Home Pyridines 142-08-5
142-08-5,MFCD00006268
Catalog No.:AA00HW7B

142-08-5 | Pyridin-2-ol

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10g
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$13.00   $9.00
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25g
98%
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$16.00   $11.00
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500g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00HW7B
Chemical Name:
Pyridin-2-ol
CAS Number:
142-08-5
Molecular Formula:
C5H5NO
Molecular Weight:
95.0993
MDL Number:
MFCD00006268
SMILES:
O=c1cccc[nH]1
Properties
Computed Properties
 
Complexity:
135  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
-0.6  

Literature

Title: Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Journal: Bioorganic & medicinal chemistry 20140315

Title: Zinc, cadmium, and mercury complexes of a pyridyloxy-substituted cyclotriphosphazene: syntheses, structures, and fluxional behavior.

Journal: Inorganic chemistry 20121015

Title: Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): a target for heart failure and platelet aggregation.

Journal: Bioorganic & medicinal chemistry letters 20120915

Title: A pyridinol acyl cofactor in the active site of [Fe]-hydrogenase evidenced by the reactivity of model complexes.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120910

Title: Synthesis of (±)-7-hydroxylycopodine.

Journal: The Journal of organic chemistry 20120907

Title: Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection.

Journal: Bioorganic & medicinal chemistry 20120901

Title: Pseudopolymorphs of chelidamic acid and its dimethyl ester.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120901

Title: Reactions of the tetrafluoroborate complex [Mo2Cp2(κ(2)-F2BF2)(μ-PPh2)2(CO)]BF4 with mono- and bidentate ligands having E-H bonds (E = O, S, Se, N, P).

Journal: Inorganic chemistry 20120702

Title: Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones.

Journal: Organic & biomolecular chemistry 20120621

Title: 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives.

Journal: European journal of medicinal chemistry 20120601

Title: Simplified bicyclic pyridinol analogues protect mitochondrial function.

Journal: Bioorganic & medicinal chemistry 20120601

Title: Stereoselective amine-catalyzed carbohydrate chain elongation.

Journal: Chemical communications (Cambridge, England) 20120528

Title: Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.

Journal: Bioorganic & medicinal chemistry 20120501

Title: Bis(acetato-κO)bis-[2-(pyridin-2-yl)ethanol-κ(2)N,O]copper(II).

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: 5-(2-Chloro-benz-yl)-4,5,6,7-tetra-hydro-thieno[3,2-c]pyridin-2-yl acetate.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: N-(3-Bromo-2-methyl-phen-yl)-2-oxo-1,2-di-hydro-pyridine-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives.

Journal: Ultrasonics sonochemistry 20120301

Title: Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation.

Journal: Chemistry & biology 20120224

Title: Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.

Journal: Journal of the American Chemical Society 20120222

Title: Biosynthesis of the iron-guanylylpyridinol cofactor of [Fe]-hydrogenase in methanogenic archaea as elucidated by stable-isotope labeling.

Journal: Journal of the American Chemical Society 20120215

Title: FeCl3⋅6H2O-catalyzed intermolecular-cascade cyclization of acetoacetanilide: aldehyde-tuned synthesis to valuable 2-pyridone analogues.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120213

Title: Construction of Escherichia coli-Arthrobacter-Rhodococcus shuttle vectors based on a cryptic plasmid from Arthrobacter rhombi and investigation of their application for functional screening.

Journal: FEMS microbiology letters 20120201

Title: Iridium-catalyzed [2+2+2] cycloaddition of α,ω-diynes with isocyanates.

Journal: The Journal of organic chemistry 20120120

Title: Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

Journal: Structure (London, England : 1993) 20120111

Title: Human metabolism of lapatinib, a dual kinase inhibitor: implications for hepatotoxicity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: Efficient synthesis of biazoles by aerobic oxidative homocoupling of azoles catalyzed by a copper(I)/2-pyridonate catalytic system.

Journal: Chemical communications (Cambridge, England) 20111228

Title: Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.

Journal: Organic & biomolecular chemistry 20111221

Title: Induction of micronuclei by 2-hydroxypyridine in water and elimination of solution genotoxicity by UVC (254 nm) photolysis.

