[1]CurrentPatentAssignee:EMORYUNIVERSITY-WO2016/99982,2016,A2Locationinpatent:Page/Pagecolumn62
[2]CurrentPatentAssignee:EMORYUNIVERSITY-WO2017/223421,2017,A1Locationinpatent:Page/Pagecolumn75
Title: Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine.
Journal: Antimicrobial agents and chemotherapy 20130901
Title: Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU).
Journal: Nuclear medicine and biology 20121001
Title: Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120401
Title: [New drugs of treatment of patients with chronic hepatitis B].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20120401
Title: Normal-phase liquid chromatography coupled with electrospray ionization mass spectrometry for chiral separation and quantification of clevudine and its enantiomer in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120215
Title: Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Journal: The Journal of biological chemistry 20120102
Title: High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells.
Journal: BMC gastroenterology 20120101
Title: [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations.
Journal: Molecular imaging 20120101
Title: [New drugs of treatment of patients with chronic hepatitis B].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: Virologic and biochemical responses to clevudine in patients with chronic HBV infection-associated cirrhosis: data at week 48.
Journal: Journal of viral hepatitis 20110401
Title: 18F-FDG PET/CT of drug-induced myopathy in a patient with chronic hepatitis B on long-term clevudine therapy.
Journal: European journal of nuclear medicine and molecular imaging 20110401
Title: Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy.
Journal: Journal of gastroenterology 20110301
Title: Clevudine for chronic hepatitis B: antiviral response, predictors of response, and development of myopathy.
Journal: Journal of viral hepatitis 20110201
Title: Automated synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module.
Journal: Nuclear medicine and biology 20110201
Title: Comparison of clevudine and entecavir for treatment-naive patients with chronic hepatitis B virus infection: two-year follow-up data.
Journal: Journal of clinical gastroenterology 20110101
Title: [Treatment efficacy of clevudine, entecavir and lamivudine in treatment-naive patients with HBeAg-positive chronic hepatitis B].
Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20101201
Title: Efficacy of initial treatment with clevudine in naive patients with chronic hepatitis B.
Journal: The Korean journal of internal medicine 20101201
Title: Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100901
Title: Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study.
Journal: The Korean journal of hepatology 20100901
Title: Clinical, biochemical, and pathological characteristics of clevudine-associated myopathy.
Journal: Journal of hepatology 20100801
Title: Focus.
Journal: Journal of hepatology 20100801
Title: Comparison between clevudine and entecavir treatment for antiviral-naïve patients with chronic hepatitis B.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20100701
Title: Treatment outcomes of clevudine versus lamivudine at week 48 in naïve patients with HBeAg positive chronic hepatitis B.
Journal: Journal of Korean medical science 20100501
Title: Clevudine demonstrates potent antiviral activity in naïve chronic hepatitis B patients.
Journal: Intervirology 20100101
Title: Polymyositis in patients taking antiviral clevudine therapy: a report of two cases.
Journal: NeuroRehabilitation 20100101
Title: Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Journal: Antiviral therapy 20100101
Title: Clevudine myopathy in patients with chronic hepatitis B.
Journal: Journal of hepatology 20091001
Title: Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
Journal: Journal of hepatology 20091001
Title: [Efficacy of 48-week clevudine therapy for chronic hepatitis B].
Journal: The Korean journal of hepatology 20090901
Title: Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20090701
Title: Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA.
Journal: Hepatology (Baltimore, Md.) 20090601
Title: [Clevudine therapy in patients with chronic hepatitis B].
Journal: The Korean journal of hepatology 20090601
Title: [Long-term clevudine therapy in nucleos(t)ide-naïve and lamivudine-experienced patients with hepatitis B virus-related chronic liver diseases].
Journal: The Korean journal of hepatology 20090601
Title: [New molecules in the treatment of chronic hepatitis B].
Journal: Presse medicale (Paris, France : 1983) 20090501
Title: Clevudine for hepatitis B.
Journal: Drugs of today (Barcelona, Spain : 1998) 20090501
Title: Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study.
Journal: Antiviral therapy 20090101
Title: Clevudine: a promising therapy for the treatment of chronic hepatitis B.
Journal: Expert opinion on investigational drugs 20081201
Title: [Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B].
Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20081101
Title: Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.
Journal: European journal of nuclear medicine and molecular imaging 20080801
Title: Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B.
Journal: Alimentary pharmacology & therapeutics 20080601
Title: [Management of chronic hepatitis B in treatment-naive patients].
Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080601
Title: [Management of antiviral-resistant chronic hepatitis B virus infection].
Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080601
Title: Evaluation of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-beta-L: -arabinofuranosyluracil ([18F]-L: -FMAU) as a PET imaging agent for cellular proliferation: comparison with [18F]-D: -FMAU and [18F]FLT.
Journal: European journal of nuclear medicine and molecular imaging 20080501
Title: In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PET.
Journal: Nuclear medicine and biology 20080101
Title: New drugs for chronic hepatitis B: a review.
Journal: American journal of therapeutics 20080101
Title: Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes.
Journal: Antiviral therapy 20080101
Title: Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression.
Journal: Hepatology (Baltimore, Md.) 20071001
Title: Tumor imaging using 1-(2'-deoxy-2'-18F-fluoro-beta-D-arabinofuranosyl)thymine and PET.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070901
Title: Radiosynthesis of 2'-deoxy-2'-[18F]-fluoro-5-methyl-1-beta-L-arabinofuranosyluracil ([18F]-L-FMAU) for PET.
Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20070801
Title: 6-Chloro-3-(((1-[11C]methyl)-2-(S)-pyrrolidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine ([11C]JHU85270), a potent ligand for nicotinic acetylcholine receptor imaging by positron emission tomography.
Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20070801
Title: Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B.
Journal: Hepatology (Baltimore, Md.) 20070501
Title: Clevudine therapy for 24 weeks further reduced serum hepatitis B virus DNA levels and increased ALT normalization rates without emergence of viral breakthrough than 12 weeks of clevudine therapy.
Journal: Intervirology 20070101
Title: A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Journal: Antiviral therapy 20070101
Title: Hepatitis B virus treatment in HIV-infected patients.
Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA 20061201
Title: Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo.
Journal: Expert review of anti-infective therapy 20060801
Title: [Advances in the study of nucleoside antiviral drugs].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Title: A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B.
Journal: Hepatology (Baltimore, Md.) 20060501
Title: [Therapeutic approach to EBV infection].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060301
Title: Cellular and virological mechanisms of HBV drug resistance.
Journal: Journal of hepatology 20060201
Title: Rapid quantitative determination of L-FMAU-TP from human peripheral-blood mononuclear cells of hepatitis B virus-infected patients treated with L-FMAU by ion-pairing, reverse-phase, liquid chromatography/electrospray tandem mass spectrometry.
Journal: Therapeutic drug monitoring 20060201
Title: Clevudine for the treatment of chronic hepatitis B virus infection.
Journal: Expert opinion on investigational drugs 20051001
Title: Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models.
Journal: The Journal of antimicrobial chemotherapy 20050501
Title: Imaging DNA synthesis in vivo with 18F-FMAU and PET.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050201
Title: Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer.
Journal: European journal of nuclear medicine and molecular imaging 20050101
Title: Drugs in development for hepatitis B.
Journal: Drugs 20050101
Title: Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.
Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20050101
Title: Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection.
Journal: Antiviral therapy 20041201
Title: Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041001
Title: Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Journal: Virology 20040915
Title: A phase II dose-escalating trial of clevudine in patients with chronic hepatitis B.
Journal: Hepatology (Baltimore, Md.) 20040701
Title: [New approaches in the treatment of hepatitis B].
Journal: Deutsche medizinische Wochenschrift (1946) 20040521
Title: Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.
Journal: Nuclear medicine and biology 20040501
Title: Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model.
Journal: Molecular imaging 20040401
Title: New treatment of chronic hepatitis B.
Journal: Seminars in liver disease 20040101
Title: Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031201
Title: Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Journal: Antiviral chemistry & chemotherapy 20031101
Title: Effects of pyrimidine and purine analog combinations in the duck hepatitis B virus infection model.
Journal: Antimicrobial agents and chemotherapy 20030601
Title: Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU.
Journal: Nuclear medicine and biology 20030401
Title: Current and future antiviral agents for chronic hepatitis B.
Journal: The Journal of antimicrobial chemotherapy 20030301
Title: Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay.
Journal: Antimicrobial agents and chemotherapy 20030101
Title: In vitro activity of potential anti-poxvirus agents.
Journal: Antiviral research 20030101
Title: Entecavir, FTC, L-FMAU, LdT and others.
Journal: Journal of hepatology 20030101
Title: Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others).
Journal: Journal of hepatology 20030101
Title: Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies.
Journal: Bioorganic & medicinal chemistry letters 20021202
Title: Rat studies comparing 11C-FMAU, 18F-FLT, and 76Br-BFU as proliferation markers.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20021201
Title: Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.
Journal: Hepatology (Baltimore, Md.) 20020901
Title: Radiolabeled 2'-fluorodeoxyuracil-beta-D-arabinofuranoside (FAU) and 2'-fluoro-5-methyldeoxyuracil-beta -D-arabinofuranoside (FMAU) as tumor-imaging agents in mice.
Journal: Cancer chemotherapy and pharmacology 20020501
Title: [New management strategies for hepatitis B].
Journal: Gastroenterologie clinique et biologique 20020201
Title: New synthesis of L-FMAU from L-arabinose.
Journal: Nucleosides, nucleotides & nucleic acids 20020101
Title: Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection.
Journal: Intervirology 20020101
Title: Evaluation of 2'-deoxy-2'-flouro-5-methyl-1-beta-D-arabinofuranosyluracil as a potential gene imaging agent for HSV-tk expression in vivo.
Journal: Molecular imaging 20020101
Title: Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2'-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry.
Journal: Journal of medicinal chemistry 20011025
Title: In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Journal: Antimicrobial agents and chemotherapy 20010901
Title: Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax).
Journal: Hepatology (Baltimore, Md.) 20010101
Title: Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers.
Journal: Cancer letters 20010101
Title: Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.
Journal: Journal of medicinal chemistry 19990617
Title: Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
Journal: Biochemical pharmacology 19990615
Title: Synthesis and anti-hepatitis B virus activity of 9-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl) purine nucleosides.
Journal: Journal of medicinal chemistry 19970815
Title: Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents.
Journal: Journal of medicinal chemistry 19960705
Title: Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Journal: Biochemical pharmacology 19960412
Title: Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.
Journal: Antimicrobial agents and chemotherapy 19960201
Title: Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.
Journal: Antimicrobial agents and chemotherapy 19900301
Title: Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys.
Journal: Antimicrobial agents and chemotherapy 19860101
Title: Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides.
Journal: Antiviral research 19851001
Title: Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Journal: Antimicrobial agents and chemotherapy 19830701
Title: Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.
Journal: Antimicrobial agents and chemotherapy 19830601
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