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1421-65-4,MFCD00038958
Catalog No.:AA001HQA

1421-65-4 | L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

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Purity
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1g
95%
in stock  
$7.00   $5.00
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5g
95%
in stock  
$11.00   $8.00
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10g
95%
in stock  
$19.00   $14.00
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100g
95%
in stock  
$183.00   $128.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001HQA
Chemical Name:
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
CAS Number:
1421-65-4
Molecular Formula:
C10H14ClNO4
Molecular Weight:
247.6755
MDL Number:
MFCD00038958
SMILES:
COC(=O)[C@H](Cc1ccc(c(c1)O)O)N.Cl
Properties
Properties
 
Form:
Solid  
MP:
174-175℃  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
222  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  

Literature

Title: Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats.

Journal: International journal of nanomedicine 20120101

Title: Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats.

Journal: Neuroscience letters 20110915

Title: Daily motor performance after switching levodopa to melevodopa: an open-label on advanced Parkinson's disease with 'delayed-on' and/or'wearing-off'.

Journal: Minerva medica 20110401

Title: Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100915

Title: N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity.

Journal: Free radical biology & medicine 20100701

Title: A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats.

Journal: Journal of pharmaceutical sciences 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.

Journal: European journal of pharmacology 20081203

Title: L-dopa modulates motor cortex excitability in Alzheimer's disease patients.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080901

Title: Clinical efficacy of a single afternoon dose of effervescent levodopa-carbidopa preparation (CHF 1512) in fluctuating Parkinson disease.

Journal: Clinical neuropharmacology 20070101

Title: Determination, purity assessment and chiral separation of levodopa methyl ester in bulk and formulation pharmaceuticals.

Journal: Biomedical chromatography : BMC 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Determination of levodopa methyl ester and its metabolites in rat serum by CZE with amperometric detection.

Journal: Analytical and bioanalytical chemistry 20050501

Title: Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys.

Journal: Receptors & channels 20030101

Title: Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.

Journal: The international journal of biochemistry & cell biology 20021201

Title: Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum.

Journal: Neuroscience letters 20021122

Title: Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021115

Title: Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301

Title: Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.

Journal: Life sciences 20020118

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