+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Amines 1660963-42-7
1660963-42-7,MFCD30345533
Catalog No.:AA001WEA

1660963-42-7 | N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$129.00   $90.00
- +
250mg
95%
in stock  
$208.00   $145.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001WEA
Chemical Name:
N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide
CAS Number:
1660963-42-7
Molecular Formula:
C29H28F2N6O2
Molecular Weight:
530.5684
MDL Number:
MFCD30345533
SMILES:
OCCN1CCN(CC1)c1ccc(c(c1F)F)Nc1ncc2c(n1)c(ccc2)c1cccc(c1)NC(=O)C=C
Properties
Computed Properties
 
Complexity:
815  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
4.3  

Downstream Synthesis Route
331647-05-3   
N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide 

[1]Patent:WO2015/27222,2015,A2

[1]CurrentPatentAssignee:NEUPHARMAINC-WO2015/27222,2015,A2

[1]CurrentPatentAssignee:NEUPHARMAINC-WO2015/27222,2015,A2Locationinpatent:Paragraph0450

[2]CurrentPatentAssignee:NEUPHARMAINC-WO2019/157225,2019,A2Locationinpatent:Paragraph0252;0257

[1]CurrentPatentAssignee:NEUPHARMAINC-WO2015/27222,2015,A2

956100-63-3   
N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide 

[1]Patent:WO2015/27222,2015,A2

[2]Patent:WO2019/157225,2019,A2

Literature

Title: Misako Nagasaka, et al. Beyond osimertinib: The development of 3 rd-generation EGFR Tyrosine Kinase Inhibitors. J Thorac Oncol. 2020 Dec 15;S1556-0864(20)31105-9.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1660963-42-7
Building Blocks
More >
Tags:1660963-42-7 Molecular Formula|1660963-42-7 MDL|1660963-42-7 SMILES|1660963-42-7 N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide