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159190-44-0,MFCD09878280
Catalog No.:AA01E2DA

159190-44-0 | N5-(1-Iminoethyl)-L-ornithineDihydrochloride

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10mg
95%
in stock  
$272.00   $190.00
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50mg
95%
in stock  
$788.00   $552.00
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100mg
95%
in stock  
$1,374.00   $962.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E2DA
Chemical Name:
N5-(1-Iminoethyl)-L-ornithineDihydrochloride
CAS Number:
159190-44-0
Molecular Formula:
C7H17Cl2N3O2
Molecular Weight:
246.1348
MDL Number:
MFCD09878280
SMILES:
CC(=N)NCCC[C@@H](C(=O)O)N.Cl.Cl
Properties
Computed Properties
 
Complexity:
180  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  

Literature

Title: Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products.

Journal: Antioxidants & redox signaling 20120801

Title: Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization.

Journal: Biochemical and biophysical research communications 20120203

Title: Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells.

Journal: British journal of pharmacology 20110901

Title: Nitric oxide influences red blood cell velocity independently of changes in the vascular tone.

Journal: Free radical research 20110601

Title: Differential contribution of mitochondria, NADPH oxidases, and glycolysis to region-specific oxidant stress in the anoxic-reoxygenated embryonic heart.

Journal: American journal of physiology. Heart and circulatory physiology 20110301

Title: Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage?

Journal: Journal of biosciences 20110301

Title: Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats.

Journal: Journal of biomedical science 20110101

Title: Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.

Journal: Oral diseases 20101101

Title: Effect of selective inhibitors of nitric oxide synthesis on the course of experimental hemorrhagic shock.

Journal: Bulletin of experimental biology and medicine 20101001

Title: Oxygen/ozone protects the heart from acute myocardial infarction through local increase of eNOS activity and endothelial progenitor cells recruitment.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100901

Title: Endothelial NOS-derived nitric oxide prevents injury resulting from reoxygenation in the hypoxic lung.

Journal: Free radical research 20100901

Title: Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.

Journal: Nature medicine 20090901

Title: Effects of endothelial NOS antagonism within the periaqueductal gray on cardiovascular responses and neurotransmission during mechanical, heat, and cold nociception.

Journal: Brain research 20081021

Title: Plasmodium falciparum: food vacuole localization of nitric oxide-derived species in intraerythrocytic stages of the malaria parasite.

Journal: Experimental parasitology 20080901

Title: Morphine, opioids, and the feline pulmonary vascular bed.

Journal: Acta anaesthesiologica Scandinavica 20080801

Title: The effect of nitric oxide on the production of cyclic AMP by a human osteoblast (HOS) cell line stimulated with hydroxyapatite.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080601

Title: Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier.

Journal: Endocrinology 20080401

Title: Simvastatin plus nitric oxide synthase inhibition modulates remote organ damage following skeletal muscle ischemia-reperfusion injury.

Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20080101

Title: Statin potentiates human platelet eNOS activity without enhancing eNOS mRNA and protein levels.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20080101

Title: The role of nitric oxide on the proliferation of a human osteoblast cell line stimulated with hydroxyapatite.

Journal: The Journal of oral implantology 20080101

Title: Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury.

Journal: The Journal of surgical research 20070801

Title: Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats.

Journal: Journal of vascular surgery 20070801

Title: Early and sharp nitric oxide production and anoxic depolarization in the rat hippocampus during transient forebrain ischemia.

Journal: European journal of pharmacology 20070712

Title: Differential signalling pathways involved in cholinoceptor-dependent stimulation of nitric oxide isoforms in dental pulp.

Journal: International endodontic journal 20070701

Title: L-nitroimidazole ornithine limits exercise-induced increases in cell proliferation in the hippocampus of adult mice.

Journal: Neuroreport 20060731

Title: The effect of nitric oxide on the production of prostaglandin E2 by hydroxyapatite-stimulated a human osteoblast (HOS) cell line.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20060501

Title: NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion.

Journal: Free radical biology & medicine 20060315

Title: Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury.

Journal: Journal of neurochemistry 20060201

Title: Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms.

Journal: Neuroscience letters 20060130

Title: Insulin prevents oxidant-induced endothelial cell barrier dysfunction via nitric oxide-dependent pathway.

Journal: Surgery 20060101

Title: Analysis of responses to kava kava in the feline pulmonary vascular bed.

Journal: Journal of medicinal food 20060101

Title: The release of nitric oxide from S-nitrosothiols promotes angiogenesis.

Journal: PloS one 20060101

Title: Modulation of mitochondrial Ca2+ by nitric oxide in cultured bovine vascular endothelial cells.

Journal: American journal of physiology. Cell physiology 20051001

Title: Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells.

Journal: British journal of pharmacology 20050901

Title: Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050801

Title: Neurochemistry within ventrolateral medulla and cardiovascular effects during static exercise following eNOS antagonism.

Journal: Neuroscience research 20050501

Title: Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.

Journal: The European journal of neuroscience 20050401

Title: eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.

Journal: Regulatory peptides 20050215

Title: Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.

Journal: Journal of the American Chemical Society 20050126

Title: No hemoglobin but NO: the icefish (Chionodraco hamatus) heart as a paradigm.

Journal: The Journal of experimental biology 20041001

Title: Cilostazol inhibits high glucose-mediated endothelial-neutrophil adhesion by decreasing adhesion molecule expression via NO production.

Journal: Microvascular research 20040901

Title: IL-5-Induced Eosinophils Suppress the Growth of Leishmania amazonensis In Vivo and Kill Promastigotes In Vitro in Response to Either IL-4 or IFN-gamma.

Journal: DNA and cell biology 20040701

Title: Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA.

Journal: Regulatory peptides 20040615

Title: Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

Journal: International journal of molecular medicine 20040401

Title: Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells.

Journal: American journal of physiology. Cell physiology 20040201

Title: Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.

Journal: Journal of herbal pharmacotherapy 20040101

Title: Role of the nitric-oxide synthase isoforms during morphine-induced hyperthermia in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20031001

Title: Control of cardiovascular function in the icefish Chionodraco hamatus: involvement of serotonin and nitric oxide.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030201

Title: Effect of endogenously generated nitric oxide on the energy metabolism of peritoneal macrophages.

Journal: Physiological chemistry and physics and medical NMR 20030101

Title: Different effects of eNOS and nNOS inhibition on transient forebrain ischemia.

Journal: Brain research 20020809

Title: Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice.

Journal: Journal of leukocyte biology 20011101

Title: Evidence for a spontaneous nitric oxide release from the rat median eminence: influence on gonadotropin-releasing hormone release.

Journal: Endocrinology 20010601

Title: Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.

Journal: Biochemistry 20010508

Title: Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla.

Journal: The Journal of experimental biology 20010501

Title: Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats.

Journal: The Journal of pharmacology and experimental therapeutics 20010201

Title: Nitric oxide generation by hemocytes of the mussel Mytilus galloprovincialis.

Journal: Nitric oxide : biology and chemistry 20010201

Title: Production and role of nitric oxide in the alveolar immune response to Pneumocystis carinii.

Journal: The Journal of eukaryotic microbiology 20010101

Title: Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension.

Journal: Life sciences 20000101

Title: Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9.

Title: Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

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