinal chemistry 20080227

Title: Cross BC, et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78.

Title: Zhang L, et al. IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol. 2014 Jul 10;15:29.

Title: Kemp K, et al. The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem. 2013 Nov 15;288(46):33272-82.

Title: Tufanli O, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404.

Title: Nam ST, et al. Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Sykactivation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C. Toxicol Appl Pharmacol. 2017 Oct 1;332:25-31.

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Tags:14003-96-4 Molecular Formula|14003-96-4 MDL|14003-96-4 SMILES|14003-96-4 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde