Home Pyridines 1452-77-3
1452-77-3,MFCD00151999
Catalog No.:AA003TP8

1452-77-3 | Pyridine-2-carboxamide

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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA003TP8
Chemical Name:
Pyridine-2-carboxamide
CAS Number:
1452-77-3
Molecular Formula:
C6H6N2O
Molecular Weight:
122.1246
MDL Number:
MFCD00151999
SMILES:
NC(=O)c1ccccn1
NSC Number:
524473
Properties
Properties
 
BP:
528.5°C at 760 mmHg  
Form:
Solid  
MP:
110 °C (dec.)(lit.)  
Refractive Index:
1.5350 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
114  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.2  

Literature

Title: Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Journal: Journal of medicinal chemistry 20151112

Title: Anion complexation and transport by isophthalamide and dipicolinamide derivatives: DNA plasmid transformation in E. coli.

Journal: Journal of the American Chemical Society 20120822

Title: Palladium-catalyzed alkenylation and alkynylation of ortho-C(sp2)-H bonds of benzylamine picolinamides.

Journal: Organic letters 20120615

Title: Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination.

Journal: Organic letters 20120615

Title: Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans.

Journal: PLoS genetics 20120501

Title: Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

Journal: Organic & biomolecular chemistry 20120421

Title: Structural polymorphism of human telomere G-quadruplex induced by a pyridyl carboxamide molecule.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: Evaluation of WO2012003387, Gilead's ASK1 inhibitors.

Journal: Expert opinion on therapeutic patents 20120401

Title: N-(3-Bromo-2-methyl-phen-yl)-2-oxo-1,2-di-hydro-pyridine-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Metal ion-assisted transformations of 2-pyridinealdoxime and hexafluorophosphate.

Journal: Dalton transactions (Cambridge, England : 2003) 20120314

Title: Highly efficient syntheses of azetidines, pyrrolidines, and indolines via palladium catalyzed intramolecular amination of C(sp3)-H and C(sp2)-H bonds at γ and δ positions.

Journal: Journal of the American Chemical Society 20120111

Title: Heterocycle synthesis via direct C-H/N-H coupling.

Journal: Journal of the American Chemical Society 20120111

Title: New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.

Journal: European journal of medicinal chemistry 20120101

Title: Cobalt(II), nickel(II) and copper(II) complexes of a hexadentate pyridine amide ligand. Effect of donor atom (ether vs. thioether) on coordination geometry, spin-state of cobalt and M(III)-M(II) redox potential.

Journal: Dalton transactions (Cambridge, England : 2003) 20111028

Title: Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models.

Journal: Pharmacology, biochemistry, and behavior 20111001

Title: 4,4'-Bipyridine-3-(thio-phen-3-yl)acrylic acid (1/2).

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Palladium-catalyzed alkylation of ortho-C(sp2)-H bonds of benzylamide substrates with alkyl halides.

Journal: Organic letters 20110916

Title: Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1.

Journal: ChemMedChem 20110905

Title: Bis(μ(2)-pyridine-2-carboxamide oximato)bis-[(pyridine-2-carboxamide oxime)zinc] dinitrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Progress in structure based drug design for G protein-coupled receptors.

Journal: Journal of medicinal chemistry 20110714

Title: Lanthanide directed self-assembly formations of Tb(III) and Eu(III) luminescent complexes from tryptophan based pyridyl amide ligands.

Journal: Chemical communications (Cambridge, England) 20110707

Title: Photoinduced intramolecular tryptophan oxidation and excited-state behavior of [Re(L-AA)(CO)3(α-diimine)](+) (L = pyridine or imidazole, AA = tryptophan, tyrosine, phenylalanine).

Journal: Inorganic chemistry 20110704

Title: Synthesis and cytotoxic evaluation of novel N-methyl-4-phenoxypicolinamide derivatives.

