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152121-53-4,MFCD12405019
Catalog No.:AA003JYU

152121-53-4 | Pd 169316

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1mg
95%
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$11.00   $8.00
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5mg
95%
in stock  
$25.00   $18.00
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10mg
95%
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$37.00   $26.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003JYU
Chemical Name:
Pd 169316
CAS Number:
152121-53-4
Molecular Formula:
C20H13FN4O2
Molecular Weight:
360.3412
MDL Number:
MFCD12405019
SMILES:
Fc1ccc(cc1)c1nc([nH]c1c1ccncc1)c1ccc(cc1)[N+](=O)[O-]
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Gallagher,TimothyF.;Seibel,GeorgeL.;Kassis,Shouki;Laydon,JeffreyT.;Blumenthal,MaryJane;Lee,JohnC.;Lee,Dennis;Boehm,JeffreyC.;Fier-Thompson,SusanM.;Abt,JeffreyW.;Soreson,MargaretE.;Smietana,JuanitaM.;Hall,RalphF.;Garigipati,RaviS.;Bender,PaulE.;Erhard,KarlF.;Krog,ArnoldJ.;Hofmann,GlennA.;Sheldrake,PeterL.;McDonnell,PeterC.;Kumar,Sanjay;Young,PeterR.;Adams,JerryL.[BioorganicandMedicinalChemistry,1997,vol.5,#1,p.49-64]

[1]Gallagher,TimothyF.;Seibel,GeorgeL.;Kassis,Shouki;Laydon,JeffreyT.;Blumenthal,MaryJane;Lee,JohnC.;Lee,Dennis;Boehm,JeffreyC.;Fier-Thompson,SusanM.;Abt,JeffreyW.;Soreson,MargaretE.;Smietana,JuanitaM.;Hall,RalphF.;Garigipati,RaviS.;Bender,PaulE.;Erhard,KarlF.;Krog,ArnoldJ.;Hofmann,GlennA.;Sheldrake,PeterL.;McDonnell,PeterC.;Kumar,Sanjay;Young,PeterR.;Adams,JerryL.[BioorganicandMedicinalChemistry,1997,vol.5,#1,p.49-64]

[1]Gallagher,TimothyF.;Seibel,GeorgeL.;Kassis,Shouki;Laydon,JeffreyT.;Blumenthal,MaryJane;Lee,JohnC.;Lee,Dennis;Boehm,JeffreyC.;Fier-Thompson,SusanM.;Abt,JeffreyW.;Soreson,MargaretE.;Smietana,JuanitaM.;Hall,RalphF.;Garigipati,RaviS.;Bender,PaulE.;Erhard,KarlF.;Krog,ArnoldJ.;Hofmann,GlennA.;Sheldrake,PeterL.;McDonnell,PeterC.;Kumar,Sanjay;Young,PeterR.;Adams,JerryL.[BioorganicandMedicinalChemistry,1997,vol.5,#1,p.49-64]

[1]BioorganicandMedicinalChemistry,1997,vol.5,p.49-64

[1]Gallagher,TimothyF.;Seibel,GeorgeL.;Kassis,Shouki;Laydon,JeffreyT.;Blumenthal,MaryJane;Lee,JohnC.;Lee,Dennis;Boehm,JeffreyC.;Fier-Thompson,SusanM.;Abt,JeffreyW.;Soreson,MargaretE.;Smietana,JuanitaM.;Hall,RalphF.;Garigipati,RaviS.;Bender,PaulE.;Erhard,KarlF.;Krog,ArnoldJ.;Hofmann,GlennA.;Sheldrake,PeterL.;McDonnell,PeterC.;Kumar,Sanjay;Young,PeterR.;Adams,JerryL.[BioorganicandMedicinalChemistry,1997,vol.5,#1,p.49-64]

Literature

Title: A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference.

Journal: The Journal of biological chemistry 20150424

Title: Quinoline compound KM11073 enhances BMP-2-dependent osteogenic differentiation of C2C12 cells via activation of p38 signaling and exhibits in vivo bone forming activity.

Journal: PloS one 20150101

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: p38 Mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland.

Journal: Cellular & molecular biology letters 20120301

Title: Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.

Journal: The Journal of biological chemistry 20120217

Title: Translocation and oligomerization of Bax is regulated independently by activation of p38 MAPK and caspase-2 during MN9D dopaminergic neurodegeneration.

Journal: Apoptosis : an international journal on programmed cell death 20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase.

Journal: The Journal of biological chemistry 20110610

Title: [The role of serine/threonine and tyrosine protein kinases in the depression of cholinosensitivity in Helix lucorum neurons in the cellular correlate of habituation].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20110101

Title: High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α.

Journal: Journal of nutritional science and vitaminology 20110101

Title: Differentiation and neural integration of hippocampal neuronal progenitors: signaling pathways sequentially involved.

Journal: Hippocampus 20100801

Title: ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK.

Journal: Chemico-biological interactions 20100730

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression.

Journal: American journal of physiology. Cell physiology 20090901

Title: Role PKA and p38 MAPK on ROS production in neutrophil age-related: Lack of IL-10 effect in older subjects.

