Home Other Building Blocks 159182-43-1
159182-43-1,MFCD08703099
Catalog No.:AA01E2D9

159182-43-1 | L-755507

Pack Size
Purity
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1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$263.00   $184.00
- +
25mg
98% by HPLC
in stock  
$582.00   $408.00
- +
50mg
98% by HPLC
in stock  
$947.00   $663.00
- +
100mg
98% by HPLC
in stock  
$1,592.00   $1,114.00
- +
500mg
98% by HPLC
in stock  
$4,996.00   $3,498.00
- +
1000mg
98% by HPLC
in stock  
$7,957.00   $5,570.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E2D9
Chemical Name:
L-755507
CAS Number:
159182-43-1
Molecular Formula:
C30H40N4O6S
Molecular Weight:
584.7268
MDL Number:
MFCD08703099
SMILES:
CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)CCNC[C@@H](COc1ccc(cc1)O)O
Properties
Computed Properties
 
Complexity:
817  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
17  
XLogP3:
4.3  

Literature

Title: Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?

Journal: American journal of physiology. Renal physiology 20120115

Title: The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.

Journal: British journal of pharmacology 20100701

Title: Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Journal: Journal of medicinal chemistry 20100114

Title: Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Journal: Journal of medicinal chemistry 20090409

Title: The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.

Journal: Molecular pharmacology 20081101

Title: Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Journal: Circulation 20011113

Title: (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.

Journal: Journal of medicinal chemistry 20010426

Title: 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

Journal: Bioorganic & medicinal chemistry letters 19980818

Title: Epidemiology and infection control.

Journal: Dimensions in health service 19751201

Title: Sato M, et al. The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonylamino-N---[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propylaminoethyl-phenyl-benzenesulfonamide (L755507) and antagonist (S)-N---[--(acetamidomethyl)phenoxy-2-hydroxypropylamino-ethylphenylbenzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74(5):1417-28.

Title: Guoling Li, et al. Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells. Sci Rep. 2017; 7: 8943.

Title: Murakami Y, et al. An effective double gene knock-in strategy using small-molecule L755507 in the medaka fish (Oryzias latipes). Genesis. 2022;60(1-2):e23465.

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