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165450-17-9,MFCD09039056
Catalog No.:AA001W2V

165450-17-9 | Neotame

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Purity
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5g
99% (contains <5%H2O)
in stock  
$7.00   $5.00
- +
10g
99% (contains <5%H2O)
in stock  
$9.00   $7.00
- +
100g
99% (contains <5%H2O)
in stock  
$39.00   $28.00
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500g
99% (contains <5%H2O)
in stock  
$167.00   $117.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001W2V
Chemical Name:
Neotame
CAS Number:
165450-17-9
Molecular Formula:
C20H30N2O5
Molecular Weight:
378.4626
MDL Number:
MFCD09039056
SMILES:
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NCCC(C)(C)C
Properties
Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
12  
XLogP3:
-0.1  

Upstream Synthesis Route

[1]Patent:US6914151,2005,B1,.Locationinpatent:Page/Pagecolumn5-6

[2]ActaCrystallographicaSectionC:CrystalStructureCommunications,1999,vol.55,#8,p.1365-1368

[3]SyntheticCommunications,1999,vol.29,#24,p.4461-4467

[1]Patent:CN105585514,2016,A,.Locationinpatent:Paragraph0036;0037

Downstream Synthesis Route

[1]Patent:US6914151,2005,B1.Locationinpatent:Page/Pagecolumn5-6

[2]ActaCrystallographica,SectionC:CrystalStructureCommunications,1999,vol.55,p.1365-1368

[3]SyntheticCommunications,1999,vol.29,p.4461-4467

165450-17-9   
N-(3,3-dimethylbutyl)-L-α-aspartyl-L-phenylalanine 

[1]JournalofChemicalCrystallography,2005,vol.35,p.233-241

C6H13O4S(1-)*Na(1+) 
  22839-65-2    165450-17-9 

[1]Patent:CN105585514,2016,A.Locationinpatent:Paragraph0036;0037

Literature

Title: Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.

Journal: Journal of chromatography. A 20121109

Title: Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.

Journal: Biochemical and biophysical research communications 20121019

Title: Artificial sweeteners--a recently recognized class of emerging environmental contaminants: a review.

Journal: Analytical and bioanalytical chemistry 20120701

Title: Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners.

Journal: Journal of the Academy of Nutrition and Dietetics 20120501

Title: Nonnutritive, low caloric substitutes for food sugars: clinical implications for addressing the incidence of dental caries and overweight/obesity.

Journal: International journal of dentistry 20120101

Title: Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds.

Journal: PloS one 20120101

Title: Taste quality and intensity of 100 stimuli as reported by rats: the taste-location association task.

Journal: Frontiers in behavioral neuroscience 20120101

Title: The content of high-intensity sweeteners in different categories of foods available on the Polish market.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

Title: Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20120101

Title: Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.

Journal: Biochemical and biophysical research communications 20111216

Title: Advantame--an overview of the toxicity data.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

Title: Pharmacokinetics and metabolism of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

Title: [Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation].

Journal: Se pu = Chinese journal of chromatography 20111001

Title: Molecular mechanism of species-dependent sweet taste toward artificial sweeteners.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

Title: Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.

Journal: Analytical and bioanalytical chemistry 20110601

Title: Nonnutritive sweeteners, fructose, and other aspects of diet.

Journal: Diabetes care 20110501

Title: Sugar substitutes: Health controversy over perceived benefits.

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: [Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20101101

Title: Retention behaviour of some high-intensity sweeteners on different SPE sorbents.

Journal: Talanta 20101015

Title: Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.

Journal: The Journal of biological chemistry 20100903

Title: Determination of neotame in beverages, cakes and preserved fruits by column-switching high-performance liquid chromatography.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100901

Title: [Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20100801

Title: Gain weight by 'going diet?' Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010.

Journal: The Yale journal of biology and medicine 20100601

Title: Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.

Journal: Journal of molecular biology 20100514

Title: Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20100309

Title: Standards of medical care in diabetes--2010.

Journal: Diabetes care 20100101

Title: Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).

Journal: Analytical and bioanalytical chemistry 20090701

Title: Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.

Journal: Journal of agricultural and food chemistry 20090422

Title: Standards of medical care in diabetes--2009.

Journal: Diabetes care 20090101

Title: Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora.

Journal: The Journal of heredity 20090101

Title: Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study.

Journal: Journal of AOAC International 20090101

Title: [Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20090101

Title: Development of rebiana, a natural, non-caloric sweetener.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

Title: The potential toxicity of artificial sweeteners.

Journal: AAOHN journal : official journal of the American Association of Occupational Health Nurses 20080601

Title: [Simultaneous determination of neotame, alitame and aspartame in foods by HPLC].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080201

Title: Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation.

Journal: Journal of chromatography. A 20070720

Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Journal: BMC structural biology 20070101

Title: Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice.

Journal: Chemical senses 20060701

Title: The G protein-coupled receptor subset of the chicken genome.

Journal: PLoS computational biology 20060601

Title: The heterodimeric sweet taste receptor has multiple potential ligand binding sites.

Journal: Current pharmaceutical design 20060101

Title: Artificial sweeteners: no calories...sweet!

Journal: FDA consumer 20060101

Title: Quantitation of crystalline and amorphous forms of anhydrous neotame using 13C CPMAS NMR spectroscopy.

Journal: Journal of pharmaceutical sciences 20051201

Title: Artificial sweeteners--do they bear a carcinogenic risk?

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20041001

Title: Different functional roles of T1R subunits in the heteromeric taste receptors.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20040928

Title: Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners.

Journal: Journal of the American Dietetic Association 20040201

Title: Evaluation of certain food additives and contaminants.

Journal: World Health Organization technical report series 20040101

Title: [Effect of food additive Neotame (N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine-1-methyl) on glucose level in blood of patients with diabetes mellitus type 2].

Journal: Voprosy pitaniia 20040101

Title: Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies.

Journal: Regulatory toxicology and pharmacology : RTP 20031001

Title: Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions.

Journal: Regulatory toxicology and pharmacology : RTP 20031001

Title: Crystal structure of neotame anhydrate polymorph G.

Journal: Pharmaceutical research 20021001

Title: Conformational flexibility and hydrogen-bonding patterns of the neotame molecule in its various solid forms.

Journal: Journal of pharmaceutical sciences 20020901

Title: Neotame anhydrate polymorphs. II: Quantitation and relative physical stability.

Journal: Pharmaceutical research 20020901

Title: Neotame - a new artificial sweetener.

Journal: The Medical letter on drugs and therapeutics 20020819

Title: Dehydration kinetics of neotame monohydrate.

Journal: Journal of pharmaceutical sciences 20020601

Title: Neotame anhydrate polymorphs I: preparation and characterization.

Journal: Pharmaceutical research 20020301

Title: Structure, dynamics, and stability of beta-cyclodextrin inclusion complexes of aspartame and neotame.

Journal: Journal of agricultural and food chemistry 20010401

Title: Modifying the temporal profile of the high-potency sweetener neotame.

Journal: Journal of agricultural and food chemistry 20010201

Title: Liang Chi, et al. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules. 2018 Feb 9;23(2):367.

Title: Anuradha Kumari, et al. Stability of Aspartame and Neotame in Pasteurized and In-Bottle Sterilized Flavoured Milk. Food Chem. 2016 Apr 1;196:533-8.

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