Title: Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.
Journal: Journal of medicinal chemistry 20180927
Title: Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Journal: Journal of medicinal chemistry 20131024
Title: Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110601
Title: Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells.
Journal: Toxicology and applied pharmacology 20091115
Title: Targets for neuroprotection in Parkinson's disease.
Journal: Biochimica et biophysica acta 20090701
Title: [Therapy of Parkinson's disease--up to date].
Journal: Rinsho shinkeigaku = Clinical neurology 20081101
Title: Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Journal: Journal of medicinal chemistry 20080925
Title: Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.
Journal: Molecular and cellular neurosciences 20080901
Title: CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Journal: Molecular and cellular neurosciences 20080901
Title: Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080116
Title: Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease.
Journal: Neurology 20071009
Title: Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells.
Journal: Nature neuroscience 20070601
Title: A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption.
Journal: Journal of neurochemistry 20060301
Title: Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
Journal: Expert opinion on investigational drugs 20051101
Title: Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706
Title: Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20050601
Title: Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis.
Journal: Frontiers in bioscience : a journal and virtual library 20050101
Title: Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040815
Title: Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity.
Journal: Experimental neurology 20040801
Title: American Chemical Society--227th annual meeting. Neuroprotection. 28 March - 1 April 2004, Anaheim, CA, USA.
Journal: IDrugs : the investigational drugs journal 20040501
Title: Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Journal: Brain research 20040402
Title: Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.
Journal: Biochimica et biophysica acta 20040311
Title: Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347.
Journal: Journal of neurochemistry 20040201
Title: Mixed-lineage kinases: a target for the prevention of neurodegeneration.
Journal: Annual review of pharmacology and toxicology 20040101
Title: JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents.
Journal: The Journal of biological chemistry 20030620
Title: K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.
Journal: The Journal of biological chemistry 20021220
Title: Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis.
Journal: Journal of neurochemistry 20021101
Title: Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity.
Journal: Journal of neurochemistry 20020901
Title: Mixed lineage kinase activity of indolocarbazole analogues.
Journal: Bioorganic & medicinal chemistry letters 20020121
Title: Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020101
Title: The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.
Journal: Cancer journal (Sudbury, Mass.) 20020101
Title: Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.
Journal: Progress in medicinal chemistry 20020101
Title: Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
Journal: The Journal of biological chemistry 20010706
Title: CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.
Journal: Journal of neurochemistry 20010501
Title: Stress kinase inhibition modulates acute experimental pancreatitis.
Journal: World journal of gastroenterology 20010415
Title: Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20000101
Title: CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
Journal: The Journal of pharmacology and experimental therapeutics 19990201