Journal: Journal of hazardous materials 20111215

Title: Consequence of one-electron oxidation and one-electron reduction for aniline.

Journal: Journal of molecular modeling 20111201

Title: Bis(2,2'-bipyridine)(pyridin-2-olato)ruthenium(II) hexa-fluorido-phosphate benzene hemisolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: 'Twisted' scorpionates: synthesis of a tris(2-pyridonyl)borate (Thp) ligand; lessons in the requirements for successful B(L2D)3 type ligands.

Journal: Chemical communications (Cambridge, England) 20111114

Title: An acetate prodrug of a pyridinol-based vitamin E analogue.

Journal: Pharmaceutical research 20111101

Title: Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: first structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20111101

Title: The S1/S2 exciton interaction in 2-pyridone·6-methyl-2-pyridone: Davydov splitting, vibronic coupling, and vibronic quenching.

Journal: The Journal of chemical physics 20111021

Title: Consensus features of CP-MLR and GA in modeling HIV-1 RT inhibitory activity of 4-benzyl/benzoylpyridin-2-one analogues.

Journal: Journal of enzyme inhibition and medicinal chemistry 20111001

Title: 1-Methyl-3-(4-chloro-benzo-yl)imidazo[1,2-a]pyridin-1-ium-2-olate.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1.

Journal: ChemMedChem 20110905

Title: The structural basis of RNA-catalyzed RNA polymerization.

Journal: Nature structural & molecular biology 20110901

Title: Time-dependent density functional theory study of the excited-state dihydrogen bonding: clusters of 2-pyridone with diethylmethylsilane and triethylgermanium.

Journal: Journal of molecular modeling 20110801

Title: Intermolecular clamping by hydrogen bonds: 2-pyridone⋅NH3.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20110711

Title: 2-(1,2-Dihydro-2-oxopyridin-3-yl)-1,3-benzothia-zol-3-ium bromide monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Synthesis of pyridin-2(1H)-one derivatives via enamine cyclization.

Journal: The Journal of organic chemistry 20110520

Title: Synthesis of acyclovir and HBG analogues having nicotinonitrile and its 2-methyloxy 1,2,3-triazole.

Journal: Nucleosides, nucleotides & nucleic acids 20110501

Title: Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives.

Journal: Molecules (Basel, Switzerland) 20110420

Title: Regulation of lipid peroxidation in the retina under the effect of bright light.

Journal: Bulletin of experimental biology and medicine 20110401

Title: A theoretical study of the mechanism for the homogeneous catalytic reversible dehydrogenation-hydrogenation of nitrogen heterocycles.

Journal: Physical chemistry chemical physics : PCCP 20110307

Title: Locations and reorientations of multi-ring-fused 2-pyridones in ganglioside G(M1) micelles.

Journal: Langmuir : the ACS journal of surfaces and colloids 20110301

Title: Possibilities of regulating disorders in functional activity of the retina with antioxidants under conditions of high-intensity light exposure.

Journal: Bulletin of experimental biology and medicine 20110301

Title: Electron-induced phase transition in hydrogen-bonded solid-state 2-pyridone.

Journal: The journal of physical chemistry. A 20110217

Title: Rigid dimers formed through strong interdigitated H-bonds yield compact 1D supramolecular helical polymers.

Journal: Small (Weinheim an der Bergstrasse, Germany) 20110207

Title: Ligand self-assembling through complementary hydrogen-bonding in the coordination sphere of a transition metal center: the 6-diphenylphosphanylpyridin-2(1H)-one system.

Journal: Journal of the American Chemical Society 20110202

Title: (R)-(+)-Dimeth-yl[4-oxido-2-oxo-1-(1-phenyl-eth-yl)-1,2,5,6-tetra-hydro-pyridin-3-yl]sulfonium.

Journal: Acta crystallographica. Section E, Structure reports online 20110201

Title: Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

Journal: PloS one 20110101

Title: Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photodynamic medicine.

Journal: PloS one 20110101

Title: Excitonic splittings in jet-cooled molecular dimers.

