Title: Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy.
Journal: Seizure 20120301
Title: Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: Dose-dependent pharmacokinetics of toxic metabolites is not related to increased toxicity following high-dose valproic acid in rats.
Journal: Journal of applied toxicology : JAT 20101101
Title: Formulations of valproate alter valproate metabolism: a single oral dose kinetic study.
Journal: Therapeutic drug monitoring 20091001
Title: The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid.
Journal: Archives of pharmacal research 20090701
Title: Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes.
Journal: FEBS letters 20081015
Title: Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Title: Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20061201
Title: Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
Journal: Biochemical pharmacology 20050515
Title: Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence?
Journal: Critical care (London, England) 20050101
Title: Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.
Journal: Chemico-biological interactions 20010928
Title: Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status.
Journal: Chemical research in toxicology 19950101
Title: Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.
Journal: Neurology 19920401
Title: Valproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicity.
Journal: Epilepsia 19920101
Title: On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid.
Journal: Die Naturwissenschaften 19910601
Title: Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.
Journal: Toxicology letters 19891001
