Home Other Building Blocks 141-05-9
141-05-9,MFCD00009191
Catalog No.:AA001FN9

141-05-9 | 2-Butenedioic acid (2Z)-, 1,4-diethyl ester

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
95%
in stock  
$12.00   $8.00
- +
100g
95%
in stock  
$16.00   $11.00
- +
500g
95%
in stock  
$25.00   $18.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001FN9
Chemical Name:
2-Butenedioic acid (2Z)-, 1,4-diethyl ester
CAS Number:
141-05-9
Molecular Formula:
C8H12O4
Molecular Weight:
172.1785
MDL Number:
MFCD00009191
SMILES:
CCOC(=O)/C=C\C(=O)OCC
NSC Number:
8394
Properties
Properties
 
BP:
225°C at 760 mmHg  
Form:
Solid  
MP:
−10 °C(lit.)  
Refractive Index:
n20/D 1.441(lit.)  
Solubility:
14mg/l  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
164  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
0.9  

Literature

Title: Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.

Journal: Chemical research in toxicology 20170417

Title: High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.

Journal: Archives of toxicology 20170101

Title: SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Pyrethroid resistance in Phytoseiulus macropilis (Acari: Phytoseiidae): cross-resistance, stability and effect of synergists.

Journal: Experimental & applied acarology 20160101

Title: A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Journal: Archives of toxicology 20151201

Title: Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150601

Title: Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells.

Journal: Archives of toxicology 20140201

Title: [Pyrethroid resistance mechanisms in the body lice Pediculus humanus humanus L.: detoxification enzyme systems].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20140101

Title: NCTC 2544 and IL-18 production: a tool for the identification of contact allergens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130401

Title: Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK(+/-)) cell cultures.

Journal: Toxicology mechanisms and methods 20120901

Title: Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

Journal: Free radical biology & medicine 20120815

Title: Simplified bicyclic pyridinol analogues protect mitochondrial function.

Journal: Bioorganic & medicinal chemistry 20120601

Title: A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts.

Journal: Cell death and differentiation 20120401

Title: Chlorantraniliprole susceptibility in Leptinotarsa decemlineata in the north Xinjiang Uygur autonomous region in China.

Journal: Journal of economic entomology 20120401

Title: Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin.

Journal: Archives of toxicology 20120201

Title: Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20120201

Title: The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120101

Title: Acrylonitrile-induced gastric toxicity in rats: the role of xanthine oxidase.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.

Journal: Archives of toxicology 20111201

Title: An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111201

Title: Relating skin sensitizing potency to chemical reactivity: reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than S(N)Ar- and S(N)2- reactive chemicals.

Journal: Chemical research in toxicology 20111121

Title: Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat.

Journal: Archives of toxicology 20110901

Title: Effect of glutathione depletion, hyperthermia, and a 100-mT static magnetic field on an hsp70/luc reporter system.

Journal: Bioelectromagnetics 20110901

Title: Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium-ERK1/2-Nrf2 pathway.

Journal: Free radical biology & medicine 20110701

Title: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

Journal: Chemico-biological interactions 20110530

Title: Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway.

Journal: Cellular signalling 20110501

Title: Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.

Journal: Archives of biochemistry and biophysics 20110401

Title: Characterisation of spinosad resistance in the housefly Musca domestica (Diptera: Muscidae).

Journal: Pest management science 20110301

Title: Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent.

Journal: Chemical research in toxicology 20110114

Title: High molecular weight isoforms of growth hormone in cells of the immune system.

Journal: Cellular immunology 20110101

Title: The protective role of Tropaeolum majus on blood and liver toxicity induced by diethyl maleate in rats.

Journal: Toxicology mechanisms and methods 20101101

Title: Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.

Journal: Biochemistry 20101005

Title: Cellular antioxidant levels influence muscle stem cell therapy.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20101001

Title: Reactivity of vinyl ethers and vinyl ribosides in UV-initiated free radical copolymerization with acceptor monomers.

Journal: Biomacromolecules 20100913

Title: Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate.

Journal: American journal of respiratory cell and molecular biology 20100901

Title: A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.

Journal: Cutaneous and ocular toxicology 20100901

Title: Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100901

Title: Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress.

Journal: Molecular and cellular endocrinology 20100729

Title: Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells.

Journal: Toxicology and applied pharmacology 20100515

Title: Rat brain endothelial cells are a target of manganese toxicity.

Journal: Brain research 20100422

Title: Sensitization to dimethyl fumarate with multiple concurrent patch test reactions.