Journal: Chimia 20110101

Title: Models for the prediction of receptor tyrosine kinase inhibitory activity of substituted 3-aminoindazole analogues.

Journal: Scientia pharmaceutica 20110101

Title: Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.

Journal: PloS one 20110101

Title: Structural studies of biomolecules in the gas phase by chirped-pulse Fourier transform microwave spectroscopy.

Journal: Faraday discussions 20110101

Title: Synthesis of 2-pyridones and iminoesters via Rh(III)-catalyzed oxidative coupling between acrylamides and alkynes.

Journal: Organic letters 20101203

Title: Novel proton transfer fluorescence probe 2-hydroxy-pyridine and 5-(4-fluorophenyl)-2-hydroxypyridine for studying native, denatured and renatured state of protein Bovine Serum Albumin.

Journal: Journal of photochemistry and photobiology. B, Biology 20101202

Title: The hydrogen-bonded 2-pyridone dimer model system. 2. Femtosecond mid-infrared pump-probe study.

Journal: The journal of physical chemistry. A 20101125

Title: Concise synthesis of bicyclic pyridinol antioxidants.

Journal: Organic letters 20101119

Title: Tautomerism and microsolvation in 2-hydroxypyridine/2-pyridone.

Journal: The journal of physical chemistry. A 20101104

Title: Unusual light spectroscopic properties of a 2-pyridone-based multi-ring-fused fluorescent scaffold.

Journal: Journal of fluorescence 20101101

Title: Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Density functional theory calculations on the mononuclear non-heme iron active site of Hmd hydrogenase: role of the internal ligands in tuning external ligand binding and driving H2 heterolysis.

Journal: Journal of the American Chemical Society 20101006

Title: catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κO:O] hexa-fluorido-phosphate].

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter?

Journal: Inorganic chemistry 20100906

Title: The hydrogen-bonded 2-pyridone dimer model system. 1. Combined NMR and FT-IR spectroscopy study.

Journal: The journal of physical chemistry. A 20100729

Title: Kinetics of solid state photodimerization of 1,4-dimethyl-2-pyridinone in its molecular compound.

Journal: The journal of physical chemistry. A 20100715

Title: Bis[4-(4-pyridyl-meth-oxy)phenol-κN]silver nitrate monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: In silico characterization of cytisinoids docked into an acetylcholine binding protein.

Journal: Bioorganic & medicinal chemistry letters 20100615

Title: Intramolecular 1,6-addition to 2-pyridones. Mechanism and synthetic scope.

Journal: The Journal of organic chemistry 20100604

Title: 1-[(2-Chloro-8-methyl-quinolin-3-yl)-meth-yl]pyridin-2(1H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100501

Title: Photoionization of 2-pyridone and 2-hydroxypyridine.

Journal: Physical chemistry chemical physics : PCCP 20100414

Title: Excited-state dynamics of the 2-hydroxypyridine-ammonia complex.

Journal: The journal of physical chemistry. A 20100311

Title: Metabolic profiling of Arabidopsis thaliana epidermal cells.

Journal: Journal of experimental botany 20100301

Title: Large-scale asymmetric synthesis of a cathepsin S inhibitor.

Journal: The Journal of organic chemistry 20100219

Title: Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives.

Journal: Journal of medicinal chemistry 20100128

Title: Tyrosine analogues for probing proton-coupled electron transfer processes in peptides and proteins.

Journal: Journal of the American Chemical Society 20100120

Title: Noncovalent synthesis of hierarchical zinc phosphates from a single Zn(4)O(12)P(4) double-four-ring building block: dimensionality control through the choice of auxiliary ligands.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100118

Title: Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells.

Journal: BMC cancer 20100101

Title: Models for antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines.

Journal: Scientia pharmaceutica 20100101

Title: Amidine dications as superelectrophiles.

Journal: Journal of the American Chemical Society 20091216

Title: Analytical energy gradient for reference interaction site model self-consistent field explicitly including spatial electron density distribution.