Journal: Mechanisms of ageing and development 20090901

Title: Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK.

Journal: Veterinary immunology and immunopathology 20090615

Title: 15-Deoxy-Delta-Prostaglandin J(2) Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats.

Journal: Immune network 20090401

Title: Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells.

Journal: Journal of biochemistry 20090201

Title: The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells.

Journal: Journal of cellular physiology 20081001

Title: Identification of RIP1 kinase as a specific cellular target of necrostatins.

Journal: Nature chemical biology 20080501

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: p38MAP Kinase activity is required for human primary adipocyte differentiation.

Journal: FEBS letters 20071211

Title: Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.

Journal: Biochimica et biophysica acta 20071201

Title: P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells.

Journal: Journal of neurochemistry 20071201

Title: Myocardial ischemia/reperfusion causes VDAC phosphorylation which is reduced by cardioprotection with a p38 MAP kinase inhibitor.

Journal: Proteomics 20071201

Title: Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells.

Journal: Biochemical and biophysical research communications 20071019

Title: Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.

Journal: The Biochemical journal 20070715

Title: Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401

Title: Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth.

Journal: Biochemical and biophysical research communications 20070216

Title: Intrinsically active variants of all human p38 isoforms.

Journal: The FEBS journal 20070201

Title: Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101

Title: Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20060801

Title: N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.

Journal: Oncogene 20060504

Title: p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis.

Journal: Stem cells (Dayton, Ohio) 20060501

Title: HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

Journal: Journal of leukocyte biology 20051001

Title: Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells.

Journal: Biochimica et biophysica acta 20050930

Title: Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.

Journal: Molecular biology of the cell 20050901

Title: Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.

Journal: Journal of cellular biochemistry 20050901

Title: Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase.

Journal: Life sciences 20050520

Title: Kinetic studies of small molecule interactions with protein kinases using biosensor technology.

Journal: Analytical biochemistry 20050515

Title: Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

Journal: Chemico-biological interactions 20050115

Title: A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050105

Title: p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling.

Journal: Journal of cell science 20041215

Title: Effects of inhibitors of the tyrosine signalling cascade on antigen challenge of guinea pig airways in vitro.

Journal: Annals of the Academy of Medicine, Singapore 20040901

Title: Vasopressin phosphorylates HSP27 in aortic smooth muscle cells.

Journal: Journal of cellular biochemistry 20040815

Title: Inhibitor of p42/44 mitogen-activated protein kinase, but not p38 MAPK, attenuated antigen challenge of guinea pig airways in vitro.

Journal: International immunopharmacology 20040801

Title: Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.

Journal: The Journal of biological chemistry 20040507

Title: Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.

Journal: Journal of cellular biochemistry 20040401

Title: A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells.

Journal: Cell death and differentiation 20040301

Title: All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells.

Journal: Oncogene 20040115

Title: Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.

Journal: The Journal of biological chemistry 20031226

Title: The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.

Journal: Biochemical and biophysical research communications 20031017

Title: Inhibition of p38 mitogen-activated protein kinase interferes with cell shape changes and gene expression associated with Schwann cell myelination.

Journal: Experimental neurology 20030901

Title: Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis.

Journal: International journal of molecular medicine 20030801

Title: Mechanism of simvastatin on induction of heat shock protein in osteoblasts.

Journal: Archives of biochemistry and biophysics 20030701

Title: Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.

Journal: Archives of biochemistry and biophysics 20030701

Title: Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation.

Journal: American journal of physiology. Endocrinology and metabolism 20030601

Title: Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.

Journal: European journal of pharmacology 20030418

Title: Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.

Journal: The Journal of biological chemistry 20030411

Title: Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

Journal: The Journal of biological chemistry 20030103

Title: Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes.

Journal: The Journal of biological chemistry 20020906

Title: Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology 20020901

Title: Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.

Journal: Blood 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.

Journal: The Journal of biological chemistry 20020412

Title: Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.

Journal: The Journal of biological chemistry 20020315

Title: Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.

Journal: Biochimica et biophysica acta 20020213

Title: 1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase.

Journal: Archives of biochemistry and biophysics 20020201

Title: p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.

Journal: Neurobiology of disease 20020201

Title: Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases.

Journal: Cancer research 20011201

Title: Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism.

Journal: Cardiovascular research 20011101

Title: Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27.

Journal: The Journal of investigative dermatology 20011101

Title: Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells.

Journal: Journal of neurochemistry 20011001

Title: Overexpression of calbindin-D28K induces neurite outgrowth in dopaminergic neuronal cells via activation of p38 MAPK.

Journal: Biochemical and biophysical research communications 20010928

Title: Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.

Journal: Brain research 20010209

Title: MEK and p38MAPK inhibitors potentiate TNF-alpha induced apoptosis in U937 cells.

Journal: Anticancer research 20010101

Title: Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.

Journal: Cell stress & chaperones 20010101

Title: Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons.

Journal: Cellular & molecular biology letters 20010101

Title: p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.

Journal: The Journal of biological chemistry 20000714

Title: Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons.

Journal: Journal of neurochemistry 20000601

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Tags:152121-53-4 Molecular Formula|152121-53-4 MDL|152121-53-4 SMILES|152121-53-4 Pd 169316