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1420-04-8,MFCD01941566
Catalog No.:AA00HW7D

1420-04-8 | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

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5g
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25g
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100g
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500g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00HW7D
Chemical Name:
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)
CAS Number:
1420-04-8
Molecular Formula:
C15H15Cl2N3O5
Molecular Weight:
388.2027
MDL Number:
MFCD01941566
SMILES:
Clc1ccc(c(c1)C(=O)Nc1ccc(cc1Cl)[N+](=O)[O-])O.NCCO
Properties
Computed Properties
 
Complexity:
414  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Literature

Title: Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.

Journal: Nature medicine 20161001

Title: The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway.

Journal: The Journal of surgical research 20160601

Title: Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.

Journal: The Biochemical journal 20160501

Title: Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss.

Journal: Biochemical and biophysical research communications 20160205

Title: Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer.

Journal: The international journal of biochemistry & cell biology 20160201

Title: Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.

Journal: International immunopharmacology 20160201

Title: Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells.

Journal: BMC gastroenterology 20160101

Title: Discovery of Small-Molecule Modulators of the Human Y4 Receptor.

Journal: PloS one 20160101

Title: A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20160101

Title: Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide.

Journal: PLoS neglected tropical diseases 20151001

Title: Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition.

Journal: The Prostate 20150901

Title: Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.

Journal: Biochemical and biophysical research communications 20150814

Title: Controlled delivery of bPEI-niclosamide complexes by PEO nanofibers and evaluation of its anti-neoplastic potentials.

Journal: Colloids and surfaces. B, Biointerfaces 20150701

Title: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.

Journal: Neoplasia (New York, N.Y.) 20150701

Title: WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.

Journal: Oncogene 20150601

Title: Niclosamide inhibits the proliferation of human osteosarcoma cell lines by inducing apoptosis and cell cycle arrest.

Journal: Oncology reports 20150401

Title: Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.

Journal: Gynecologic oncology 20140701

Title: Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140615

Title: Niclosamide enhances ROS-mediated cell death through c-Jun activation.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20140601

Title: Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.

Journal: Fertility and sterility 20140501

Title: Effect of niclosamide on basal-like breast cancers.

Journal: Molecular cancer therapeutics 20140401

Title: Antihelminthic niclosamide modulates dendritic cells activation and function.

Journal: Cellular immunology 20140101

Title: Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.

Journal: Molecular cancer therapeutics 20131001

Title: Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.

Journal: Cellular signalling 20130401

Title: Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells.

Journal: PloS one 20130101

Title: Growth inhibition of ovarian tumor-initiating cells by niclosamide.

Journal: Molecular cancer therapeutics 20120801

Title: [Effect of niclosamide spreading oil on killing schistosome cercariae].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120601

Title: Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Journal: The Journal of biological chemistry 20120518

Title: Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

Journal: Chinese journal of cancer 20120401

Title: Detection of Taenia solium taeniasis coproantigen is an early indicator of treatment failure for taeniasis.

Journal: Clinical and vaccine immunology : CVI 20120401

Title: Education and Imaging. Gastrointestinal: An unexpected cause of refractory iron deficiency anemia; Taenia SPP. on capsule endoscopy.

Journal: Journal of gastroenterology and hepatology 20120401

Title: [Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120401

Title: Effects of Bayluscide on Bithynia siamensis goniomphalos, the first intermediate host of the human liver fluke, Opisthorchis viverrini, in laboratory and field trials.

Journal: Parasitology international 20120301

Title: [Studies on standardization of methods for screening molluscicides in laboratory IV sensitivity of Oncomelania snails from different months to niclosamide].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120201

Title: Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress.

Journal: British journal of cancer 20120103

Title: [Snail control effect of film covering method in fish ponds and ditches].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20111201

Title: [Determination of niclosamide ethanolamine residue in rice and paddy field by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20111101

Title: [Studies on spray of niclosamide ethanolamine salt. I. development and effect assessment of spray of niclosamide ethanolamine salt].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20111001

Title: Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death.

Journal: BMB reports 20110801

Title: [Molluscicidal effect of LDS in mountainous areas of Yunnan Province].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110801

Title: Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

Journal: Journal of the National Cancer Institute 20110706

Title: Niclosamide: an established antihelminthic drug as a potential therapy against S100A4-mediated metastatic colon tumors.

Journal: Journal of the National Cancer Institute 20110706

Title: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Journal: Cancer research 20110615

Title: [Molluscicidal effect of film on ditches in mountainous schistosomiasis endemic regions].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110401

Title: [Study on preservation of niclosamide in water samples].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110401

Title: [Surveillance and forecast system of schistosomiasis in Jiangsu Province. IV. Establishment of Schistosoma japonicum cercaria-killing method by spraying niclosamide suspension on water surface].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

Title: [Toxicity of niclosamide with plastic film mulching to fish].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

Title: [Evaluation on molluscicidal effect of suspension concentrate of metaldehyde and niclosamide].

Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

Title: [Preparation of the compound MCT-01 and its antihymenolepidiasis activity].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

Title: [The antihymenolepidiasis activity of MCT-31: preparation and study].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

Title: A strategy for emergency treatment of Schistosoma japonicum-infested water.

Journal: Parasites & vectors 20110101

Title: Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.

Journal: PloS one 20110101

Title: [The preparation of antihymenolepidiasis activity of MCT-44].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

Title: Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos.

Journal: Chemosphere 20100901

Title: Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100801

Title: A human case of Hymenolepis diminuta in a child from eastern Sicily.

Journal: The Korean journal of parasitology 20100601

Title: Human taeniasis in western Romania and its relationship to multicultural food habits and influences.

Journal: Foodborne pathogens and disease 20100501

Title: Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20100401

Title: Human infection with Bertiella studeri (Cestode: Anoplocephalidae) in an Egyptian worker returning back from Saudi Arabia.

Journal: Journal of the Egyptian Society of Parasitology 20100401

Title: Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species.

Journal: Cancer research 20100315

Title: Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii.

Journal: Journal of natural products 20100226

Title: Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

Journal: PloS one 20100101

Title: The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

Journal: Biochemistry 20091103

Title: Halogenated pesticide transformation by a laccase-mediator system.

Journal: Chemosphere 20091001

Title: Neurocysticercosis in the infant of a pregnant mother with a tapeworm.

Journal: The American journal of tropical medicine and hygiene 20090901

Title: A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Journal: Journal of lipid research 20090801

Title: Diphyllobothrium latum identified by capsule endoscopy--an unusual cause of iron-deficiency anemia.

Journal: Journal of gastrointestinal and liver diseases : JGLD 20090601

Title: [Molluscicidal effect and toxicity of META-Li on Oncomelania snails in the mountain area].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20090601

Title: The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.

Journal: Journal of cellular biochemistry 20090301

Title: Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Journal: PloS one 20090101

Title: Potential of some monoterpenoids and their new N-methyl carbamate derivatives against Schistosomiasis snail vector, Biomphalaria alexandrina.

Journal: Ecotoxicology and environmental safety 20081101

Title: Efficacy of temperature, and two commonly used molluscicides and fertilizers on Fasciola gigantica eggs.

Journal: Journal of the Egyptian Society of Parasitology 20080801

Title: [Snail control by using soil pasting mixed with niclosamide].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20080801

Title: A novel molluscicidal formulation of niclosamide.

Journal: Parasitology research 20080701

Title: In vitro trypanocidal activity of the anti-helminthic drug niclosamide.

Journal: Experimental parasitology 20080401

Title: [Human infection due to Bertiella sp (cestode: Anoplocephalidae) in a man originating from Yemen in Algeria].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20080401

Title: Effect of niclosamide on the tegumental surface of Haplorchis taichui using scanning electron microscopy.

Journal: Journal of helminthology 20071201

Title: [Study on molluscicidal effect of chlorosalicylicamide].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20071001

Title: Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian Cameroon.

Journal: Annals of tropical medicine and parasitology 20070901

Title: A studies on chemical control of S. mansoni intermediate host.

Journal: Pakistan journal of biological sciences : PJBS 20070801

Title: Cream formulations protecting against cercarial dermatitis by Trichobilharzia.

Journal: Parasitology research 20070601

Title: Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.

Journal: Archiv der Pharmazie 20060801

Title: [A study on the effect of Oncomelania hupensis hupensiss killed with niclosamide in China].

Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20060801

Title: [Synergic effects of synthesis arecoline in combination with snail-killing drugs niclosamide].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20060701

Title: Field trials of low dose Bayluscide on snail hosts of schistosome and selected non-target organisms in sahelian Cameroon.

Journal: Memorias do Instituto Oswaldo Cruz 20060601

Title: Role of chemotherapy of taeniasis in prevention of neurocysticercosis.

Journal: Parasitology international 20060101

Title: [Cleaning and molluscicide treatment for schistosomiasis control].

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20060101

Title: [Case report: taeniasis, is it a cause of psychiatric and neural symptoms?].

Journal: Turkiye parazitolojii dergisi 20060101

Title: Impact of certain plants and synthetic molluscicides on some fresh water snails and fish.

Journal: Journal of the Egyptian Society of Parasitology 20051201

Title: Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.

Journal: International journal of pharmaceutics 20051104

Title: Taeniasis and cysticercosis in housemaids working in affluent neighborhoods in Lima, Peru.