Journal: The Journal of chemical physics 20091207

Title: Metabolism of pyridalyl in rats: excretion, distribution, and biotransformation of dichloropropenyl-labeled pyridalyl.

Journal: Journal of agricultural and food chemistry 20091125

Title: Studies on the synthesis and activity of three tripalladium complexes containing planaramine ligands.

Journal: ChemMedChem 20091101

Title: 2-Hydroxypyridine photolytic degradation by 254 nm UV irradiation at different conditions.

Journal: Chemosphere 20091101

Title: Tetra-aqua-bis(2-oxo-1,2-dihydro-pyridine-5-sulfonato-κO)zinc(II).

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates.

Journal: The Journal of organic chemistry 20091002

Title: Assembly of unusual Zn-cluster compounds based on pyridinealcohol platforms.

Journal: Dalton transactions (Cambridge, England : 2003) 20090928

Title: Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

Journal: European journal of medicinal chemistry 20090901

Title: Photolytic removal and mineralisation of 2-halogenated pyridines.

Journal: Water research 20090901

Title: Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities.

Journal: European journal of medicinal chemistry 20090801

Title: Bis(3-hydroxy-pyridine-κN)bis-(3-nitro-benzoato-κO)zinc(II).

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Spiroborate ester-mediated asymmetric synthesis of beta-hydroxy ethers and its conversion to highly enantiopure beta-amino ethers.

Journal: The Journal of organic chemistry 20090605

Title: Photodynamic inactivation of Aeromonas hydrophila by cationic phthalocyanines with different hydrophobicity.

Journal: FEMS microbiology letters 20090501

Title: Isolation of 2-pyridone alkaloids from a New Zealand marine-derived penicillium species.

Journal: Journal of natural products 20090327

Title: Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.

Journal: European journal of medicinal chemistry 20090301

Title: Chemically bonded hybrid systems from functionalized hydroxypyridine molecular bridge: characterization and photophysical properties.

Journal: Photochemistry and photobiology 20090101

Title: Novel 3-(p-substituted phenyl)-6-bromo-4(3H)-quinazolinone derivatives of promising antiinflammatory and analgesic properties.

Journal: Acta poloniae pharmaceutica 20090101

Title: Carbon monoxide as intrinsic ligand to iron in the active site of [fe]-hydrogenase.

Journal: Metal ions in life sciences 20090101

Title: Identification of combustion intermediates in low-pressure premixed pyridine/oxygen/argon flames.

Journal: The journal of physical chemistry. A 20081225

Title: Metal-metal communication in copper(II) complexes of cyclotetraphosphazene ligands.

Journal: Inorganic chemistry 20081020

Title: The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B.

Journal: Journal of the American Chemical Society 20081015

Title: Saccharinato complexes of Ce(V) with 2-hydroxypyridine: synthesis, spectroscopic and thermal characteristics of [Ce(sac)2(SO4)(H2O)4] and [Ce(sac)2(SO4)(PyOH)2].

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001

Title: Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

Journal: Journal of medicinal chemistry 20080911

Title: Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes.

Journal: Journal of the American Chemical Society 20080813

Title: The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site.

Journal: Science (New York, N.Y.) 20080725

Title: Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

Journal: The Journal of organic chemistry 20080704

Title: Interactions of aromatic heterocycles with water: the driving force from free-jet rotational spectroscopy and model electrostatic calculations.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20080623

Title: Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Journal: Bioorganic & medicinal chemistry letters 20080615

Title: 2,4,6-Tris(1-oxo-2-pyridylsulfanylmeth-yl)mesitylene methanol solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: 2-(Mesitylmethyl-sulfan-yl)pyridine N-oxide-18-crown-6 (2/1).

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: New Fe4, Fe6, and Fe8 clusters of iron(III) from the use of 2-pyridyl alcohols: structural, magnetic, and computational characterization.

Journal: Inorganic chemistry 20080519

Title: Reactive force fields for proton transfer dynamics.

Journal: Journal of computational chemistry 20080501

Title: 2-(Benzyl-sulfan-yl)pyridine N-oxide.