Journal: Molecules (Basel, Switzerland) 20110620

Title: TTF salts of optically pure cobalt pyridine amidates; detection of soluble assemblies with stoichiometry corresponding to the solid state.

Journal: Dalton transactions (Cambridge, England : 2003) 20110227

Title: Highly sensitive and selective turn-on fluorescent and chromogenic probe for Cu2+ and ClO- based on a N-picolinyl rhodamine B-hydrazide derivative.

Journal: Organic & biomolecular chemistry 20110121

Title: Sorafenib and its tosylate salt: a multikinase inhibitor for treating cancer.

Journal: Acta crystallographica. Section C, Crystal structure communications 20110101

Title: Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10.

Journal: BMC biotechnology 20110101

Title: SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: 2D QSAR Studies of Several Potent Aminopyridine, Anilinopyrimidine and Pyridine Carboxamide-based JNK Inhibitors.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Synthesis, crystal structure, DNA-binding and cytotoxicity in vitro of novel cis-Pt(II) and trans-Pd(II) pyridine carboxamide complexes.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Amide hydrogen bonding: control of the molecular and extended structures of two symmetrical pyridine-2-carboxamide derivatives.

Journal: Acta crystallographica. Section C, Crystal structure communications 20101101

Title: Unconventional hydrogen bonding and π-stacking in two substituted pyridine carboxamides.

Journal: Acta crystallographica. Section C, Crystal structure communications 20101001

Title: Intramolecular sigma-bond metathesis/protonolysis on zirconium(IV) and hafnium(IV) pyridylamido olefin polymerization catalyst precursors: exploring unexpected reactivity paths.

Journal: Inorganic chemistry 20100802

Title: Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Bis[N-(4-chloro-phen-yl)pyridine-3-carboxamide]-silver(I) nitrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100801

Title: Kinetic and equilibrium studies of the removal of cadmium ions from acidic chloride solutions by hydrophobic pyridinecarboxamide extractants.

Journal: Journal of hazardous materials 20100715

Title: rac-N-[Hy-droxy(4-pyrid-yl)meth-yl]picolinamide: a hemiamidal.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Hybridization of long pyridine-dicarboxamide oligomers into multi-turn double helices: slow strand association and dissociation, solvent dependence, and solid state structures.

Journal: Chemistry, an Asian journal 20100601

Title: 2-Ferrocenyl-N-(6-methyl-2-pyrid-yl)benzamide.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: Bis{2-hydr-oxy-N-[2-(2-pyrid-yl)eth-yl]benzamide}copper(I) tetra-fluoridoborate.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity.

Journal: Mediators of inflammation 20100101

Title: Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes.

Journal: Journal of medicinal chemistry 20091210

Title: Interaction of nicotinamide and picolinamide with phosphatidylcholine and phosphatidylethanolamine membranes: a combined approach using dipole potential measurements and quantum chemical calculations.

Journal: Biochimica et biophysica acta 20091201

Title: 2-Carbamylpyridinium tetra-chlorido-ferrate(III).

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Bis[μ-2-(aminosulfanyl)pyridine(1-)]bis-[(η-penta-methyl-cyclo-penta-dien-yl)iridium(III)] diiodide.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: New generation of metal string complexes: strengthening metal-metal interaction via naphthyridyl group modulated oligo-alpha-pyridylamido ligands.

Journal: Chemical communications (Cambridge, England) 20090807

Title: Cobalt complex as building blocks: synthesis, characterization, and catalytic applications of {Cd2+-Co3+-Cd2+} and {Hg2+-Co3+-Hg2+} heterobimetallic complexes.

Journal: Inorganic chemistry 20090615

Title: Investigation on the complex of diperoxovanadate with picolinamide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090601

Title: Hydrogen-bonded structures of the isomeric 2-, 3- and 4-carbamoylpyridinium hydrogen chloranilates.

Journal: Acta crystallographica. Section C, Crystal structure communications 20090601

Title: Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.