Journal: Contact dermatitis 20100201

Title: Transient glutathione depletion determines terminal differentiation in HL-60 cells.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091101

Title: Peroxiredoxin 2 and peroxidase enzymatic activity of mammalian spermatozoa.

Journal: Biology of reproduction 20090601

Title: Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats.

Journal: The Journal of pharmacy and pharmacology 20090601

Title: Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen).

Journal: Archives of insect biochemistry and physiology 20090501

Title: Effect of 100 mT homogeneous static magnetic field on [Ca2+]c response to ATP in HL-60 cells following GSH depletion.

Journal: Bioelectromagnetics 20090501

Title: Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture.

Journal: Journal of neurochemistry 20090501

Title: Real-time measurement of cytosolic free calcium concentration in DEM-treated HL-60 cells during static magnetic field exposure and activation by ATP.

Journal: Bioelectromagnetics 20090401

Title: Genetic and biochemical analysis of a laboratory-selected spirodiclofen-resistant strain of Tetranychus urticae Koch (Acari: Tetranychidae).

Journal: Pest management science 20090401

Title: Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?

Journal: Toxicology letters 20090328

Title: Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord.

Journal: Journal of neuroscience research 20090215

Title: Regulation of apoptosis by Caspases under oxidative stress conditions in mice testicular cells: in vitro molecular mechanism.

Journal: Molecular and cellular biochemistry 20090201

Title: Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures.

Journal: Circulation research 20090102

Title: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides.

Journal: PLoS neglected tropical diseases 20090101

Title: The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts.

Journal: PloS one 20090101

Title: Dissecting the signaling events that impact classical nuclear import and target nuclear transport factors.

Journal: PloS one 20090101

Title: Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish.

Journal: Toxicology and applied pharmacology 20080515

Title: Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes.

Journal: Biochimica et biophysica acta 20080301

Title: Prenatal diet determines susceptibility to cardiac ischaemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine.

Journal: Life sciences 20080116

Title: Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Diethyl maleate-induced oxidative stress leads to testicular germ cell apoptosis involving Bax and Bcl-2.

Journal: Journal of biochemical and molecular toxicology 20080101

Title: Modulation of cell apoptosis by AIR.

Journal: Leukemia 20071201

Title: Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis.

Journal: Stress (Amsterdam, Netherlands) 20071101

Title: Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae.

Journal: Biogerontology 20071001

Title: Subcellular localization and cytoplasmic complex status of endogenous Keap1.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20071001

Title: [Effect of decreased GSH on sensitivity of breast cancer cells to ADM].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

Title: Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070701

Title: Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia.

Journal: European cytokine network 20070601

Title: The dietary antioxidant resveratrol affects redox changes of PPARalpha activity.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20070501

Title: Insecticide toxicity and synergism by enzyme inhibitors in 18 species of pest insect and natural enemies in crucifer vegetable crops.

Journal: Pest management science 20070501

Title: Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070401

Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Journal: Carcinogenesis 20070201

Title: Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.

Journal: Biological & pharmaceutical bulletin 20070201

Title: Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells.

Journal: Genes, chromosomes & cancer 20070101

Title: [Regulation of the 26S proteasomes' endoribonuclease activity specificity in k562 cells under effect of differentiation and apoptosis inductors].

Journal: Tsitologiia 20070101

Title: [Reprogramming of nuclear proteasomes in K562 cells undergoing apoptosis. I. Effect of glutathione-depleting agent, diethylmaleate].

Journal: Tsitologiia 20070101

Title: Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate.

Journal: BioFactors (Oxford, England) 20070101

Title: Effect of diethyl maleate induced oxidative stress on male reproductive activity in mice: redox active enzymes and transcription factors expression.

Journal: Molecular and cellular biochemistry 20061001

Title: Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro.

Journal: Basic & clinical pharmacology & toxicology 20060901

Title: S-adenosylmethionine but not glutathione protects against galactosamine-induced cytotoxicity in rat hepatocyte cultures.

Journal: Toxicology 20060515

Title: AROS-29 is involved in adaptive response to oxidative stress.

Journal: Free radical research 20060501

Title: Transcription regulation in NIH3T3 cell clones resistant to diethylmaleate-induced oxidative stress and apoptosis.

Journal: Antioxidants & redox signaling 20060101

Title: [Specificity of changes in proteasome properties in diethylmaleate-induced apoptosis of K562 cells].

Journal: Tsitologiia 20060101

Title: The effect of oxidative stress on the transport of taurine in an in vitro model of the blood-brain barrier.

