Home Amines 153-78-6
153-78-6,MFCD08459291
Catalog No.:AA003GGM

153-78-6 | 2-Aminofluorene

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5g
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  • Technical Information
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Technical Information
Catalog Number:
AA003GGM
Chemical Name:
2-Aminofluorene
CAS Number:
153-78-6
Molecular Formula:
C13H11N
Molecular Weight:
181.2331
MDL Number:
MFCD08459291
SMILES:
Nc1ccc2c(c1)Cc1c2cccc1
UN Number:
2811
Properties
Properties
 
BP:
358.3°C at 760 mmHg  
Form:
Solid  
MP:
124-128 °C(lit.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
213  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
3.1  

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Title: Effect of N-2-acetylaminofluorene and 2-aminofluorene adducts on DNA binding and synthesis by yeast DNA polymerase eta.

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Journal: The journal of physical chemistry. B 20090507

Title: Kinetics of deoxy-CTP incorporation opposite a dG-C8-N-2-aminofluorene adduct by a high-fidelity DNA polymerase.

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Title: Effects of luteolin on distribution and metabolism of 2-aminofluorene in male Sprague-Dawley rats.

Journal: In vivo (Athens, Greece) 20080101

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Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050801

Title: Diallyl disulfide inhibits N-acetyltransferase activity and gene expression in human esophagus epidermoid carcinoma CE 81T/VGH cells.

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Title: Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines.

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Title: Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells.

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Journal: Toxicology letters 20041102

Title: Evidence for arylamine N-acetyltransferase activity in Klebsiella pneumoniae.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20040801

Title: Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.

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Title: Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.

Journal: Chemical research in toxicology 20040301

Title: Inhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfide.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040201

Title: Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis.

Journal: Molecular pharmacology 20040101

Title: The inhibition of N-acetyltransferase activity and gene expression in human bladder cancer cells (T24) by shikonin.

Journal: In vivo (Athens, Greece) 20040101

Title: PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS).

Journal: Anticancer research 20040101

Title: N-acetyltransferase activity is involved in paclitaxel-induced N-acetylation of 2-aminofluorene in human bladder cancer cells (T24).

Journal: Anticancer research 20040101

Title: Shikonin inhibits the growth and N-acetylation of 2-aminofluorene in Helicobacter pylori from ulcer patients.

Journal: Anticancer research 20040101

Title: N-ethylphenyl acetamide (EPA) inhibits DNA synthesis and N-acetylation of 2-aminofluorene in human colon tumor cells (colo 205).

Journal: Anticancer research 20040101

Title: Paclitaxel inhibits N-acetyltransferase activity and gene expression in human stomach tumor cells (SC-M1).

Journal: Research communications in molecular pathology and pharmacology 20040101

Title: Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa).

Journal: Research communications in molecular pathology and pharmacology 20040101

Title: Effects of tamoxifen on DNA adduct formation and arylamines N-acetyltransferase activity in human breast cancer cells.

Journal: Research communications in molecular pathology and pharmacology 20040101

Title: Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease.

Journal: Biochemistry 20031104

Title: Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene.

Journal: Journal of protein chemistry 20031101

Title: Aloe-emodin inhibited N-acetylation and DNA adduct of 2-aminofluorene and arylamine N-acetyltransferase gene expression in mouse leukemia L 1210 cells.

Journal: Leukemia research 20030901

Title: Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030601

Title: Curcumin inhibited the arylamines N-acetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells (A549).

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030601

Title: Paclitaxel (taxol) inhibits the arylamine N-acetyltransferase activity and gene expression (mRNA NAT1) and 2-aminofluorene-DNA adduct formation in human bladder carcinoma cells (T24 and TSGH 8301).

Journal: Pharmacology & toxicology 20030601

Title: Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole.

Journal: Molecular pharmacology 20030501

Title: Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Time-resolved resonance Raman and density functional study of an azirine intermediate in the 2-fluorenylnitrene ring-expansion reaction to form a dehydroazepine product.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20030317

Title: Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.

Journal: Pharmacogenetics 20030301

Title: Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay.

Journal: Mutagenesis 20030301

Title: Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa.

Journal: Phytotherapy research : PTR 20030301

Title: Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101

Title: Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101

Title: Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene accompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line.

Journal: Anticancer research 20030101

Title: Paclitaxel affects the amounts of the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats.

