Home Fluorides 1437321-24-8
1437321-24-8,MFCD28502441
Catalog No.:AA001I7L

1437321-24-8 | 5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$14.00   $10.00
- +
2mg
97%
in stock  
$23.00   $16.00
- +
5mg
97%
in stock  
$34.00   $24.00
- +
50mg
97%
in stock  
$130.00   $91.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001I7L
Chemical Name:
5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-
CAS Number:
1437321-24-8
Molecular Formula:
C31H26F2N4O6
Molecular Weight:
588.5581
MDL Number:
MFCD28502441
SMILES:
COc1cc2c(ccnc2cc1OC)Oc1ccc(cc1F)NC(=O)c1cn(C(C)C)c(=O)n(c1=O)c1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
4.7  

Downstream Synthesis Route
Literature

Title: Sheila M, et al. CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers. [abstract In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C275.

Title: Jay F, et al. Antitumor activity of the dual AXL/c-Met inhibitor CEP-40783 in Champions primary TumorGraft? models of human non-small cell lung cancer (NSCLC). [abstract In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C272.

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SDS
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Tags:1437321-24-8 Molecular Formula|1437321-24-8 MDL|1437321-24-8 SMILES|1437321-24-8 5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-