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15291-75-5,MFCD07437829
Catalog No.:AA00380H

15291-75-5 | Ginkgolide a

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10mg
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25mg
99%(HPLC)powder
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50mg
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100mg
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1000mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00380H
Chemical Name:
Ginkgolide a
CAS Number:
15291-75-5
Molecular Formula:
C20H24O9
Molecular Weight:
408.3992
MDL Number:
MFCD07437829
SMILES:
O=C1OC2C(C1C)(O)C13C4(C2)C(OC3=O)CC(C24C(O1)OC(=O)C2O)C(C)(C)C
NSC Number:
603665
Properties
Computed Properties
 
Complexity:
893  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
10  
XLogP3:
0.6  

Literature

Title: Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells.

Journal: Planta medica 20120801

Title: Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Journal: Magnetic resonance in chemistry : MRC 20120801

Title: Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.

Journal: The Journal of pharmacology and experimental therapeutics 20101201

Title: Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

Journal: Phytotherapy research : PTR 20100301

Title: Chemical constituents of the bark of Machilus wangchiana and their biological activities.

Journal: Journal of natural products 20091201

Title: Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080501

Title: [Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080501

Title: Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080401

Title: Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315

Title: Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B.

Journal: Clinical and experimental pharmacology & physiology 20070701

Title: Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence.

Journal: Cancer letters 20070618

Title: Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301

Title: Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.

Journal: Journal of AOAC International 20070101

Title: Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.

Journal: Acta poloniae pharmaceutica 20070101

Title: Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.

Journal: Toxicology and applied pharmacology 20061201

Title: Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.

Journal: IUBMB life 20060401

Title: LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity.

Journal: Journal of pharmaceutical and biomedical analysis 20060224

Title: Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060201

Title: [Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201

Title: Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.

Journal: Phytochemistry 20041101

Title: A method for extraction and quantification of Ginkgo terpene trilactones.

Journal: Analytical chemistry 20040801

Title: Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A.

Journal: Basic & clinical pharmacology & toxicology 20040801

Title: Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices.

Journal: Phytotherapy research : PTR 20040701

Title: Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors.

Journal: European journal of pharmacology 20040628

Title: Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC.

Journal: Analytical and bioanalytical chemistry 20040601

Title: Determination of specific receptor sites for platelet activating factor in bovine neutrophils.

Journal: American journal of veterinary research 20040501

Title: A new geranylgeranyl diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides.

Journal: DNA sequence : the journal of DNA sequencing and mapping 20040401

Title: Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Title: Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis.

Journal: IUBMB life 20040101

Title: An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.

Journal: Journal of natural products 20031001

Title: Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide.

Journal: Molecular and cellular biochemistry 20030101

Title: Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull, 1993. 16(2): p. 210-2.

Title: Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.

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