Journal: Acta crystallographica. Section E, Structure reports online 20080501

Title: Synthesis of nickel complexes with bidentate N,O-type ligands and application in the catalytic oligomerization of ethylene.

Journal: Dalton transactions (Cambridge, England : 2003) 20080328

Title: Catalytic hydrolysis of esters of 2-hydroxypyridine derivatives for Cu2+ detection.

Journal: Inorganic chemistry 20080317

Title: Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Iromycins from Streptomyces sp. and from synthesis: new inhibitors of the mitochondrial electron transport chain.

Journal: Bioorganic & medicinal chemistry 20080215

Title: 2,2'-[2,3,5,6-Tetra-methyl-p-phenyl-ene-bis(methyl-enethio)]bis-(pyridine N-oxide).

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: 4-(4-Fluoro-phen-yl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: Helicates, boxes, and polymers from simple pyridine-alcohol ligands: the impact of the identity of the transition metal ion.

Journal: Inorganic chemistry 20080107

Title: Crystal structure and antitumor activity of the novel zwitterionic complex of tri-n-butyltin(IV) with 2-thiobarbituric acid.

Journal: Bioinorganic chemistry and applications 20080101

Title: Catalytic enantioselective approach to the stereodivergent synthesis of (+)-lasubines I and II.

Journal: The Journal of organic chemistry 20071221

Title: Reactions of sulphate radicals with substituted pyridines: a structure-reactivity correlation analysis.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20071203

Title: Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.

Journal: Journal of medicinal chemistry 20071115

Title: Conformationally rigid chelate rings in metal complexes of pyridyloxy-substituted 2,2'-dioxybiphenyl-cyclotetra- and cyclotriphosphazene platforms.

Journal: Inorganic chemistry 20071112

Title: Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.

Journal: Bioorganic & medicinal chemistry letters 20071015

Title: Cytostatic evaluations of nucleoside analogs related to unnatural base pairs for a genetic expansion system.

Journal: Bioorganic & medicinal chemistry letters 20071015

Title: Role of guiding groups in cinchona-modified platinum for controlling the sense of enantiodifferentiation in the hydrogenation of ketones.

Journal: Journal of the American Chemical Society 20070829

Title: Photolytic (UVC) and photocatalyic (UVC/TiO2) decomposition of pyridines.

Journal: Journal of hazardous materials 20070731

Title: The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis.

Journal: The Journal of organic chemistry 20070706

Title: Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Improved determination of structural changes of 2-pyridone-(H2O)1 upon electronic excitation.

Journal: The journal of physical chemistry. A 20070503

Title: Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes.

Journal: Organic letters 20070412

Title: Excited-state intramolecular proton transfer in 2-(3'-hydroxy-2'-pyridyl)benzoxazole. Evidence of coupled proton and charge transfer in the excited state of some o-hydroxyarylbenzazoles.

Journal: The journal of physical chemistry. A 20070315

Title: Use of SPE-GC/EIMS for residue analysis in wine elaborated from musts spiked with formulations of chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol.

Journal: Journal of separation science 20070301

Title: Cu-catalyzed N- and O-arylation of 2-, 3-, and 4-hydroxypyridines and hydroxyquinolines.

Journal: Organic letters 20070215

Title: Carbonarones A and B, new bioactive gamma-Pyrone and alpha-Pyridone derivatives from the marine-derived fungus Aspergillus carbonarius.

Journal: The Journal of antibiotics 20070201

Title: How resonance assists hydrogen bonding interactions: an energy decomposition analysis.

Journal: Journal of computational chemistry 20070115

Title: Ligand-promoted dehydrogenation of alcohols catalyzed by Cp*Ir complexes. A new catalytic system for oxidant-free oxidation of alcohols.

Journal: Organic letters 20070104

Title: Studies on the activity of three palladium(II) compounds of the form: trans-PdL2Cl2 where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine.

Journal: Journal of inorganic biochemistry 20070101

Title: Thrombin inhibitors with novel P1 binding pocket functionality: free energy of binding analysis.

Journal: Journal of molecular modeling 20070101

Title: Hierarchy of supramolecular synthons: persistent hydroxyl...pyridine hydrogen bonds in cocrystals that contain a cyano acceptor.

