Catalog No.:AA001HPH

1421-49-4 | 3,5-Di-tert-butyl-4-hydroxybenzoic acid

Name: Name:3,5-Di-tert-butyl-4-hydroxybenzoic acid
Brand: AABLOCKS
SKU: AA001HPH
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

98%

in stock

$13.00 $9.00

- +

25g

95%

in stock

$31.00 $22.00

- +

100g

98%

in stock

$51.00 $36.00

- +

500g

98%

in stock

$110.00 $77.00

- +

Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA001HPH

Chemical Name:

3,5-Di-tert-butyl-4-hydroxybenzoic acid

CAS Number:

1421-49-4

Molecular Formula:

C15H22O3

Molecular Weight:

250.3334

MDL Number:

MFCD24369855

SMILES:

OC(=O)c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C

Properties

BP:

340.6 °C at 760 mmHg

Form:

Solid

MP:

206-209 °C

Refractive Index:

1.5600 (estimate)

Storage:

Inert atmosphere;Room Temperature;

Computed Properties

Complexity:

285

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

4.4

Upstream Synthesis Route

1421-49-4

728-40-5

[1]BulletinoftheAcademyofSciencesoftheUSSR,DivisionofChemicalScience(EnglishTranslation),1964,p.1570-1577

[2]IzvestiyaAkademiiNaukSSSR,SeriyaKhimicheskaya,1964,#9,p.1666-1675

Downstream Synthesis Route

1421-49-4

88-26-6

[1]CurrentPatentAssignee:LANZHOUFINECHEMICAL-CN112250550,2021,ALocationinpatent:Paragraph0027;0029;0031;0033

[2]Yoheetal.[JournalofOrganicChemistry,1956,vol.21,p.1289,1291][JournalofOrganicChemistry,1959,vol.24,p.1251,1256]

1421-49-4

719-22-2

2455-14-3

[1]RussianJournalofPhysicalChemistry,1991,vol.65,p.1795-1798 ZhurnalFizicheskoiKhimii,1991,vol.65,p.3387-3392

[2]RussianJournalofPhysicalChemistry,1991,vol.65,p.1795-1798 ZhurnalFizicheskoiKhimii,1991,vol.65,p.3387-3392

1421-49-4

40056-43-7

[1]CurrentPatentAssignee:EqtPartnersAB;Galderma(in:EQTPartners)-US5200550,1993,A

[2]Mullican;Wilson;Connor;Kostlan;Schrier;Dyer[JournalofMedicinalChemistry,1993,vol.36,#8,p.1090-1099]

[3]CurrentPatentAssignee:CorporacionQuimicoFarmaceuticaEsteveSA-US2005/182041,2005,A1Locationinpatent:Page/Pagecolumn9

[4]CurrentPatentAssignee:Vachy,Robert-US2011/136748,2011,A1Locationinpatent:Page/Pagecolumn3

[5]CurrentPatentAssignee:J-PHARMACOLTD-WO2012/48058,2012,A2Locationinpatent:Page/Pagecolumn41-42

[6]Ivakhnenko,E.P.;Shif,A.I.;Prokof'ev,A.I.;Olekhnovich,L.P.;Minkin,V.I.[JournalofOrganicChemistryUSSR(EnglishTranslation),1989,vol.25,#2.2,p.319-328][ZhurnalOrganicheskoiKhimii,1989,vol.25,#2,p.357-367]

[7]Vovk,D.N.;Melezhik,A.V.;Pokhodenko,V.D.[JournalofgeneralchemistryoftheUSSR,1982,vol.52,#6,p.1201-1206][ZhurnalObshcheiKhimii,1982,vol.52,#6,p.1363-1368]

[8]Portevin,Bernard;Lonchampt,Michel;Canet,Emmanuel;DeNanteuil,Guillaume[JournalofMedicinalChemistry,1997,vol.40,#12,p.1906-1918]

[9]Petit;Bernardes-Genisson;Hoffmann;Souchard;Labidalle[ChemicalandPharmaceuticalBulletin,2000,vol.48,#11,p.1634-1638]

