Home Amines 1446502-11-9
1446502-11-9,MFCD29472245
Catalog No.:AA001JUK

1446502-11-9 | 2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-

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Purity
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1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$35.00   $25.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001JUK
Chemical Name:
2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-
CAS Number:
1446502-11-9
Molecular Formula:
C19H17F6N7O
Molecular Weight:
473.3750
MDL Number:
MFCD29472245
SMILES:
CC(CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)c1cccc(n1)C(F)(F)F)(O)C
Properties
Computed Properties
 
Complexity:
635  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.5  

Literature

Title: Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.

Journal: Blood 20170810

Title: Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

Journal: Blood 20170810

Title: Isocitrate dehydrogenase mutations in myeloid malignancies.

Journal: Leukemia 20170201

Title: Exploring the Pathway: IDH Mutations and Metabolic Dysregulation in Cancer Cells: A Novel Therapeutic Target. MAY 29, 2015

Title: Alan H. Shih, et al. AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo. Blood 2014 124:437.

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Tags:1446502-11-9 Molecular Formula|1446502-11-9 MDL|1446502-11-9 SMILES|1446502-11-9 2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-