Journal: Molecular pharmaceutics 20070101

Title: New modular and efficient approach to 6-substituted pyridin-2-yl C-nucleosides.

Journal: The Journal of organic chemistry 20060915

Title: Selective cleavage of heparin using aqueous 2-hydroxypyridine: production of an aldose-terminating fragment with high anticoagulant activity.

Journal: Biochemical and biophysical research communications 20060804

Title: 2-hydroxypyridine <--> 2-pyridone tautomerization: catalytic influence of formic acid.

Journal: The journal of physical chemistry. A 20060727

Title: Gas-phase Watson-Crick and Hoogsteen isomers of the nucleobase mimic 9-methyladenine x 2-pyridone.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20060717

Title: An approach to helical tubular self-aggregation using C2-symmetric self-complementary hydrogen-bonding cavity molecules.

Journal: Journal of the American Chemical Society 20060628

Title: Boxes, helicates, and coordination polymers: a structural and magnetochemical investigation of the diverse coordination chemistry of simple pyridine-alcohol ligands.

Journal: Inorganic chemistry 20060612

Title: Di- and trinuclear complexes derived from hexakis(2-pyridyloxy)cyclotriphosphazene. Unusual P-O bond cleavage in the formation of [{(L'CuCl)2(Co(NO3)}Cl] (L' = N3P3(OC5H4N)5(O)).

Journal: Inorganic chemistry 20060501

Title: Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: variations on the 1H-pyrimidin-2-one theme.

Journal: Bioorganic & medicinal chemistry letters 20060401

Title: Hydrogen bonding of the nucleobase mimic 2-pyridone to fluorobenzenes: an ab initio investigation.

Journal: The journal of physical chemistry. A 20060330

Title: Isomerization reaction of head-to-head alpha-pyridonato-bridged ethylenediaminepalladium(II) binuclear complex, [Pd2(en)2(C5H4NO)2]2+, in aqueous solution.

Journal: Dalton transactions (Cambridge, England : 2003) 20060328

Title: Chemical hybridizing agents for chickpea (Cicer arietinum L.): leads from QSAR analysis of ethyl oxanilates and pyridones.

Journal: Journal of agricultural and food chemistry 20060308

Title: Hydroxy- and mercaptopyridine pincer platinum and palladium complexes generated by silver-free halide abstraction.

Journal: Inorganic chemistry 20060306

Title: Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine.

Journal: BMC chemical biology 20060101

Title: ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.

Journal: Beilstein journal of organic chemistry 20060101

Title: Interaction of thioamides, selenoamides, and amides with diiodine.

Journal: Bioinorganic chemistry and applications 20060101

Title: Differential inhibitory effect of newly synthesized pyridine-2-one derivatives on the cercarial serine protease activity of the parasite Schistosoma mansoni.

Journal: Acta poloniae pharmaceutica 20060101

Title: Site-specific fluorescent labeling of RNA molecules by specific transcription using unnatural base pairs.

Journal: Journal of the American Chemical Society 20051214

Title: Di-mu-formato-1kappa2O:2kappa2O'-di-mu-pyridin-2-olato-1kappaO:2kappaN;1kappaN:2kappaO-bis[(2-pyridone-kappaO)copper(II)] acetonitrile 1.02-solvate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20051201

Title: Two competitive routes in the lactim-lactam phototautomerization of a hydroxypyridine derivative cation in water: dissociative mechanism versus water-assisted proton transfer.

Journal: The journal of physical chemistry. A 20051117

Title: Synthesis of new potentially bioactive bicyclic 2-pyridones.

Journal: Molecules (Basel, Switzerland) 20051031

Title: Routes to unique palladium A-frame complexes with a bridging fluoro-ligand.

Journal: Dalton transactions (Cambridge, England : 2003) 20051021

Title: Copper(II) chloride complexes with multimodal ligands based on the cyclotriphosphazene platform.

Journal: Dalton transactions (Cambridge, England : 2003) 20051021

Title: Palladium-catalyzed carbonylation of yne esters leading to gamma-alkylidene alpha,beta-unsaturated gamma-lactones.