[10]CurrentPatentAssignee:SERVIERMONDE-US5280024,1994,A

[11]CurrentPatentAssignee:ASHLANDINC-US5612321,1997,A

[12]CurrentPatentAssignee:ENEOS(in:ENEOSHoldings);ENEOSHOLDINGSINC-US5661153,1997,A

[13]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US4051104,1977,A

[14]CurrentPatentAssignee:RAYTHEONTECHNOLOGIESCORPORATION;CollinsAerospace(in:RaytheonTechnologies)-US4163008,1979,A

[15]CurrentPatentAssignee:CHEVRONCORP-EP636164,2000,B1

[16]Prishchenko;Livantsov;Novikova;Livantsova;Maryashkin;Milaeva[RussianJournalofGeneralChemistry,2007,vol.77,#8,p.1474-1476]Prishchenko;Livantsov;Novikova;Livantsova;Maryashkin;Milaeva[RussianJournalofGeneralChemistry,2007,vol.77,#8,p.1477-1479]Prishchenko,AndreyA.;Livantsov,MikhailV.;Novikova,OlgaP.;Livantsova,LudmilaI.;Milaeva,ElenaR.[HeteroatomChemistry,2008,vol.19,#6,p.562-568]

[17]CurrentPatentAssignee:UNIVERSITYOFLIVERPOOL(THE)-US2018/140608,2018,A1Locationinpatent:Paragraph0221;0222

[18]CurrentPatentAssignee:POLAORBISHOLDINGSINC-EP1987811,2008,A1Locationinpatent:Page/Pagecolumn8

[19]Milaeva;Shpakovsky;Maklakova;Rufanov;Neganova;Shevtsova;Churakov;Babkova;Babkov;Kosolapov;Spasov[RussianChemicalBulletin,2018,vol.67,#11,p.2025-2034][Izv.Akad.Nauk,Ser.Khim.,2018,vol.11,p.2025-2034,10]

[20]Antonets,A.A.;Dubova,L.G.;Gontcharenko,V.E.;Gracheva,YuA.;Kazak,A.A.;Lyssenko,K.A.;Milaeva,E.R.;Mironova,E.M.;Nikitin,E.A.;Pavlyukov,M.S.;Shamraeva,M.A.;Shevtsov,P.N.;Shevtsova,E.F.;Shpakovsky,D.B.;Shtil,A.A.;Tyurin,V.Yu;Vasilichin,V.A.[JournalofOrganometallicChemistry,2022,vol.959]

[21]CurrentPatentAssignee:BEIJINGGANGAUXILIARYLTDRESPONSIBILITY;TIANJIANAUXILIARYCHEMICALSCANGZHOULTD;GANGNEWMATVERANDASTOCK-CN114195659,2022,ALocationinpatent:Paragraph0067-0070;0075-0078

[22]CurrentPatentAssignee:BEIJINGTIANGANGAUXYCOLTD-CN114249649,2022,ALocationinpatent:Paragraph0070-0074;0079-0083;0087-0089;0090-0094;...

69901-39-9

69901-43-5

69901-44-6

719-22-2

2455-14-3

128-38-1

1421-49-4

[1]JournalofOrganicChemistry,1983,vol.48,p.3700-3703

69901-39-9

69901-43-5

69901-44-6

2455-14-3

1421-49-4

[1]JournalofOrganicChemistry,1983,vol.48,p.3700-3703

Literature

Title: New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.

Journal: European journal of medicinal chemistry 20120401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Determination of synthetic phenolic antioxidants and their metabolites in water samples by downscaled solid-phase extraction, silylation and gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20101008

Title: Novel compounds designed as antistress agents.

Journal: Journal of medicinal chemistry 20091126

Title: Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats.

Journal: Archives of toxicology 20011101

Title: Synergistic protective effects of antioxidant and nitric oxide synthase inhibitor in transient focal ischemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 19990201

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