Home Other Building Blocks 14152-28-4
14152-28-4,MFCD00077858
Catalog No.:AA001GGA

14152-28-4 | Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
≥98%
in stock  
$172.00   $120.00
- +
10mg
≥98%
in stock  
$319.00   $223.00
- +
50mg
≥98%
in stock  
$1,338.00   $936.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001GGA
Chemical Name:
Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
CAS Number:
14152-28-4
Molecular Formula:
C20H32O4
Molecular Weight:
336.4657
MDL Number:
MFCD00077858
SMILES:
CCCCC[C@@H](/C=C/[C@H]1C=CC(=O)[C@@H]1CCCCCCC(=O)O)O
Properties
Computed Properties
 
Complexity:
439  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
13  
XLogP3:
4.4  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: A-class prostaglandins: early findings and new perspectives for overcoming tumor chemoresistance.

Journal: Cancer letters 20120728

Title: Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.

Journal: Cancer research 20110615

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Journal: Journal of medicinal chemistry 20100722

Title: A biotinylated analog of the anti-proliferative prostaglandin A1 allows assessment of PPAR-independent effects and identification of novel cellular targets for covalent modification.

Journal: Chemico-biological interactions 20100105

Title: CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis.

Journal: Journal of lipid research 20081001

Title: Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins.

Journal: Journal of cell science 20080801

Title: Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophages.

Journal: Journal of microbiology and biotechnology 20080601

Title: Prostaglandins A1 and E1 influence gene expression in an established insect cell line (BCIRL-HzAM1 cells).

Journal: Insect biochemistry and molecular biology 20080301

Title: Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

Journal: The EMBO journal 20071212

Title: Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA1: focus on vimentin.

Journal: Journal of mass spectrometry : JMS 20071101

Title: Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective.

Journal: Biochemistry 20070605

Title: Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.

Journal: Immunology and cell biology 20070101

Title: Addition of electrophilic lipids to actin alters filament structure.

Journal: Biochemical and biophysical research communications 20061103

Title: Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1.

Journal: Molecular pharmacology 20060901

Title: Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.

Journal: European journal of pharmacology 20060807

Title: Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA(2) production and platelet activation.

Journal: Acta pharmacologica Sinica 20060501

Title: Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.

Journal: The Journal of endocrinology 20060101

Title: Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione.

Journal: FEBS letters 20051024

Title: Prostaglandin-induced neurodegeneration is associated with increased levels of oxidative markers and reduced by a mixture of antioxidants.

Journal: Journal of neuroscience research 20050701

Title: Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition.

Journal: Biochemical and biophysical research communications 20040709

Title: Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK).

Journal: AIDS (London, England) 20040618

Title: Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells.

Journal: Journal of neuroscience research 20031001

Title: Absolute stereochemistry of allylic alcohols, amines, and other ene moieties: a microscale cross metathesis/exciton chirality protocol.

Journal: Journal of the American Chemical Society 20030910

Title: Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53.

Journal: Cancer research 20030901

Title: Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.

Journal: Molecular pharmacology 20030801

Title: Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030601

Title: Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells.

Journal: Molecular carcinogenesis 20030501

Title: Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase.

Journal: The Journal of biological chemistry 20030110

Title: Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells.

Journal: Journal of neurochemistry 20021201

Title: Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701

Title: Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.

Journal: Brain research 20020621

Title: A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020515

Title: Peroxisome proliferator-activated receptor gamma agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects.

Journal: The Journal of biological chemistry 20020510

Title: A chromatographic method for the quantification of prostaglandin E(1) and prostaglandin A(1) encapsulated in an intravenous lipid formulation.

Journal: Journal of pharmaceutical and biomedical analysis 20020415

Title: Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20011001

Title: Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy.

Journal: The Journal of biological chemistry 20010803

Title: Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes.

Journal: Journal of molecular and cellular cardiology 20010801

Title: Inhibition by prostaglandin PGA1 on the multiplication of influenza virus is a dose-dependent effect.

Journal: Virus research 20010501

Title: Prostaglandin A(1) protects striatal neurons against excitotoxic injury in rat striatum.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: Effect of prostaglandin A1, arsenite and aspirin on stress proteins response in mosquito cells.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

Title: Inhibition of Mayaro virus replication by prostaglandin A(1) in Vero cells.

Journal: Intervirology 20010101

Title: Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1.

Journal: European journal of biochemistry 19980901

Title: Prostaglandins stimulate the stress-induced synthesis of hsp27 and alpha B crystallin.

Journal: Journal of cellular physiology 19970301

Title: Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19970121

Title: Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

Journal: The Journal of clinical investigation 19960415

Title: Prostaglandin A inhibits replication of human immunodeficiency virus during acute infection.

Journal: The Journal of general virology 19911101

Title: Screening for new compounds with antiherpes activity.

Journal: Antiviral research 19841001

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:14152-28-4 Molecular Formula|14152-28-4 MDL|14152-28-4 SMILES|14152-28-4 Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-