Journal: Organic letters 20050929

Title: Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

Title: An efficient unnatural base pair for a base-pair-expanded transcription system.

Journal: Journal of the American Chemical Society 20050622

Title: 6-Methyl-2-pyridone: an elusive structure finally solved.

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Title: Theoretical studies of proton-transfer reactions of 2-hydroxypyridine--(H2O)n (n = 0-2) in the ground and excited states.

Journal: The journal of physical chemistry. A 20050505

Title: Dielectric dispersion in water + 2-hydroxypyridine solid mixtures.

Journal: The journal of physical chemistry. B 20050331

Title: Density functional study on the reaction mechanism of proton transfer in 2-pyridone: effect of hydration and self-association.

Journal: The journal of physical chemistry. A 20050224

Title: Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Preparation of 2-pyridone-containing tricyclic alkaloid derivatives as potential inhibitors of tumor cell proliferation by regioselective intramolecular N- and C-acylation of 2-pyridone.

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Title: Site-specific incorporation of fluorescent probes into RNA by specific transcription using unnatural base pairs.

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Title: The versatile, efficient, and stereoselective self-assembly of transition-metal helicates by using hydrogen-bonds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041217

Title: Ring nitrogen-substituted non-steroidal estrogens: pyridine and pyrimidine analogs of the phenol in deoxyhexestrol experience resonance constraints on preferred ligand conformation.

Journal: Bioorganic & medicinal chemistry letters 20041206

Title: The Lycopodium alkaloids.

Journal: Natural product reports 20041201

Title: Infrared depletion spectra of 2-aminopyridine2-pyridone, a Watson-Crick mimic of adenine.uracil.

Journal: The Journal of chemical physics 20041101

Title: A two-unnatural-base-pair system toward the expansion of the genetic code.

Journal: Journal of the American Chemical Society 20041020

Title: Unnatural base pairs between 2- and 6-substituted purines and 2-oxo(1H)pyridine for expansion of the genetic alphabet.

Journal: Bioorganic & medicinal chemistry letters 20041004

Title: Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040920

Title: A new color of the synthetic chameleon methoxyallene: synthesis of trifluoromethyl-substituted pyridinol derivatives: an unusual reaction mechanism, a remarkable crystal packing, and first palladium-catalyzed coupling reactions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040906

Title: pH-dependent photophysical behavior of rhenium complexes containing hydroxypyridine ligands.

Journal: Applied spectroscopy 20040901

Title: 1H and 13C spectral assignment of 2(1H)-pyridone derivatives.

Journal: Magnetic resonance in chemistry : MRC 20040801

Title: Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine.

Journal: European journal of medicinal chemistry 20040801

Title: 3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells.

Journal: The Journal of biological chemistry 20040716

Title: Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation.

Journal: The Journal of pharmacy and pharmacology 20040701

Title: Biradicals/zwitterions from thermolysis of enyne-isocyanates. Application to the synthesis of 2(1H)-pyridones, benzofuro[3,2-c]pyridin-1(2H)-ones, 2,5-dihydro-1H-pyrido[4,3-b]indol-1-ones, and related compounds.

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Title: 2(1H)-pyridinone (2-pyridone): self-association and association with water. Spectral and structural characteristics: infrared study and ab initio calculations.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031201

Title: Theoretical study of the ruthenium-catalyzed cyclocotrimerization of alkynes with isocyanates and iothiocyanates: cemoselective formation of pyridine-2-one and thiopyrane-2-imine.

Journal: The Journal of organic chemistry 20031031

Title: Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.

Journal: Journal of medicinal chemistry 20031023

Title: A flexible approach toward trisubstituted piperidines and indolizidines: synthesis of 6-epi-indolizidine 223A.

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Title: [Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function].

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Title: An unnatural base pair for efficient incorporation of nucleotide analogs into RNAs.

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Title: Simple preparation of biotinylated RNA by transcription via an unnatural base pair.

Journal: Nucleic acids research. Supplement (2001) 20030101

Title: 2-Pyridone and 3-oxo-1,2,6-thiadiazine-1,1-dioxide derivatives: a new class of hydrogen bond equivalents of uracil.