Journal: Bioorganic & medicinal chemistry letters 20090515

Title: Utility of MetaSite in improving metabolic stability of the neutral indomethacin amide derivative and selective cyclooxygenase-2 inhibitor 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501

Title: IRAK-4 inhibitors for inflammation.

Journal: Current topics in medicinal chemistry 20090501

Title: The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: Dimer formation in nicotinamide and picolinamide in the gas and condensed phases probed by infrared spectroscopy.

Journal: Physical chemistry chemical physics : PCCP 20081214

Title: Synthesis, characterization and antibacterial activity of cobalt(III) complexes with pyridine-amide ligands.

Journal: European journal of medicinal chemistry 20081001

Title: A photolabile ligand for light-activated release of caged copper.

Journal: Journal of the American Chemical Society 20080917

Title: Diaqua-{2,6-bis-[N-(2-pyridinylmeth-yl)-carbamo-yl]-phenolato-κO,O}zinc(II).

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: [Synthesis and DNA-binding properties of three compounds containing pyridinecarboxamide].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20080601

Title: [N,N'-(1,2-Diphenyl-ethane-1,2-di-yl)bis-(pyridine-2-carboxamidato)]nickel(II) diethyl ether hemisolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080301

Title: cis-Bis(azido-κN)bis-(pyridine-2-carbox-amide-κN,O)nickel(II).

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: Bis[N-(8-quinol-yl)pyridine-2-carbox-amidato-κN,N',N'']manganese(III) perchlorate monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: Molecular structure, vibrational spectra, quantum chemical calculations and photochemistry of picolinamide and isonicotinamide isolated in cryogenic inert matrixes and in the neat low-temperature solid phases.

Journal: The journal of physical chemistry. A 20080110

Title: 14N NQR study of nicotinamide and related compounds.

Journal: Magnetic resonance in chemistry : MRC 20080101

Title: Matrix-assisted laser desorption/ionization signal enhancement of peptides by picolinamidination of amino groups.

Journal: Rapid communications in mass spectrometry : RCM 20080101

Title: Characterisation of the substrate specificity of the nitrile hydrolyzing system of the acidotolerant black yeast Exophiala oligosperma R1.

Journal: Studies in mycology 20080101

Title: Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding.

Journal: Pest management science 20071001

Title: Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.

Journal: Biochimica et biophysica acta 20070901

Title: Solution equilibria of copper(II) complexation with N,N'-(2,2'-azanediylbis(ethane-2,1-diyl))dipicolinamide: a bio-distribution and dermal absorption study.

Journal: Journal of inorganic biochemistry 20070801

Title: Mechanism of activation of a hafnium pyridyl-amide olefin polymerization catalyst: ligand modification by monomer.

Journal: Journal of the American Chemical Society 20070627

Title: Development of a disposable mercury ion-selective optode based on trityl-picolinamide as ionophore.

Journal: Analytica chimica acta 20070522

Title: Structural variation in copper(I) complexes with pyridylmethylamide ligands: structural analysis with a new four-coordinate geometry index, tau4.

Journal: Dalton transactions (Cambridge, England : 2003) 20070307

Title: [Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis].

Journal: Advances in gerontology = Uspekhi gerontologii 20070101

Title: Effects of hydrogen bonding on the ring stretching modes of pyridine.

Journal: The journal of physical chemistry. A 20061221

Title: Copper(I) coordination chemistry of (pyridylmethyl)amide ligands.

Journal: Inorganic chemistry 20061113

Title: Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Multinuclear copper complexes of pyridylmethylamide ligands.

Journal: Dalton transactions (Cambridge, England : 2003) 20060421

Title: Electrophilic activation of lactams with Tf2O and pyridine: expedient synthesis of (+/-)-tetraponerine T4.

Journal: Organic letters 20051124

Title: Novel metal-linked face-to-face porphyrazine dimer.