Journal: Advances in experimental medicine and biology 20060101

Title: Comparative toxicity of fumigants and a phosphine synergist using a novel containment chamber for the safe generation of concentrated phosphine gas.

Journal: PloS one 20060101

Title: Application of multivariate curve resolution methods to on-flow LC-NMR.

Journal: Journal of chromatography. A 20051125

Title: Decreased tissue accumulation of 6-deoxy-6-[18F]fluoro-L-ascorbic acid in glutathione-deficient rats induced by administration of diethyl maleate.

Journal: Biological & pharmaceutical bulletin 20051001

Title: Chlorpyrifos resistance in mosquito Culex quinquefasciatus.

Journal: Journal of medical entomology 20050901

Title: Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion.

Journal: American journal of physiology. Heart and circulatory physiology 20050801

Title: Apoptosis vs. necrosis: glutathione-mediated cell death during rewarming of rat hepatocytes.

Journal: Biochimica et biophysica acta 20050610

Title: Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

Journal: Journal of cellular physiology 20050601

Title: Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis.

Journal: Free radical biology & medicine 20050515

Title: Up-regulation of glutathione biosynthesis in NIH3T3 cells transformed with the ETV6-NTRK3 gene fusion.

Journal: Molecules and cells 20050227

Title: Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.

Journal: The Journal of biological chemistry 20050211

Title: Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes.

Journal: European journal of pharmacology 20050131

Title: Heme oxygenase expression in cultured human trophoblast cells during in vitro differentiation: effects of hypoxia.

Journal: Placenta 20050101

Title: Differential regulation of three genes encoding glutathione S-transferases in Schizosaccharomyces pombe.

Journal: Molecules and cells 20041231

Title: Effect of acrolein and glutathione depleting agents on thioredoxin.

Journal: Toxicology 20041115

Title: Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041101

Title: Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041001

Title: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

Journal: Biochemistry 20040928

Title: Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration.

Journal: Molecular microbiology 20040601

Title: Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C.

Journal: Hepatology (Baltimore, Md.) 20040501

Title: Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.

Journal: Hepatology (Baltimore, Md.) 20040501

Title: Human erythrocyte recycling of ascorbic acid: relative contributions from the ascorbate free radical and dehydroascorbic acid.

Journal: The Journal of biological chemistry 20040409

Title: Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.

Journal: Circulation research 20040319

Title: BAG3 protein regulates stress-induced apoptosis in normal and neoplastic leukocytes.

Journal: Leukemia 20040201

Title: [Selective effect of inductors of apoptosis on the endoribonuclease activity of 26S proteasomes and alpha-RNP particles in K562 cells: possible involvement of 26S proteasomes and alpha-RNP in the regulation of RNA stability].

Journal: Tsitologiia 20040101

Title: Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.

Journal: Biochemical and biophysical research communications 20031024

Title: Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).

Journal: Glia 20030901

Title: Caspase-3 activation is an early event and initiates apoptotic damage in a human leukemia cell line.

Journal: Apoptosis : an international journal on programmed cell death 20030801

Title: Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity.

Journal: The Journal of biological chemistry 20030606

Title: Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20030601

Title: Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice.

Journal: Biology of reproduction 20030501

Title: Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.

Journal: Experimental biology and medicine (Maywood, N.J.) 20030501

Title: Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation.

Journal: Journal of neurochemistry 20030401

Title: 3-methylindole-induced toxicity to human bronchial epithelial cell lines.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030201

Title: Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells.

Journal: Free radical biology & medicine 20030101

Title: [The correlation of tolerance to cerebral ischemia and body temperature with glutathione concentration].

Journal: Biomeditsinskaia khimiia 20030101

Title: Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity.

Journal: Journal of neurochemistry 20021201

Title: Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.

Journal: The Journal of biological chemistry 20021122

Title: Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion.

Journal: Toxicology letters 20021005

Title: Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020801

Title: Effects of diethylmaleate on DNA damage and repair in the mouse brain.

Journal: Free radical biology & medicine 20020715

Title: Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.

Journal: The Journal of pharmacology and experimental therapeutics 20020701

Title: Cytoprotective effects of nitrates in a cellular model of hydronephrosis.

Journal: Kidney international 20020701

Title: Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20020701

Title: Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues.

Journal: Molecular microbiology 20020701

Title: Microwave-assisted Stille-coupling of steroidal substrates.

Journal: Steroids 20020701

Title: Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20020701

Title: Modulation of hepatocyte thiol content by medium composition: implications for toxicity studies.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020601

Title: Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20020601

Title: Role of oxidative stress in advanced glycation end product-induced mesangial cell activation.

Journal: Kidney international 20020601

Title: Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia.

Journal: Journal of neurochemistry 20020501

Title: Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse.

Journal: Toxicon : official journal of the International Society on Toxinology 20020401

Title: Diethylmaleate, a pro-oxidant, attenuates experimental ischaemia-reperfusion-induced lung injury.

Journal: The British journal of surgery 20020401

Title: Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier.

Journal: Investigative ophthalmology & visual science 20020301

Title: Transcriptional and physiological responses of HepG2 cells exposed to diethyl maleate: time course analysis.

Journal: Physiological genomics 20020227

Title: Cystathionine pathway-dependent cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived cell cultures.

Journal: Alternatives to laboratory animals : ATLA 20020101

Title: Improved antioxidant effect of idebenone-loaded polyethyl-2-cyanoacrylate nanocapsules tested on human fibroblasts.

Journal: Pharmaceutical research 20020101

Title: Generation of prooxidant conditions in intact cells to induce modifications of cell cycle regulatory proteins.

Journal: Methods in enzymology 20020101

Title: GSH is required to recycle ascorbic acid in cultured liver cell lines.

Journal: Antioxidants & redox signaling 20011201

Title: Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases.

Journal: Cancer 20011101

Title: Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione.

Journal: Free radical biology & medicine 20011015

Title: Mechanisms of ascorbic acid recycling in human erythrocytes.

Journal: Biochimica et biophysica acta 20011003

Title: Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants.

Journal: Archives of biochemistry and biophysics 20010901

Title: Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo.

Journal: Microvascular research 20010901

Title: Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status.

Journal: Blood 20010715

Title: Regulation of p21waf1/cip1 expression by intracellular redox conditions.

Journal: IUBMB life 20010701

Title: Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.

Journal: Biochimica et biophysica acta 20010606

Title: Behavioral and biochemical effects of glutathione depletion in the rat brain.

Journal: Brain research bulletin 20010601

Title: Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes.

Journal: Pharmacology & toxicology 20010401

Title: Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

Title: Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats.

Journal: Japanese journal of pharmacology 20010401

Title: Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages.

Journal: The Journal of biological chemistry 20010330

Title: GSH role on platelet-derived growth factor receptor tyrosine phosphorylation induced by H2O2.

Journal: Biochemical and biophysical research communications 20010209

Title: Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents.

Journal: The Journal of biological chemistry 20010112

Title: Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells.

Journal: Biochemical and biophysical research communications 20010112

Title: Changes in the levels of glutathione after cellular and cutaneous damage induced by squalene monohydroperoxide.

Journal: Journal of biochemical and molecular toxicology 20010101

Title: Comparative susceptibility and possible detoxification mechanisms for selected miticides in banks grass mite and two-spotted spider mite (Acari: Tetranychidae).

Journal: Experimental & applied acarology 20010101

Title: Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding.

Journal: Free radical biology & medicine 20001215

Title: Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression.

Journal: Biochimica et biophysica acta 20000907

Title: Glutathione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20000801

Title: Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.

Journal: Hepatology (Baltimore, Md.) 20000801

Title: Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

Journal: Molecular pharmacology 20000701

Title: Induction of metalloelastase mRNA in murine peritoneal macrophages by diethylmaleate.

Journal: Biochimica et biophysica acta 19990419

Title: Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status.

Journal: Hepatology (Baltimore, Md.) 19990201

Title: Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.

Journal: The Biochemical journal 19981101

Title: Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.

Journal: Molecular and cellular biochemistry 19950705

Title: Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.

Journal: Archives of biochemistry and biophysics 19950201

Title: Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19920601

Title: The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate.

Journal: Japanese journal of cancer research : Gann 19920101

Title: The radiosensitizing effects of misonidazole (MISO) in combination with diethyl maleate (DEM) in mouse mammary tumors.

Journal: International journal of radiation oncology, biology, physics 19861001

Title: Detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or aroclor.

Journal: Anticancer research 19860101

Title: Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partial hepatectomized, and preneoplastic/neoplastic liver.

Journal: Toxicology and applied pharmacology 19850915

Title: Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19840401

Title: Lipid peroxidation: a possible mechanism of cephaloridine-induced nephrotoxicity.

Journal: Toxicology and applied pharmacology 19830101

Title: Antifungal properties of 2-bromo-3-fluorosuccinic acid esters and related compounds.

Journal: Journal of medicinal chemistry 19770401

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:141-05-9 Molecular Formula|141-05-9 MDL|141-05-9 SMILES|141-05-9 2-Butenedioic acid (2Z)-, 1,4-diethyl ester |Organic_Building_Blocks