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15060-55-6,MFCD00136013
Catalog No.:AA0034E3

15060-55-6 | Ammonium Tetrathiomolybdate

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1g
99%
in stock  
$62.00   $44.00
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5g
99%
in stock  
$185.00   $129.00
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25g
99%
in stock  
$678.00   $475.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034E3
Chemical Name:
Ammonium Tetrathiomolybdate
CAS Number:
15060-55-6
Molecular Formula:
H8MoN2S4
Molecular Weight:
260.2969
MDL Number:
MFCD00136013
SMILES:
[S-][Mo](=S)(=S)[S-].[NH4+].[NH4+]
Properties
Properties
 
Form:
Solid  
MP:
>300 °C(lit.)  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
19.1  
Covalently-Bonded Unit Count:
5  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  

Literature

Title: Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro.

Journal: Redox report : communications in free radical research 20140101

Title: Responsiveness of prehaemolytic copper poisoning in sheep from a specific pathogen-free environment to a relatively high dose of tetrathiomolybdate.

Journal: The Veterinary record 20120908

Title: Residual effects of Mycobacterium avium infection on susceptibility of sheep to copper toxicity and efficacy of treatment with tetrathiomolybdate.

Journal: The Veterinary record 20120707

Title: Effects of clonidine and idazoxan on tetrathiomolybdate-induced copper and lysosomal enzyme excretion into sheep bile.

Journal: Research in veterinary science 20120601

Title: Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.

Journal: BMC cancer 20120101

Title: Role of the rumen in copper and thiomolybdate absorption.

Journal: Nutrition research reviews 20111201

Title: Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20111001

Title: Prognostic significance of neurologic examination findings in Wilson disease.

Journal: Parkinsonism & related disorders 20110801

Title: Antitumor activity of nifurtimox is enhanced with tetrathiomolybdate in medulloblastoma.

Journal: International journal of oncology 20110501

Title: The significance of copper chelators in clinical and experimental application.

Journal: The Journal of nutritional biochemistry 20110401

Title: Development of a new bimodal imaging methodology: a combination of fluorescence microscopy and high-resolution secondary ion mass spectrometry.

Journal: Journal of microscopy 20101001

Title: Tetrathiomolybdate mediated rearrangement of aziridinemethanol tosylates: a thia-aza-Payne rearrangement.

Journal: The Journal of organic chemistry 20100820

Title: Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate.

Journal: Journal of inorganic biochemistry 20100801

Title: Is there a role for tetrathiomolybdate in the treatment of primary biliary cirrhosis?

Journal: Translational research : the journal of laboratory and clinical medicine 20100301

Title: Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial.

Journal: Translational research : the journal of laboratory and clinical medicine 20100301

Title: Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate.

Journal: BMC cancer 20100101

Title: Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis.

Journal: Molecular cancer 20100101

Title: Antiangiogenic tetrathiomolybdate protects against Her2/neu-induced breast carcinoma by hypoplastic remodeling of the mammary gland.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

Title: Redox-related antimelanoma activity of ATN-224.

Journal: Melanoma research 20091201

Title: Direct synthesis of functionalized unsymmetrical beta-sulfonamido disulfides by tetrathiomolybdate mediated aziridine ring-opening reactions.

Journal: The Journal of organic chemistry 20091016

Title: Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine.

Journal: Translational research : the journal of laboratory and clinical medicine 20090801

Title: Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate.

Journal: Experimental biology and medicine (Maywood, N.J.) 20090601

Title: Status epilepticus in Wilson's disease.

Journal: Epileptic disorders : international epilepsy journal with videotape 20090601

Title: Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms.

Journal: Microvascular research 20090501

Title: A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer.

Journal: Investigational new drugs 20090401

Title: Molybdenum X-ray absorption edges from 200 to 20,000eV: the benefits of soft X-ray spectroscopy for chemical speciation.

Journal: Journal of inorganic biochemistry 20090201

Title: Role of copper ion in the pathogenesis of type 2 diabetes.

Journal: Endocrine journal 20090101

Title: Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081115

Title: Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis.

Journal: Translational research : the journal of laboratory and clinical medicine 20081101

Title: Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis.

Journal: Experimental neurology 20080901

Title: Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes.

Journal: Experimental biology and medicine (Maywood, N.J.) 20080801

Title: Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20080520

Title: Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224).

Journal: British journal of cancer 20080226

Title: Effects of ammonium tetrathiomolybdate, an oncolytic/angiolytic drug on the viability and proliferation of endothelial and tumor cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20071201

Title: Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Reversible precipitation of bovine serum albumin by metal ions and synthesis, structure and reactivity of new tetrathiometallate chelating agents.

Journal: Journal of inorganic biochemistry 20071101

Title: Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway.

Journal: Experimental cell research 20070910

Title: Novel chalcogenides of thymidine and uridine: synthesis, properties and applications.