Journal: The American journal of tropical medicine and hygiene 20050901

Title: Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout.

Journal: Journal of agricultural and food chemistry 20050629

Title: Transport of Schistosoma japonicum cercariae and the feasibility of niclosamide for cercariae control.

Journal: Parasitology international 20050301

Title: Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic.

Journal: The AAPS journal 20050301

Title: [Treatment of intestinal helminthiasis with albendazole].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20050101

Title: Metabolism of niclosamide in sediment and water systems.

Journal: Journal of agricultural and food chemistry 20040922

Title: Human Monieziasis expansa: the first Egyptian parastic zoonosis.

Journal: Journal of the Egyptian Society of Parasitology 20040801

Title: The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity.

Journal: The Journal of parasitology 20040801

Title: Case of megaloblastic anemia caused by intestinal taeniasis.

Journal: Annals of hematology 20040701

Title: Comparison of the physical and chemical stability of niclosamide crystal forms in aqueous versus nonaqueous suspensions.

Journal: Drug development and industrial pharmacy 20040701

Title: Physical transformation of niclosamide solvates in pharmaceutical suspensions determined by DSC and TG analysis.

Journal: Die Pharmazie 20040701

Title: Bertiella studeri infection: resistance to niclosamide.

Journal: The Ceylon medical journal 20040601

Title: Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs.

Journal: Bioorganic & medicinal chemistry 20040515

Title: Purging the worm: management of Taenia solium taeniasis.

Journal: Lancet (London, England) 20040320

Title: Species identification after treatment for human taeniasis.

Journal: Lancet (London, England) 20040320

Title: Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate.

Journal: AAPS PharmSciTech 20040301

Title: Influence of moisture on the crystal forms of niclosamide obtained from acetone and ethyl acetate.

Journal: AAPS PharmSciTech 20040301

Title: Molluscicidal effect of nicotinanilide and its intermediate compounds against a freshwater snail Lymnaea luteola, the vector of animal schistosomiasis.

Journal: Memorias do Instituto Oswaldo Cruz 20040301

Title: Aqueous photolysis of niclosamide.

Journal: Journal of agricultural and food chemistry 20040225

Title: Polymeric controlled release formulations of niclosamide for control of Biomphalaria alexandrina, the vector snail of schistosomiasis.

Journal: Macromolecular bioscience 20040220

Title: Preparation and physicochemical properties of niclosamide anhydrate and two monohydrates.

Journal: International journal of pharmaceutics 20040128

Title: [Efficacy of the Russian anthelmintic agent trichlorophen].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20040101

Title: Measures for the prevention and control of Taenia solium taeniosis and cysticercosis.

Journal: Acta tropica 20030601

Title: The first human infection with Bertiella studeri in Vietnam.

Journal: The Southeast Asian journal of tropical medicine and public health 20030601

Title: [Preliminary test of the effect of niclosamide-impregnated tissue for the prevention of Schistosoma japonicum infection].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20030101

Title: Effects of fertilizer and soil components on pesticide photolysis.

Journal: Journal of agricultural and food chemistry 20021204

Title: Detection of the damage caused to DNA by niclosamide using an electrochemical DNA-biosensor.

Journal: Biosensors & bioelectronics 20021201

Title: Rapid loss of lampricide from catfish and rainbow trout following routine treatment.

Journal: Journal of agricultural and food chemistry 20021106

Title: Per oral removal of tapeworm following vomiting after surgery.

Journal: Anesthesia and analgesia 20021001

Title: The molluscicidal activity of niclosamide (Bayluscide WP70(R)) on Melanoides tuberculata (Thiaridae), a snail associated with habitats of Biomphalaria glabrata (Planorbidae).

Journal: Memorias do Instituto Oswaldo Cruz 20020701

Title: Effect of soil moisture and sample depth on pesticide photolysis.

Journal: Journal of agricultural and food chemistry 20020424

Title: Voltammetric determination of niclosamide at a glassy carbon electrode.

Journal: The Analyst 20020101

Title: [Sensitivity of Oncomelania snail to niclosamide in China].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101

Title: Meckel's diverticulitis due to Taenia saginata: case report.

Journal: East African medical journal 20010201

Title: [Parasitologic finding in a Saharan girl].

Journal: Enfermedades infecciosas y microbiologia clinica 20010101

Title: Biochemical and metabolic peculiarities of some parasites availing as targets for therapy.

Journal: Le Journal medical libanais. The Lebanese medical journal 20010101

Title: [Climbing-upward inhibition of Oncomelania hupensis by niclosamide combination].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20010101

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Tags:1420-04-8 Molecular Formula|1420-04-8 MDL|1420-04-8 SMILES|1420-04-8 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)