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159414-99-0,MFCD12912404
Catalog No.:AA007WHH

159414-99-0 | Dmt-2'-f-dc(ac) amidite

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$42.00   $29.00
- +
1g
98%
in stock  
$105.00   $74.00
- +
5g
98%
in stock  
$330.00   $231.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007WHH
Chemical Name:
Dmt-2'-f-dc(ac) amidite
CAS Number:
159414-99-0
Molecular Formula:
C41H49FN5O8P
Molecular Weight:
789.8286
MDL Number:
MFCD12912404
SMILES:
N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(c2ccc(cc2)OC)(c2ccc(cc2)OC)c2ccccc2)O[C@H]([C@@H]1F)n1ccc(nc1=O)NC(=O)C
Properties
Computed Properties
 
Complexity:
1360  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
56  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
18  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CHINOOKTHERAPEUTICSINC-WO2017/106740,2017,A1Locationinpatent:Paragraph00216;00217

[1]CurrentPatentAssignee:CHINOOKTHERAPEUTICSINC-WO2017/106740,2017,A1

[1]CurrentPatentAssignee:CHINOOKTHERAPEUTICSINC-WO2017/106740,2017,A1

octadecanedioicacidmono-triisopropylsilylester 
 
(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite 
  98796-51-1    146954-75-8    253586-13-9    253586-14-0   
3'-fluorescein-dT-CPG 
 
5'-(HOOC-(CH<SUB>2</SUB>)<SUB>16</SUB>-CONH-(CH<SUB>2</SUB>)<SUB>2</SUB>-O-(CH<SUB>2</SUB>)<SUB>2</SUB>-OPO<SUB>2</SUB>H-GGAC<SUP>F</SUP>C<SUP>F</SUP>AC<SUP>F</SUP>C<SUP>F</SUP>GC<SUP>F</SUP>AU<SUP>F</SUP>C<SUP>F</SUP>U<SUP>F</SUP>C<SUP>F</SUP>U<SUP>F</SUP>AC<SUP>F</SUP>AdTdT<SUP>FAM</SUP>)-3',2'F-pyrimidineisindicatedbyasuperscript<SUP>F</SUP>intheoligonucleotidesequence 

[1]Patent:WO2018/175592,2018,A1.Locationinpatent:Page/Pagecolumn27-30

octadecanedioicacidmono-triisopropylsilylester 
 
(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite 
  98796-51-1    146954-75-8    253586-13-9    253586-14-0   
dT-CPG 
 
5'-(HOOC-(CH<SUB>2</SUB>)<SUB>16</SUB>-CONH-(CH<SUB>2</SUB>)<SUB>2</SUB>-O-(CH<SUB>2</SUB>)<SUB>2</SUB>-OPO<SUB>2</SUB>H-GGAC<SUP>F</SUP>C<SUP>F</SUP>AC<SUP>F</SUP>C<SUP>F</SUP>GC<SUP>F</SUP>AU<SUP>F</SUP>C<SUP>F</SUP>U<SUP>F</SUP>C<SUP>F</SUP>U<SUP>F</SUP>AC<SUP>F</SUP>AdTdT)-3',2'F-pyrimidineisindicatedbyasuperscript<SUP>F</SUP>intheoligonucleotidesequence 

[1]Patent:WO2018/175592,2018,A1.Locationinpatent:Page/Pagecolumn27-31

Literature

Title: George Edwin KATIBAH, et al. Compositions and methods for activating "stimulator of interferon gene"-dependent signaling. WO2017075477A1.

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