Journal: Inorganic chemistry 20051114

Title: Mechanistic explanation to the catalysis by pyrazinamide and ethambutol of reaction between rifampicin and isoniazid in anti-TB FDCs.

Journal: Journal of pharmaceutical and biomedical analysis 20051004

Title: Bivalent and trivalent iron complexes of acyclic hexadentate ligands providing pyridyl/pyrazine-amide-thioether coordination.

Journal: Inorganic chemistry 20050808

Title: In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.

Journal: Chemical & pharmaceutical bulletin 20050401

Title: The amide rotational barrier in isonicotinamide: Dynamic NMR and ab initio studies.

Journal: The journal of physical chemistry. A 20050217

Title: Supramolecular copper hydroxide tennis balls: self-assembly, structures, and magnetic properties of octanuclear [Cu(8)L(8)(OH)(4)](4+) clusters (HL = N-(2-pyridylmethyl)acetamide).

Journal: Inorganic chemistry 20041101

Title: Correlation of mass spectrometry identified bacterial biomarkers from a fielded pyrolysis-gas chromatography-ion mobility spectrometry biodetector with the microbiological gram stain classification scheme.

Journal: Analytical chemistry 20041101

Title: Molecular, supramolecular and solution structures of peroxovanadium complexes with ON and O3N donor set ligands: two new types of cationic-anionic peroxovanadium(V) peroxovanadates(V).

Journal: Dalton transactions (Cambridge, England : 2003) 20041021

Title: Picolinamidium squarate and di-p-toluidinium squarate dihydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20040801

Title: Diaquabis(pyridine-2-carboxamide-kappa2N1,O2)nickel(II) disaccharinate tetrahydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20040701

Title: Tris[N-(4-fluorophenyl)pyridine-2-carboxamidato-kappa2N,N']cobalt(III) trihydrate: a novel meridional complex.

Journal: Acta crystallographica. Section C, Crystal structure communications 20040501

Title: New pyridine carboxamide ligands and their complexation to copper(II). X-Ray crystal structures of mono-, di, tri- and tetranuclear copper complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20040321

Title: Solid-state and solution properties of cationic lanthanide complexes of a new neutral heptadentate N4O3 tripodal ligand.

Journal: Inorganic chemistry 20031201

Title: The amide rotational barriers in picolinamide and nicotinamide: NMR and ab initio studies.

Journal: Journal of the American Chemical Society 20030820

Title: Synthesis and characterization of cobalt(III) complexes containing 2-pyridinecarboxamide ligands and their application in catalytic oxidation of ethylbenzene with dioxygen.

Journal: Chemical communications (Cambridge, England) 20030607

Title: ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.

Journal: Advances in experimental medicine and biology 20030101

Title: Amination of pyridylketenes: experimental and computational studies of strong amide enol stabilization by the 2-pyridyl group.

Journal: Journal of the American Chemical Society 20021120

Title: Spontaneous reduction of a low-spin Fe(III) complex of a neutral pentadentate N(5) Schiff base ligand to the corresponding Fe(II) species in acetonitrile.

Journal: Inorganic chemistry 20021021

Title: Unusual reactivity of methylene group adjacent to pyridine-2-carboxamido moiety in iron(III) and cobalt(III) complexes.

Journal: Inorganic chemistry 20020520

Title: Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies.

Journal: Chemical & pharmaceutical bulletin 20020301

Title: Oxygen capture by lithiated organozinc reagents containing aromatic 2-pyridylamide ligands.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010903

Title: Molecularly imprinted polymers from nicotinamide and its positional isomers.

Journal: Journal of molecular recognition : JMR 20010101

Title: Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats.

Journal: Cancer research 19780701

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Tags:1452-77-3 Molecular Formula|1452-77-3 MDL|1452-77-3 SMILES|1452-77-3 Pyridine-2-carboxamide |Heterocyclic_Building_Blocks |Organic_Building_Blocks