Journal: Carbohydrate research 20070702

Title: Wilson disease--a practical approach to diagnosis, treatment and follow-up.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070701

Title: Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate.

Journal: Translational research : the journal of laboratory and clinical medicine 20070501

Title: Comparison of lowering copper levels with tetrathiomolybdate and zinc on mouse tumor and doxorubicin models.

Journal: Translational research : the journal of laboratory and clinical medicine 20061201

Title: Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060815

Title: Promising pharmacologic innovations in treating pulmonary fibrosis.

Journal: Current opinion in pharmacology 20060601

Title: Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro.

Journal: The Journal of endocrinology 20060601

Title: The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model.

Journal: Journal of inorganic biochemistry 20060501

Title: Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.

Journal: Archives of neurology 20060401

Title: Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinoma.

Journal: Archives of otolaryngology--head & neck surgery 20060301

Title: Copper kinetics and hepatic glutathione levels in the copper exposed frog Rana ridibunda after tetrathiomolybdate treatment.

Journal: Bulletin of environmental contamination and toxicology 20060301

Title: Novel therapeutic approaches to the treatment of Wilson's disease.

Journal: Expert opinion on pharmacotherapy 20060201

Title: Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice.

Journal: The Journal of laboratory and clinical medicine 20051101

Title: Chemistry of tetrathiomolybdate: aziridine ring opening reactions and facile synthesis of interesting sulfur heterocycles.

Journal: Journal of the American Chemical Society 20050921

Title: Anticopper therapy against cancer and diseases of inflammation and fibrosis.

Journal: Drug discovery today 20050815

Title: Effects of tetrathiomolybdate in a mouse model of retinal neovascularization.

Journal: Investigative ophthalmology & visual science 20050101

Title: Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.

Journal: CNS drugs 20050101

Title: Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats.

Journal: Arthritis research & therapy 20050101

Title: Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis.

Journal: Journal of inorganic biochemistry 20041201

Title: [Wilson's disease and its pharmacological treatment].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101

Title: Solid state imposed vibrational coupling between nu1 and nu3 modes of tetrahedral ions.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20041001

Title: Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice.

Journal: Experimental biology and medicine (Maywood, N.J.) 20040901

Title: Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy.

Journal: Expert opinion on pharmacotherapy 20040801

Title: [Wilson disease in 2003].

Journal: Orvosi hetilap 20031214

Title: Wilson disease.

Journal: Mayo Clinic proceedings 20030901

Title: Selective reduction of anomeric azides to amines with tetrathiomolybdate: synthesis of beta-D-glycosylamines.

Journal: The Journal of organic chemistry 20030627

Title: Antiangiogenic therapy through copper chelation.

Journal: Expert opinion on therapeutic targets 20030601

Title: Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media.

Journal: Reproduction (Cambridge, England) 20030501

Title: Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice.

Journal: The Journal of laboratory and clinical medicine 20030301

Title: Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy.

Journal: Archives of neurology 20030301

Title: [Wilson's disease: physiopathological, clinical and therapeutic considerations].

Journal: Gastroenterologia y hepatologia 20030101

Title: Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation.

Journal: Journal of cellular and molecular medicine 20030101

Title: The involvement of a multicopper oxidase in iron uptake by the green algae Chlamydomonas reinhardtii.

Journal: Plant physiology 20021201

Title: Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma.

Journal: Neoplasia (New York, N.Y.) 20020901

Title: Diagnosis and treatment of Wilson's disease.

Journal: Current neurology and neuroscience reports 20020701

Title: Kayser-Fleischer ring as the presenting sign of Wilson disease.

Journal: American journal of ophthalmology 20020601

Title: Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group.

Journal: Chemical communications (Cambridge, England) 20020421

Title: Radiotherapy and antiangiogenic TM in lung cancer.

Journal: Neoplasia (New York, N.Y.) 20020301

Title: Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.

Journal: Journal of inorganic biochemistry 20020115

Title: Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration.

Journal: Transactions of the American Ophthalmological Society 20020101

Title: Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.

Journal: FEBS letters 20011102

Title: Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.

Journal: The Journal of biological chemistry 20010706

Title: Peptides mimicking the N-terminal Cu(II)-binding site of bovine serum albumin: synthesis, characterization and coordination with Cu(II) ions.

Journal: Journal of inorganic biochemistry 20010501

Title: UV/visible spectrophotometric studies of the interactions of thiomolybdates, copper(II) and other ligands.

Journal: Journal of inorganic biochemistry 20010501

Title: Treatment of Wilson's disease: what are the relative roles of penicillamine, trientine, and zinc supplementation?

Journal: Current gastroenterology reports 20010201

Title: Treatment of the neurologic manifestations of Wilson's disease.

Journal: Archives of neurology 19950401

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