Journal: In vivo (Athens, Greece) 20030101

Title: N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski).

Journal: In vivo (Athens, Greece) 20030101

Title: Curcumin decreases the DNA adduct formation, arylamines N-acetyltransferase activity and gene expression in human colon tumor cells (colo 205).

Journal: In vivo (Athens, Greece) 20030101

Title: Effects of (-)-menthol on the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats.

Journal: In vivo (Athens, Greece) 20030101

Title: Deacylation of N-arylformamides and N-arylacetamides by formamidase in rat liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201

Title: Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays.

Journal: Phytotherapy research : PTR 20021101

Title: Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021001

Title: Quercetin glucuronides inhibited 2-aminofluorene acetylation in human acute myeloid HL-60 leukemia cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20021001

Title: Comments on the history and importance of aromatic and heterocyclic amines in public health.

Journal: Mutation research 20020930

Title: Metabolic oxidation of carcinogenic arylamines by p450 monooxygenases: theoretical support for the one-electron transfer mechanism.

Journal: Mutation research 20020930

Title: Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells.

Journal: Neurochemical research 20020901

Title: Chemical models for cytochrome P450 as a biomimetic metabolic activation system in mutation assays.

Journal: Mutation research 20020826

Title: Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.

Journal: Biological chemistry 20020601

Title: Time-resolved resonance Raman spectroscopy and density functional study of 2-fluorenylnitrene and its dehydroazepine products.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020503

Title: The effect of paclitaxel on 2-aminofluorene-DNA adducts formation and arylamine N-acetyltransferase activity and gene expression in human lung tumor cells (A549).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501

Title: The effect of paclitaxel on gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501

Title: Transformation of mutagenic aromatic amines into non-mutagenic species by alkyl substituents. Part II: alkylation far away from the amino function.

Journal: Mutation research 20020325

Title: A correlative study on antimutagenic and chemopreventive activity of Acacia auriculiformis A. Cunn. and Acacia nilotica (L.) Willd. Ex Del.

Journal: Drug and chemical toxicology 20020201

Title: Effects of butylated hydroxyanisole and butylated hydroxytoluene on DNA adduct formation and arylamine N-acetyltransferase activity in human bladder tumour cells.

Journal: Journal of applied toxicology : JAT 20020101

Title: Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20020101

Title: Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20020101

Title: Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.

Journal: Teratogenesis, carcinogenesis, and mutagenesis 20020101

Title: Hydrocortisone affects the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats.

Journal: Anticancer research 20020101

Title: Induction of light emission by luminescent bacteria treated with UV light and chemical mutagens.

Journal: Journal of applied genetics 20020101

Title: Oral administration of 5-methoxypsoralen affects the distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats.

Journal: In vivo (Athens, Greece) 20020101

Title: Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells.

Journal: The American journal of Chinese medicine 20020101

Title: Reversion mutation in dark variants of luminous bacteria and its application in gene toxicant monitoring.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

Title: Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Metabolic activation of three arylamines and two organophosphorus insecticides by coriander (Coriandrum sativum) a common edible vegetable.

Journal: Toxicology letters 20011215

Title: Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells.

Journal: Journal of assisted reproduction and genetics 20011201

Title: Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells.

Journal: Urological research 20011201

Title: Transient-resonance Raman and density functional theory investigation of 4-biphenylylnitrenium, 2-fluorenylnitrenium, and diphenylnitrenium ions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20011119

Title: Transformation of mutagenic aromatic amines into non-mutagenic species by alkyl substituents. Part I. Alkylation ortho to the amino function.

Journal: Mutation research 20011115

Title: Studies on the antimutagenesis of Phyllanthus orbicularis: mechanisms involved against aromatic amines.

Journal: Mutation research 20011115

Title: N-benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in short-term genotoxicity assays.

Journal: Mutagenesis 20011101

Title: S9 induction by the combined treatment with cyclohexanol and albendazole.

Journal: Mutagenesis 20011101

Title: Vitamin C inhibited DNA adduct formation and arylamine N-acetyltransferase activity and gene expression in rat glial tumor cells.

Journal: Neurochemical research 20011001

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Tags:153-78-6 Molecular Formula|153-78-6 MDL|153-78-6 SMILES|153-78-6 2-Aminofluorene |Organic_Building_Blocks