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Home Other Building Blocks 1449277-10-4
1449277-10-4,MFCD30489735
Catalog No.:AA003AQL

1449277-10-4 | GNE-495

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$63.00   $44.00
- +
5mg
97%
in stock  
$106.00   $75.00
- +
25mg
97%
in stock  
$359.00   $252.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003AQL
Chemical Name:
GNE-495
CAS Number:
1449277-10-4
Molecular Formula:
C22H20FN5O2
Molecular Weight:
405.4249
MDL Number:
MFCD30489735
SMILES:
Fc1cccc(c1)c1ccc2c(n1)c(N)ncc2C(=O)NC1CN(C1)C(=O)C1CC1
Properties
Computed Properties
 
Complexity:
668  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1.6  

Upstream Synthesis Route

[1]Nature,2015,vol.519,#7544,p.425-430

[1]Patent:WO2013/113669,2013,A1,.Locationinpatent:Page/Pagecolumn112-113

[2]ACSMedicinalChemistryLetters,2015,vol.6,#8,p.913-918

[1]Patent:WO2013/113669,2013,A1,

[2]Nature,2015,vol.519,#7544,p.425-430

[3]ACSMedicinalChemistryLetters,2015,vol.6,#8,p.913-918

[1]Patent:WO2013/113669,2013,A1,

[2]Nature,2015,vol.519,#7544,p.425-430

[3]ACSMedicinalChemistryLetters,2015,vol.6,#8,p.913-918

[1]Nature,2015,vol.519,#7544,p.425-430

[2]ACSMedicinalChemistryLetters,2015,vol.6,#8,p.913-918

Literature

Title: Prognostic factors in polyarteritis.

Journal: The Journal of rheumatology 19751201

Title: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.

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SDS
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