Journal: Journal of computer-aided molecular design 20030101

Title: Hydrogen bond vibrations of 2-aminopyridine.2-pyridone, a Watson-Crick analogue of adenine.uracil.

Journal: Journal of the American Chemical Society 20021204

Title: A comparison of crop and non-crop plants as sensitive indicator species for regulatory testing.

Journal: Pest management science 20021201

Title: Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic-acid-containing 2-pyridones under physiological conditions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20021018

Title: X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.

Journal: Biochemistry 20020903

Title: Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione: alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks.

Journal: The Journal of organic chemistry 20020823

Title: Design and synthesis of novel inhibitors of gelatinase B.

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Title: CYP1A1 induction by pyridine and its metabolites in HepG2 cells.

Journal: Archives of biochemistry and biophysics 20020815

Title: Stereoselective synthesis of 2,5,6-trisubstituted piperidines.

Journal: Organic letters 20020613

Title: Single crystal EPR of Cu(II) doped Cd(C5H5NO)6(BF4)2--an example of reduced metal hyperfine coupling constant.

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Title: Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung.

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Title: Imidazopyridinium and pyridopyrimidium bromides: synthesis and hydrolysis.

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Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.

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Title: Influence of intermolecular hydrogen bonds on the tautomerism of pyridine derivatives.

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Title: Molecular modeling analysis: 'Why is 2-hydroxypyridine soluble in water but not 3-hydroxypyridine?'.

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Title: Synthesis of an optically active, bicyclic 2-pyridone dipeptide mimetic.

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Title: An unnatural base pair for incorporating amino acid analogs into proteins.

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Title: Solvent effects on the electronic absorption spectra and acid strength of some substituted pyridinols.

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Title: Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria.

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Title: [Experience in treating cysticercosis of the brain with azinox].

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Title: Inhibition of tyrosine phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine.

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Title: Infrared studies of tautomerism in 2-hydroxypyridine 2-thiopyridine and 2-aminopyridine.

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Title: Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones.

Journal: The Journal of organic chemistry 20011019

Title: Unprecedented oxidation of a phenylglycinol-derived 2-pyridone: enantioselective synthesis of polyhydroxypiperidines.

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Title: An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones.

Journal: The Journal of organic chemistry 20011005

Title: Pyridone annulation by 4 + 2 coupling of dienolates with nitriles and nitrile equivalents. A solution to the acetonitrile problem.

Journal: The Journal of organic chemistry 20011005

Title: Enzymatic synthesis of aza-l-tyrosines.

Journal: Bioorganic & medicinal chemistry letters 20010820

Title: Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides.

Journal: Bioorganic & medicinal chemistry letters 20010820

Title: Cytotoxicity of 2-aldo- and 2-ketopyridine-N(4)-substituted thiosemicarbazones and mode of action in human Tmolt4 cells.

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Title: Hydrogen-bonded complexes of 2-pyridone with centrosymmetric and non-centrosymmetric dicarboxylic acids.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010501

Title: Solid-state structure and solution behavior of eight-coordinate Sm(III) poly(pyrazolyl)borate compounds.

Journal: Inorganic chemistry 20010312

Title: A short stereoselective preparation of dienamides from cyclobutene compounds. Application in the synthesis of a new cyclohexene nucleoside.

Journal: The Journal of organic chemistry 20010126

Title: Oxodesmosine and isooxodesmosine, candidates of oxidative metabolic intermediates of pyridinium cross-links in elastin.

Journal: Archives of biochemistry and biophysics 20010101

Title: Synthesis and biological evaluation of pyridin-2-one nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Substitution mode of the amide fragment in some new N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl]pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity.

Journal: Polish journal of pharmacology 20010101

Title: Triplex formation involving 2',4'-BNA with 2-pyridone base analogue: efficient and selective recognition of C:G interruption.

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Title: Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19940817

Title: Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.

Journal: Journal of medicinal chemistry 19921016

Title: 2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.

Journal: Journal of medicinal chemistry 19910901

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