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149709-44-4,MFCD00921225
Catalog No.:AA001LVR

149709-44-4 | (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$48.00   $33.00
- +
5mg
98% by HPLC
in stock  
$179.00   $125.00
- +
10mg
98% by HPLC
in stock  
$258.00   $180.00
- +
250mg
97%
in stock  
$288.00   $202.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001LVR
Chemical Name:
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
CAS Number:
149709-44-4
Molecular Formula:
C22H25NO5
Molecular Weight:
383.4376
MDL Number:
MFCD00921225
SMILES:
C[C@@H](C(=O)O)C[C@@H](Cc1ccc(cc1)c1ccccc1)NC(=O)CCC(=O)O
Properties
Computed Properties
 
Complexity:
521  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
3  

Literature

Title: Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).

Journal: Journal of clinical pharmacology 20100401

Title: Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.

Title: Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72(8):917-24.

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SDS
Tags:149709-44-4 Molecular Formula|149709-44-4 MDL|149709-44-4 SMILES|149709-44-4 (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid